Concentrations of sodium fluoride of 0.3,1.6,8.0, 20.0 and40.0 mmol/L can significantly inhibit the activity of the enzyme with proportions of 6.6%,18.0%,41.0%, 55.5% and 63.1%,respectively, and with a half inhibitory concentration of 14.8 mmol/L re。 flecting an obvious dose-effect and time-effect relationship。
AIM:Antipyretic dose-response and time-effect relationship of promethazine have been observedRESULTS:(1)Different antipyretic effect of promethazine on endotoxin-induced febrile rabbits were produced at 3 defferent dosage of 1mg,5mg,10mg/kg.
Objective] To understand the dose/time-effect relationship of cytotoxicity of cadmium to human umbilical vein endothelial cell(HUVEC) and identify potential disruptions of secretive function caused by cadmium in HUVEC cells.
Each dose of PLC inhibited collagen induced platelet aggregation significantly ( P <0 05) and this inhibition effect showed a significant time effect relationship, but the inhibition effect was weaker than in ASA group ( P <0 05).
Each dose of PLC inhibited AA induced platelet aggregation significantly ( P <0 05), and this inhibition effect showed a significant time effect relationship, but did not show a significant dose effect relationships.
The results showed that the Mercury could marked improve AST, ALP activity in the serum (P<0.01), reduce the activity of GSH Px in the liver tissue (P<0.01) and it induce lipid peroxidation to improve the MDA content in the liver tissue (P<0.01) in a time effect rule;
Selenite could marked reduce AST, ALT, ALP activity in the serum (P<0.01), improve the activity of GSH Px in the liver tissue (P<0.01) and it prevent lipid peroxidation to reduce the MDA content in the liver tissue (P<0.01) in a time effect rule.
The effect is determined to carry on dosage and time to it, the result displays the good dosage and time effect relation. This may be indicated that three weedicides have potential of mutagenic activity.
TNT was incubated with human erythrocytes and its toxicity was observed. It indicated that TNT induced tl:e simultaneous production of MetHb and O2 with GSH depletion, which demostra ted dramatic relationship of dose-effect and time-effect.