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癌基因
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  oncogene
    Clinical Significance and Detection of the Oncogene and Tumor Suppressor Gene in Clinical Samples of the Bladder Cancer
    膀胱癌癌基因与抑癌基因检测及临床意义
短句来源
    Investigation of the Relationship between Point Mutation of Ha-Ras Oncogene and Biologic Behaviors of Bladder Cancer
    Ha-ras癌基因点突变与膀胱癌生物学行为关系的研究
短句来源
    THE SIGNIFICANCE OF THE EXPRESSION OF ras ONCOGENE P_(21) IN BLADDER CANCER
    膀胱癌细胞癌基因ras产物P_(21)的表达及其临床意义
短句来源
    Immunohistochemical Evaluation of the ras and C-erbB-2 Oncogene Protein Product in Bladder Carcinoma
    膀胱癌组织中癌基因ras和C-erbB-2蛋白产物的免疫组织化学研究
短句来源
    The influence of HESW and antitunor-drug on the expression of C-myc oncogene in human bladder tumor cell line.
    HESW与抗癌药物对膀胱癌细胞C-myc癌基因表达的影响
短句来源
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  oncogenes
    Amplification and Expression of Oncogenes in Urinary Tract Tumors and Their Clinical Significance
    泌尿系肿瘤癌基因扩增、表达的检测及临床意义
短句来源
    Exptessions of TGFα gene and oncogenes in human bladder carcinoma cell line BIU-87
    TGFα基因和某些癌基因在人膀胱癌细胞系BIU-87中的表达
短句来源
    Preliminary analysis of primarily cultured cells of human renal cell carcinoma and expression of the oncogenes
    人肾细胞癌细胞的原代培养及癌基因表达初步分析
短句来源
    Influence on the Oncogenes Expression of Renal Cell Carinoma(RCC) Cells Transduced with Human TNFα Gene
    转人TNFα基因对肾细胞癌细胞癌基因表达的影响
短句来源
    Oncogenes (C-erbB1, C-erb B2) amplification and expression in urinary bladder cancer and its clinical significance
    膀胱癌C-erbB-1、C-erbB-2原癌基因扩增、表达的检测及临床意义
短句来源
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  oncogen
    Advances of Suppressive Oncogen P53 and Nephroblastoma
    抑癌基因P53与肾母细胞瘤的研究进展
短句来源
    \ Methods\ Oncogen ras product P21 protein in 32 cases of penis cancer,32 cases of paracarcinoma tissues and in 16 cases of normal penis tissues were detected by immunohistochemical ABC method.
    方法用免疫组化ABC法检测32例阴茎癌、32例癌旁组织和16例正常阴茎组织的癌基因ras产物P21蛋白。
短句来源
    Method Oncogen ras product p21 protein in 32 cases of penis cancer,32 cases of paracarcinoma tissues and in 16 cases of normal penis tissues were detected by immunohistochemical ABC method.
    方法用免疫组化ABC法检测32例阴茎癌、32例癌旁组织和16例正常阴茎组织的癌基因ras产物p21蛋白。
短句来源
  “癌基因”译为未确定词的双语例句
    Enhancement of Sensitivity of Bladder Tumor Cells to MMC by Liposome Conjugated C-myc Antisense Oligonucleotides and Expression of C-myc Oncoprotein in Bladder Cancer
    反义c-myc寡核苷酸提高膀胱癌细胞对MMC的敏感性和c-myc癌基因蛋白在膀胱移行细胞癌表达的临床意义
短句来源
    The Effect of KLF6 Gene Recombinant Plasmid on Prostate Cancer Cell Line PC-3
    转染抑癌基因KLF6对前列腺癌PC-3细胞作用的实验研究
短句来源
    The Study of Tumor Suppression Function of RB1 Gene in Human Bladder Carcinoma Cells in Vitro
    RB_1抑癌基因对人膀胱癌细胞抑癌作用的体外研究
短句来源
    Correlation between the expression of c-erbB-2 oncoprotein and the number of Ag-NORs in human bladder carcinomas
    膀胱癌c-erbB-2癌基因蛋白表达与Ag-NORs定量计数的关系
短句来源
    Effect of IL-6 on c-myc protooncogene expression in human mesangial cells and the down-regulation by Emodin
    IL-6对人系膜细胞c-myc原癌基因表达的影响以及大黄素的拮抗作用
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  oncogene
Changes in the Cell Shape and Actin Cytoskeleton during the Ras Oncogene-Induced Transformation: A Possible Role of Rho Kinase
      
A study was made of the effect of activated oncogene N-RAS on the function of tumor suppressor p53 and the proliferating ability of rat embryo fibroblasts REF52.
      
