Conclusion NF-κ B may regulate the expression of genes associated with graft rejection, and thus play a role of center-control in the occurance and development of corneal graft rejective reaction.
CONCLUSION: NF-κB may be involved in the occurrence of corneal graft rejective reaction and plays a role of center-control in the immunity of corneal graft by regulating the expressions of genes associated with graft rejection, such as ICAM-1. Ciclosporin A can inhibit the corneal graft rejective reaction by inhibiting NF-κB nuclear translocation and activity.
Conclusion NF- κ B may regulate the expression of genes associated with graft rejective and corneal neovascularization(CNV), such as ICAM- 1 and VEGF expression, and thus play a role of center- control in the occurrence and development of corneal graft rejective reaction.
MPF(M phase Promoting Factor) which is made up of Cdc2 as the active subunit and Cyclin B as the regular subunit is a key factor in cell division. Cdc2 is the active part of the MPF, which can active multiple Ser/Thr.
Recent findings reveal that the target of rapamycin TOR controls an unusually abundant and diverse set of readouts all of which are important for cell growth, suggesting that this conserved kinase is such a central regulator.
近年来研究表明,雷帕霉素靶(mammalian target of rapamycin,mTOR)蛋白在细胞生长的信号转导过程中具有十分重要的作用,是细胞生长的中心调控因子。
VEGF is the only diffusible endothelial cell-specific mitogen that induces endo-thelial-cell proliferation and increases vascular permeability, so it is also called vascular permeability factor ( VPF). VEGF is a central angiogenesis-stimulator.
By using N 2O synchronized HeLa cells as a model, the effect of PKC activation and inhibition on HeLa cell G 1 to S phase progression was investigated. It was found that this process was remarkably influenced by TPA and GF 109203X treatment, which was the activator and inhibitor of PKC respectively. TPA (100 μg/L) could promote G 1/S progression; on the contrary, it was inhibited by GF 109203X (4 mg/L) treatment. Further study discovered this change was related to PKC activity. TPA treatment promoted P...
Ninety-seven Erhualian pig (Sus scrofa Erhua) from 21 litters were divided into 6 groups according to their day age distribution, group 1: 49 d, group 2: 58-60 d, group 3: 61-70 d, group 4: 71-80 d, group 5: 81-90 d, group 6: 228 d. The longissimus over the last second to third vertebra thoracica and the middle part of the semitendinosus were taken to study the muscular histological characteristics by tissue paraffin section-image analyzing method. The longissimus over the second to fifth vetebra lumbalis w...
Mitochondria play a major role in apoptosis triggered by many stimuli.The various death signals induce di-rectly and indirectly(through Bcl-2family proteins)the increase of mitochondrial membrane permeability,the release of cytochrome c and the activation of caspases.The mechanisms that lead to this permeability are not yet completely under-stood.Here,we review briefly the mechanisms of mitochondrial control during apoptosis and the possible effects of ioniz-ing radiation in their mechanisms.