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乳腺癌
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  breast cancer
    Epistiostanol Its Toxicity Antiestrogen Effect and Inhibition on Mice Breast Cancer
    国产环硫雄醇的毒性、抗雌激素活性及其对小鼠乳腺癌的抑制作用
短句来源
    Aminoglutethimide in therapy of advanced breast cancer with respect to estrogen receptor status
    氨格鲁米特治疗不同雌激素受体状态的复发转移乳腺癌
短句来源
    A Measurement of Estradiol Receptor Level in Human Breast Cancer
    人乳腺癌雌二醇受体水平的测定
短句来源
    High Performance Liquid Chromatography Assay for Estrogen Receptor in Human Breast Cancer
    高效液相色谱法测定的雌激素受体临床应用于人乳腺癌
短句来源
    Effects of Tamoxifen On MCF-7 Human Breast Cancer Cell Cycle Kinetics
    三苯氧胺对MCF-7人乳腺癌细胞系周期动力学影响
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  mammary cancer
    Methods: Sixty ASA I ~ II patients undergoing elective radical operation for mammary cancer,were randomly allocated into two groups with thirty cases each:domestic propofol group and import propofol group. General status of two groups'patients was identical.
    方法 60例ASA Ⅰ~Ⅱ级无心脑疾患的乳腺癌择期手术的患者,随机分为两组,进口丙泊酚(得普利麻)组和国产丙泊酚(力蒙欣)组,每组30例,两组患者的一般状况基本相同。
短句来源
    The compounds of bavachin, isobavachin, 8-C-prenyl-7,4'-Dihydroxyfiavone and 8-C-prenylapigenin were evaluated for their estrogenic activity on sensitivehuman mammary cancer in MCF-7 cell culture. The results showed they all had estrogenic activity in MCF-7 cell culture.
    对化合物补骨脂黄酮、异补骨脂黄酮、8-C-异戊烯基-7,4′-二羟基黄酮、8-C-异戊烯基芹黄素进行了植物雌激素样活性测定,结果表明它们对雌激素敏感性人乳腺癌细胞株MCF-7均具有雌激素样活性。
短句来源
    The ehuricoic acid in its fruiting body can be used for synthesis of steroid drug, which is the main drug of endocrine disease、impotence and some diseases of department of obstetrics & gynecology, it could be used for the adjunctive drug of mammary cancer、carcinoma of prostate and other malignant tumor.
    其子实体中的齿孔酸可用于合成甾体药物,是治疗内分泌疾病,雄性器官衰退及某些妇科疾病的主要药物,也是治疗乳腺癌、前列腺癌等恶性肿瘤的辅助药物。
短句来源
    It is concluded that the traditional Chinese medicine Gusongbao might increase the immunologic function, regulate calcium phosphorus metabolism, maintain bone density and improve osteoporosis can be used in therapy and prevention of osteoporosis and is especially suitable for ovarian carcinoma, carcinoma of endometrium and mammary cancer, in which administration of should be cautious or contraindicated.
    结果指出,中药骨松宝可提高免疫功能,调节钙磷代谢,保持骨质密度,改善骨质疏松程度,可用于治疗和预防骨质疏松,尤其对雌激素禁忌或慎用者(卵巢癌和子宫内膜腺癌、乳腺癌)更为理想
短句来源
  “乳腺癌”译为未确定词的双语例句
    THE STATUS OF STEROID RECEPTORS AND HORMONE RESPONSE IN 7,12-DIMETHYLBENZ(a)ANTHRACENE(DMBA)INDUCED RAT MAMMARY TUMOR
    7,12-二甲基苯蒽诱发大鼠乳腺癌的激素依赖性及孕、雌激素受体状况
短句来源
    Here, we aim to elucidate its possible mechanisms in mitochondria initiated apoptotic pathway involved in human BEL-7402 and MCF-7 cells.
    本研究主要利用人肝癌BEL-7402和乳腺癌MCF-7细胞研究了力达霉素对线粒体凋亡通路相关因子的影响。
短句来源
    The patients were treated with a single dose of 60 mg·m-2for 15 min i.v.
    乳腺癌化疗病人15min内静注吡柔比星60mg.
短句来源
    m-2 for 15-min i.v. infusion. The blood samples were obtained at the following times: before infusion, 5, 10min after the beginning of the infusion, and 0, 5, 10, 30min, 1, 2, 4, 8, 12, 24, 48h after the end of the injection, then the program of WinNonlin was used to calculate the pharmacokinetic parameters.
    乳腺癌化疗患者15分钟内静注吡柔比星60mg·m-2,在注射开始0、5、10min、注射结束时、结束后5、10、30min、1、2、4、8、12、24、48h取血测定浓度,使用WinNonlin软件拟合,计算药动学参数。
    The main results are summarized as following:(1) Effects of DHEA on Cancer ChemopreventionBy using two stage chemical transformation model of Balb/3T3 cells in vitro, we have demonstrated that DHEA 10~(-5) mol/L could significantly inhibited DMBA and TPA induced malignant transformation by 69.0%.
    采用DMBA诱发的Sprague-Dawley大鼠乳腺癌和Balb/3T3细胞体外二阶段转化模型,观察DHEA的癌化学预防。 实验结果表明DHEA(10~(-7)mol/L和10~(-5)mol/L)可显著抑制DMBA和TPA联合转化Balb/3T3细胞,抑制率分别为44.8%和69.0%。
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  breast cancer
Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell pr
      
