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   帕罗西汀 在 精神病学 分类中 的翻译结果: 查询用时:0.037秒
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帕罗西汀     
相关语句
  paroxetine
    Both the two groups took oral drug according to increasing law and got to the therapy capacity within one week, Paroxetine 20mg/d, Lorazepam 1~4mg/d.
    两组均按递增法口服给药,1周内达到治疗量,帕罗西汀20mg/d、劳拉西泮1~4mg/d。
短句来源
    The observation group begun to carry out cognitive behavior therapy in the second week and reduced gradually the drug capacity at the end of the fourth week, just maintain with Paroxetine 10mg/d, Lorazepam 0.5~1mg/d.
    观察组于第2周开始接受认知行为治疗,并于用药第4周末开始逐渐减量,以帕罗西汀10mg/d、劳拉西泮0.5~1mg/d维持。
短句来源
    Methods Thirty six patients with senile depression were treated with paroxetine, and measured with Hamilton depressive scale (HAMD), Hamilton anxiety scale (HAMA) and treatment emergent symptom scale (TESS) before treatment and 2,4,6,8 weeks after treatment.
    方法对入组的36例老年期抑郁障碍的患者使用帕罗西汀进行治疗,使用汉密尔顿抑郁量表(HAMD)与汉密尔顿焦虑量表(HAMA)及副反应量表(TESS)在治疗前,治疗后2、4、6、8周进行评定。
短句来源
    The efficacy in venlafaxine group was better than that in paroxetine group,and the rates of marked improvement and full recovery in venlafaxine group and paroxetine group were 70.6% and 52.6% respectively.
    文拉法辛组疗效优于帕罗西汀组,两组显效率分别为70.6%和52.6%,不良反应发生率无明显差异。
短句来源
    Methods 36 subjects were randomly divided into research group(n=18) receiving conventional therapy plus paroxetine and control group(n=18) plus placebo for 8 weeks.
    方法将36例糖尿病伴发焦虑抑郁障碍患者随机分为研究组与对照组各18例,均给予糖尿病常规治疗。 研究组联用帕罗西汀治疗,对照组联用安慰剂治疗,疗程8 w。
短句来源
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  paroxetive
    Objective To compare the curative effects and safety of paroxetive and amitriptyline in the treatment of somatoform disorders.
    目的比较帕罗西汀与阿米替林治疗躯体形式障碍的疗效及安全性。
短句来源
    Methods 66 patients with somatoform disorder were randomly divided into research(paroxetive,n=36)and control(amitriptyline,n=30)groups for 6 weeks.
    方法将66例躯体形式障碍患者随机分为研究组(帕罗西汀组)36例,对照组(阿米替林组)30例。 疗程6w。
短句来源
    Conclusion Paroxetive has therapeutic equivalence to amitriptyline,higher safety and better compliance in somatoform disorders.
    结论帕罗西汀与阿米替林治疗躯体形式障碍疗效相当,但帕罗西汀的安全性较阿米替林高,依从性好。
短句来源
    A control study of paroxetive and amitriptyline in the treatment of somatoform disorders
    帕罗西汀与阿米替林治疗躯体形式障碍对照研究
短句来源
  domestic paroxetine
    Comparison study of domestic paroxetine and amitriptyline in treatment of somatoform disorders randomized double - blind study
    帕罗西汀与阿米替林治疗躯体形式障碍的随机双盲对照研究
短句来源
    A Comparative Trial of Domestic Paroxetine Versus Fluoxetine in the Treatment of Depression
    帕罗西汀与氟西汀治疗抑郁症的疗效比较
短句来源
  paxil
    Effect of Paxil and berhomine on poststroke anxiety-depression and neurological recovery
    脑卒中后焦虑抑郁及神经功能恢复与帕罗西汀及丙咪嗪的干预效应(英文)
短句来源
    The scores for Hamilton Depression Scale and Hamilton Anxiety Scale were obviously lower in Paxil group and imipramine group at 2, 4, 8 and 12 week than those in the control group (P < 0.01-0.001), but similar between the former two groups at 12 weeks (P > 0.05).
    ②各组患者治疗前后焦虑、抑郁恢复情况:治疗后2,4,8,12周帕罗西汀组与丙咪嗪组汉密顿抑郁量表、汉密顿焦虑量表评分明显低于对照组(P<0.01~0.001)。 治疗12周后帕罗西汀组和丙咪嗪组比较差异无显著性意义(P>0.05)。
短句来源
    Paxil and imipramine on resulted in curative rates of anxiety and depression of 86.6% and 85.1%, respectively, which were obviously higher than that of the control group (46.6%);
    ③帕罗西汀与丙咪嗪对焦虑、抑郁症状有效率为86.6%及85.1%,明显优于对照组(46.6%),帕罗西汀、丙咪嗪和对照组神经功能恢复的有效率分别为89.6%,70.3%;
短句来源
    the improvement rate of neurological function in Paxil group, imipramine group and control group was 89.6%, 70.3% and 56.6%, respectively, with that of Paxil group significantly higher than that of the control group (P < 0.01), but the difference between imipramine group and control group was not significant (P > 0.05).
    56.6%,帕罗西汀组明显高于对照组(P<0.01),丙咪嗪组与对照组比较(P>0.05)。
短句来源

