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激素非依赖性前列腺癌细胞
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  independent prostate cancer cells
     Growth Inhibitory Effects and Mechanism of ATRA Combined with IFN-α and Rh_2 on Hormone Independent Prostate Cancer Cells
     ATRA联合IFN-α及Rh_2对激素非依赖性前列腺癌细胞的生长抑制作用及其机制的研究
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  hormone-independent prostate cancer cell
     Objective To construct an eukaryotic expression vector of human ERβ(hERβ) full length gene which named pEGFP-C1-hERβ and transfect it into hormone-independent prostate cancer cell line PC-3M.
     目的:构建人雌激素受体β(hERβ)全长基因的真核表达载体pEGFP-C1-hERβ,并转染激素非依赖性前列腺癌细胞株PC-3M。
短句来源
     AIM: To study the role of androgen receptor (AR) in hormone-dependent and hormone-independent prostate cancer cell proliferation by knocking down AR expression with adenovirus-delivered siRNA.
     目的 :利用RNA干涉技术抑制雄激素受体 (AR)的表达 ,研究AR在激素依赖性和激素非依赖性前列腺癌细胞增殖中的作用。
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  “激素非依赖性前列腺癌细胞”译为未确定词的双语例句
     Role of ERβ on Proliferation and Apoptosis in Hormone Independent Prostate Cancer Cell Line PC-3 and PC-3M
     ERβ对激素非依赖性前列腺癌细胞株PC-3和PC-3M增殖和凋亡的影响
短句来源
     Objective To study the inhibitory effect of(3,3)-Diindolylmethane(DIM) on PC3M cells.
     目的:探讨3,3-二吲哚基甲烷(3,3-Diindolylmethane,DIM)对人激素非依赖性前列腺癌细胞PC3M的生长抑制作用。
短句来源
     Inhibitory effect of DIM on growth of human prostate cancer cell PC3M
     DIM对人激素非依赖性前列腺癌细胞PC3M的生长抑制作用
短句来源
     The effect of Cyclin D1 antisense oligodexoyneucleotides on the proliferation of an drogen-independent prostate cancer cells
     细胞周期素D1反义寡核苷酸对激素非依赖性前列腺癌细胞增殖的影响
短句来源
     Conclusions Chlorophyll derivative based photodynamic therapy is able to induce apoptosis of PC3 in vitro. Mitochondria is presumed to be the primary target of photodynamic therapy and trigger the apoptotic pathway.
     结论叶绿素光敏剂结合650nm半导体激光照射能诱导激素非依赖性前列腺癌细胞PC3出现凋亡改变,线粒体是光动力学的原始靶位,叶绿素-光动力学疗法通过线粒体途经激活细胞凋亡。
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  相似匹配句对
     Effect and Possible Mechanism of Melatonin on the Hormone Independent Human Prostatic Carcinoma Cell
     褪黑素对人激素依赖性前列腺癌细胞的作用及其部分机制
短句来源
     Establishment of Androgen-independent Human Prostate Cancer LNCaP Cell Model and Study on Molecular Alterations
     激素依赖性LNCaP前列腺癌细胞亚系模型的建立及机制的研究
短句来源
     Establishment of androgen-independent human prostate cancer cell strain,LNCaP C-81
     人类雄激素依赖性前列腺癌细胞模型的建立
短句来源
     Inhibitory effect of DIM on growth of human prostate cancer cell PC3M
     DIM对人激素依赖性前列腺癌细胞PC3M的生长抑制作用
短句来源
     Inhibition of polypeptide extract from scorpion venom(PESV) against proliferation of Prostate cancer androgen-independent cell lines in vitro
     蝎毒多肽提取物对激素依赖性前列腺癌细胞增殖抑制作用的实验研究
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  independent prostate cancer cells
Quercetin is a novel antitumor and antioxidant, whose molecular mechanism involved in cell cycle arrest in androgen independent prostate cancer cells remains unclear.
      