The title compounds were evaluated for their efficacy in inhibiting MDA-MB-231 breast cancer cell proliferation.
      
Determination of telomerase activity in stem cells and non-stem cells of breast cancer
      
In this study, telomerase activity was measured and compared in breast cancer stem cells and non-stem cells that were phenotypically sorted by examining surface marker expression.
      
The phagocytic potency of macrophages isolated from blood of breast cancer patients was lower than engulfment ability of macrophages obtained from healthy donors and depended on tumor degree.
      
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  mammary cancer
We investigated the molecular mechanism of Lovastatin anti-tumor function through the study of its effect on membrane ion flow, gap junctional intercellular communication (GJIC), and the pathways of related signals in MCF-7 mammary cancer cells.
      
Objective: To determine the effect of cis-9, trans-1 1-conjugated linoleic acid on the cell cycle of mammary cancer cells (MCF-7) and the possible mechanism of the inhibitory effect of c9,t11-CLA.
      
Therefore, it could be regarded as an effective remedy for treatment of HDB and prevention of mammary cancer genesis.
      
Clinical study on treatment of mammary cancer by Shenqi Fuzheng Injection (参芪 扶正注射液) in cooperation with chemotherapy
      
Reversal of adriamycin resistance in human mammary cancer cells by small interfering RNA of MDR1 and MDR3 genes
      
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  mastocarcinoma
In the second case report, histologic findings confirmed a thoracic intramedullary metastasis of a mastocarcinoma.
      


AT-290, p-bis (2-chloroethyl) aminomethyl phenylalanine, synthesized at our Institutc, is a new derivative of nitrogen mustard. Animal experiments showed that AT-290 had a significant antitumor activity. The results on toxicity and antitumor activity were as follows: 1. The acute and subacute intraperitoneal LD_(50) for mice were 4 and 1.6 mg/kg/day respectively. The subacute oral LD_(50) in mice was 11 mg/kg/day and the subacute intraperitoneal LD_(50) in rats was 1 mg/kg/day. 2. In 3 dogs, intravenous injections...

AT-290, p-bis (2-chloroethyl) aminomethyl phenylalanine, synthesized at our Institutc, is a new derivative of nitrogen mustard. Animal experiments showed that AT-290 had a significant antitumor activity. The results on toxicity and antitumor activity were as follows: 1. The acute and subacute intraperitoneal LD_(50) for mice were 4 and 1.6 mg/kg/day respectively. The subacute oral LD_(50) in mice was 11 mg/kg/day and the subacute intraperitoneal LD_(50) in rats was 1 mg/kg/day. 2. In 3 dogs, intravenous injections of 75 γ/kg/day of AT-290 for 10 days produced no remarkable influence on the general behavior, erythrocyte, leukocyte and platelet counts, bleeding and coagulation time, urinalysis and EKG, but caused a significant lymphocytopenia in the peripheral blood. In another 6 dogs, AT-290 at the dosages of 150 and 300 γ/kg exhibited an inhibiting effect upon the bone marrow, as evidenced by a peripheral leukopenia and thrombopenia, delayed bleeding time, and hematopoitic depression in the bone marrow. The animals treated with 75 and 150 γ/kg gradually recovered after cessation of the drug, while those given 300 γ/kg died in 13—19 days. 3. AT-290 inhibited significantly the growth rate of Jensen sarcoma and fibrosarcoma M-57 in rats. Experiments on 3 ascites tumors of mice (Ehrlich ascites carcinoma, spindle cell sarcoma and mammary adenocarcinoma) showed that AT-290 significantly prolonged the survival time of the tumor-bearing mice.