 

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      paroxetine
    This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS).
          
    Further trials of antidepressant medication were unsuccessful, including paroxetine (clinical deterioration), lofepramine (ECG changes and clinical deterioration), and trazodone (priapism).
          
    On a C8 column with a mixture of perchlorate buffer and acetonitrile as mobile phase fluoxetine, norfluoxetine and the internal standard (paroxetine) were eluted in less than 9 min, without interference from the biological matrix.
          
    The analytes and the internal standard (IS) paroxetine were extracted by liquid-liquid extraction with a mixture of saturated ethyl acetate:dichloromethane (4:1) and were separated using an isocratic mobile phase on a XTerra RP18 column.
          
    Comparison of the effects of amitriptyline and paroxetine in the treatment of fibromyalgia syndrome
          
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      其他


    Objective To evaluate the efficacy and side-effects of paroxetine. Methods A double-blind controlled trial was designed for comparing paroxetine with amitriptyline to treat depression. Thirty-two inpatients with depression were randomly assigned to take paroxetine (n=16) or amitriptyline (n=16) for six weeks. The efficacy and side-effects were evaluated by Hamilton Depression Scale(HAMD), clinical Global Impression( CGI), Hamilton Anxiety Scale (HAMA) and Treatment Emergent Symptoms Scale...

    Objective To evaluate the efficacy and side-effects of paroxetine. Methods A double-blind controlled trial was designed for comparing paroxetine with amitriptyline to treat depression. Thirty-two inpatients with depression were randomly assigned to take paroxetine (n=16) or amitriptyline (n=16) for six weeks. The efficacy and side-effects were evaluated by Hamilton Depression Scale(HAMD), clinical Global Impression( CGI), Hamilton Anxiety Scale (HAMA) and Treatment Emergent Symptoms Scale (TESS) before treatment and weekly during therapy. Results There was no significant difference in recovery ratio and reduction of scores of HAMD, HAMA and CGI between paroxitine and amitriptyline group. There were much less cardiovascular, nervous system, vegetative nervous system and other side-effects in paroxetine than in amitriptyline group. The main side-effects of paroxetine were slight dry mouth and constipation. Conclusions The results showed that paroxetine was a safe and effective antidepressant drug.

