② The frequency of cytochrome P450 1A1 gene MSP 1 site genotypes distribution: The distributions of m1/m1, m1/m2, m2/m2 had no obvious differences between the Alzheimer disease group and normal control group (42.2%, 41.5%, 16.3%; 49.3%, 37.7%, 13.0%, χ2=1.483, P > 0.05).
① The distribution of the gene frequency of cytochrome P450 1A1 alleles: The frequencies of alleles of m1 and m2 in the Alzheimer disease group were 63.0% and 37.0%, respectively, with were insignificantly different from those in the normal control group (68.1%, 31.9%, χ2=1.605, P > 0.05).
Objective: To investigate the protective effect of nerve growth factor(NGF) on PC12 cells apoptosis induced by β-amyloid protein(Aβ),thus to explore the therapeutic action of NGF for Alzheimer’s disease.
Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
Prospects of Non-drug Approaches to Alzheimer's Disease
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.