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代谢物     
相关语句
  metabolite
    Analysis of the Main Cannabis Metabolite THC-COOH
    大麻的体内代谢物THC-COOH的分析
短句来源
    GC-MS/MS of Pethidine and His Metabolite in Urine
    尿液中哌替啶及其代谢物的GC-MS/MS检验法
短句来源
    Detection of Methadone and Its Main Metabolite in Urine
    尿中美沙酮及代谢物的检测
    Methaqualone and 2-methyl-3 [2- (hydroxymethyl) phenyl]- 4 (3H) quinazolinone (metabolite I) concentrations in human serum wereanalyzed quantitatively by reverse high performance liquid chromatography (RP-HPLC).
    本文建立了用反相高效液相色谱法(RP-HPLC)测定人血清中安眠酮及其苯甲基羟化代谢物-2-甲基-3[2-(羟甲基)-苯基]-4(3H)喹唑酮(Ⅰ)的浓度。
短句来源
    Purer midazolam metabolite (α -OH midazolam) was obtained by optimization of incubation conditions.
    通过优化药物体外代谢的条件,获得了较高纯度的咪达唑仑代谢物(α-OH咪达唑仑)对照品。
短句来源
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  metabolites
    Determinationof Heroin metabolites in human urine by internal SPE-GC/MS method
    内标法固相提取-GC/MS检测海洛因吸食者尿液中代谢物
短句来源
    Determination of heroin metabolites in biological fluids,tissues and hair of heroin addicts using GC/MS-SIM
    GC/MS研究海洛因代谢物在吸毒者体内的分布
短句来源
    Study of diphacinone and its metabolites in rabbit urine by HPLC-DAD
    兔尿中敌鼠及其代谢物的HPLC-DAD分析
短句来源
    A Study of the Conditions for Enzyme-hydrolysis of the Conjugates of Diazepam Metabolites in the Urine
    地西泮代谢物的结合物水解条件研究
短句来源
    Analysis of metabolites of heroin in urine by GC/ECD
    用GC/ECD方法分析海洛因中毒尿液吗啡代谢物
短句来源
更多       
  main metabolites
    The analysis of benzodiazepines and its main metabolites by thin-layer chromatography
    苯并二氮类药物及其主要代谢物的薄层色谱分析
短句来源
    Analysis of diazepam and its main metabolites in urine by GC-ECD
    尿中地西泮及其代谢物的气相色谱电子捕获检测法分析
短句来源
    Objective A method for the analysis of eleven benzodiazepine in beverages,blood and urine and seven main metabolites of benzodiazepine in urine by solid phase extraction and high performance thin layer chromatography is described in this paper.
    目的建立饮料、血、尿中 11种常见苯并二氮类药物及尿中 7种主要代谢物的薄层色谱分析法(HPTLC)。
短句来源
    Objective A rapid and highly sensitive method, based on the high performance thin-layer chromatography, was described for the qualitative and semiquantitative determination of 7-aminon-itramepam, the main metabolites of nitramepam, in human urine.
    目的 建立用高效薄层色谱法定性及半定量测定人尿中硝西泮的代谢物7-氨基硝西泮(7ANIZ)含量的方法。
短句来源
    Objective A method was developed for the determination diazepam and its main metabolites,nordiazepam, and oxazepam and then in urine by GC-ECD.
    目的 建立尿中地西泮及其代谢物替马西泮、去甲西泮和奥沙西泮的GC/ECD分析方法。
短句来源
  its metabolite
    The determination of heroin and its metabolite in human hair
    毛发中海洛因及其代谢物的分析综述
短句来源
    The animal experiment shows that this method is applicable. Notonly the methaqualone but also its metabolite can be detected using thismethod.
    动物中毒实验表明,此法实用,不仅能检出安眠酮,而且还可检出存在的代谢物;
短句来源
    This paper prerented a new method for idcntificating methamidophos in blood and its metabolite O、S-dimethylphosphate in urine by GC/SPD and GC/MS. Tributyl phosphate was used as interstandard for identificating metamidophos.
    本文利用GC/MS和GC/FPD法测定了生物体内的甲胺磷(MAP)及其代谢物O、S-二甲基磷酸酯(O、S-DMP).血中WAP以乙、乙酸乙酯混合溶剂提取、以磷酸三丁酯为内标测定;
短句来源

