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   胃癌发生 的翻译结果: 查询用时:1.659秒
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胃癌发生     
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  gastric carcinogenesis
     Relationship between alterations of p16~(INK4a) and p14~(ARF) genes of CDKN2A locus and gastric carcinogenesis
     CDKN2A位点p16~(INK4α)、p14~(ARF)基因变异与胃癌发生的关系
短句来源
     Analysis of Expression p21~(WAF1/CIP1) and p53 Protein in Gastric Carcinogenesis
     p21~(WAF1/CIP1)和p53蛋白表达在胃癌发生发展过程中的研究
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     The Expression of PS2, CD44V6 and MMP-9 in Gastric Carcinogenesis and Their Predictive Values for Lymph Node Metastasis
     PS2、CD44V6和MMP-9表达与胃癌发生、发展及其淋巴结转移的关系
短句来源
     Correlation of hMSH2、hMLH1 Gene Expressions to Gastric Carcinogenesis
     错配修复基因hMSH2、hMLH1基因表达与胃癌发生关系的研究
短句来源
     Purpose To investigate the cyclinE and p21 WAF1/CIP1 protein in gastric carcinogenesis and the significance of their expression in gastric carcinoma(GC).
     目的 :探讨cyclinE和p2 1WAF1/CIP1蛋白在胃癌发生发展中的作用及其表达的意义。
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  gastric cancer development
     Methods:By means of polymerase chain reaction-single strand conform action polymorphism(PCR-SSCP)37 cases of gastric mucosa were searched for Brg1 gene mutation in exon 4 and 16.By immunohistochemistry the expression of Brg1 protein in 30 cases of gastric adenocarcinoma was analyzed for their role in gastric cancer development and prognosis.
     方法:应用聚合酶链反应及单链构象多态性(PCR-SSCP)技术检测37例胃腺癌和正常胃组织中Brg1基因第4和16外显子的基因突变,同时应用免疫组化技术分析30例胃癌组织B rg1蛋白的表达,初步探讨其和胃癌发生、发展及预后的关系。
短句来源
     Objective:To observe the effects of H2O2 ? SOD and Mucosta on P53 and P21ras protein expressions in human gastric cancer cell line MGC-803 and explore the role of oxygen free radical(OFR)in gastric cancer development. Methods:MGC-803 cells were cultured and given H2O2?
     目的:观察H2O2、SOD和膜固思达对人胃癌细胞系MGC-803细胞P53、P21ras蛋白表达的影响,探讨氧自由基在胃癌发生发展中的作用。
短句来源
     A STUDY OF THE RELATION BETWEEN MUTATION OF P53 GENE AND GASTRIC CANCER DEVELOPMENT
     P~(53)基因突变与胃癌发生关系的研究
短句来源
     The above results suggest that deletion or decrease of 15-PGDH expression may play an important role in the gastric cancer development, progression, infiltration and metastasis.
     15-PGDH表达缺失或减少可能是胃癌发生、发展,以及胃癌浸润转移的重要机制之一。
短句来源
     Objective To study the kinetics of MG7 expression in the process of gastric cancer development.
     目的 探讨在胃癌发生发展过程中MG7抗原表达的动态变化及意义。
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  pathogenesis of gastric cancer
     Study on Helicobcater Pylori infection and expression of P53 protein on the pathogenesis of gastric cancer
     胃癌发生过程中幽门螺杆菌感染与P53蛋白表达
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     Objective To study the expression and significance of c-erbB-2 and ras oncoproteinsp185 and p21 in the tissue of gastric cancer,gastric mucosal atypical hyperplasia and gastritis; and investi-gate the role of p185 and p21 in pathogenesis of gastric cancer.
     目的研究胃癌、胃黏膜不典型增生和胃炎组织中c-erbB-2和ras癌基因产物p185和p21蛋白的表达,以探讨p185和p21蛋白在胃癌发生、发展过程中的作用。
短句来源
     AIM: To observe the expression of PTEN protein in gastric cancer and precancerous lesions, and to investigate the relationship between PTEN expression and the pathogenesis of gastric cancer.
     目的:观察抑癌基因PTEN编码产物在胃黏膜癌变过程中的表达,探讨PTEN表达与胃癌发生的关系。
短句来源
     1. To investigate the expression of c-met in gastric cancer cells and specimen of gastric cancer both in mRNA and protein levels and its roles in the pathogenesis of gastric cancer.
     研究肝细胞生长因子(HGF)受体即c-met的mRNA和蛋白在胃癌细胞株和胃癌组织标本中的表达及其在胃癌发生、发展中的作用。
短句来源
     Objective To explore the relationship and significance of Hp infection and expression of iNOS in the pathogenesis of gastric cancer.
     目的探讨在胃癌发生过程中Hp感染与iNOS表达的关系及意义。
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  carcinoma occurred
     Fifty percent of the stump carcinoma occurred at the anastomotic stomas,42 9%at the residual lesser curvature and 7.1%at the cardia.
     残胃癌发生在吻合口占 5 0 % ,残胃小弯侧 4 2 9% ,贲门部 7 1%。
短句来源
     Fifty percent of the stump carcinoma occurred at the anastomotic stomas,52% at the residual lesser curvature and 7.1% at the cardiausio.
     残胃癌发生在吻合口占52%,残胃小弯侧占40.9%,贲门部占7.1%。
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  gastric carcinogenesis
The findings in this study suggest that LOH and MSI of FHIT gene may induce aberrant extron expression, which might play a role in gastric carcinogenesis.
      
