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心血管系统疾病
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心脏纤维化
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  cardiac fibrosis
     Expression of Short Isoform of Leptin Receptor mRNA and Observation of Cardiac Fibrosis in Hearts of Streptozotocin-Diabetic Rats
     STZ糖尿病大鼠心肌短型瘦素受体基因的转录表达及心脏纤维化观察
短句来源
     Effects of Myofibroblasts on the Cardiac Fibrosis of the Infarcted Rat Heart
     肌成纤维细胞在大鼠急性心肌梗死后心脏纤维化中作用的研究
短句来源
     Results Ob-Ra mRNA was expressed in myocardium of streptozotocin - diabetic and control rats with no significant difference between them (P>0.05),but there was higher expression of leptin receptor mRNA in cultured myocardial fibroblasts of diabetic rat.Distinct cardiac fibrosis was found and compained by the decreased heart function in diabetic rats.
     结果 STZ糖尿病大鼠和对照鼠心肌均可转录表达短型瘦素受体mRNA ,两组之间无显著差别 ,但糖尿病心肌成纤维细胞短型瘦素受体mRNA表达较高 ,伴心功能减退和显著的心脏纤维化病理改变。
短句来源
     Conclusions The coexistence of cardiac fibrosis and increased expression of Ob-Ra mRNA in myocardial fibroblasts were found in diabetic rats.
     结论 糖尿病大鼠心脏成纤维细胞短型瘦素受体表达增加与心脏纤维化并存。
短句来源
  myocardial fibrosis
     Effects of Losartan and Captopril on Myocardial Fibrosis in Spontaneously Hypertensive Rats
     氯沙坦或卡托普利对自发性高血压大鼠心脏纤维化的干预研究
短句来源
     The Therapeutics of Myocardial Fibrosis
     心脏纤维化的干预治疗
短句来源
     The pathological bases of LVH include myocytes hypertrophy, alterations of the vascular beds in coronary system and myocardial fibrosis, which is mainly caused by the abnormally proliferation and collagen synthesis of cardiac fibroblasts (CFs).
     业已证实,心脏成纤维细胞的增殖及心脏间质胶原网络的重构是左室肥厚由代偿向失代偿转变的重要病理过程,在此过程中体液因素起到了关键性的作用。 作为垂体后叶分泌的血管活性肽,精氨酸升压素(AVP)可诱导CFs增殖和胶原合成,参与了心脏纤维化的进程,但具体信号传导机制目前尚不十分清楚。
短句来源
     Objective To explore the effects of mesenchymal stem cells (MSCs) on myocardial fibrosis in hypertensive rat and try to find a novel way to regress ventricular remodeling and improve the organ damage in hypertension.
     目的研究骨髓问质干细胞(MSCs)对于自发性高血压大鼠心脏纤维化的修复作用,探讨MSCs逆转心室重构的可能性。
短句来源
     Conclusion MSCs transplantation regulate collagen content in heart by inhibiting synthesis or stimulating degradation of collagen through HO-1 way. Regression of myocardial fibrosis and ventricular remodeling, may eventually lead to function improvement.
     结论MSCs移植治疗可以通过调节组织局部胶原的合成与降解,改变心脏局部胶原纤维的含量,从而有效地逆转高血压心脏纤维化的过程,这种结构的变化同样伴有功能的改变。
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  “心脏纤维化”译为未确定词的双语例句
     Conclusion: AcSDKP can inhibit proliferation and collagen synthesis in cultured rat cardiac fibroblasts mediated by PDGF.
     结论:AcSDKP对PDGF介导的心脏成纤维增殖和胶原合成均有明显抑制作用,这可能与其抗心脏纤维化的作用相关。
短句来源
     Morphological characteristics were measured with hematoxylin and eosin (HE), Elastic Van-Gieson, irnmunohistochemistry staining in the infarction and non-infarction myocardium, the activation and proliferation of MyoFb and collagen volume fraction (CVF) were assessed or calculated respectively with compute-assisted image analysis system (Image-Pro Plus, Version: 4.5).
     心脏标本经HE、Elastic Van-Gieson和免疫组织化学染色后,利用计算机辅助图像分析系统(Image-Pro Plus,Version:4.5)计算心肌梗死区和非梗死区肌成纤维细胞数量、增殖和心脏纤维化情况。
短句来源
     MSCs Engraftment Regresses Myocardium Fibrosis and Improves Heart Function in Spontaneously Hy- pertensive Rat
     骨髓间质干细胞移植对自发性高血压大鼠心脏纤维化及心功能的影响
短句来源
     Left ventricular hypertrophy (LVH) is regarded as an independent risk factor for the mortality and disability of essential hypertension (EH) or other cardiovascular diseases, so the prevention and regression of LVH has been the goal of the treatment to EH.
     高血压左室肥厚是影响高血压病及其它心血管疾病死亡率和致残率的独立危险因子,预防和逆转左室肥厚已成为目前高血压病治疗的重要目标。 左室肥厚的病理改变主要表现为心肌细胞的肥大、冠脉系统血管床的变化及由于心脏成纤维细胞(CFs)增殖和胶原沉积所导致的心脏纤维化
短句来源
     Arginine Vasopressin (AVP), a kind of vascular peptide secreted from pituitary,was implicated in the proliferation and collagen synthesis of CFs, but the signal transduction pathway is still unclear. Ca2+ is involved in myocardial hypertrophy induced by a variety of stimuli and calcineurin is the most important molecule in the Ca2+ signal system.
     本研究在细胞和分子水平上,观察了CaN对AVP诱导CFs增殖和胶原合成的调控作用,研究CaN信号通路与其它信号传导第四军医大学硕士学位论文途径的关系,旨在探讨AVP促进CFs增殖和胶原合成的信号传导机制及CaN信号传导通路在心脏纤维化过程中的作用,为左室肥厚和心脏纤维化的防治提供新的理论依据和思路。
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  cardiac fibrosis
We found that noise stress significantly increased the microvessel wall area, the number of microvessels with an outer diameter >amp;gt;19 μm, the degree of cardiac fibrosis, and the extent of ischemic myocardial lesions in SHR, but not in NWR.
      
