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   阿尔茨海默病 在 临床医学 分类中 的翻译结果: 查询用时:1.033秒
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阿尔茨海默病     
相关语句
  alzheimer disease
    Objective To Assess brain structural changes in patients with Alzheimer disease using 3- dimentional magnetic resonance images.
    目的用 MRI三维测量法研究阿尔茨海默病 (Alzheimer Disease,AD)患者的脑形态结构变化特点。
短句来源
    Purpose To study the metabolic alterations of probable Alzheimer disease with proton magnetic resonance spectroscopy for better understanding the pathophysiology of Alzheimer disease.
    目的 用磁共振质子波谱 (MRS)的方法研究阿尔茨海默病 (AD)额叶代谢的改变。
短句来源
    Objective To compare the discriminative ability of MRI linear measurements and volumetric measurements between patients with Alzheimer disease (AD) and control subjects, and to evaluate their clinical value.
    目的 比较内颞叶结构的MRI线性测量与体积测量鉴别阿尔茨海默病 (Alzheimerdisease ,AD)患者与正常者的能力 ,同时为AD的临床诊断寻找简单实用的影像学测量指标。
短句来源
    Objective:To assess diagnostic value of MRI and discuss the correlation of mental harm and MRI features of hippocampal region in Alzheimer disease (AD).
    目的 :评价MRI对阿尔茨海默病 (AD)的诊断价值 ,探讨海马区MRI表现及其与认知功能损害的相关性。
短句来源
  alzheimer ' s disease
    A study of changes of fas antigen in cerebrospinal fluid of patients with Alzheimer's disease
    阿尔茨海默病患者脑脊液中Fas抗原含量的变化
短句来源
    MRI study on the hippocampal atrophy due to mild Alzheimer's disease
    轻度阿尔茨海默病海马萎缩的磁共振研究
短句来源
    The study of the diagnosis of Alzheimer's disease using I8F-FDG PET.
    阿尔茨海默病~(18)F-FDG PET显像诊断的研究
短句来源
    The clinical progress of PET/SPECT receptor imaging of Alzheimer' s disease
    阿尔茨海默病PET/SPECT受体显像的临床研究进展
短句来源
    Study on Alzheimer's disease and vascular dementia using PET
    阿尔茨海默病与血管性痴呆的~(18)F-FDG PET脑显像
短句来源
更多       
  alzheimer ′ s disease
    Quantitative MR study of corpus callosum in Alzheimer′s disease and vascular dementia
    阿尔茨海默病与血管性痴呆的胼胝体MR定量研究
短句来源
    The role of MR-diffusion tensor imaging in the assessment of Alzheimer′s disease
    MR扩散张量成像在阿尔茨海默病评估中的作用
短句来源
    To detect the levels of β amyloid protein(Aβ)in cerebrospinal fluid(CSF)of patients with Alzheimer′s disease(AD)and vascular dementia(VD).
    研究了阿尔茨海默病 (Alzheimer′sdisease ,AD)和血管性痴呆 (vasculardementia ,VD)患者脑脊液中淀粉样蛋白(Aβ1-4 2 )的含量并探讨其意义。
短句来源
    Objective To explore the value of low field strength (0.3 T) MR in the diagnosis of Alzheimer′s disease(AD) and vascular dernentia (VD).
    目的探讨0.3T磁共振(MRI)对阿尔茨海默病(Alzheimer'sdisease,AD)和血管性痴呆(Vasculardementia,VD)的诊断价值。
短句来源
    Neuropsychological study and SPECT findings in patients with Alzheimer′s disease
    阿尔茨海默病的神经心理学和单光子发射计算机断层扫描研究
短句来源
更多       
  alzheimer ’ s disease
    Prevention and nursing progress on Alzheimer’s disease
    阿尔茨海默病的预防及护理进展
短句来源

 

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      alzheimer disease
    Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
          
    We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
          
    It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
          
    Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
          
    Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
          
    更多          
      alzheimer ' s disease
    Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
          
    Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
          
    Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
          
    Prospects of Non-drug Approaches to Alzheimer's Disease
          
    According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
          
    更多          
      alzheimer ′ s disease
    The apoE gene has been identified as a major susceptibility locus for late-onset Alzheimer′s disease (LOAD).
          


    Objective To present a rapid, sensitive and safe procedure for the determination of human apolipoprotein E alleles.Methods Genomic DNA was extracted from 0.5ml whole blood by a non phenol protocol. After PCR and restriction enzyme digestion,short DNA fragments were detected by a simplified silver staining method. This technique was used to assay apolipoprotein E alleles in 19 patients with sporadic Alzheimer's disease and 41 normal aged persons. Results The short DNA fragments were visualized clearly on polyacrylamide...