Having a selective advantage, these cells gradually displaced N-RAS-expressing cells arrested in G1, so that one month after oncogene induction the culture mostly consisted of morphologically normal, actively proliferating Ras-negative cells.
      
Potential RNase targets in a tumor cell and the role of modulation of calcium-dependent potassium channels and the ras oncogene in RNase-induced cell damage are considered.
      
RHOA (3p21.31) is a potential oncogene, causing cell malignant transformation.
      
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  oncogenes
It is concluded that at different stages of tumor progression the activity of different MMPs is displayed, which is regulated by various growth factors and oncogenes.
      
It has been reported that rol plant oncogenes located in Ri-plasmids of Agrobacterium rhizogenes activated synthesis of secondary metabolites in the transformed plant cells.
      
A p53 mutation is required for stable transformation of REF52 cells by themyc andras oncogenes
      
It is known that neoplastic transformation of rodent primary embryonic fibroblasts culturedin vitro requires coexpression at least of two cooperating oncogenes.
      
Transfection with the E1A and E1B-19kDa Oncogenes Does Not Prevent Rat Embryo Fibroblasts from Cell-Cycle Arrest after γ-Irradia
      
更多          
  oncogen
The differential transcriptional activity of this oncogen in cancer cells and the adjacent normal pancreatic cells on the same section was evident in sections from 5 cases where normal pancreas was present.
      
Many biological functions such as the capacity to code for the synthesis of new proteins and, in particular, the oncogenic property (oncogen) have already been assigned to specific regions (on physical maps) of their DNA.
      
These observations suggest that this tumor model may be valuable for the study of macrophage function as well as therapeutic approaches to oncogen-expressing retrovirus-induced tumors.
      
We have performed immunocytochemical analysis of the expression of epidermal growth factor receptor (EGF-R or proto-oncogen c-erbB-1) and estrogen receptor (ER) in 70 cases of human breast carcinoma.
      
Le déséquilibre entre survie cellulaire et mort cellulaire est une des altérations-clés du processus d'oncogenèse.
      
更多          


Paraffin-embedded tumor sections from 53 patients with bladder oaneer, and paraffin-embedded bladder mucosa sections from 7 patients with non-neoplastic urologic diseases were taken and stained with SGI-oncpgema 1, a monoclonal antibody against ras oncoprotein P21, and ABO immunohistochemioal procedures. The results were analysed in combination with the histopathologioal grading and slage of the tumors and the outcome of patients. The P21 expression was positive in 32 of the 53 cases (60.4%) with bladder cancer,...

Paraffin-embedded tumor sections from 53 patients with bladder oaneer, and paraffin-embedded bladder mucosa sections from 7 patients with non-neoplastic urologic diseases were taken and stained with SGI-oncpgema 1, a monoclonal antibody against ras oncoprotein P21, and ABO immunohistochemioal procedures. The results were analysed in combination with the histopathologioal grading and slage of the tumors and the outcome of patients. The P21 expression was positive in 32 of the 53 cases (60.4%) with bladder cancer, and negative in all 7 oases with non-neoplastic urologio diseases. We also found that the rates of P21 positive expression decreased with higher tumor grades and stages. Recurrent rates for tumor cases with P21 positive expression was 17.6% and 82 A % for cases with negative P21 expressions. Follow-up analysis revealed that there was a close correlation between the expression of P21 and prognosis. In the 32 patients with P21 positive expression only 3 (9.4%) died of tumor spread and in 21 patients with negative P21 expression 17 (81%) died of tumor spread, indicating that P21 positive expression is a good prognostic parameter for patients with bladder cancer.

