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阿尔茨海默病     
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  alzheimer disease
    The detective range of conventional ELISA for measuring recombinant tau and abnormally phosphorylated tau purified from Alzheimer disease brain was 1ng to 32 ng. It was 0 75pg to 200pg and 0 5pg to 50pg by ELISA dienzyme substrate recycle. Compared with the conventional method, the sensitivity of the technique established in the present study increased 400 and 1300 times, with a enlarged detective range of 8 5 and 10 times, respectively.
    用传统ELISA测定纯化tau蛋白和阿尔茨海默病异常磷酸化tau蛋白的范围值分别为 1~ 32ng和 0 2~ 10ng ,而此法的测定范围值分别为 0 75~ 2 0 0pg和 0 5~ 5 0 pg ,比传统ELISA的灵敏度分别提高 130 0倍和4 0 0倍 ,可测定范围值亦分别扩大了 8 5倍和 2倍 .
短句来源
    It could detect abnormally phosphorylated tau in cerebrospinal fluid of Alzheimer disease and used effectively for the diagnosis of the disease.
    可准确测定阿尔茨海默病患者脑脊液样品中的微量tau蛋白和异常磷酸化tau蛋白 ,为阿尔茨海默病的早期诊断和鉴别诊断提供了新技术 .
短句来源
    Therefore, these studies provide novel insight into the regulation of tau phosphorylation and the molecular mechenism of abnormal hyperphosphorylation of tau in Alzheimer disease brain.
    这一研究为阐明调节tau蛋白磷酸化水平的机理和阿尔茨海默病脑中tau异常过度磷酸化的分子机制提供了新的线索
短句来源
  alzheimer ' s disease
    Neither the Tumor Necrosis Factor α-308 A/G Polymorphism Nor the α2-macroglobulin Polymorphism was Associated with Late-onset Alzheimer's disease in the Chinese Population
    中国人群中肿瘤坏死因子α-308A/G基因多态和α2-巨球蛋白基因缺失多态与晚发性阿尔茨海默病无相关性(英文)
短句来源
    Study indicated that over-expression and activation of complement accompany with the whole pathogenesis in Alzheimer's disease, the lesions mediated by complement is one of the important links of action mechanism of Aβtoxicity.
    研究资料显示,补体系统的活化伴随着阿尔茨海默病(Alzheimer’s disease,AD)的整个病理过程,补体系统介导的损害是Aβ细胞毒性作用机制中的重要环节之一。
短句来源
    Pathologically increased accumulation of copper in central neurons induce severe neurological disorders, such as neurological degeneration, mental retardation, which has been postulated to play a role in the pathogenesis of Wilson's disease (WD) and Alzheimer's disease (AD).
    中枢神经元中含铜量病理性的升高会引起严重的神经学紊乱,如神经退行性病变和智力障碍,人们推测这与威尔逊病(WD)和阿尔茨海默病(AD)的发病机制有关。
短句来源
    Objective: Alzheimer's disease (AD), by far the single most frequent cause of dementia, affects 4% to 10% of the over 65s, becomes increasingly common with advancing age.
    目的:阿尔茨海默病(Alzheimer's disease,AD)是一种严重危害人类健康的神经退行性疾患,是老年性痴呆最常见的形式之一。 65岁以上的老年人口发病率约为5%~10%,患病风险随年龄的增长而急剧上升。
短句来源
    However, in succedent research it was found that Mints can directly interact with APP which play an important role in Alzheimer's disease (AD). Mints interact with APP through their PTB domain and prolong the half-life of APP in neuron and reduce the secretion of neurotoxin A P which can form senile plaque of AD.
    在研究可以与阿尔茨海默病(Alzheimer's disease,AD)淀粉样蛋白前体(amyloid precursor protein,APP)结合的蛋白质时,发现X11分子可以通过其PTB结构域与APP结合,从而延长APP在细胞内的半衰期,并减少具有神经毒性且参与AD老年斑形成的β-淀粉样蛋白(amyloid β,Aβ)的分泌。
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  alzheimer ’ s disease
    Objective: To investigate the protective effect of nerve growth factor(NGF) on PC12 cells apoptosis induced by β-amyloid protein(Aβ),thus to explore the therapeutic action of NGF for Alzheimer’s disease.
    目的:研究神经生长因子(NGF)对β淀粉样蛋白(Aβ)诱导鼠肾上腺嗜咯瘤细胞(PC12)凋亡的作用,从而探讨NGF对阿尔茨海默病的治疗作用。
短句来源
    Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, characterized mostly by cognitive deficits and progressive loss of memory.
    阿尔茨海默病(Alzheimer’s disease,AD)是一种神经系统退行性疾病,临床表现为进行性学习、记忆和认知功能障碍,智力减退乃至完全痴呆。
短句来源
    Accumulation and deposition of amyloid-βpeptide (AβP) in brain areas have been widely believed to play a critical role in the pathogenesis of Alzheimer’s disease (AD).
    阿尔茨海默病(Alzheimer’s disease, AD)是一种不可逆的原发性神经退行性疾病,主要表现为进行性学习和记忆功能的障碍。
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  “阿尔茨海默病”译为未确定词的双语例句
    The cDNA of dUTP pyrophosphatase (dUTPase) in human nucleus was amplified by PCR from the cDNA library of the AD patient's brain, then cloned into the fusion expression vector of GST——pGEX 4T 1, and highly expressed in E. coli BL21. The fusion prottein GST dUTPase was purified by affinity chromatography, thrombin digestion and gel filtration on Sephacryl S100, and dUTPase was finally obtained.
    以阿尔茨海默病 (Alzheimer’sdisease ,AD)患者脑cDNA文库质粒为模板 ,用PCR方法扩增得到人细胞核dUTP焦磷酸酶 (dUTPase)的cDNA ,将其克隆到谷胱甘肽 S 转移酶 (GST)融合表达载体pGEX 4T 1中 ,并在大肠杆菌BL2 1中获得高效表达 .
短句来源
    Objective To test the effect of short interfering RNAs (siRNAs) of β-site APP cleaving enzyme (BACE) on inhibiting the expression of BACE in mammalian cells Methods The gene of EGFP, U6 promoter and β-secretase targeting siRNA were cloned by PCR.
    目的探讨β淀粉样前体蛋白裂解酶(β-site APP cleaving enzyme,BACE)的短干扰RNA(short interfering RNAs,siRNA)对BACE在神经母细胞瘤细胞中的表达的影响,为阿尔茨海默病(AD)的治疗提供新的手段。
短句来源
    Objective: To investigate whether short interfering RNAs(siRNAs) of β-site APP cleaving enzyme(BACE) can inhibit the expression of BACE in mammalian cells.
    目的:探讨β淀粉样前体蛋白裂解酶(-βsite APP cleav ing enzym e,BACE)的短干扰RNA(short interfering RNA s,siRNA)是否能抑制BACE在哺乳动物细胞中的表达,为阿尔茨海默病(AD)的治疗提供新的手段。
短句来源
    Construction of Transgene and Transgenic Mice of Amyloid Precursor Protein Gene with Swedish Mutation
    阿尔茨海默病相关转基因小鼠模型的构建
短句来源
    AD will be understood better than before through the study on Mints proteins, and this will provide new idea for the therapy.
    通过对Mint分子的研究,我们对阿尔茨海默病的认识不断深入,这将有可能对该病的治疗提供新郑州大学2004年硕士研究生毕业论文M,ntZ分子在正常大鼠脊髓中表达与分布的研究思路。
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  alzheimer disease
Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
      