Objective: To setup an animal model of gastric carcinogenesis by Helicobacter pylori (Hp) for basic, prevention and therapeutic research of Hp-related diseases.
      
The effect ofHelicobacter pylori infection on hMSH2 and P53 proteins in gastric carcinogenesis
      
Analysis of inactivation of hMLH1 by promoter hypermethylation and microsatellite instability in gastric carcinogenesis
      
The role of expression of mismatch repair proteins hMSH2 and hMLH1 in gastric carcinogenesis and its clinical significance
      
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  gastric cancer development
Thus, BRAF mutations, which are present in a variety of other human cancers, do not seem to be involved in gastric cancer development.
      
Molecular basis of gastric cancer development and progression
      
pylori strains are likely to play a crucial role in gastric cancer development.
      
However, its expression and potential role in gastric cancer development and progression has not been explored.
      
Therefore, we provided both clinical and experimental evidence to indicate that Sp1 might impact gastric cancer development and progression through regulating angiogenesis, a critical aspect of cancer biology.
      
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  pathogenesis of gastric cancer
Study on the association betweenHelicobacter Pylori infection and the pathogenesis of gastric cancer by using molecuar biologica
      
Recent epidemiological observations have indicated that the role ofHelicobacter pylori (HP) infection in the pathogenesis of gastric cancer is an important but unresolved issue.
      
Helicobacter pylori infection has been implicated in many pathobiologic changes that are linked with the pathogenesis of gastric cancer.
      
Helicobacter pylori infection is an important factor in the pathogenesis of gastric cancer.
      
Considerable evidence supports the role of genetic factors in the pathogenesis of gastric cancer.
      
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  carcinoma occurred
In control rats receiving CsA at doses of 5 mg/kg per day or 12.5 mg/kg per day, no bladder carcinoma occurred.
      
Progression to carcinoma occurred in only one of the 77 patients; she showed grade 1 adenocarcinoma.
      
Gastric stump carcinoma occurred more frequently in patients with gastric ulcer.
      
In 20 of these patients (69%) the carcinoma occurred in a sporadic and in 9 (31%) patients in a familial form.
      
Thyroid carcinoma occurred 9 times more often in r-HPT patients strengthening the indication for surgery in irradiated subjects.
      
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  其他


Pathomorphological changes in glandular stomach of the rats induced by 20-MCA are described. Stomach of 59 rats treated with 20-MCA impregnated thread are examined histologically in from 2 weeks to 6 months, The histologic changes In the glandular stomach at or near the site of carcinogen are proliferation of mucous neck cells, formation of sinus or ulcer with adenomatous hpperplasia, intestinal metaplasia and atypical glandular hyper plasia, and early and invasive carcinoma. It is suggested that the abnormal...

Pathomorphological changes in glandular stomach of the rats induced by 20-MCA are described. Stomach of 59 rats treated with 20-MCA impregnated thread are examined histologically in from 2 weeks to 6 months, The histologic changes In the glandular stomach at or near the site of carcinogen are proliferation of mucous neck cells, formation of sinus or ulcer with adenomatous hpperplasia, intestinal metaplasia and atypical glandular hyper plasia, and early and invasive carcinoma. It is suggested that the abnormal proliferation and differentiation of the mucous neck cells may play an important role in the process of gastric carcinogensis in rats. Intestinal metaplasia and atypical glandular hyperplasia observed adjacent to the carcinoma are considered to be an important precancerous lesions.

