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轻链蛋白
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  light chain protein
     A myeloma cell line CZ-1 secreting λ light chain protein was used as an object of study. The CZ-1 cell morphology was observed by Wright's staining, the CD49e expression on cell suface after treatment with 2ME2 was detected by flow cytometry, the concentration of λ light chain protein in the supernatant was assayed by immuno-scattering turbidity method.
     以自行建立的、能分泌λ轻链蛋白的骨髓瘤细胞系CZ -1细胞为研究对象,通过瑞氏染色观察其形态变化,用流式细胞术分析2ME2作用后细胞表面标志CD49e的表达率,采用免疫比浊法测定培养上清液中λ轻链蛋白浓度。
短句来源
     Light chain protein play an important role in renal failure in LCD. The measurement of serum light chain and immunogolobulin are important to LCD diagnosis and prognosis .
     轻链蛋白是LCD患者肾功能损害的重要致病因素,测定血清、尿液Ig和轻链含量并计算κ/λ比值是诊断LCD和判断预后的重要依据。
短句来源
     IEM demonstrated that amyloid fibrils labeled with colloid gold was combined with a kind of light chain protein which was confirmed as the light chain type of AL.
     免疫电镜可观察到轻链蛋白被标记于淀粉样纤维部位 ,证实 15例均为轻链型AL。
短句来源
     The statistical difference from the control group was significant; the concentration of λ light chain protein increased from control group 29.3±2.77 μg/ml to 35.97±2.6 μg/ml (P<0.05) after exposure to 0.1 μmol/L 2ME2 for 72 hours, and the treatment of 0.5 μmol/L 2ME2 up-regulated λ light chain protein to 79.67±1.88 μg/ml (P<0.01) continuously.
     0.1和0.5μmol/L2ME2处理72小时后, CZ-1细胞分泌λ轻链蛋白分别由29.3±2.77μg/ml增至35.97±2.6μg/ml(P<0·05)和增至79.67±1.88μg/ml(P<0.01),显示浓度效应依赖关系。
短句来源
     Results The transfected Sp2/0 clones selected by mycophenolic acid, expressed L-PGDS human-mouse chimeric light chain protein steadily, which was affirmed by ELISA and RT-PCR.
     结果在筛选后的转染细胞上清中检测到抗人L-PGDS人-鼠嵌合轻链蛋白,且其细胞中存在相应嵌合轻链mRNA。
  “轻链蛋白”译为未确定词的双语例句
     Light chain secretion in the supernatant was increased from (35.97±2.60)μg/ml to (79.67±1.88)μg/ml (P<0.05) .
     CZ 1细胞分泌轻链蛋白由(35. 97±2. 60)μg/ml升高到(79. 67±1. 88)μg/ml,差异有统计学意义(P<0. 05)。
短句来源
     Free light chain was detected in the serum of 88.2% patients and in the urine of 58.8% patients,with λ chain as the dominant type.
     血清轻链蛋白阳性率为88.2%,尿中轻链蛋白阳性率为58.8%,以λ链蛋白为主。
短句来源
     ②The level of light chain κ in urine of type κ LCD was higher than normal (P< 0.05);
     ②LCD患者κ型仅尿κ轻链蛋白含量明显高于正常组 (P <0 .0 5 ) ;
短句来源
     Results ①The levels of light chain κ in serum and urine of type κ MM patients were higher than that of normal healthy controls (P<0.05);
     结果 ①MM患者κ型血清与尿κ轻链蛋白含量明显高于正常组 (P <0 .0 5 ) ;
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     Results 3.0 mg/L of recombinant bovine enterokinase catalytic subunit protein was obtained from flask culture and the percentage of cleaved IL-11/MBP fusion protein with enterokinase recognition site was more than 90%.
     结果:培养液中重组牛肠激酶轻链蛋白表达量为3.0mg/L。 对含有肠激酶酶切位点的IL-11/MBP融合蛋白进行酶切,结果表明,酶解率可达到90%以上。
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  相似匹配句对
     MLL protein;
     MLL蛋白;
短句来源
     protein binding;
     蛋白结合;
短句来源
     Analysis of Cotton(Gossypium hirsutum L.) Plants Transformed with a Silkworm Fibroin Light Chain Gene
     对转蚕丝芯蛋白轻链基因棉花的分析
短句来源
     Detecting of urinary free light cbain using ELISA method and its application to monoclonal gammapathies
     尿轻链酶联免疫测定在M蛋白病中的意义
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  light chain protein
Our approach (RT-PCR with fish-specific mlc1, mlc2, and mlc3 primers) failed to reveal the larval form of myosin light chain protein found previously by protein electrophoresis of loach fry muscle extract.
      
