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肿瘤患者
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  cancer patients
    Survey and analysis of nutrient support drug utilization in cancer patients
    肿瘤患者营养支持药物利用调查分析
短句来源
    The study's expected objectives is to prepare controlled release membranes of anti-tumor drug Lomustine(CCNU), Vincristine(VCR) using collagen protein as polymer material carrier, then planted into the tumor of cancer patients after operation, to achieve the goal of constant drug release.
    本文研究的目的是利用胶原蛋白材料作为药物的载体,制备抗肿瘤药物洛莫司汀(Lomustine,CCNU),长春新碱(Vincristine,VCR)的控制释放膜,用于肿瘤患者术后的局部埋植,实现药物的恒定释放。
短句来源
    The effect of radiation on natural killer cell (NK) activity and the modulatory effect of interferon (IFN-α) were studied in vitro on mouse splenic lymphocytes against YAC-1 cells and peripheral lymphocytes of cancer patients against K562 cells, using 4hr 51Cr release method.
    采用4h51Cr释放法,分别以小鼠脾脏淋巴细胞对YAC-1细胞和肿瘤患者外周血淋巴细胞对K562细胞的体外自然杀伤(NK)活性为指标,研究受电离辐射后小鼠脾脏NK细胞活性的变化以及干扰素(IFN-α)对NK细胞活性的影响;
短句来源
    Objective:The pharmacokinetics of recombinant huma n tumor necrosis factor α mutant(rhTNFαD11a) was studied in cancer patients.
    目的 :在肿瘤患者中观察重组人肿瘤坏死因子α突变体rhTNF αD11a的药代动力学。
短句来源
    THE PROTECTIVE EFFECT OF TEA PIGMENT ON IMMUNE FUNCTION OF CANCER PATIENTS DURING RADIOTHERAPY AND CHEMOTHERAPY
    茶色素对放化疗中肿瘤患者免疫功能的作用
短句来源
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  cancer patient
    NK cell activity of cancer patient was significntly lower than that of normal control (P<0.01) and was decreased further after radiotherapy (P<0.05).
    肿瘤患者的NK细胞活性明显低于正常对照组(P<0.01),放疗后NK细胞活性进一步降低(P<0.05)。
短句来源
    For5cases of cancer patient ,after high dose arterial perfusion of 5-Fu,local and peripheral blood concentration has no significant difference(P>0.05).
    5例肿瘤患者大剂量动脉灌注5-Fu后,局部动脉和外周静脉血药浓度无显著性差异(P>0.05)。
短句来源
    In addition to study the toxicity of swainsonine, the scholars still study its activities of anticancer according to its inhibitory action on alpha-mannosidase. The results showed that swainsonine can reduce tumor cell metastasis, inhibit tumor growth in mice and cancer patient, and stimulate the host immune system, enhance immune cell tumoricidal activity.
    除了研究SW的毒性外 ,学者们还根据其可抑制α 甘露糖甙酶的活性 ,对其抗肿瘤活性进行了研究 ,发现其可抑制肿瘤细胞的转移和实体瘤在小鼠和肿瘤患者身上的生长 ,刺激宿主的免疫系统 ,增强免疫细胞对肿瘤的杀伤活性。
短句来源
  “肿瘤患者”译为未确定词的双语例句
    Studies on the pharmacokinetics of Zinc Gluconate in 40 Patients with Malignant Tumors
    40例肿瘤患者口服葡萄糖酸锌片的药代动力学研究
短句来源
    Pharmacokinetics of floxuridine in patients with trophoblastic Tumors
    氟尿苷在滋养细胞肿瘤患者中的临床药动学研究
短句来源
    Application of antibiotics in cancer hospital: a survey analysis
    肿瘤患者抗生素应用现状调查分析
短句来源
    Radiotherapy is one of major clinical methods in treatment of most tumors.
    放射治疗是肿瘤治疗主要手段之一,资料显示有70%的肿瘤患者需行放射治疗。
短句来源
    Results:Five dosage groups were studied in twenty patients.
    结果 :2 0例肿瘤患者进入试验 ,分别进行了 5个剂量组的研究。
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  cancer patients
The phagocytic potency of macrophages isolated from blood of breast cancer patients was lower than engulfment ability of macrophages obtained from healthy donors and depended on tumor degree.
      