    Objective To present a rapid, sensitive and safe procedure for the determination of human apolipoprotein E alleles.Methods Genomic DNA was extracted from 0.5ml whole blood by a non phenol protocol. After PCR and restriction enzyme digestion,short DNA fragments were detected by a simplified silver staining method. This technique was used to assay apolipoprotein E alleles in 19 patients with sporadic Alzheimer's disease and 41 normal aged persons. Results The short DNA fragments were visualized clearly on polyacrylamide gel processed by silver staining. It took 24 hours from DNA extraction to the final result. The ε4 allele frequency in patients with sporadic Alzheimer's disease was 0.29, much higher than that in control group (0.02, P<0.001) . Conclusion PCR in combination with silver staining can satisfy the need for high resolution and high effciency in the determination of apolipoprotein E alleles and can be used as a routine procedure in clinical and epidemiological investigations.

    目的介绍一种高效、灵敏、安全的载脂蛋白E等位基因检测法。方法采用非酚法快速提取人全血基因组DNA,PCR扩增包含两个等位基因决定位点的DNA片段,扩增产物经限制性酶切后进行聚丙烯酰胺凝胶电泳,用简易银染法显示酶切片段。结果银染显示出清晰易辨的DNA酶切小片段,整个检测过程24小时完成。将此法初步用于19例散发性阿尔茨海默病患者和41名无精神神经疾患老年人载脂蛋白E等位基因的检测,测得ε4等位基因频率分别为0.29和0.02,两者之间差异非常显著(P<0.001)。结论PCR结合银染法检测载脂蛋白E等位基因,在尽量避免使用有害试剂的同时,提高了检测灵敏度和效率,因此适用于临床及流行病学调查时对大批标本的检测

    Objective The purpose of this study was to demonstrate the significance of single photon emission computed tomography (SPECT) in diagnosis of Alzheimer′s disease (AD) and to illustrate its correlation with scores of neuropsychological tests. Methods 22 AD patients and 23 age, gender and education matched normal subjects were studied with SPECT and neuropsychological tests. Results The values in SPECT radioactive count ratio and scores of neuropsychological tests were lower in the AD patients than that in...

    Objective The purpose of this study was to demonstrate the significance of single photon emission computed tomography (SPECT) in diagnosis of Alzheimer′s disease (AD) and to illustrate its correlation with scores of neuropsychological tests. Methods 22 AD patients and 23 age, gender and education matched normal subjects were studied with SPECT and neuropsychological tests. Results The values in SPECT radioactive count ratio and scores of neuropsychological tests were lower in the AD patients than that in normal subjects. Difference in SPECT values between AD patients and controls varied with gender. The value of SPECT in right parietal lobe was significantly different between mild, moderate and severe cases within AD group ( P <0.05). Score of MMSE in AD patients was correlated to radioactive count ratio in right parietal lobe ( r =0.51, P < 0.05). Conclusion The results of this study suggest the importance of SPECT in early diagnosis of AD, and the values of SPECT are correlated to their scores of neuropsychological tests.

    目的验证单光子发射计算机断层扫描(SPECT)在阿尔茨海默病(AD)诊断中的价值,并了解其与神经心理测定的相关性。方法对22例AD和23名年龄、性别及教育程度均相匹配的正常人进行神经心理学有关量表的评定和SPECT检查。结果AD组各神经心理学测验量表评分及SPECT放射性计数比值均低于正常对照组。两组男性间SPECT放射性计数比值在左右颞上回的差异有非常显著性(P<0.01),左颞下回、左右丘脑和扣带回的差异有显著性(P<0.05)。两组女性间SPECT放射性计数比值在左右颞上、颞下回及左右顶叶的差异有非常显著性(P<0.01)。轻度与中、重度AD之间右顶叶的差异有显著性(P<0.05)。AD患者的简易智能状态检查评分与右顶叶放射性计数比值相关(r=0.51,P<0.05)。结论SPECT对AD早期诊断具有重要意义,并与神经心理测定值有一定相关性。

    Objective To explore the immunoreactivities of phosphorylated

    目的探讨阿尔茨海默病(Alzheimersdisease,AD)患者脑脊液(CSF)磷酸化神经丝(PNF)和双螺旋丝(PHF)免疫活性的变化及临床意义。方法采用竞争抑制型ELISA检测AD的CSF中PNF和PHF的免疫活性,并与对照组即多发梗死性痴呆(MID)、其他神经疾病(ODC)、精神分裂症(SCH)及正常人(NC)进行比较。结果AD组CSF中PNF活性与MID、NC、SCH无显著性差异。AD组CSF中PHF活性高于各对照组,而其PNF/PHF比值低于各对照组,有显著性意义。PHF值与对照组个体间重叠的4例AD中仅1例其PNF/PHF值与相应的MID有重叠。结论单纯测定CSF中PNF免疫活性对AD的鉴别诊断无意义,测定CSF中PHF活性与PNF/PHF比值相结合可提高AD的诊断正确率,有可能发展为有临床意义的实验室诊断试验。

     
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