Construction of Recombinant BCG Secreting IL-2 and IFN-α 2a and Immunotherapeutic Effect on Mice with Bladder Cancer
Clinical Observation and Experimental Study of Primary Nephritis Treated by BCG
Prophylactic effects of Zhuling and BCG on postoperative recurrence of bladder cancer
Intravesical instiliations of large doses of BCG in the treatment of superficial bladder carcinoma(report of 14 cases)
Postoperative Alternative Infusion of Mitornycin C and BCG Rotatedly to Prevent Recurrence of Bladder Carcinoma
Objective To investigate the efficacy of CpG-ODN 2006,the effective component of BCG vaccine,on cytokines production of human peripheral blood mononuclear cells (HPBMCs).
目的 探讨 卡介苗 (BCG)细胞核有效成分CpG ODN 2 0 0 6对人外周血单个核细胞 (HPBMCs)细胞因子表达的作用。
PREVENTION OF POSTOPERATIVE BLADDER CANCER RECURRENCE WITH INTRA-BLADDER PERFUSION OF SMALL DOSAGE OF BCG VACCINE
Research on the Prevention Against the Recrudesce of Bladder Cancer with Bcg Vaccine
Methods:5mg of BCG vaccine were poured into the bladder after operation in 167 patients who were diagnosed as superficial bladder cancer.
方法 :对术后 167例浅表性膀胱癌应用 5mg 卡介苗行膀胱腔内灌注。
METHODS: According to the reports in literature, intra-cavitary perfusion of mitomycin, thio-TEPA, cisapride or BCG vaccine were separately carried out in 78 patients who had had partial cystectomy for carcinoma of urinary bladder, then these four therapeutic schemes were eualuated using cost-effectiveness analysis.
方法:根据文献,选择78例膀胱部分切除的浅表性膀胱癌患者,分别于腔内灌注丝裂霉素、 噻替哌、顺铂、 卡介苗,并运用药物经济学的成本-效果分析方法对几种治疗方案进行分析评价。
Objective: To evaluate the intravesical instillation of pirarubicin(THP) plus bacillus calmette-guerin(BCG) for bladder cancer and the changes and predictive value of the urinary cytokine levels of IL-8.Methods: Sixty-two patients were subjected to removal of bladder cancer,and then intravesical instillation of THP plus BCG or only BCG.
目的:比较吡喃阿霉素(tetrahydropyranyl-doxorubicin,THP)加 卡介苗(bacillus calmette-guerin,BCG)与单用BCG膀胱灌注预防膀胱肿瘤复发的效果及灌注引起的副作用,测定灌注前后白细胞介素8(in-terleukin-8,IL-8)的变化,并探讨IL-8变化与药物灌注预防肿瘤复发效果之间的关系。
Enhancement of bacillus Calmette-Guerin attachment to the bladder wall:experimental study
STUDY ON PROPHYLACTIC EFFICACY ON BLADDER CANCER RECURRENCE BY PROCEEDING WITH BACILLUS CALMETTE-GUERIN (BCG) WASHING IN THE BLADDER
Expression of Toll-like Receptors in Human Bladder Cancer and Bacillus Calmette-Guerin Inducement
Study on Toll-like receptors expression and cytokine production induced by bacillus Calmette-Guerin in human bladder cancer cell
Intravesical Instillation of Bacille Calmette Guerin and Mitomycin for the Prevention of Bladder Neoplasmas Recurrenec
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Presently, one of the most potent immunotherapies is the application of bacillus Calmette Guerin ( BCG) to prevent recurrences of the superficial bladder cancer.
Therefore, current studies aim at developing recombinant BCG (r BCG) strains secreting Th1-like cytokines to improve the effectiveness of the therapy.
Peripheral blood monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette-Guerin activated killer (BAK) cells, and the effect of anticancer BAK cells was studied.
Recombinant IFN-α-2b- BCG, wild-type BCG (w BCG), wild-type BCG and IFN-α-2b were coincubated with PBMCs respectively in vitro, and the proliferation of PBMC was detected with MTT in different time.
The result of MTT showed that the proliferation of PBMC in the recombinant BCG group was more powerful than in the other two groups (P >amp;lt; 0.05).
Construction, expression and identification of a recombinant BCG vaccine encoding human mycobacterium tuberculosis heat shock pr
The recombinants were electroporated into BCG to construct the recombinant BCG vaccine and induced by heating.
Recurrent soft tissue infection following accidental inoculation with BCG vaccine
Antitumor activity of two BCG vaccine preparations against the lewis lung carcinoma in mice
Two BCG vaccine preparations were prepared following different production methods.
The expression of foreign gene,Schistosoma Japonicum 26 ku antigen (Sj26GST),in Bacillus Calmette-Guerin (BCG),Mycobacterium CM.
Bacillus Calmette-Guerin (BCG) instillation in the bladder results in a massive local inflammatory response that has secondary antitumor properties.
Analysis of mucosal bladder leucocyte subpopulations in patients treated with intravesical Bacillus Calmette-Guerin
Cytokine production by the human bladder carcinoma cell line T24 in the presence of bacillus Calmette-Guerin (BCG)
The study was initiated as an in vitro approach to the situation existing during intravesical bacillus Calmette-Guerin (BCG) instillation in patients with superficial bladder cancer.
We have used recombinant Bacille Calmette Guerin (BCG) strains overexpressing Ag 85A and Ag 85C to immunize BALB/c mice to investigate the immunogenicity of these strains.
Cloning and expression of a candidate malarial epitope in bacille Calmette Guerin