本文介绍新的氮芥衍生物 AT-290 卽对-双(β-氯乙基)氨甲基苯丙氨酸二盐酸盐的毒性试验及实验治疗的结果。 1.本药在小鼠腹腔注射的急性LD_(50)为4毫克/公斤,亚急性口服和腹腔注射的LD_(50)分别为11及1.6毫克/公斤,大鼠腹腔注射的亚急性LD_(50)为1毫克/公斤。 2.狗毒性试验证明,AT-290 在75微克/公斤静脉注射每天1次连续10天,对狗的一般状态、体重、红、白血球数、血小板数、出血时间、凝血时间、尿及心电图检查均无明显影响;但却对淋巴细胞表现出明显抑制作用。150及300微克/公斤时,可抑制动物的骨髓机能,主要表现为白血球总数及血小板减少、出血时间延长、骨髓中幼稚细胞消失,对淋巴球的作用与75微克/公斤组同。这些情况在150微克/公斤组停药后一定时间自行恢复,而大剂量组(300微克/公斤)则动物死亡。 3.本药腹腔注射时对三种小白鼠腹水型肿瘤(Ehrlich腹水癌、梭形细胞肉瘤腹水型及腹水型乳腺癌)均有明显抑制作用,可延长动物的生存时间至2倍以上,对小白鼠实体型肿瘤(淋巴白血病L-2、Ehrlich癌、Crocker肉瘤及梭形细胞肉瘤) 均无明显抑制作用。对大白鼠J...

本文介绍新的氮芥衍生物 AT-290 卽对-双(β-氯乙基)氨甲基苯丙氨酸二盐酸盐的毒性试验及实验治疗的结果。 1.本药在小鼠腹腔注射的急性LD_(50)为4毫克/公斤,亚急性口服和腹腔注射的LD_(50)分别为11及1.6毫克/公斤,大鼠腹腔注射的亚急性LD_(50)为1毫克/公斤。 2.狗毒性试验证明,AT-290 在75微克/公斤静脉注射每天1次连续10天,对狗的一般状态、体重、红、白血球数、血小板数、出血时间、凝血时间、尿及心电图检查均无明显影响;但却对淋巴细胞表现出明显抑制作用。150及300微克/公斤时,可抑制动物的骨髓机能,主要表现为白血球总数及血小板减少、出血时间延长、骨髓中幼稚细胞消失,对淋巴球的作用与75微克/公斤组同。这些情况在150微克/公斤组停药后一定时间自行恢复,而大剂量组(300微克/公斤)则动物死亡。 3.本药腹腔注射时对三种小白鼠腹水型肿瘤(Ehrlich腹水癌、梭形细胞肉瘤腹水型及腹水型乳腺癌)均有明显抑制作用,可延长动物的生存时间至2倍以上,对小白鼠实体型肿瘤(淋巴白血病L-2、Ehrlich癌、Crocker肉瘤及梭形细胞肉瘤) 均无明显抑制作用。对大白鼠Jensen肉瘤及纤维肉瘤M-57疗效则很显著。

In anabolic metabolism the precursor of melanin is an indolic compound. It is of interest to study some compound containing both nitrogen mustard and indole group in order to find effective agents against melanoma. A seies of these compounds were synthesized in this Institute. After pharmacological studies two drugs (designated as AT-267 and AT-346,Fig,1)were found to be more powerful than others. (1)Intragastric administrations of AT-267, AT-346, and sarcolysin (PAM) at the 1/6 acute LD_(50) produced a marked...

In anabolic metabolism the precursor of melanin is an indolic compound. It is of interest to study some compound containing both nitrogen mustard and indole group in order to find effective agents against melanoma. A seies of these compounds were synthesized in this Institute. After pharmacological studies two drugs (designated as AT-267 and AT-346,Fig,1)were found to be more powerful than others. (1)Intragastric administrations of AT-267, AT-346, and sarcolysin (PAM) at the 1/6 acute LD_(50) produced a marked inhibitory effect on sarcoma 180, spindle cell sarcoma, reticulum cell sarcoma (L-Ⅱ), sarcoma AK, Ehrlich carcinoma (solid form), and mammary carcinoma (ascitic form) in mice, but no effect on Ehrlich ascites carcinoma. The former two drugs exhibited also a definite inhibition on melanoma and brain tumour (B-22)in mice, and Jensen sarcoma in rats. (2)In mice, the acute LD_(50) after intragastric administration of AT-267, AT-346, and PAM were found to be 120, 16, and 33 mg/kg, and the subacute LD_(50) to be 33, 6.8, and 10 mg/kg respectively. The chemotherapeutic indices (MTD/MED) of AT-267 and AT-346 for sarcoma 180 were about 6 and 13 respectively. (3)In dogs, oral administration of 0.9 and 2.7 mg/kg/day of AT-346 for 10 days caused a definite depression on the heamopoietic organs. At autopsy and microscopic examinations heamorrhage points in intestinal mucosa and a slight degree of fatty degeneration in liver were found. In the group of 0.3 mg/kg, white cell counts slightly decreased but other examinations did not show any alterations. Three monkeys were given AT-346 at the total dosages of 5, 56, and 122 mg respectively, and the heamopoietic depression was noticed in two animals (receiving 56 and 122 mg).