本文报道用20-甲基胆蒽诱发大白鼠腺胃胃癌的实验结果,对大白鼠实验性胃癌的发生和发展过程进行病理形态学变化的观察,并对胃癌的组织发生进行初步探讨,指出粘液颈细胞的增殖和分化过程的异常是胃癌组织发生的一个重要环节。肠上皮化生和非典型增生,特别是肠化生伴有重度非典型增生是一种值得高度重视的癌前变。

Sarcosineethylesler and Sodium nitrite, precursor compounds of nitrosamine, were used to induce carcinogenesis in the esophagus in Wistar rats. Cancer developed not only in the esophagus but also in the forestomach. The carcinoma cell infiltrated the muscular layer and the se/osa membrane. Metastasis to other organs occurred, which has not been reported in literature.The new retinoic analogue RI, N-(4-Ethoxycarbophenyl) Retinamide, synthesized in China, had marked inhibitory effect on the carcinogenesis of the...

Sarcosineethylesler and Sodium nitrite, precursor compounds of nitrosamine, were used to induce carcinogenesis in the esophagus in Wistar rats. Cancer developed not only in the esophagus but also in the forestomach. The carcinoma cell infiltrated the muscular layer and the se/osa membrane. Metastasis to other organs occurred, which has not been reported in literature.The new retinoic analogue RI, N-(4-Ethoxycarbophenyl) Retinamide, synthesized in China, had marked inhibitory effect on the carcinogenesis of the esophageal and forestomach epithelium. The incidence of carcinoma in the esophagus and forestomach was 81.8% in the control group, and was reduced to 11.6% in the experimental group (P<0.01). Phagocytic index was used to represent the function of the reticulo-endothelium system. Macrophages were stimulated slightly in the experimental group, but there is no statistical difference between the two groups.Barium meal radiography was used to follow the course of the developmemt of the esophageal epithelial malignancy. It accurately revealed the development and the site of the tumor.

本文用亚硝胺类致癌物的前体物—肌氨酸乙酯和亚硝酸钠混合灌喂大鼠,不但能引起食管上皮的增生及癌,同时可见前胃癌的发生,并且癌侵犯肌层、浆膜及远处转移,后者文献未见报导。国产维甲酸衍生物RI,N-(4-乙氧羰基苯基)维甲酰胺,对食管前胃癌变的发生发展均有明显的抑制作用,对照组癌的发生率为81.8%,RI组下降为11.6%,P<0.01。应用网状内皮系统(RES)功能测定,RI对吞噬功能有轻度刺激,但无统计学意义。X光钡餐造影可用于追随大鼠食管癌变过程及显示癌的发生及发展及其所在部位,有助于实验进程的观察。

It is believed that fungus and nitrogen may be introduced into the body through the process of food-chain. A carcinogic nitrose-compound may be synthesized by mycotoxin or other metabolites together with nitrites, guanidines and amines present in the stomath. Consequently, gastric carcinoma may be developed gradually in cases of chronic gastritis. It is under such hypothesis that the authors undertook a comprechensive survey of gastric carcinoma in areas of high as well as low incidence in our country. The result...

It is believed that fungus and nitrogen may be introduced into the body through the process of food-chain. A carcinogic nitrose-compound may be synthesized by mycotoxin or other metabolites together with nitrites, guanidines and amines present in the stomath. Consequently, gastric carcinoma may be developed gradually in cases of chronic gastritis. It is under such hypothesis that the authors undertook a comprechensive survey of gastric carcinoma in areas of high as well as low incidence in our country. The result of this survey revealed that a high discovery rate of Aspergillus versicolor was found in the gastric juice of an empty stomach. The difference between the high and low incidence areas is significant statistically (p<0.001). Aspergillus versicolor was found to be closely associated with the pH value and the levels of acidity and NO_2 in the gastric juice. It was also well correlated with the results of biospy of gastric mucosa. It is already known that the sterigmate-cystin produced by Aspergillus versicolor may induce gastric adenocarcinoma in laboratory animals. Therefore, the authors assume that this fungus may have a definite association with human gastric carcinoma. Further studies are necessary to elucidate its role in the pathogenesis of the disease.

作者等根据假设,即真菌与氮素通过食物链过程进入人体,由于真菌毒素或其代谢产物与胃内亚硝酸盐、胍类、胺类等合成致癌性亚硝基化合物,并在慢性胃炎的基础上逐渐发展为胃癌,在我国胃癌高,低发区进行了综合考察。本文报告考察结果,发现胃液内杂色曲霉(Aspergillus versicolor)检出率最高,高低发区对比差异显著(p<0.001)。此菌与胃液的pH值、酸度、NO_2~-含量、胃粘膜活检结果关系密切。已知杂色曲霉产的杂色曲霉素(sterigmatocystin)可诱发大鼠的腺胃癌,因此考虑此菌与人胃癌的发生可能有关,但是否为因果关系,尚需进一步实验研究。

 
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