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
      
It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
      
Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
      
Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
      
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  alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          
  alzheimer ′ s disease
The apoE gene has been identified as a major susceptibility locus for late-onset Alzheimer′s disease (LOAD).
      


Objective: To find the effect of IL-1 on APP gene expression in vivo. Methods: Rat intracere-broventricular(i. c. v. ) injection; northern hybridization. Results: For the first time we have reported that in vivo IL-1β can increase APP mRNA expression and that this enhancement is time dependent.Concluslon:To some degree IL-1β can enhance APP gene expression both in vivo and in vitro. The results suggest a role of IL-1β in the neuronal mechanisms related to β9-amloid protein deposition in AD.

目的:研究在整体动物水平白细胞介素1(interleukin1,IL-1)对β淀粉样前体蛋白(βamyloidprecursorprotein,APP)基因表达的影响。方法:大鼠侧脑室注射;Northern杂交。结果:首次证实IL-1β在整体动物水平可以诱导大鼠脑组织APPmRNA表达的增加,而且这种诱导作用具有时间依赖性。结论:IL-1β在体内、外均可诱导神经组织内APP基因的表达增加,进而在阿尔茨海默病(Alzheimerdisease,AD)中与促进β淀粉样蛋白(βamyloidprotein,βAP)的沉积可能密切相关。

Objective To prepare the human neurotrophin-3(hNT-3) by genetic engineering method, and provide materials for estimating its therapeutical effects on neurodegenerative disorders of central nervous system, including Alzheimer's disease. Methods Identified by sequence analysis, the mature hNT-3 gene was recombined into the prokaryotic expression plasmid pBV220, thus the expression vector pBV/mhNT-3 was constructed and expressed in E. coli. The relative molecular mass of the novel protein was estimated...