In this review, we summarized recent advances made in delineating molecular mechanisms underlying stromal epithelial interaction and clonal interaction between androgen-dependent and androgen-independent prostate cancer cells in vivo and in culture.
      
GC79/TRPS1 expression in androgen-dependent prostate cancer cells is repressed by androgens, while GC79/TRPS1 expression is hardly detectable in androgen-independent prostate cancer cells under cell culture conditions.
      
This suggests that lack of GC79/TRPS1 expression could be a mechanism for the inability to induce the apoptotic pathway in androgen-independent prostate cancer cells after androgen withdrawal.
      
Resveratrol Antagonizes EGFR-Dependent Erk1/2 Activation in Human Androgen-Independent Prostate Cancer Cells with Associated Iso
      
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  hormone-independent prostate cancer cell
We also demonstrated that the growth of hormone-independent prostate cancer cell lines can be inhibited by the anti-NF-κB reagent N-acetyl-L-cysteine (NAC).
      


AIM: To study the role of androgen receptor (AR) in hormone-dependent and hormone-independent prostate cancer cell proliferation by knocking down AR expression with adenovirus-delivered siRNA. METHODS: Four well-designed siRNAs were synthesized and inserted into the adenovirus plasmid pShuttle-H1-Ri. The recombinant pShuttle-H1-Ri-AR plasmid was then co-transfected with pcDNA-AR to HEK293 cell line and Western blot was used to detect the inhibitory efficiency of different siRNAs on AR expression. Recombinant...

AIM: To study the role of androgen receptor (AR) in hormone-dependent and hormone-independent prostate cancer cell proliferation by knocking down AR expression with adenovirus-delivered siRNA. METHODS: Four well-designed siRNAs were synthesized and inserted into the adenovirus plasmid pShuttle-H1-Ri. The recombinant pShuttle-H1-Ri-AR plasmid was then co-transfected with pcDNA-AR to HEK293 cell line and Western blot was used to detect the inhibitory efficiency of different siRNAs on AR expression. Recombinant adenovirus containing more efficient siRNAs were prepared and used to infect three different humane prostate cancer cell lines including LNCapC4-2B and CWR22Rv1. The efficiency of knocking down AR expression was detected by Western blot. The effect of AR-knocking down on cell proliferation was detected by MTT colorimetric assay. RESULTS: All of the four designed siRNAs could knock down AR expression in transient co-transfection. Infecting with recombinant adenovirus containing more efficient siRNAs in hormone-dependent and hormone-independent prostate cancer cell lines specifically knocked down AR expression with high efficiency. Knocking down AR expression significantly decreased the proliferation rate in all these prostate cancer cells. CONCLUSION: The suppressed expression of AR in prostate cell lines mediated by siRNA could efficiently inhibit the cell proliferation, and these results show that AR plays an important role in the proliferation of hormone-dependent and hormone-independent prostate cancer cells. AR is an important therapeutic target for the treatment of prostate cancer.

目的 :利用RNA干涉技术抑制雄激素受体 (AR)的表达 ,研究AR在激素依赖性和激素非依赖性前列腺癌细胞增殖中的作用。方法 :设计、合成针对AR的 4种不同的小干涉RNA(siRNA) ,连接到带有人H1启动子的腺病毒载体质粒pShuttle -H1-Ri中 ,构建成能产生AR -siRNA的质粒pShuttle -H1-Ri-AR ,与能表达AR的质粒pcDNA -AR共转染HEK2 93细胞 ,Westernblot检测不同的siRNA对AR表达的抑制效率 ,选取抑制效率高的siRNA制备重组腺病毒 ,感染LNCap、C4 - 2B和CWR2 2Rv13种对雄激素有不同反应性的人前列腺癌细胞 ,采用Westernblot检测感染后细胞中AR的表达程度 ,并用MTT比色法测定细胞的增殖活性。结果 :4种siRNA都能抑制共转染AR的表达 ,用抑制效率高的siRNA制备重组腺病毒感染 3种靶细胞后 ,均能特异性地抑制 3种细胞中AR的表达 ,细胞的增殖活性也随之明显下降。结论 :AR -siRNA通过抑制激素依赖性和激素非依赖性前列腺癌细胞中AR的表达 ,有效地抑制细胞的增殖 ,AR...