作者发現两个吲(口朶)氮芥化合物AT-267和AT-346均有明显的抗肿瘤作用,其中尤以AT-346的疗效較佳,因此进行了它的疗效与毒性研究并与溶肉瘤素进行了比較。主要結果如下:(1)AT-267,AT-346和溶肉瘤素分别口服1/6的急性LD_(50)剂量对小鼠肉瘤180,棱形細胞肉瘤,网织細胞肉瘤,AK肉瘤,Ehrlich癌实体型和乳腺癌均有显著的抑制作用。前两个药对小鼠黑色素瘤,脑瘤22和大鼠Jensen肉瘤也均有一定的抑制作用。(2)AT-267,AT-346和溶肉瘤素口服对小白鼠的急性LD_(50)分别为120,16和33毫克/公斤,亚急性LD_(50)分别为33,6.8,10毫克/公斤。AT-267和AT-346对肉瘤180的治疗指数(MTD/MED)分别为6.7和13.4。它們对大白鼠的亚急性LD_(50)分别为21和7毫克/公斤。(3)給狗每天口服AT-346 0.9和2.7毫克/公斤,共10天,可見造血系統的抑制及食量的降低,組織学检查除发現腸粘膜下出血及肝脏輕度的脂肪性变外,未見有其他的异常。給0.3毫克/公斤組,除白血球略有降低外,也未見有其他的异常发現。猴2只在10天内分别...

作者发現两个吲(口朶)氮芥化合物AT-267和AT-346均有明显的抗肿瘤作用,其中尤以AT-346的疗效較佳,因此进行了它的疗效与毒性研究并与溶肉瘤素进行了比較。主要結果如下:(1)AT-267,AT-346和溶肉瘤素分别口服1/6的急性LD_(50)剂量对小鼠肉瘤180,棱形細胞肉瘤,网织細胞肉瘤,AK肉瘤,Ehrlich癌实体型和乳腺癌均有显著的抑制作用。前两个药对小鼠黑色素瘤,脑瘤22和大鼠Jensen肉瘤也均有一定的抑制作用。(2)AT-267,AT-346和溶肉瘤素口服对小白鼠的急性LD_(50)分别为120,16和33毫克/公斤,亚急性LD_(50)分别为33,6.8,10毫克/公斤。AT-267和AT-346对肉瘤180的治疗指数(MTD/MED)分别为6.7和13.4。它們对大白鼠的亚急性LD_(50)分别为21和7毫克/公斤。(3)給狗每天口服AT-346 0.9和2.7毫克/公斤,共10天,可見造血系統的抑制及食量的降低,組織学检查除发現腸粘膜下出血及肝脏輕度的脂肪性变外,未見有其他的异常。給0.3毫克/公斤組,除白血球略有降低外,也未見有其他的异常发現。猴2只在10天内分别用AT-346总量56和122毫克,均見造血器官的輕度抑制,用总量5毫克的另1只猴則未見明显的异常改变。

Inclusion of sodium molybdate(Mo)in the buffer could stabilize the steroid bindingactivity,inhibit the degradation and minimize the structural heterogenicity of receptors.Effects of M_0 on human breast tumor and benign and malignant endometrial cytosol es-trogen(ER)and progesterone receptors(PR)were studied by glycerol gradient centrifuga-tion and chromatographed on agarose in buffers containing 20 mMM_0.The sedimenta-tion coefficients(S_(20,w))of the receptors were evaluated by glycerol gradient centrifuga-tion...