 

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  metabolite
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
Biological Evaluation of a Secondary Metabolite, 9-O-methylfusarubin, from Fusarium oxysporum
      
Surprisingly, in the corresponding control set (cultivation of laccase-negative clone without atrazine) an unidentified metabolite having a retention time and UV-spectrum similar to those of atrazine was also found.
      
It has been demonstrated in model experiments that the decrease in the content of BET in the culture fluid is accounted for by the toxin interaction with an attendant product, the exogenous metabolite (EM).
      
Biotransformation of β-carotene with enzyme preparations isolated from the mycelium of Blakeslea trispora resulted in the formation of its hydroxylated metabolite and apocarotenals, products of oxidative degradation of this compound.
      
更多          
  metabolites
PRODUCTION OF ANTIBACTERIAL AND ANTIFUNGAL METABOLITES BY STREPTOMYCES VIOLACEUSNIGER AND MEDIA OPTIMIZATION STUDIES FOR THE MAX
      
Significant (p?=?0.0061) increases of radioactivity were observed in kidney, spleen, and thyroid, which could be exampled by the effects of the extract and/or by the generation of active metabolites.
      
Many low-molecular weight metabolites were identified by 1H-NMR spectra of the rat serum.
      
The results showed that NPEOs and its metabolites existed in all the samples of the influent, effluent, and sludge.
      
Hence, the concentrations of some small metabolites, such as nonylphenol (NP), nonylphenol monoethoxylate (NP1EO), and nonylphenol diethoxylate (NP2EO) were elevated in the effluent.
      
更多          
  main metabolites
DNA damaging effects of carbofuran and its main metabolites on mice by micronucleus test and single cell gel electrophoresis
      
In urine, the main metabolites observed were the 6H-dibenzo[b,d]pyran-6-one derivatives, as aglycones or glucuronides.
      
In the first part the urinary levels of its main metabolites, 2,5-hexanedione and 2,5-dimethylpyrroles, were measured in 108 patients and 108 healthy controls, matched by age and sex.
      
Liquid chromatographic method for the simultaneous determination of sulphasalazine and its main metabolites in biological fluids
      
An HPLC procedure was developed for the simultaneous determination of salicylazosulphapyridine, and its main metabolites 5-aminosalicylic acid and sulphapyridine, in human serum and synovial fluid.
      
更多          
  its metabolite
In all producer strains, the synthesis of these enzymes was induced by arabinose and its metabolite arabitol.
      
Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused gui
      
This led to the suggestion that the electrophysiological effects of amiodarone during long-term treatment might be partly the result of the accumulation of its metabolite desethylamiodarone.
      
To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested.
      
The ability of the selective nigral toxin 1-methyl-4-phenyl-1,2,3,6tetrahydropyridine (MPTP) (via its metabolite MPP+) to destroy nigral dopamine cells selectively by inhibiting complex I of the mitochondrial energy chain may provide a clue.
      
更多          
  其他


An analytical method for the determination of both methaqualone and2'-hydroxymethylmethaqualone in internal organs has been established usingFinnigan Mat 1020 GC/MS instrument with SE-54 fused-silica capillary co-lumn.The animal experiment shows that this method is applicable.Notonly the methaqualone but also its metabolite can be detected using thismethod.This method is rapid,sensitive and accurate.The detection limitis 15μg/ml.The method has been successfully used in criminal cases.

