The h~2 of the first-degree and second-degree relatives were respectively86.50±8.79%,68.80±11.97%,Whose average is 80.30±2.25%,By the way,the group of severe smoking of the first-degree relatives has the highest q and h~2.Conclusion:Infants and young children with asthma has evident clustering in families.
Results: Main variates related to the genesis of colon cancer were lower digestive tract diseases (Odds Ratio,OR=3.910), history of colorectal cancer of first degree relatives (OR=3.298), psychological depression (OR=2.224), alcohol consumption (OR=1.721), and white collar clerks (OR=3.068).
[Results] Esophageal cancer possessed the character of familial aggregation in Anxi. Both of the results of Li-Mantel-Gart’s method and Penrose’s method showed that the genetic mode of esophageal cancer belonged to polygenetics with segregation ration 0.0433(95%CI =0.0338～0.0528). The heritability of first degree relatives was 38.66%±2.67%.
Objective To explore the clinical significance of combined detection of glutamic acid decarboxylase antibody(GADA) insulin autoantibody(IAA) and islet cell autoantibody(ICA) in first degree relatives of patients with type 1 diabetes mellitus(DM1).
Results The values of Hcy and ACLA (IgG, IgM) in the primary group and recurrent group were both significantly higher than those of control group and first degree relative group of DVT recurrent patients (P<0.01).
Results: (1) Schizophrenia group: the prevalence rate of schizophrenia was 1.1% (no significant difference with 0.655% in population from the epidemic survey in the seven areas of China in 1993, P>0.05) in the proband's relatives, and was 4. 79% in the praband's first-degree relative (higher than 0.655%, P<0.05).
When other diseases were referred to, the men with 1 first-degree relative suffered from cancer had greater risk to develop prostate cancer than those without family history of cancers (OR = 2.25, 95% CI = 0.69-7.31).
family history information) is equivalently valid for first-degree relatives and for index subjects (i.e.
However, this unproven assumption is the basis for the frequent, possibly inappropriate, use of instruments validated for patients and control subjects in family studies which focus on frequencies of psychiatric disorders in first-degree relatives.
Consequently, there is a need to compare the validity of family history information for both disorders in index subjects and their first-degree relatives.
Validity was assessed by comparison of family history information for dementia and depression with interview-derived diagnoses in 75 index subjects and 195 age-matched first-degree relatives.
In agreement with the study hypothesis, the sensitivity of surrogate information on dementia was significantly reduced in first-degree relatives in comparison with index subjects.
First degree relatives of cases were more frequently reported to have psychiatric problems.
We investigated the prevalence of autoimmune diseases in 245 MS patients and 245 age- and sex-matched normal controls (NC), originating from and living in North-east Italy, and their first degree relatives, using a case-control method.
A total of 185 first degree relatives of 68 restrictive AN patients with adolescent onset followed up for 5 to 18 years and 198 first degree relatives of 68 normal women were investigated.
Prevalence of family history in vasovagal syncope and haemodynamic response to head up tilt in first degree relatives
Morbid risk in first degree relatives is four to six times higher than the population prevalence of about 1%.
The majority of these children had at least one first degree relative with diabetes mellitus.
12.8% of the probands had a first degree relative with Type 1 diabetes, and it was twice as common that this relative was a father as a mother.
Most studies evaluating immune markers for prediction of Type 1 (insulin-dependent) diabetes mellitus have focused on first degree relatives, although only 10 % of newly-diagnosed patients have an affected first degree relative.
Type 1 and Type 2 diabetic patients were just as likely to have a first degree relative with hypertension (60.5 vs 65.5%).
Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relative
In contrast, family studies have shown the approximate lifetime risk of a first-degree relative of a bipolar proband to be 5% to 10%.
The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with the disease.
Of the probands 73 (25.1%) had at least one first-degree relative with IDDM.
Methods: We examined γδ T cell receptor (TCR) phenotype, cell proliferation, and cytolytic activity following culture with irradiated primary leukemia blasts from a haploidentical first-degree relative.
Twenty-six (16%) of patients in Group 1 compared with 23 (11%) in Group 2 had at least 1 first-degree relative with colorectal cancer (p=0.23).