Inclusion of sodium molybdate(Mo)in the buffer could stabilize the steroid bindingactivity,inhibit the degradation and minimize the structural heterogenicity of receptors.Effects of M_0 on human breast tumor and benign and malignant endometrial cytosol es-trogen(ER)and progesterone receptors(PR)were studied by glycerol gradient centrifuga-tion and chromatographed on agarose in buffers containing 20 mMM_0.The sedimenta-tion coefficients(S_(20,w))of the receptors were evaluated by glycerol gradient centrifuga-tion and the mean value was 9.7±0.3S(n=31).The stoke radii(R_s)were distinguishedby gel filtration and the mean value was 75±4(?)(n=22).The molecular weight(M)and axial ratio(a/b)of the receptors were calculated by combining the data from ultra-centrifuged and gel filtration analysis and the mean values of M=304,000,and a/b=10.The concentration of ER and PR were determined by charcoal-dextron assay follow-ing incubation of cytosols with various concentrations of [~3H]E_2 or [~3H] R 5020 in bufferscontaining 20 mMMo from 47 cases of human breast cancer,10 malignant endometriumand 10 benign endometrium.The ER and PR (>3 fmol/mg protein)finds in the breasttumor specimens were 48% and 72%,respectively.90% of malignant uterine speci-mens contained PR,and 100% of benign endometrium with ER and PR.The concent-tration of PR was the highest,458±275 fmol/mg protein,in benign endometrial samplesfrom premenopausal women.Dissociation constants(Kd)were evaluated from 24 speci-mens.The mean value for Kd of [~3H] E_2 binding to cytosol from breast cancer was 0.4 nMand that for Kd of [~3H] R 5020 binding to cytosol from both breast and uterine malignanttumors was 2-3 nM.

钼酸钠(M_0)能稳定受体对甾体的结合活力、并抑制其降解和减少其结构的多相性。在有M_0存在的缓冲系统中,通过对人类乳腺癌、良性和恶性的子宫内膜细胞溶质雌激素受体(ER)和孕激素受体(PR)进行梯度超离心和琼脂糖凝胶过滤的研究,得到的结果为:受体的沉降系数(S_(20,w))的平均值为9.7±0.3S(n=31),其流体力学半径(R_(?))的平均值为75±4(?)(n=22);综合超离心和凝胶过滤的分析资料计算得到,M_0稳定时受体分子量(M)的平均值为304,000,轴比(a/b)=10。本文报告了47例人乳腺肿瘤、10例恶性子宫内膜、10例良性子宫内膜的细胞溶质ER 和PR 的浓度及受体阳性、阴性及可疑的分布。乳腺肿瘤的ER 阳性率为48%,PR 阳性率为72%(>3fmol/mg 蛋白为阳性),90%恶性子宫内膜的PR 为阳性;100%良性子宫内膜的ER 或PR 均为阳性。绝经前妇女的良性子宫内膜的PR 浓度最高,为458±275fmol/mg 蛋白。对24例标本均测定了解离常数(K_d),其中乳腺和恶性子宫内膜组织中PR-[~3H]R5020复合物的K_d 平均值为2-3nM,乳腺...

钼酸钠(M_0)能稳定受体对甾体的结合活力、并抑制其降解和减少其结构的多相性。在有M_0存在的缓冲系统中,通过对人类乳腺癌、良性和恶性的子宫内膜细胞溶质雌激素受体(ER)和孕激素受体(PR)进行梯度超离心和琼脂糖凝胶过滤的研究,得到的结果为:受体的沉降系数(S_(20,w))的平均值为9.7±0.3S(n=31),其流体力学半径(R_(?))的平均值为75±4(?)(n=22);综合超离心和凝胶过滤的分析资料计算得到,M_0稳定时受体分子量(M)的平均值为304,000,轴比(a/b)=10。本文报告了47例人乳腺肿瘤、10例恶性子宫内膜、10例良性子宫内膜的细胞溶质ER 和PR 的浓度及受体阳性、阴性及可疑的分布。乳腺肿瘤的ER 阳性率为48%,PR 阳性率为72%(>3fmol/mg 蛋白为阳性),90%恶性子宫内膜的PR 为阳性;100%良性子宫内膜的ER 或PR 均为阳性。绝经前妇女的良性子宫内膜的PR 浓度最高,为458±275fmol/mg 蛋白。对24例标本均测定了解离常数(K_d),其中乳腺和恶性子宫内膜组织中PR-[~3H]R5020复合物的K_d 平均值为2-3nM,乳腺癌组织中ER-[~3H]E_2复合物的K_d 平均值为0.4nM。

 
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