Objective To prepare the human neurotrophin-3(hNT-3) by genetic engineering method, and provide materials for estimating its therapeutical effects on neurodegenerative disorders of central nervous system, including Alzheimer's disease. Methods Identified by sequence analysis, the mature hNT-3 gene was recombined into the prokaryotic expression plasmid pBV220, thus the expression vector pBV/mhNT-3 was constructed and expressed in E. coli. The relative molecular mass of the novel protein was estimated by SDS-PAGE, and its bioactivity was measured by chicken embroy dorsal root ganglion (DRG) culture. Results The recombinant pBV/mhNT-3 produced a novel protein of 15×10 3 in E. coli, which matches the relative molecular mass of hNT-3. The expressed protein mainly recovered as inclusion body. After purification and renaturation, it could promote survival and neurite outgrowth of DRG neurons. Conclusion The gene encoding mature hNT-3 could highly express hNT-3 in E. coli.

【目的】应用基因工程方法制备人神经营养素 3(hNT 3)蛋白 ,为探讨其对阿尔茨海默病等中枢神经退行性疾病的治疗作用提供材料。【方法】将通过序列分析确定的hNT 3成熟区基因重组至原核表达质粒pBV2 2 0中 ,构建了重组表达载体 pBV/mhNT 3 ,在大肠杆菌中表达后 ,SDS PAGE法测定表达蛋白的相对分子质量 ,鸡胚背根节培养法检测其生物学活性。【结果】pBV/mhNT 3可在大肠杆菌中表达出一相对分子质量为 15× 10 3 的新蛋白 ,与hNT 3蛋白相对分子量相符。表达蛋白主要以包涵体形式存在 ,经纯化复性后 ,可明显促进鸡胚背根节的生长。【结论】人神经营养素 3成熟区基因可在大肠杆菌内高效表达hNT 3。

We have investigated the effects of sodium azide, a specific inhibitor of cytochrome c oxidase (COX), on the microtubule morphology and cell viability of nerve cells. Human neuroblastoma SH SY5Y cells were exposed to sodium azide to check mitochondrial complex Ⅳ activity by microassay method, cell viability by MTT method and microtubules by confocal microscopy and image analyzer. Exposed to 16~64 mmol/L sodium azide for 1 hour, the mitochondrial complex Ⅳ activity decreased dose dependently. MTT assay showed...

We have investigated the effects of sodium azide, a specific inhibitor of cytochrome c oxidase (COX), on the microtubule morphology and cell viability of nerve cells. Human neuroblastoma SH SY5Y cells were exposed to sodium azide to check mitochondrial complex Ⅳ activity by microassay method, cell viability by MTT method and microtubules by confocal microscopy and image analyzer. Exposed to 16~64 mmol/L sodium azide for 1 hour, the mitochondrial complex Ⅳ activity decreased dose dependently. MTT assay showed a dose and time dependent decrease of cultured nerve cells which were treated with 16~128 mmol/L sodium azide for 1~8 hours. Exposed to 64 mmol/L sodium azide for 4 hours, the processes of cells were shortened, almost disappeared, cell bodies became round and bright under contrast microscope. Meanwhile, microtubles were disassembled and became disorderly, the content and distribution of tubulin (microtubule protein) were reduced, expecially in the processes. It is indicated that sodium azide inhibits the assembly and polymerization of tubulin in microtubules. The damage of axons induced by microtubule collapse further blocks the intercellular signal transduction and intracellular material transportation which are essential to a cell. [

观察线粒体呼吸链复合体 (即细胞色素 C氧化酶 )抑制剂叠氮钠 (Na N3 )对神经细胞微管结构和细胞存活率的影响 ,探讨线粒体缺陷在阿尔茨海默病发病中的作用。将叠氮钠与传代培养的人神经母细胞瘤细胞系 SH- SY5Y细胞共同孵育 ,用微测量法测定线粒体复合体 活性 ,MTT法测定细胞存活率 ,激光共聚焦显微镜和图像分析系统观察细胞微管结构。叠氮钠 1 6~ 6 4 mmol/L与培养的神经细胞共孵育 1 h,剂量依赖性地导致细胞线粒体细胞色素 C氧化酶活性下降 ;叠氮钠 (1 6~ 1 2 8mmol/L)作用 1~ 8h,细胞存活率下降 ,呈时间及剂量依赖性 ;叠氮钠 1 6 ,6 4 mmol/L作用 4h,使细胞微管结构损伤 ,尤以突起内最为显著。叠氮钠与培养的神经细胞共孵育导致神经细胞损伤 ,其机制与线粒体缺陷致细胞骨架系统异常有关

 
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