    评估帕罗西汀和阿米替林治疗抑郁症病人的临床疗效。  方法 采用随机、双盲对照的研究方法 ,帕罗西汀组和阿米替林组各 1 6例 ,治疗 6周。  结果 帕罗西汀与阿米替林疗效相似 ,帕罗西汀的植物神经、心血管、神经系统及其它副作用显著少于阿米替林 ;帕罗西汀主要副作用为轻度口干、便秘。  结论 帕罗西汀是一种安全而有效的抗抑郁剂

    Objective The purpose of this study was to investigate the clinical efficacy and the side effects of paroxetine in the treatment of obsessive compulsive disorder (OCD). Methods 42 patients who met the Chinese Classification and Diagnostic Criteria for Mental Disorders, the Second Revised Edition (CCMD 2 R) for OCD were involved in this study. Paroxetine efficacy in treatment of OCD were assessed with Y BOCS, MSCPOR, and the side effects were evaluated with Treatment Emergent Symptom Scale (TESS) compared...

    Objective The purpose of this study was to investigate the clinical efficacy and the side effects of paroxetine in the treatment of obsessive compulsive disorder (OCD). Methods 42 patients who met the Chinese Classification and Diagnostic Criteria for Mental Disorders, the Second Revised Edition (CCMD 2 R) for OCD were involved in this study. Paroxetine efficacy in treatment of OCD were assessed with Y BOCS, MSCPOR, and the side effects were evaluated with Treatment Emergent Symptom Scale (TESS) compared with clomipramine and placebo. Results The therapeutic efficacy in paroxetine group was similar to that in clomipramine ( P >0.05), both effects of paroxetine and clomipramine were better than that of placebo ( P <0.01). However the side effects of paroxetine were lighter than clomipramine. Conclusion The results indicate that both paroxetine and clomipramine is effective in the treatment of OCD, but paroxetine showed more advantages for its convenient administration and low daily dosage and the side effects of it were light.

    目的探讨帕罗西汀对强迫症的临床疗效及副反应。方法对42例强迫症患者应用帕罗西汀(15例)与氯丙咪嗪(15例)、安慰剂(12例)进行对照治疗。采用YaleBrown强迫量表(YBOCS)、Marks恐怖强迫量表(MSCPOR)、汉密尔顿抑郁量表(HAMD)、副反应量表和临床疗效评定标准,分别评定疗效和副反应。结果帕罗西汀组与氯丙咪嗪组疗效近似(P>0.05),帕罗西汀组与氯丙咪嗪组的显效率(痊愈+显著进步)差异无显著性(χ2=0.14,P>0.05),均明显优于安慰剂组(P<0.01)。各组治疗前后量表的评分显示,YBOCS、MSCPOR、HAMD总分,帕罗西汀组和氯丙咪嗪组治疗后减分率均高于安慰剂组(P<0.01),前两组比较差异无显著性(P>0.05)。帕罗西汀组副反应较氯丙咪嗪组少且轻微。结论帕罗西汀与氯丙咪嗪对强迫症均有较好的疗效,但帕罗西汀具有日服剂量小、给药方法简便、副反应轻微等优点

    Objective The study was to explore the serotonergic and dopeminergic function in centralnervous system and to determine the pharmacological mechanisms of typical and atypical antipsychotics. Methods78 inpatients with schizophrenia were treated with a fixed dose of risperidone 6 mg daily or haloperidol 20 mg perday for 12-week in a double-blind, randomized design. The symptoms were evaluated by PANSS before and aftertreatment. Prolactin and cortisol responses to paroxetine challenge test were measured at pre-...