目的 :利用RNA干涉技术抑制雄激素受体 (AR)的表达 ,研究AR在激素依赖性和激素非依赖性前列腺癌细胞增殖中的作用。方法 :设计、合成针对AR的 4种不同的小干涉RNA(siRNA) ,连接到带有人H1启动子的腺病毒载体质粒pShuttle -H1-Ri中 ,构建成能产生AR -siRNA的质粒pShuttle -H1-Ri-AR ,与能表达AR的质粒pcDNA -AR共转染HEK2 93细胞 ,Westernblot检测不同的siRNA对AR表达的抑制效率 ,选取抑制效率高的siRNA制备重组腺病毒 ,感染LNCap、C4 - 2B和CWR2 2Rv13种对雄激素有不同反应性的人前列腺癌细胞 ,采用Westernblot检测感染后细胞中AR的表达程度 ,并用MTT比色法测定细胞的增殖活性。结果 :4种siRNA都能抑制共转染AR的表达 ,用抑制效率高的siRNA制备重组腺病毒感染 3种靶细胞后 ,均能特异性地抑制 3种细胞中AR的表达 ,细胞的增殖活性也随之明显下降。结论 :AR -siRNA通过抑制激素依赖性和激素非依赖性前列腺癌细胞中AR的表达 ,有效地抑制细胞的增殖 ,AR对维持激素依赖性和激素非依赖性前列腺癌细胞的增殖活性具有十分重要的作用 ,是治疗前列腺癌的重要靶分子。

Objective To observe the effect of docetaxol on androgen-independent prostate cancer cell line PC-3 in vitro and in vivo. Methods Cell morphology, MTT, flow cytometer, immunocytochemical method were used toobserve the effect of 10-6mol/L、10-7mol/L、10-8mol/L docetaxol on prostate cancer cell line PC-3 in vitro. MaleBALB/C-nu mice with PC-3 prostate cancer cell lines were treated by docetaxol in vivo. Serum PSA of mice, weightsof mice and PSA expression in xenograft tumors of mice by immunohistochemical...

Objective To observe the effect of docetaxol on androgen-independent prostate cancer cell line PC-3 in vitro and in vivo. Methods Cell morphology, MTT, flow cytometer, immunocytochemical method were used toobserve the effect of 10-6mol/L、10-7mol/L、10-8mol/L docetaxol on prostate cancer cell line PC-3 in vitro. MaleBALB/C-nu mice with PC-3 prostate cancer cell lines were treated by docetaxol in vivo. Serum PSA of mice, weightsof mice and PSA expression in xenograft tumors of mice by immunohistochemical methods were measured. Results Theconcentration of docetaxol above 10-7mol/L enhanced the growth suppression (suppression ratio≥47.5%, P<0.05), apoptosis(apoptosis ratio≥16.8%, P<0.01) and down-regulation of the expression of cyclin D1 (expression ratio≤10.8%, P<0.05),compared with the control 25.5%. Serum PSA of mice (9513)ng/ml P<0.01, weight of xenograft tumors (3.70.4)g, P<0.01and PSA expression in tumors (66.03.8)%, P<0.05 with PC-3prostate cancer cell lines of nude mice were all decreasedsignificantly in docetaxol group than in control except weights of mice (22.62.5)g, P<0.05. Conclusion Docetaxol canenhance the growth suppression and induce apoptosis of PC-3 cells in vitro and in vivo. It shows great potential in thetreatment of androgen-independent carcinoma of prostate.