TNFα-antagonism attenuates the development of experimental diabetic cardiomyopathy associated with a reduction of intramyocardial inflammation and cardiac fibrosis.
      
Cardiac Fibrosis as a Cause of Diastolic Dysfunction
      
The interaction of coronary tone and cardiac fibrosis
      
Aldosterone has direct effects on the vasculature and has been associated with vascular smooth muscle cell hypertrophy, endothelial dysfunction, cardiac fibrosis, proteinuria, and renal vascular injury.
      
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  myocardial fibrosis
Midwall myocardial fibrosis in Becker-Kiener muscular dystrophy
      
In chronic myocarditis, viremia is often absent and myocardial fibrosis and dilated cardiomyopathy (DCM) resulting in heart failure can occur.
      
MRI is a sensitive tool detecting myocardial fibrosis on late images after application of paramagnetic contrast agents.
      
Patchy or homogenous myocardial fibrosis in Becker muscular dystrophy
      
Transforming growth factor-β receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression o
      
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To study the effect of genistein on the proliferation of cardiac fibroblasts(CF), CFs were cultured from neonatal rat hearts, DNA synthesis of the cells was determined by incorporation of [ 3H]TdR into DNA, the cell cycle was measured by flow cytometric analysis. Genistein(0.5-50 μmol·L -1 ) attenuated 2.5% fetal calf serum-induced proliferation of CF in concentration-dependent manner. Genistein(50 μmol·L -1 ) arrested CF cell progression at G 2/M phase. The results suggest that genistein be a potential...

To study the effect of genistein on the proliferation of cardiac fibroblasts(CF), CFs were cultured from neonatal rat hearts, DNA synthesis of the cells was determined by incorporation of [ 3H]TdR into DNA, the cell cycle was measured by flow cytometric analysis. Genistein(0.5-50 μmol·L -1 ) attenuated 2.5% fetal calf serum-induced proliferation of CF in concentration-dependent manner. Genistein(50 μmol·L -1 ) arrested CF cell progression at G 2/M phase. The results suggest that genistein be a potential substance for treatment of cardiac fibrosis.

观察木黄酮对心肌成纤维细胞 (CF)增殖的影响 .采用培养的新生大鼠CF ,以 [3 H]TdR参入率作为细胞增殖指标 ;流式细胞仪分析细胞周期 .结果显示木黄酮 (0 .5~ 50 μmol·L- 1)具有浓度依赖性地抑制 2 .5%胎牛血清刺激CF增殖的作用 ,并将CF细胞周期阻抑在G2 /M期 ;提示木黄酮有望成为防治心脏纤维化的物质

Purpose To observe whether the leptin receptor mRNA is expressed and cardiac fibrosis is present in hearts of Streptozotocin - diabetic rats. Methods The experiment was done at twelfth week after the onset of diabetes.After blood pressure and cardiac function were mearsured,the rats were sacrificed then cardiac tissue and cultured myocardial fibroblasts were used for RT?PCR to show the expression of leptin receptor mRNA.The ultrastructure of myocardium were examed by electron microscopy.Serum leptin,insulin...