There is a possibility that the paralog of mlc1 encodes larval myosin light chain protein (larval MLC) previously reported in a number of fish species.
      
Taken together, these data suggest that protein kinase C might be involved in the increased phosphorylation of cardiac myosin light chain protein in myocardial hypertrophy.
      
The LjGln1 gene encodes a cytosolic glutamine synthetase and the LjKrm (Kinesin repeat motif) gene encodes a polypeptide with similarity to a repeated motif present in the microtubule-associated kinesin light chain protein.
      
The protein predicted from the cDNA matches partial amino acid sequence derived from essential light chain protein that copurifies with native nonmuscle myosin heavy chain.
      
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  light-chain
Furthermore, this decrease in actomyosin ATPase activity was partially restored with the reassociation of light chains with light-chain-deficient-myosin.
      
Minute quantities of IgM and free light-chain (mostly lambda) components were found in 2 out of 11 and 5 out of 14 samples respectively.
      
The gammaglobulin abnormalities found on isoelectric focusing were identified as microheterogeneous, oligoclonal IgG with predominantly kappa light-chain determinants.
      
Amyloid deposits in both cases reacted with anti-human prealbumin sera but not with antisera to human AA and anti-human immunoglobulin light-chain amyloids, including Aκ and Aλ.
      
The latter group also had a significant excess of light-chain production, particularly free κ when compared to multiple sclerosis patients without local synthesis of IgA.
      
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This report describes the clinical and immunologic characteristics of 2 patients with light chain multiple myeloma. Free monoclonal K light chain appears in the urine as Bence-Jones protein. The excretion of light chain protein exceeds 1g/24 hours in both patients. This is associated with a reduction of normal immunoglobulins in the serum and an increase in plasma cells in the bone marrow. Clinically they are characterized by osteolytic lesions, renal failure and hypercalcaemia. The response to chemotherapy...

This report describes the clinical and immunologic characteristics of 2 patients with light chain multiple myeloma. Free monoclonal K light chain appears in the urine as Bence-Jones protein. The excretion of light chain protein exceeds 1g/24 hours in both patients. This is associated with a reduction of normal immunoglobulins in the serum and an increase in plasma cells in the bone marrow. Clinically they are characterized by osteolytic lesions, renal failure and hypercalcaemia. The response to chemotherapy was unsatisfactory in both cases. One patient died of renal failure and infection shortly after the diagnosis was established, indicating that multiple myeloma which secretes only light chain protein is more aggressive and runs much shorter course.

本文报告二例K型轻链型多发性骨髓瘤,尿中皆检出较多游离的K型轻链蛋白,伴血中各种正常免疫球蛋白偏低,骨髓中浆细胞明显增多,临床上有明显溶骨改变、肾功能衰退及高血钙症;对化疗反应较差。其中一例诊断后不久死于肾功能衰竭与感染。结合文献对该病的临床特征、免疫学发现、诊断及其肾病问题作了讨论。

A cDNA library was constructed inLgtll vectors,complementary to the mRNA isolatedfrom a mouse hybridoma raised against potato virus Y(PVY).Thirty cDNA clones were selected from thecDNA library by in situ immunohybridization with goat anti-mouse kappa-chain-specific antibody conjugat-ed to alkaline phosphatase from which one clone k6,having the largest insert was characterized by se-quence analysis.The result showed that the immunoglobulin messenger RNA corresponding to k6 was 956nucleotides in length excluding...

