中心调控 center-control(3) 目前没有对本词条修改信息

center-control     Conclusion NF-κ B may regulate the expression of genes associated with graft rejection, and thus play a role of center-control in the occurance and development of corneal graft rejective reaction.     结论:核因子-κB可能通过调控免疫和炎症相关基因的表达,参与角膜移植排斥反应的发生,在角膜移植免疫中起着中心调控者的作用。 短句来源     CONCLUSION: NF-κB may be involved in the occurrence of corneal graft rejective reaction and plays a role of center-control in the immunity of corneal graft by regulating the expressions of genes associated with graft rejection, such as ICAM-1. Ciclosporin A can inhibit the corneal graft rejective reaction by inhibiting NF-κB nuclear translocation and activity.     结论:核因子-κB可能通过调控细胞间黏附分子-1等基因的表达,参与角膜移植排斥反应的发生,在角膜移植免疫中起着中心调控者的作用。 而免疫抑制剂CsA通过减弱核因子-κB核转位和发挥活性,抑制排斥反应。 短句来源     Conclusion NF- κ B may regulate the expression of genes associated with graft rejective and corneal neovascularization(CNV), such as ICAM- 1 and VEGF expression, and thus play a role of center- control in the occurrence and development of corneal graft rejective reaction.     结论:NF-κB可能通过调控ICAM-1、VEGF等基因的表达,参与角膜移植排斥反应及角膜新生血管形成,起着中心调控者的作用。 短句来源 查询“中心调控”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句

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Objective To investigate the expression of NF-κ B in corneal graft rejective reaction in rats. Methods The model of orthotopical corneal transplantation was developed in rats. The rats were divided into two groups: syngeneic control (Wistar to Wistar) and allograft group (Wistar to SD). Immunohistochemistry staining was used to analyze NF-κ B expression of corneal graft in each group. Results NF-κ B was weakly expressed on keratocytes, corneal endothelial cells and not expressed on corneal endothelial cells...             目的:研究核因子-κB在角膜移植排斥反应中的作用,为进一步研究角膜移植排斥反应发病机制及治疗提供新的思路。方法:建立大鼠穿透性角膜移植动物模型,用免疫组织化学染色法检测角膜移植术后植片中核因子-κB表达,并以植片排斥反应指数(RI)及病理学表现作参照。结果:同基因移植组角膜植片中的角膜基质细胞及内皮细胞有核因子-κB的微弱表达;同种异体移植组角膜上皮细胞、内皮细胞、基质层细胞及新生血管内皮细胞核因子-κB表达增强。各组间核因子-κB的表达强度差异有显著性(P<0.01)。且核因子-κB的表达强度与排斥反应指数(RI)具有明显的正相关性(r=0.883,P<0.01)。结论:核因子-κB可能通过调控免疫和炎症相关基因的表达,参与角膜移植排斥反应的发生,在角膜移植免疫中起着中心调控者的作用。 文摘来源          AIM: To investigate the role of nuclear factor-kappa B (NF-κB) in corneal graft rejective reaction, so as to provide new thought for the further research of the pathogenesis and treatment of corneal graft rejective reaction. METHODS: The experiment was carried out in the Department of Ophthalmology, Zhujiang Hospital of Southern Medical University between December 2004 and February 2005. Grouping: homogenic transplantation group (5 Wistar rats as donors and 10 Wistar rats as recipients), allograft group (5 ...             目的:探讨核因子-κB在角膜移植排斥反应中的作用,为进一步研究角膜移植排斥反应发病机制及治疗提供新的思路。方法:实验于2004-12/2005-02在南方医科大学珠江医院眼科完成。实验分组:同基因移植组Wistar大鼠5只为供者,Wistar大鼠10只为受者;同种异体移植组Wistar大鼠5只为供者,SD大鼠10只为受者。同种异体移植+环孢素A治疗组Wistar大鼠5只为供者,SD大鼠10只为受者。建立大鼠穿透性角膜移植动物模型,用免疫组织化学染色法检测角膜移植术后植片中核因子-κB和细胞间黏附分子-1表达,显微镜下记数植片中央区400倍视野中阳性细胞数的平均值,并以植片排斥反应指数及病理学表现作参照。结果:纳入实验大鼠30只,均进入结果分析。①同基因移植组角膜植片中的角膜上皮细胞、基质细胞及内皮细胞有核因子-κB和细胞间黏附分子-1的微弱表达,表达强度分别为3.16±1.25,2.83±1.54;同种异体移植组角膜上皮细胞、内皮细胞、基质层细胞及新生血管内皮细胞核因子-κB和细胞间黏附分子-1表达增强,分别为16.77±2.76,13.63±1.93;同种异体移植环孢素A治疗组角膜上皮细胞、内皮细胞、基质层... 文摘来源          Objective To investigate the expressions of nuclear factor- κ B(NF- κ B), intercellular adhesion molecule- 1 (ICAM- 1) and vascular endothelial growth factor (VEGF) in rat corneas, and to analyze their roles in the corneal allograft rejection. Method Five Wistar rats were applied, and the expressions and distributions of NF- κ B, ICAM- 1 and VEGF in cornea were detected with immunohistochemical methods and image analysis. Results NF- κ B and ICAM- 1,VEGF were weekly expressed in basal layer of corneal epit...             目的:研究核因子-κB(NF-κB)及其下游因子细胞间黏附分子-1(ICAM-1)、血管内皮生长因子(VEGF)在正常角膜中的表达规律,为进一步研究角膜移植排斥反应的发病机制及治疗提供新的思路。方法:健康清洁级Wistar大鼠5只,体重200～250g。10%水合氯醛溶液腹腔注射麻醉后立即摘除眼球共10个,剪下完整角膜(带角膜缘),置于4%多聚甲醛溶液固定,常规石蜡包埋,切片。每份标本连续制作4张4μm切片,1张行HE染色,其余3张分别用于NF-κB、ICAM-1、VEGF的免疫组织化学染色(SABC法)检测。结果:正常的大鼠角膜中,NF-κB及其下游因子ICAM-1、VEGF在角膜上皮层细胞内有较弱的基础表达,主要表达在基底层细胞;而在角膜基质层及内皮细胞未见阳性表达;NF-κB、ICAM-1、VEGF在正常大鼠角膜的表达部位及表达强度具有良好的一致性。结论:NF-κB可能通过调控ICAM-1、VEGF等基因的表达,参与角膜移植排斥反应及角膜新生血管形成,起着中心调控者的作用。 文摘来源

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