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Human hair samples from various areas were collected and analyzed for multielement contents. A correlation analysis was performed to determine the relation between trace element contents in hair and prevalence rate of Kaschin- Beck disease. It was shown that the low content of selenium in the environment is one of the important factor causing the disease. The same conclusion was reached by both epidemio-logical investigation, and geochemical study.The other possible factors were also discussed. 本文通过对大骨节病病区低硒环境和病区发样品的重复采样和多元素含量的测定及其与大骨节病病情的相关分析,探讨了大骨节病的致病因素。研究表明,环境低硒是大骨节病发生的重要因素之一。人发硒与大骨节病检出率密切相关,且由永寿大骨节病考察队流行病学组和生态环境组调查数据得到了相同的结论。本文还探讨了除低硒外,其它与硒有关、可能与之结合致病的因素。 The behavior, memory and synaptic protein phosphorylation of the main brain areas were compared between mice reared in enriched conditions (EC) and impoverished conditions (IC), and the changes of levels of synaptic protein phospohorylation in both untrained and trained mice were observed. Synaptosomes were prepared from mice reared in different types of environment and following training. The protein phosphorylation levels were detected by labelling with γ-~(32)P-ATP in vitro. The main results are as follows:... The behavior, memory and synaptic protein phosphorylation of the main brain areas were compared between mice reared in enriched conditions (EC) and impoverished conditions (IC), and the changes of levels of synaptic protein phospohorylation in both untrained and trained mice were observed. Synaptosomes were prepared from mice reared in different types of environment and following training. The protein phosphorylation levels were detected by labelling with γ-~(32)P-ATP in vitro. The main results are as follows: (1) The alterations of protein phosphorylation of cerebellum of EC mice may be related to their adaptation to the complex environment; (2) Memory was facilitated by the environmental enrichment; (3) Levels of protein phosphoryation of EC's left and right hippocampi rose significantly through training. These data suggest that the different behaviors and memory of EC and IC mice may be related to the changes of protein phosphorylation of the relative brain areas, which are induced by different environments. 本实验通过离体测定小鼠脑突触蛋白磷酸化水平探讨了丰富和单调环境饲养下小鼠行为、记忆差异的脑内突触化学机制。结果如下:(1)丰富环境小鼠小脑半球突触蛋白磷酸化水平的显著变化可能与小鼠对环境的适应有关;(2)丰富环境可增强记忆保持力;(3)两组小鼠行为训练后各脑区突触蛋白磷酸化水平的变化有差异,丰富环境组小鼠左、右海马测定值均升高。表明:不同环境小鼠行为、记忆的差异可能与环境对某些脑区突触蛋白磷酸化作用的影响有关。 The behavior, memory and synaptic protein phosphorylation of the main brain areas were compared between mice reared in enriched conditions (EC) and impoverished conditions (IC), and the changes of levels of synaptic protein phospohorylation in both untrained and trained mice were observed. Synaptosomes were prepared from mice reared in different types of environment and following training. The protein phosphorylation levels were detected by labelling with γ-~(32)P-ATP in vitro. The main results are as follows:... The behavior, memory and synaptic protein phosphorylation of the main brain areas were compared between mice reared in enriched conditions (EC) and impoverished conditions (IC), and the changes of levels of synaptic protein phospohorylation in both untrained and trained mice were observed. Synaptosomes were prepared from mice reared in different types of environment and following training. The protein phosphorylation levels were detected by labelling with γ-~(32)P-ATP in vitro. The main results are as follows: (1) The alterations of protein phosphorylation of cerebellum of EC mice may be related to their adaptation to the complex environment; (2) Memory was facilitated by the environmental enrichment; (3) Levels of protein phosphoryation of EC's left and right hippocampi rose significantly through training. These data suggest that the different behaviors and memory of EC and IC mice may be related to the changes of protein phosphorylation of the relative brain areas, which are induced by different environments. 本实验通过离体测定小鼠脑突触蛋白磷酸化水平探讨了丰富和单调环境饲养下小鼠行为、记忆差异的脑内突触化学机制。结果如下:(1)丰富环境小鼠小脑半球突触蛋白磷酸化水平的显著变化可能与小鼠对环境的适应有关;(2)丰富环境可增强记忆保持力;(3)两组小鼠行为训练后各脑区突触蛋白磷酸化水平的变化有差异,丰富环境组小鼠左、右海马测定值均升高。表明:不同环境小鼠行为、记忆的差异可能与环境对某些脑区突触蛋白磷酸化作用的影响有关。
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