Purpose To observe whether the leptin receptor mRNA is expressed and cardiac fibrosis is present in hearts of Streptozotocin - diabetic rats. Methods The experiment was done at twelfth week after the onset of diabetes.After blood pressure and cardiac function were mearsured,the rats were sacrificed then cardiac tissue and cultured myocardial fibroblasts were used for RT?PCR to show the expression of leptin receptor mRNA.The ultrastructure of myocardium were examed by electron microscopy.Serum leptin,insulin were assessed by immunoassay. Results Ob-Ra mRNA was expressed in myocardium of streptozotocin - diabetic and control rats with no significant difference between them (P>0.05),but there was higher expression of leptin receptor mRNA in cultured myocardial fibroblasts of diabetic rat.Distinct cardiac fibrosis was found and compained by the decreased heart function in diabetic rats. Conclusions The coexistence of cardiac fibrosis and increased expression of Ob-Ra mRNA in myocardial fibroblasts were found in diabetic rats.

目的 研究瘦素受体在STZ糖尿病大鼠心肌中转录表达及心脏的纤维化情况。方法 用STZ制备糖尿病大鼠模型 ,在病程 12周时测定大鼠血压和心功能后处死 ,取心肌组织和分离、培养心脏成纤维细胞 ,用RT PCR检测长、短型瘦素受体mRNA转录表达 ,PCR产物测序 ,电镜观察心肌的超微结构。血清瘦素、胰岛素放射免疫测定。结果 STZ糖尿病大鼠和对照鼠心肌均可转录表达短型瘦素受体mRNA ,两组之间无显著差别 ,但糖尿病心肌成纤维细胞短型瘦素受体mRNA表达较高 ,伴心功能减退和显著的心脏纤维化病理改变。结论 糖尿病大鼠心脏成纤维细胞短型瘦素受体表达增加与心脏纤维化并存。

AIM:To study the effects and mechanisms of Danshen (Radix Salviae miltiorrhizae) on isopr ote renol induced cardiac hypertrophy and fibrosis in mice. METHOD: C a rdiac hypertrophy and fibrosis in mice were induced by subcutaneous administrati on of isoproterenol. Enalapril(10 mg/kg·d -1 )and the water extract from Danshen(5,10 g/kg·d -1 ) were administered by gavage to treat the mice. The mo rpholog ical changes and weight of the heart ventricle and kidneys,the activity of angiot ensin converting enzyme(ACE),the...

AIM:To study the effects and mechanisms of Danshen (Radix Salviae miltiorrhizae) on isopr ote renol induced cardiac hypertrophy and fibrosis in mice. METHOD: C a rdiac hypertrophy and fibrosis in mice were induced by subcutaneous administrati on of isoproterenol. Enalapril(10 mg/kg·d -1 )and the water extract from Danshen(5,10 g/kg·d -1 ) were administered by gavage to treat the mice. The mo rpholog ical changes and weight of the heart ventricle and kidneys,the activity of angiot ensin converting enzyme(ACE),the content of nitric oxide(NO) in the serum,he ar t and kidneys and the content of hydroxyproline(Hyp) in the heart and kidneys were determined after 14 days of treatment. RESULT: The results showing significant cardiac hypertrophy and fibrosis in mice were induced by sc isoproterenol for 14 d. The weight of heart ventricle,ACE,Hyp increased an d N O d ecreased in model group,which was significantly counteracted by both Danshen a nd enalapril. CONCLUSION: Danshen can reverse the cardiac hyper trophy and fibrosis induced by isoproterenol in mice.

目的 :探讨丹参对心肌肥厚和纤维化的影响及作用机制 ;方法 :异丙肾上腺素皮下注射致小鼠心肌肥厚和纤维化模型 ,并观察经依那普利 (10mg/kg·d-1 )和丹参 (5,10g/kg·d-1 )治疗后 ,对小鼠的左心室重量 ,组织形态 ,血清、心、肾组织中的血管紧张素Ⅰ转化酶 (ACE)活性、一氧化氮 (NO)含量及羟脯氨酸 (Hyp)含量的影响 ;结果 :与对照组比较 ,模型组心脏重量增加 ,出现纤维化病变 ,心、肾中的ACE活性增高 ,NO含量减少 ,而依那普利组和丹参高低剂量组与模型组相比 ,心肌肥厚和纤维化病变减轻 ,心、肾中的ACE含量降低 ,丹参高低剂量组在血清中的NO含量显著增高 ;结论 :丹参有良好的抗心脏纤维化作用 ,该作用可能与其抑制ACE和增加NO含量有关。

 
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