助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   阿尔茨海默病 在 基础医学 分类中 的翻译结果: 查询用时:0.044秒
图标索引 在分类学科中查询
所有学科
基础医学
精神病学
中药学
临床医学
药学
中医学
神经病学
生物学
特种医学
更多类别查询

图标索引 历史查询
 

阿尔茨海默病     
相关语句
  alzheimer ' s disease
    Establishment of the Transgenic Model of Alzheimer's Disease and the Study of Pathogenesis
    阿尔茨海默病转基因动物模型的建立与发病机理研究
短句来源
    Set up Alzheimer's Disease Cell Apoptosis Model with PC-12 Cell Induced by Aβ_(25-35)
    Aβ诱导PC-12细胞凋亡建立阿尔茨海默病细胞模型(英文)
短句来源
    Examination of Alzheimer's disease model with spatial reference memory and spatial working memory
    空间参考记忆和空间工作记忆检测阿尔茨海默病模型的研究
短句来源
    A Study of Animal Model with Alzheimer's Disease
    阿尔茨海默病动物模型制备方法的研究
短句来源
    Epidemiological studies have established that the epsilon 4 allele of the apolipoprotein (apo) E gene (APOE) constitutes an important risk factor for Alzheimer's disease (AD).
    流行病学调查显示,载脂蛋白E基因(apolipoprotein E gene,APOE)的ε4等位基因是阿尔茨海默病(Alzheimer's disease,AD)的重要危险因素。
短句来源
更多       
  alzheimer ′ s disease
    Establishment of novel animal model with Alzheimer′s disease
    一种新型阿尔茨海默病动物模型的建立
短句来源
    The experimental study on an animal model of Alzheimer′s disease by intraventricular injection of the immunotoxin 192-IgG-saporin
    免疫毒素192-IgG-saporin侧脑室注射建立阿尔茨海默病动物模型的实验研究
短句来源
    Establishment of Alzheimer′s disease rat model by intrathecal injection with aluminum chloride
    鞘内注射三氯化铝建立阿尔茨海默病大鼠模型
短句来源
  alzheimer ’ s disease
    Alzheimer’s disease (AD) is a kind of neural degeneration disease with progressive memory decrease and irreversible cognitive damage. Its characteristical pathogenesis is the deposition of multiple extracellularβ-amyloid(Aβ), microglia cells and complement activation,cytokine releasing which lead to neurofibrillary tangles(NFTs) and neuron loss.
    大量研究显示:阿尔茨海默病(Alzheimer’s disease, AD)是一种临床表现为进行性记忆和后天获得性知识不可逆性损失的渐进性神经退行性疾病,其发病的始动因素是细胞外大量的淀粉样蛋白Aβ(β-amyloid)的沉积,从而促发了小胶质细胞和补体系统的活化失控及功能异常,炎症因子大量释放,最终导致神经纤维缠结、胆碱能神经元丧失,自身神经组织受到损害。
短句来源
  “阿尔茨海默病”译为未确定词的双语例句
    Many researches indicate that Mints are the important material which regulate APP metablism and Aβ production.
    许多研究表明Mints是调节APP代谢和Aβ产生的重要物质,被认为在阿尔茨海默病的病因、病理过程中发挥着极为重要的作用。
短句来源
    Conclusion: An AD cell model using the PC-12 cells induced with Aβ25-35 displays a series of changes related to apoptosis, which may be related to elevation of [Ca2+]i.
    结论:Aβ_(25-35)诱导PC-12细胞活力下降、细胞内Ca~(2+)浓度上升及细胞凋亡,可作为较理想的阿尔茨海默病细胞模型。
短句来源
    Aim To study the effect of basic fibroblast growth factor(bFGF) on neurogenesis in dentate gyrus of rat model of AD and to explore the application prospect of bFGF in treatment of AD with unilateral fimbria fornix transection.
    目的了解碱性成纤维细胞生长因子(bFGF)对海马伞切断造成的阿尔茨海默病(AD)模型大鼠海马齿状回神经发生的影响,探讨bFGF治疗AD的前景。
短句来源
    Conclusion The study showed that the fused B cell epitope of Aβ_(1-42) could be displayed on the surface of rAnsB-TTP-Aβ_(1-15),which is hope for develop to a future vaccine a gainst Alzheimers disease.
    结论:获得了在AnsB多聚酶分子表面呈现有Aβ1-15表位的融合蛋白rAnsB-TTP-Aβ1-15,为抗阿尔茨海默病疫苗研究奠定了基础。
短句来源
    Injection of bradykinin to hippocampus induces Alzheimer-like phosphorylation of tau and abnormal behavior in rat
    海马注射缓激肽复制阿尔茨海默病神经原纤维变性动物模型
短句来源
更多       
查询“阿尔茨海默病”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  alzheimer disease
Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
      
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
      
It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
      
Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
      
Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
      
更多          
  alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          
  alzheimer ′ s disease
The apoE gene has been identified as a major susceptibility locus for late-onset Alzheimer′s disease (LOAD).
      


Objective: To find the effect of IL-1 on APP gene expression in vivo. Methods: Rat intracere-broventricular(i. c. v. ) injection; northern hybridization. Results: For the first time we have reported that in vivo IL-1β can increase APP mRNA expression and that this enhancement is time dependent.Concluslon:To some degree IL-1β can enhance APP gene expression both in vivo and in vitro. The results suggest a role of IL-1β in the neuronal mechanisms related to β9-amloid protein deposition in AD.

