4.Important analogs of the vitamin D metabolite include 24,24-F_2 -25-OH-D_3 and the 26,26,26,27,27,27,-F_6-25-OH-D_3.These have been used to show that the 24-hydroxylation,the 26-hydroxylation,and the lactone formation do not play a significant role in the function of vit- amin D.
4.维生素 D 代谢物的重要类似物,包括24,24,-F_2-25-OH-D_3和26,26,26,27,27,27,-F6-25-OH-D_3。 曾使用这些化合物证明了,24-羟化作用、26-羟化作用和内酯的形成,这些途径在维生素 D 的功能中不起重要作用。
High performance liquid chromatography (HPLC) is a separation analysis method of physics or physical chemistry and it has the ability to separate and analyze similar medicine and metabolin at the same time.
This thesis concerns the application of the technology of nuclear magnetic resonance (NMR) in the study of the complex system of new drugs, including drug metabolites in the biofluids and the biologically active components in Traditional Chinese Medicine.
应用核磁共振谱(nuclear magnetic resonance spectroscopy，NMR)技术对药物研究的复杂体系中药物及其代谢物进行研究，包括以下三个部分：
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
Biological Evaluation of a Secondary Metabolite, 9-O-methylfusarubin, from Fusarium oxysporum
Surprisingly, in the corresponding control set (cultivation of laccase-negative clone without atrazine) an unidentified metabolite having a retention time and UV-spectrum similar to those of atrazine was also found.
It has been demonstrated in model experiments that the decrease in the content of BET in the culture fluid is accounted for by the toxin interaction with an attendant product, the exogenous metabolite (EM).
Biotransformation of β-carotene with enzyme preparations isolated from the mycelium of Blakeslea trispora resulted in the formation of its hydroxylated metabolite and apocarotenals, products of oxidative degradation of this compound.
Analysis of drug metabolites by gas chromatography-mass spectrometry using glass capillary columns
A comparative study of the chromatography of hydroxylated dialkyldithiocarbamates as models for drug metabolites
Hydroxylated dialkyldithiocarbamates have been used as model compounds to test the suitability of packed column supercitical fluid chromatography for the analysis of drug metabolites.
The strong retention of the ionised glucuronide and sulphate conjugates of morphine is a particularly useful feature of the porous graphitic carbon packing material which has general applicability to the analysis of polar or ionised drug metabolites.
Covalent binding of drug metabolites to DNA - a tool of predictive value