A cDNA library was constructed inLgtll vectors,complementary to the mRNA isolatedfrom a mouse hybridoma raised against potato virus Y(PVY).Thirty cDNA clones were selected from thecDNA library by in situ immunohybridization with goat anti-mouse kappa-chain-specific antibody conjugat-ed to alkaline phosphatase from which one clone k6,having the largest insert was characterized by se-quence analysis.The result showed that the immunoglobulin messenger RNA corresponding to k6 was 956nucleotides in length excluding the poly(A)region,among which 31 bases code for the 5’non-codingregion,57 for the leader sequence of the protein,657 for the mature protein and 2ll for the3’non-codingregion. Comparison of deduced amino acid sequences of the protein and other kappa light chains showedthat they share a 100%identity in their constant regions (CL) and 93.7%identity in their variable regions(VL).The kappa light chain encoded by k6 was considered to be specific to PVY since only one type oflight chain was expressed in the hybridoma.

从大量繁殖的D73杂交瘤细胞中,提取制备其基因组mRNA,并以此为模版,经反转录途径获得基因组cDNA,随后将其插入到λgtll中,构建了马铃薯Y病毒小鼠单克隆抗体cDNA基因文库。通过免疫原位杂交,从该基因文库中筛选出含有抗体轻链基因的阳性克隆,进一步将其插入到pGEM-7Zf(+)质粒中,经酶谱和DNA序列分析确定,完整的轻链基因被获得。该基因含有956个核苷酸碱基[不包括Poly(A)尾巴],其中包括5’一端非编码区31个核苷酸碱基,编码轻链信号肽的57个核苷酸碱基,编码成熟蛋白的657个核苷酸碱基和3’一端非编码区的211个核苷酸碱基。与已知的其它k轻链(kappa)基因(MRK16)相比,核苷酸序列同源性为98.7%,由核苷酸序列所推导出的氨基酸的序列同源性为97.0%。该同源性在不同功能区域之间存在着差异,其中在保守区(CL),氨基酸的序列同源性为100%,而在可变区(VL),同源性为93.7%,其变异主要发生在三个不同的区域,即所谓的抗原识别位点(CDR)。该蛋白被认为对马铃薯Y病毒是特异性的,因为D73杂交瘤细胞只能够表达一种轻链蛋白

The levels of immunoglobulin,light chain,heavy chain/light chain ratio and Kappa/Lambda light chain ratio in serum and Kappa/Lambda ratio in urine were measured in 26 cases with light chain disease(LCD)by mephelometry method.The results showed that 1.The levels of immunoglobulins in serum of LCD were much lower than healthy controls( P <0.01).2.Although the levels of Kappa or Lambda in serum might be higher than or the same as healthy controls,Kappa/Lambda...

The levels of immunoglobulin,light chain,heavy chain/light chain ratio and Kappa/Lambda light chain ratio in serum and Kappa/Lambda ratio in urine were measured in 26 cases with light chain disease(LCD)by mephelometry method.The results showed that 1.The levels of immunoglobulins in serum of LCD were much lower than healthy controls( P <0.01).2.Although the levels of Kappa or Lambda in serum might be higher than or the same as healthy controls,Kappa/Lambda ratio was abnormal and total concentration of light chains was more than heavy chains( P <0.01).3.The concentration of abnormal Kappa or Lambda light chains in urine was more than the same light chain in serum of LCD( P <0.01).4.The Lambda type were more often present than Kappa type in LCD,all Kappa/Lambda ratios in serum and urine were less than 1 especially the Lambda type,but Kappa/Lambda ratios in serum and urine were more than 2 especially the Kappa type.Light chain protein play an important role in renal failure in LCD.The measurement of serum light chain and immunogolobulin are important to LCD diagnosis and prognosis .

用速率散射比浊测定26例轻链病(LightChainDisease,LCD)血清、尿液中IgG、A、M和轻链κ、λ含量并计算重链/轻链比值和κ/λ比值。结果表明:血清IgG含量均明显低于正常对照(P<0.01);血清κ或λ含量高于或等于正常对照,但κ/λ比值异常,轻链蛋白总和大于重链蛋白总和;尿液中异常升高的κ或λ轻链含量高于血清同一轻链水平(P<0.01);LCD以λ型多于κ型,λ型血清和尿液中κ/λ比值明显小于1,而κ型血清和尿液中κ/λ比值明显大于2。轻链蛋白是LCD患者肾功能损害的重要致病因素,测定血清、尿液Ig和轻链含量并计算κ/λ比值是诊断LCD和判断预后的重要依据。

 
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