    Objective The study was to explore the serotonergic and dopeminergic function in centralnervous system and to determine the pharmacological mechanisms of typical and atypical antipsychotics. Methods78 inpatients with schizophrenia were treated with a fixed dose of risperidone 6 mg daily or haloperidol 20 mg perday for 12-week in a double-blind, randomized design. The symptoms were evaluated by PANSS before and aftertreatment. Prolactin and cortisol responses to paroxetine challenge test were measured at pre- and post-treatment,as compared with 18 normal controls. Results At pre-treatment, baseline cortisol level and paroxetine-evokedcortisol response was significantly higher but baseline prolactin level was significantly lower paroxetine-stimulatedprolactin level in patient group. After treatment, the baseline prolactin levels of patients in both risperidone andhaloperidol groups were significantly increased and higher than that of normal control. No difference in prolactinresponse to paroxetine stimulation was noted between risperidone and haloperidol groups. Baseline cortisol levelswere markedly lower in both treatment groups than before treatment but a significant reduction for risperidonegroup. There was a significant decrease in cortisol response to paxoxetine challenge test in risperidone treatmentgroup but no difference in haloperidol treatment group when compared with both before treatment and normalcontrol. Conclusions The hyperactivity of dopamine and serotonin function may exist in patients withschizophrenia before treatment. Risperidone treatment can reduce the elevated 5-HT function of patient to normallevel. But haloperidol treatment doesn't produce significant influence on 5-HT function. Both risperidone andhaloperidol can ichibit the dopamine function considerably in the central nervous system.

    目的探讨精神分裂症中枢5-羟色胺(5-HT)、多巴胺(DA)功能,以及非典型、典型抗精神病药对它们的影响。方法采用随机、双盲法应用固定剂量利培酮6mg/d、氟哌啶醇20mg/d治疗78例精神分裂症患者,共12周。治疗前后测定皮质醇、催乳素对帕罗西汀激发试验的反应,并以18名正常人为对照组。结果治疗前患者组基础皮质醇[(106±41)μg/L]、皮质醇对帕罗西汀激发试验的反应(曲线下面积AUC为717±229)高于对照组[(73±25)μg/L及AUC585±163],而基础催乳素[(5±7)μg/L]低于对照组[(9±5)μg/L]、催乳素对帕罗西汀激发试验的应答比对照组呈降低趋势(AUC49±41对68±43,P>0.05)。治疗后,两组患者的催乳素基础值比治疗前均增高(P均<0.05);两组之间帕罗西汀介导的催乳素反应差异无显著性。治疗后,两组皮质醇的基础值[(74±32)μg/L及(82±27)μg/L]均较治疗前降低,其中利培酮治疗后降低更为明显。利培酮治疗后皮质醇对帕罗西汀激发试验的反应(AUC518±213)降低,并与对照组差异无显著性,...

    目的探讨精神分裂症中枢5-羟色胺(5-HT)、多巴胺(DA)功能,以及非典型、典型抗精神病药对它们的影响。方法采用随机、双盲法应用固定剂量利培酮6mg/d、氟哌啶醇20mg/d治疗78例精神分裂症患者,共12周。治疗前后测定皮质醇、催乳素对帕罗西汀激发试验的反应,并以18名正常人为对照组。结果治疗前患者组基础皮质醇[(106±41)μg/L]、皮质醇对帕罗西汀激发试验的反应(曲线下面积AUC为717±229)高于对照组[(73±25)μg/L及AUC585±163],而基础催乳素[(5±7)μg/L]低于对照组[(9±5)μg/L]、催乳素对帕罗西汀激发试验的应答比对照组呈降低趋势(AUC49±41对68±43,P>0.05)。治疗后,两组患者的催乳素基础值比治疗前均增高(P均<0.05);两组之间帕罗西汀介导的催乳素反应差异无显著性。治疗后,两组皮质醇的基础值[(74±32)μg/L及(82±27)μg/L]均较治疗前降低,其中利培酮治疗后降低更为明显。利培酮治疗后皮质醇对帕罗西汀激发试验的反应(AUC518±213)降低,并与对照组差异无显著性,而氟哌啶醇组皮质醇反应与治疗前差异光显著性(P>0.05)。结论精神分裂症患者治疗前可能有中枢DA功能亢进和5-HT功能增高。利培酮治疗使患者原来过高的中枢5-HT功能接近正常,而氟哌啶醇

     
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