目的 观察多西紫杉醇对激素非依赖性前列腺癌细胞系PC-3的体内外作用,并探讨其可能的作用机制。方法 应用光镜形态学、MTT法、流式细胞仪和免疫细胞化学法观察了10-6mol/L、10-7mol/L、10-8mol/L浓度多西紫杉醇在体外对前列腺癌细胞系PC-3的作用和对细胞DNA含量及Cyclin D1表达的影响。观察PC-3细胞荷瘤裸鼠使用20mg/kg多西紫杉醇治疗前后的体重、肿瘤重量、血清PSA和肿瘤PSA免疫组化的变化。结果 10-7mol/L以上浓度多西紫杉醇对前列腺癌细胞系PC-3有明显的生长抑制作用(抑制率≥47.5%,P<0.05),增强诱导凋亡作用(凋亡率≥16.8%,P<0.01),下调Cyclin D1的表达(表达率≤10.8%),与阳性对照组Cyclin D1表达率25.5%相比有显著差异(P<0.05)。治疗前后裸鼠体重无明显变化,但肿瘤重量(3.70.4)g、血清PSA(9513)ng/ml和肿瘤PSA免疫组化的表达率(66.03.8)%在治疗组显著低于对照组(P<0.05或0.01)。结论 多西紫杉醇对激素非依赖性前列腺癌细胞系PC-3及荷瘤鼠肿...

目的 观察多西紫杉醇对激素非依赖性前列腺癌细胞系PC-3的体内外作用,并探讨其可能的作用机制。方法 应用光镜形态学、MTT法、流式细胞仪和免疫细胞化学法观察了10-6mol/L、10-7mol/L、10-8mol/L浓度多西紫杉醇在体外对前列腺癌细胞系PC-3的作用和对细胞DNA含量及Cyclin D1表达的影响。观察PC-3细胞荷瘤裸鼠使用20mg/kg多西紫杉醇治疗前后的体重、肿瘤重量、血清PSA和肿瘤PSA免疫组化的变化。结果 10-7mol/L以上浓度多西紫杉醇对前列腺癌细胞系PC-3有明显的生长抑制作用(抑制率≥47.5%,P<0.05),增强诱导凋亡作用(凋亡率≥16.8%,P<0.01),下调Cyclin D1的表达(表达率≤10.8%),与阳性对照组Cyclin D1表达率25.5%相比有显著差异(P<0.05)。治疗前后裸鼠体重无明显变化,但肿瘤重量(3.70.4)g、血清PSA(9513)ng/ml和肿瘤PSA免疫组化的表达率(66.03.8)%在治疗组显著低于对照组(P<0.05或0.01)。结论 多西紫杉醇对激素非依赖性前列腺癌细胞系PC-3及荷瘤鼠肿瘤均有明显的生长抑制和诱导凋亡作用,显示了多西紫杉醇用于治疗激素非依赖性前列腺癌的可能性和价值。

Objective To explore the inhibitory effects of Anti-PSCA mAb in treatments of human prostate cancer xenografts in mice.Methods Solid tumors in mice were produced by subcutaneous injection with PC-3 cells in the flanks of mice.We picked out 10 mice bearing human prostate cancer xenografts.They were divided into a treatment group(N 1=5)and a control group(N 2=5).200 μg Anti-PSCA mAb was injected into abdominal cavity in the treatment group and PBS in the control group.Anti-PSCA mAb and PBS were administered...

Objective To explore the inhibitory effects of Anti-PSCA mAb in treatments of human prostate cancer xenografts in mice.Methods Solid tumors in mice were produced by subcutaneous injection with PC-3 cells in the flanks of mice.We picked out 10 mice bearing human prostate cancer xenografts.They were divided into a treatment group(N 1=5)and a control group(N 2=5).200 μg Anti-PSCA mAb was injected into abdominal cavity in the treatment group and PBS in the control group.Anti-PSCA mAb and PBS were administered once a day for three days.The mice survival conditions of two groups were recorded during 5 weeks.The PSA in serum,the tumor weights and dimensions of survived mice were measured.The tumor volume inhibition rate was calculated.Routine pathological slides of tumor tissue were observed under light microscope to evaluate the range of tumor tissues damaged by Anti-PSCA mAb.Ultrastructure was observed with transmission electron microscope.Results The average PSA levels in serum of the two groups were (3.28±0.55) ng/ml and (7.26±0.43) ng/ml respectively.The weights of tumors of the two groups were(0.95±0.17) g and (3.08±0.18) g respectively.The volumes of them were (164.59±14.08)mm 3 and (548.49±19.79)mm 3.There are remarkable differences between the treatment group and the control group(P<0.05).The tumor volume inhibition rate of the treatment group was 69.98%.Pathological examination showed necrosis and plenty of inflammtory cells infiltrated in tumor tissues.Apoptosis was observed by transmission electron microscope.Conclusion Anti-PSCA mAb could significantly inhibit the growth of human prostate cancer xenografts in mice.