We studied p53 gene mutations in 26 primary tumors of colorectal cancer patients.
      
Allele UGT1A1*28 was present at a higher frequency than the wild-type UGT1A1*1 allele in breast cancer patients as compared to controls (P = 0.002, OR = 1.79, CI 1.23-2.63).
      
The high activity of aromatase in endometrium in endometrium cancer patients without myoma corresponds to a worse prognosis.
      
Micronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients
      
更多          
  cancer patient
Recently we detected the ST13 gene expression in tumor tissue and adjacent normal tissue of the same colorectal cancer patient and investigated if the ST13 gene expression might have any prognostic value.
      
With regard to nutritional support of the cancer patient, evaluation of quality of life (QL) is more appropriate than morbidity and survival related parameters.
      
Paraneoplastic Erythroderma in a Prostate Cancer Patient
      
Comparative Analysis of the Effects of Belly Board and Bladder Distension in Postoperative Radiotherapy of Rectal Cancer Patient
      
Transient Fungemia Due to Rhodotorula rubra in a Cancer Patient: Case Report and Review of the Literature
      
更多          


In a previous communication,we have reported the physiological disposition of N-C~(14)-formylsarcolysine.In as much as the tracer technic does not distinguish the unchanged drug from its metabolite(s),a highly specific method is developed for the determination of N-formylsarcolysine in biological samples. One ml of sample (whole blood,tissue homogenate (1:5),urine (1:1),bile and feces (1:10)) was pipetted into a centrifuge tube containing 20-40 mg of sodium bicarbonate and well shaken until dissolved.To the...

In a previous communication,we have reported the physiological disposition of N-C~(14)-formylsarcolysine.In as much as the tracer technic does not distinguish the unchanged drug from its metabolite(s),a highly specific method is developed for the determination of N-formylsarcolysine in biological samples. One ml of sample (whole blood,tissue homogenate (1:5),urine (1:1),bile and feces (1:10)) was pipetted into a centrifuge tube containing 20-40 mg of sodium bicarbonate and well shaken until dissolved.To the alkaline sample,10 ml of absolute alcohol was added to precipitate protein.The protein-free supernatant was evaporated to dryness under reduced pressure.The residue was dissolved in 5 ml of 0.1 M acetate buffer (pH 3.6) and extracted three times with 5 ml volumes of ethyl acetate.The pooled extract was again evaporated to dryness.The residue was dissolved in 5 ml of absolute alcohol and the light absorptions measured at 240,258 and 280 mμ.Since the absorption curve obtained from biological specimens is the additive effect of the absorption due to the blank specimen (which is essentially a straight line between 240 and 280 mμ,fig.1,Ⅲ) plus the actual N-formylsarcolysine curve,it is evident that the peak absorption at 258 mμ cannot be used as a measurement of drug concentra- tion without subtracting an unknown fraction contributed by the blank specimen.Based on the absorption spectrum of N-formylsarcolysine (fig.1,I),points A,B and C represent the optical densities at 258 (maximum absorption),240 and 280 mμ res- pectively.When a line was drawn from A perpendicular to the abscissa and crosses BC at D,the distance between A and D was found to be proportional to the quantity of N-formylsarcolysine in the sample.Interference by blank materials may thus be elimi- nated.The magnitude of D may also be calculated according to the equation: D=0.55B+0.45C. This method was shown to be very sensitive and highly specific. Five hours after an oral dose of N-formylsarcolysine (200 mg/kg) to normal rats, about 7.9% of the dose could be recovered from the gastrointestinal tract as unchanged drug.Since in vitro experiments showed that N-formylsarcolysine was rapidly meta- bolized to compounds not determined by this method,the disappearance of N-formyl- sarcolysine from the gastrointestinal tract does not reflect the actual absorption of the drug. When injected intravenously to rats and rabbits,N-formylsarcolysine disappeared rapidly from the blood with a biological half life of 12-15 minutes.In normal rats, about 23.8% of the administered dose was excreted in the urine in five hours.During the same period,the urinary excretion by rabbits was about 12.5%.In rats with a biliary cannula,as much as 12.4% of an intravenously injected dose could be reco- vered from the bile in five hours. One hour after N-formylsarcolysine (100 mg/kg) was given intravenously to normal rats or rats bearing Yoshida solid carcinoma,appreciable concentration was found in the kidneys,relatively low concentrations were present in the liver,while only trace amounts were present in the tumour and other tissues examined. When a dose of 300 mg of N-formylsarcolysine was given orally to patients suffer- ing from seminoma of the testis,very low concentrations of unchanged drug were found in the blood.About 7.1% of the administered dose was excreted in the urine. The hydroxy form of N-formylsarcolysine was shown to be the main metabolite in rats as well as in patients.