本文用癌基因ras产物P_(21)的单克隆抗体SCI-oncogema 1及ABC免疫酶标染色法对53例膀胱癌和7例泌尿系非肿瘤病人的膀胱粘膜石蜡切片进行染色,结合肿瘤的病理学分级和分期以及病人随访结果进行分析,表明弱例膀胱癌中P_(21)阳性者达32例(60.4%),而7例泌尿系非肿瘤病人的膀胱粘膜标本其P_(21)均为阴性。还发现在膀胱癌P_(21)的阳性率随着病理分级和分期的上升而明显下降,P_(21)阳性膀胱癌其复发率为17.6%,而P_(21)阴性膀胱癌的复发率则高达82.4%。经分析还发现P_(21)表达与膀胱癌预后有密切的相关性,32例P_(21)阳性膀胱癌患者中死于肿瘤者仅3例(9.4%),而21例P_(21)阴性膀胱癌患者中死于肿瘤者多达17例(81%)。提示P_(21)阳性可考虑作为膀胱癌预后较好的客观依据之一。

An expression of ras oncogene protein (p21) was assessed with immunohistochemistry in normal, dysplasia, benign hyperplasia, chronic prostatitis and prostatic carcinomatous tissues. The results showed that the positivity rate of p21 was higher in prostatic carcinoma than that in other prostatic lesions and was markedly correlated to histologic tumor grade. The expression level of p21 was more intentive in prostatic dysplasia surrounding carcinoma than that in simple prostatic dysplasia. It is suggested that...

An expression of ras oncogene protein (p21) was assessed with immunohistochemistry in normal, dysplasia, benign hyperplasia, chronic prostatitis and prostatic carcinomatous tissues. The results showed that the positivity rate of p21 was higher in prostatic carcinoma than that in other prostatic lesions and was markedly correlated to histologic tumor grade. The expression level of p21 was more intentive in prostatic dysplasia surrounding carcinoma than that in simple prostatic dysplasia. It is suggested that overexpression of ras oncogene p21 product may play an important role in progressing from dysplasia to cancer and may be used as a new tumor marker for assessment of biological behavior of prostatic carcinoma.

用抗ras癌基因蛋白质产物p21单克隆抗体SCI-oncogema I,采用常规ABC免疫组织化学方法检测了66例前列腺癌、46例前列腺非典型增生、20例慢性前列腺炎、50例良性前列腺增生和6例正常前列腺组织石蜡标本中p21的表达,结果显示,前列腺癌的阳性表达率明显高于其他几组病变(P<0.01),其阳性表达率随肿瘤组织学分级增高而增高。前列腺癌周的不典型增生组织对p21的反应强度显著高于单纯性不典型增生组织。上述结果说明,ras癌基因产物p21的过量表达,在前列腺非典型增生向前列腺癌的发展过程中起着重要作用,并且可以作为一种新的肿瘤标记物来估计前列腺癌的生物学行为。

The expression of c-erbB-2 oncoprotein was detected by using immunohistochemical method and the number of nucleolar organizer region (Ag-NOR) was counted by siler colloid technique in 56 cases of human bladder carcinoma. The results showed that the expression of c-erbB-2 oncoprotein was associated with the differentiation of bladder cancer. The number of Ag-NORs in positive cases expressing c-erbB-2 oncoprotein was higher than that in negative cases expressing c-erbB-2 oneoprotein and the expression of c-erbB-2...

The expression of c-erbB-2 oncoprotein was detected by using immunohistochemical method and the number of nucleolar organizer region (Ag-NOR) was counted by siler colloid technique in 56 cases of human bladder carcinoma. The results showed that the expression of c-erbB-2 oncoprotein was associated with the differentiation of bladder cancer. The number of Ag-NORs in positive cases expressing c-erbB-2 oncoprotein was higher than that in negative cases expressing c-erbB-2 oneoprotein and the expression of c-erbB-2 product was closely associated with the unmber of Ag-NORs in bladder cancer. Thus, both c-erbB-2 oncoprotein and the Ag-NORs are helpful marker in evaluating the differentiation of bladder carcinoma.

采用免疫组化方法和胶质银染色技术对56例膀胱移行上皮癌组织的c-erbB-2癌基因蛋白表达产物进行检测和对嗜银蛋白核仁组成区(Ag-NORs)进行定量计数,结果显示:c-erbB-2蛋白产物表达与膀胱癌的分化程度有关,高分级肿瘤的表达水平高于低分级肿瘤。在c-erbB-2表达阳性的肿瘤标本中的Ag-NORs计数(5.23±0.65)明显高于c-erbB-2表达阴性的标本(3.34±0.42)(P<0.01),因此,c-erbB-2的蛋白产物表达阳性与Ag-NORs计数较高密切相关。c-erbB-2蛋白产物检测和Ag-NORs定量计数均可作为膀胱癌恶性程度估价的辅助指标。

 
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