目的 探索鼠源性抗前列腺干细胞抗原单克隆抗体 (Anti PSCAmAb)对裸鼠实体性前列腺癌移植瘤的治疗效果。方法  (1 )BALB/c裸小鼠皮下注射激素非依赖性前列腺癌细胞株PC 3细胞 ,细胞数为 2× 1 0 6/只 ,建立前列腺癌实体性移植瘤的动物模型。 (2 )选择肿瘤体积大小相近的1 0只荷瘤鼠 ,随机分成治疗组 (N1 =5 )和对照组 (N2 =5 )。治疗组荷瘤鼠腹腔注射Anti PSCAmAb2 0 0 μg ,3天一次 ,连续三次 ;对照组使用等量PBS。 (3)观察 5周 ,记录实验鼠存活情况 ,检测血清前列腺特异抗原 (PSA) ,处死存活的裸鼠 ,测量残存肿瘤的重量、体积并计算肿瘤体积抑制率。取肿瘤组织进行光镜及透射电镜检查。结果 治疗组和对照组的裸鼠均存活 ,血清PSA平均值分别为 :(3 2 8± 0 5 5 )ng/ml和 (7 2 6± 0 4 3)ng/ml;平均瘤重分别为 (0 95± 0 1 7) g和 (3 0 8± 0 1 8)g ;肿瘤体积分别为 (1 6 4 5 9± 1 4 0 8)mm3 和 (5 4 8...

目的 探索鼠源性抗前列腺干细胞抗原单克隆抗体 (Anti PSCAmAb)对裸鼠实体性前列腺癌移植瘤的治疗效果。方法  (1 )BALB/c裸小鼠皮下注射激素非依赖性前列腺癌细胞株PC 3细胞 ,细胞数为 2× 1 0 6/只 ,建立前列腺癌实体性移植瘤的动物模型。 (2 )选择肿瘤体积大小相近的1 0只荷瘤鼠 ,随机分成治疗组 (N1 =5 )和对照组 (N2 =5 )。治疗组荷瘤鼠腹腔注射Anti PSCAmAb2 0 0 μg ,3天一次 ,连续三次 ;对照组使用等量PBS。 (3)观察 5周 ,记录实验鼠存活情况 ,检测血清前列腺特异抗原 (PSA) ,处死存活的裸鼠 ,测量残存肿瘤的重量、体积并计算肿瘤体积抑制率。取肿瘤组织进行光镜及透射电镜检查。结果 治疗组和对照组的裸鼠均存活 ,血清PSA平均值分别为 :(3 2 8± 0 5 5 )ng/ml和 (7 2 6± 0 4 3)ng/ml;平均瘤重分别为 (0 95± 0 1 7) g和 (3 0 8± 0 1 8)g ;肿瘤体积分别为 (1 6 4 5 9± 1 4 0 8)mm3 和 (5 4 8 4 9± 1 9 79)mm3 ,P <0 0 5 ,治疗组与对照组间均有显著性差异。治疗组肿瘤体积抑制率为 6 9 98%。光镜显示治疗组肿瘤组织内出现大片组织坏死性改变 ,并可见大量炎症细胞浸润 ,透射电镜显示肿瘤细胞的凋亡现象。结论 Anti PSCAmAb对裸鼠前列腺癌实体性移植瘤有显著的治疗

 
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