本文报告用分光光度计,采用三波长法在生物样品(血、尿、组织、胆汁及粪等)中测定N-甲酰溶肉瘤素(简称 N-甲)的方法;并用此法观察了 N-甲在动物及人体内的吸收、分布及排泄。本法特异性高,灵敏度为0.10 O.D.相当于样品中含 N-甲11.5微克。大鼠口服 N-甲200毫克/公斤后5小时,由胃肠道内容物可回收剂量的7.9%,而在所排出的粪中并无可测定的药物存在。体外实验证明 N-甲在胃肠道内容物的代谢很快。可见,药物由胃肠道消失的速度并不能反映其自胃肠道吸收的情况。静脉注射后,N-甲在大鼠及家兔的血中消失很快。其在血中的生物半衰期大鼠为12分钟,家兔为15分钟。给正常或肿瘤大鼠静脉注射 N-甲100毫克/公斤后1小时,药物含量以肾脏最高,肝次之,脾、肺、心等组织仅含痕迹量。肿瘤组织的药物含量亦很低。大鼠静脉注射 N-甲100毫克/公斤后5小时,由尿可回收剂量的23.8%,其中96.3%为前两小时所排出。由胆汁亦可回收剂量的12.4%。家兔静脉注射 N-甲50毫克/公斤后,12小时内可自尿排出剂量的12.5%,其中92.6%为前两小时所排出。成年男性肿瘤患者一次口服 N-甲300毫克后5小时内,血...

本文报告用分光光度计,采用三波长法在生物样品(血、尿、组织、胆汁及粪等)中测定N-甲酰溶肉瘤素(简称 N-甲)的方法;并用此法观察了 N-甲在动物及人体内的吸收、分布及排泄。本法特异性高,灵敏度为0.10 O.D.相当于样品中含 N-甲11.5微克。大鼠口服 N-甲200毫克/公斤后5小时,由胃肠道内容物可回收剂量的7.9%,而在所排出的粪中并无可测定的药物存在。体外实验证明 N-甲在胃肠道内容物的代谢很快。可见,药物由胃肠道消失的速度并不能反映其自胃肠道吸收的情况。静脉注射后,N-甲在大鼠及家兔的血中消失很快。其在血中的生物半衰期大鼠为12分钟,家兔为15分钟。给正常或肿瘤大鼠静脉注射 N-甲100毫克/公斤后1小时,药物含量以肾脏最高,肝次之,脾、肺、心等组织仅含痕迹量。肿瘤组织的药物含量亦很低。大鼠静脉注射 N-甲100毫克/公斤后5小时,由尿可回收剂量的23.8%,其中96.3%为前两小时所排出。由胆汁亦可回收剂量的12.4%。家兔静脉注射 N-甲50毫克/公斤后,12小时内可自尿排出剂量的12.5%,其中92.6%为前两小时所排出。成年男性肿瘤患者一次口服 N-甲300毫克后5小时内,血中的药物浓度很低,但给药后12小时内可自尿排出剂量的7.1%,其中82.6%为前两小时所排出。用纸层离法证明,大鼠及肿瘤病人口服 N-甲后尿中的代谢物主要为羟基水解产物

A method for the determination of MTX in biological fluids was described in this paper. Ten rabbits of 2.5~3 kg each was infused with MTX 40~300 mg/kg. Ten patients with malignant tumor aged from 8~53 each received 1~4 g MTX intravenously. A normal hemogram and normal liver and renal functions were prerequisite for this study. After 2~4 hours CF (9~12 mg) was given intramuscularly to rescue every 6 hours for 12 doses.Both MTX in biological fluids of rabbits and patients were extracted and measured with a model-210...

