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代谢物     
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  metabolite
     OBJECTIVE To study the influence of thiopurine methyltransferase(TPMT) activity on the pharmacokinetics(PK) of 6-mercaptopurine,which is the intermediate metabolite of azathioprine.
     目的通过对硫唑嘌呤中间代谢物6-巯基嘌呤(6-mercaptopurine,6-MP)药动学的研究,初步探讨巯嘌呤甲基转移酶(thiopurine methyltransferase,TPMT)活性对6-MP药动学的影响。
短句来源
     Results The average rates of recovery of the metabolite of oxcarbazepine in high,medium and low concentrations(120.0,60.0,12.0 mg·kg~(-1))were 100.43%,99.33% and 99.17%,respectively.
     结果奥卡西平代谢物的高、中、低(120.0,60.0,12.0 mg.L-1)3种浓度平均回收率分别为100.43%,99.33%,99.17%,日内、日间差RSD均<6%(n=5);
短句来源
     4.Important analogs of the vitamin D metabolite include 24,24-F_2 -25-OH-D_3 and the 26,26,26,27,27,27,-F_6-25-OH-D_3.These have been used to show that the 24-hydroxylation,the 26-hydroxylation,and the lactone formation do not play a significant role in the function of vit- amin D.
     4.维生素 D 代谢物的重要类似物,包括24,24,-F_2-25-OH-D_3和26,26,26,27,27,27,-F6-25-OH-D_3。 曾使用这些化合物证明了,24-羟化作用、26-羟化作用和内酯的形成,这些途径在维生素 D 的功能中不起重要作用。
短句来源
     GC-MS/MS of Pethidine and His Metabolite in Urine
     尿液中哌替啶及其代谢物的GC-MS/MS检验法
短句来源
     Results:The assay was linear from 0.05 to 10.0μg·mL~(-1) for each enantiomer of esmolol and 0.03 to 10.0μg· mL~(-1)for each enantiomer of metabolite.
     结果:艾司洛尔对映体在0.05~10μg·mL~(-1)范围内线性关系良好,代谢物对映体在0.03~10μg·mL~(-1)范围内线性关系良好。
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  metabolites
     STUDIES ON PLANT PHOSPHOENOLPYRUVATE CARBOXYLASE Ⅱ. METABOLITES REGULATION AND OLEATE INHIBITION OF PEP CARBOXYLASE FROM SORGHUM LEAVES
     植物磷酸烯醇式丙酮酸羧化酶的研究——Ⅱ.高粱叶片PEP羧化酶的代谢物调节特性和油酸抑制效应
短句来源
     STUDIES ON METABOLITES PRODUCED BY STREPTOMYCES RAMULOSUS TUE-34 I. THE STRUCTURE DETERMINATION OF TWO β-OXOTRYPTAMINE DERIVATIVES
     小枝链霉菌Tue-34产生的代谢物的研究——Ⅰ.两种β-氧代色胺衍生物的结构测定
短句来源
     STUDIES ON METABOLITES PRODUCED BY STREPTOMYCES RAMULOSES Tue-34 Ⅱ. THE STRUCTURAL ELUCIDATION OF OXYPLICACETIN, A NEW MEMBER OF AMICETIN GROUP
     小枝链霉菌Tue-34产生的代谢物的研究——Ⅱ.友菌素族抗生素的新成员——氧褶皱菌素的结构研究
短句来源
     Inhibition of Carnitine Acetyltransferase by Metabolites of 4-Pentenoic Acid
     戊烯—4—酸的代谢物对肉毒碱乙酸基转移酶的抑制作用
短句来源
     STUDIES OF 1-ACETYL-3-O-TOLUYL-5-FLUOROURACIL 3. HPLC IN DETERMINATION OF THE MAIN METABOLITES A-OT-FU IN SERUM
     1—乙酰基-3-邻-甲基苯甲酰基-5-氟尿嘧啶的研究——Ⅲ、高效液相色谱法测定小鼠主要代谢物的血药浓度
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  metabolin
     The elimination half life of curcumin in mice was 22.6 minutes, but that of metabolin of FM01 in mice was 31.2 minutes.
     姜黄素小鼠体内血浆消除半衰期为22.6min,FM01小鼠体内代谢物血浆消除半衰期为31.2min。
短句来源
     Clinically further study about change of metabolin in brain and it's correlation with clinic after cerebral infarction in different period is scarceful.
     目前临床上对脑梗死后不同时间脑内代谢物的变化及其与临床的相关性尚缺乏更深入的研究。
短句来源
     Effect of Mental Stress on Hippocampal Volume and Metabolin Level in Rats in Vivo: A Study of Magnetic Resonance Imaging and Spectroscopy
     磁共振成像和频谱技术在体观察精神应激对大鼠海马体积和代谢物水平的影响
短句来源
     High performance liquid chromatography (HPLC) is a separation analysis method of physics or physical chemistry and it has the ability to separate and analyze similar medicine and metabolin at the same time.
     高效液相色谱法是一种物理或物理化学的分离分析方法,能同时分离分析结构相似的药物和代谢物
短句来源
     DETECTION OF NITRIC OXIDE METABOLIN AND ANALYSIS OF ITS CORRELATION WITH VIRUS HEPATITIS
     一氧化氮代谢物的测定及其与病毒性肝炎若干相关因素的分析
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  drug metabolites
     This thesis concerns the application of the technology of nuclear magnetic resonance (NMR) in the study of the complex system of new drugs, including drug metabolites in the biofluids and the biologically active components in Traditional Chinese Medicine.
     应用核磁共振谱(nuclear magnetic resonance spectroscopy,NMR)技术对药物研究的复杂体系中药物及其代谢物进行研究,包括以下三个部分:
短句来源
     This method is rapid, convenient, and suitable for the rapid identification of drug metabolites in biologic samples.
     该方法快速,简便,适合于生物样品中药物代谢物的快速鉴定。
短句来源