作者在 Finnigan Mat 1020 GC/MS 仪上,应用 SE-54熔融硅毛细柱,建立了生物试样中安眠酮、2'-羟甲基安眠酮的分析方法。动物中毒实验表明,此法实用,不仅能检出安眠酮,而且还可检出存在的代谢物;在实际应用中,具有快速、灵敏、准确等特点。检测限为15ng,并已用于刑事案件的鉴定工作中。

Methaqualone and 2-methyl-3 [2- (hydroxymethyl) phenyl]- 4 (3H) quinazolinone (metabolite I) concentrations in human serum wereanalyzed quantitatively by reverse high performance liquid chromatography (RP-HPLC). The concentrations of methaqualone ranging from 1-35μg/ml were in good linear relationship(Correlation coefficient r = 0. 9980, regression line y = 0. 06324x-0. 1029), The average recovery of methaqualone reached as high as 102.08±9. 987(SD)% (n= 5). The detective limit was 1 ng. The relative quantity...

Methaqualone and 2-methyl-3 [2- (hydroxymethyl) phenyl]- 4 (3H) quinazolinone (metabolite I) concentrations in human serum wereanalyzed quantitatively by reverse high performance liquid chromatography (RP-HPLC). The concentrations of methaqualone ranging from 1-35μg/ml were in good linear relationship(Correlation coefficient r = 0. 9980, regression line y = 0. 06324x-0. 1029), The average recovery of methaqualone reached as high as 102.08±9. 987(SD)% (n= 5). The detective limit was 1 ng. The relative quantity of metabolite I was determined according to the linear concentration of methaqulone. RP-HPLC assay is proved to be useful in determening blood methaqualone and metabolite I concentrations in forensic toxicology.

本文建立了用反相高效液相色谱法(RP-HPLC)测定人血清中安眠酮及其苯甲基羟化代谢物-2-甲基-3[2-(羟甲基)-苯基]-4(3H)喹唑酮(Ⅰ)的浓度。安眠酮浓度在1-35μg/ml范围内呈直线相关(相关系数r=0.9980;回归方程y=0.06324x—0.1029),方法回收率平均为102.08±9.987(SD)%(n=5),检出限为1ng。其代谢物Ⅰ按原型安眠酮的线性浓度测定其相对量。本法为测定中毒者体内安眠酮及其代谢物Ⅰ的血浓度提供可行的手段。

An analytical method has been established for the determination of triazol am and its major metabolites in urine, 20ml urine sample was extracted with ethyl ether at PH 9. The extract was dried by anhydrous sodium sulfate, and then was concentrated to 0.5ml, and finally was analyzed by EI/CI/MS.Mass spectrum analysis was carried out with Finnigan Mat 1020 GC/MS/DS instrument with EI and CI source. In CI source methane was used as the reag ent gas. Source pressure was 0.35 torr,2ul sample were introduced into...

An analytical method has been established for the determination of triazol am and its major metabolites in urine, 20ml urine sample was extracted with ethyl ether at PH 9. The extract was dried by anhydrous sodium sulfate, and then was concentrated to 0.5ml, and finally was analyzed by EI/CI/MS.Mass spectrum analysis was carried out with Finnigan Mat 1020 GC/MS/DS instrument with EI and CI source. In CI source methane was used as the reag ent gas. Source pressure was 0.35 torr,2ul sample were introduced into the ion source by solid probe.The described method has many merits such as rapidness sensitivity. when triazolam administed orally at dosage level of 0.5mg,1-hydroxymethyl triazolam in urine can be detected. The method has been successfully used in criminal case investigation.

本文在综合文献的基础上,建立了尿中三唑苯二氮(艹卓)及其主要代谢物的鉴定方法。本法以20ml尿样,在PH为9时,用乙醚提取。提取物用无水硫酸钠脱水,K、D、浓缩到0.5ml,固体进样杆直接进行EI/CI/MS分析;质谱分析在Finnigan Mat 1020 GC/MS/DS仪上进行。EI、CI源,甲烷作反应气,源室压力0.35吒。2ul样品由固体进样杆进样,其温度程序:初温60℃,以120℃/min速率升温到350℃。所建立的分析方法快速、灵敏,口服给药量为0.5mg时,可检出尿中1—羟甲基三唑苯二氮(艹卓)。

 
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