A method for the determination of MTX in biological fluids was described in this paper. Ten rabbits of 2.5~3 kg each was infused with MTX 40~300 mg/kg. Ten patients with malignant tumor aged from 8~53 each received 1~4 g MTX intravenously. A normal hemogram and normal liver and renal functions were prerequisite for this study. After 2~4 hours CF (9~12 mg) was given intramuscularly to rescue every 6 hours for 12 doses.Both MTX in biological fluids of rabbits and patients were extracted and measured with a model-210 UV spcctrophotometer at 306 nm.The equation of the standard curve of MTX was shown to be: Y=0.0456X+0.000092, that of calibrated curve of MTX in plasma was: Y=0.0441X+0.0389, while that of the calibrated curve of MTX in urine was: Y=0.0469X+0.0417. The recovery of MTX by this method was about 95%.For the save use of HD-MTX-CFR, the MTX levels in plasma and it's excretion in urine were also studied.

本文研究了生物液中甲氨喋呤(MTX)的测定方法。10只家兔,体重2.5~3kg,剂量为40~30 mg/kg;恶性肿瘤患者10人,年龄8~53岁,肝肾功能正常,每次给以1~4g的MTX。注入2~4小时后,以甲酰四氢叶酸钙(CF)救援,CF(9~12mg)肌注,每6小时一次,共12次。兔和病人生物液中MTX经提取后,在UV-210紫外分光光度计306nm处测定,MTX的标准曲线方程Y=0.0456X+0.000092;血浆MTX校正曲线方程Y=0.0441 X+0.0389;尿中MTX校正曲线方程Y=0.0469+0.0417;用本法测得MTX的回收率约95%。 为了HD-MTX-CFR的安全应用,我们研究了MTX的血浆水平和尿中MTX的排泄。

Ungeremine (Ⅱ, AT-1840), an alkaloid from Ungernia minor, was partially synthesized from lycorine. It was shown to possess marked inhibitory action against EAC, P-388, L-1210, Lewis lung carcinoma and Yoshida ascites sarcoma. Some related compounds (Ⅳ~ⅩⅣ) were prepared and screened on EAC in mice to study the SAR. It seems that the presence of phenolic betaine in the molecule of Ⅱ bears some relationship to its antitumour acitivity. From this point of view, 9-demethylberberine and 9-demethytpalmatine (ⅫⅠ and...

Ungeremine (Ⅱ, AT-1840), an alkaloid from Ungernia minor, was partially synthesized from lycorine. It was shown to possess marked inhibitory action against EAC, P-388, L-1210, Lewis lung carcinoma and Yoshida ascites sarcoma. Some related compounds (Ⅳ~ⅩⅣ) were prepared and screened on EAC in mice to study the SAR. It seems that the presence of phenolic betaine in the molecule of Ⅱ bears some relationship to its antitumour acitivity. From this point of view, 9-demethylberberine and 9-demethytpalmatine (ⅫⅠ and ⅩⅣ), two betaine type compounds, were thus prepared from antitumour inactive berberine and palmatine. The screening results supported the above betaine hypothesis.Ungeremine had been tried on 464 patients with various types of advanced neoplastic diseases. Preliminary data showed that it could improve the general conditions and relieve pain. In 15.7% cases the tumour mass was reduced markedly to less than half of their original volumes. No serious side effect was observed.

恩其明(ungeremine,Ⅱ,AT-1840)对小鼠艾氏腹水癌,L_(1210)、P_(388)、Lewis肺癌以及大鼠吉田肉瘤腹水型有明显抑制作用。为了研究其构效关系合成了有关化合物Ⅳ~ⅩⅣ。 Ⅱ_a已推荐临床试用,经464例各种中晚期肿瘤患者的J临床观察,有效率(肿瘤缩小1/2以上)为15.7%,对卵巢癌、胃癌等肿瘤有一定疗效,且副反应低,对血象、心、肝、肾等主要脏器均无明显影响。

 
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