目的:研究在整体动物水平白细胞介素1(interleukin1,IL-1)对β淀粉样前体蛋白(βamyloidprecursorprotein,APP)基因表达的影响。方法:大鼠侧脑室注射;Northern杂交。结果:首次证实IL-1β在整体动物水平可以诱导大鼠脑组织APPmRNA表达的增加,而且这种诱导作用具有时间依赖性。结论:IL-1β在体内、外均可诱导神经组织内APP基因的表达增加,进而在阿尔茨海默病(Alzheimerdisease,AD)中与促进β淀粉样蛋白(βamyloidprotein,βAP)的沉积可能密切相关。

Objective Molecular cloning and sequencing of the human brain-derived neurotrophic factor(hBDNF) gene. Methods Extracting the human genomic DNA from the white blood cells as templates,the hBDNF gene was cloned by using PCR and T-vector cloning method.The positive clone was screened and identified by the restriction enzymes,and then the cloned amplified fragment was sequenced and analyzed.Results Compared the cloned hBDNF gene with the GenBank(M61181) sequence,we demonstrated that both of sequence were from...

Objective Molecular cloning and sequencing of the human brain-derived neurotrophic factor(hBDNF) gene. Methods Extracting the human genomic DNA from the white blood cells as templates,the hBDNF gene was cloned by using PCR and T-vector cloning method.The positive clone was screened and identified by the restriction enzymes,and then the cloned amplified fragment was sequenced and analyzed.Results Compared the cloned hBDNF gene with the GenBank(M61181) sequence,we demonstrated that both of sequence were from the initiation codon ATG to the termination TAG identically. The cloned hBDNF gene was 744bp length.Conclusion Cloning the hBDNF gene from the human genomic DNA has paved the way for further study on gene therapy of Alzheimer's Disease(AD).

目的 克隆人脑源性神经营养因子 (hBDNF)基因并进行序列分析。方法 提取健康成人末梢血白细胞基因组DNA作为模板 ,应用PCR技术和T 载体克隆法克隆hBDNF基因 ,筛选阳性克隆、酶切鉴定 ,并进行序列测定和分析。结果 DNA序列测定的结果与GenBank提供的已知序列 (M6 1 1 81 )比较 ,所克隆的hBDNF基因从起始密码子ATG到终止密码子TAG全长共744bp ,序列完全相同。结论 自人基因组DNA中克隆hBDNF基因 ,为进一步开展阿尔茨海默病 (AD)的基因治疗积累了资料。

To determine the relationship between the activity of NOS and the low protein phosphatase which might participate in neurofibrillary degeneration in AD. Rat pheochromocytoma cells were cultured with different dose of okadaic acid (OA), and the activity of nitric oxide synthase (NOS) was detected by β NADPH diaphorase histochemistry. NOS activity increased slightly after incubated the cells with 1 nmol/L OA for 48 hours and increased significantly with 10 nmol/L OA for 24 or 48 hours. Conclusions The inhibition...

To determine the relationship between the activity of NOS and the low protein phosphatase which might participate in neurofibrillary degeneration in AD. Rat pheochromocytoma cells were cultured with different dose of okadaic acid (OA), and the activity of nitric oxide synthase (NOS) was detected by β NADPH diaphorase histochemistry. NOS activity increased slightly after incubated the cells with 1 nmol/L OA for 48 hours and increased significantly with 10 nmol/L OA for 24 or 48 hours. Conclusions The inhibition of PP 2A and PP 1 might increase the production of NO through activation of NOS. A positive correlation between the inhibition of protein phosphatase(s) and the increase of NOS was also implied.

蛋白磷酸酶降低参与阿尔茨海默病 (AD)神经元退化 ,本文旨在探讨一氧化氮 (NO)在 tau蛋白过度磷酸化引起 AD脑神经元退化中的可能作用。采用 β-还原型尼克酰胺腺嘌呤二核苷酸磷酸 -黄递酶 (β- NADPH- d)组织化学技术研究不同剂量蛋白磷酸酶抑制剂岗田酸 (OA)对嗜铬细胞瘤细胞株 (PC12 )一氧化氮合成酶 (NOS)活性的影响。结果显示 1nmol/ L OA与 PC12共培养 48小时 ,NOS活性轻度增强 ;当增加 OA浓度至 10 nmol/ L 时 ,培养 2 4和 48小时均可见 NOS活性明显增强。结果表明根据 1nmol/ L OA抑制蛋白磷酸酶 (PP) - 2 A,而 10 nmol/ L OA除完全抑制 PP- 2 A外 ,还部分抑制 PP- 1,提示 PP- 2 A和 PP- 1的抑制均可增强 NOS活性使 NO产生增加。关于蛋白磷酸酶活性降低和 NO产生增多与 AD的关系和作用有待继续研究

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关阿尔茨海默病的内容
在知识搜索中查有关阿尔茨海默病的内容
在数字搜索中查有关阿尔茨海默病的内容
在概念知识元中查有关阿尔茨海默病的内容
在学术趋势中查有关阿尔茨海默病的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社