 

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  metabolite
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
Biological Evaluation of a Secondary Metabolite, 9-O-methylfusarubin, from Fusarium oxysporum
      
Surprisingly, in the corresponding control set (cultivation of laccase-negative clone without atrazine) an unidentified metabolite having a retention time and UV-spectrum similar to those of atrazine was also found.
      
It has been demonstrated in model experiments that the decrease in the content of BET in the culture fluid is accounted for by the toxin interaction with an attendant product, the exogenous metabolite (EM).
      
Biotransformation of β-carotene with enzyme preparations isolated from the mycelium of Blakeslea trispora resulted in the formation of its hydroxylated metabolite and apocarotenals, products of oxidative degradation of this compound.
      
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  metabolites
PRODUCTION OF ANTIBACTERIAL AND ANTIFUNGAL METABOLITES BY STREPTOMYCES VIOLACEUSNIGER AND MEDIA OPTIMIZATION STUDIES FOR THE MAX
      
Significant (p?=?0.0061) increases of radioactivity were observed in kidney, spleen, and thyroid, which could be exampled by the effects of the extract and/or by the generation of active metabolites.
      
Many low-molecular weight metabolites were identified by 1H-NMR spectra of the rat serum.
      
The results showed that NPEOs and its metabolites existed in all the samples of the influent, effluent, and sludge.
      
Hence, the concentrations of some small metabolites, such as nonylphenol (NP), nonylphenol monoethoxylate (NP1EO), and nonylphenol diethoxylate (NP2EO) were elevated in the effluent.
      
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  drug metabolites
Analysis of drug metabolites by gas chromatography-mass spectrometry using glass capillary columns
      
A comparative study of the chromatography of hydroxylated dialkyldithiocarbamates as models for drug metabolites
      
Hydroxylated dialkyldithiocarbamates have been used as model compounds to test the suitability of packed column supercitical fluid chromatography for the analysis of drug metabolites.
      
The strong retention of the ionised glucuronide and sulphate conjugates of morphine is a particularly useful feature of the porous graphitic carbon packing material which has general applicability to the analysis of polar or ionised drug metabolites.
      
Covalent binding of drug metabolites to DNA - a tool of predictive value
      
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