助手标题  
全文文献 工具书 数字 学术定义 翻译助手 学术趋势 更多
查询帮助
意见反馈
   阿尔茨海默病 在 神经病学 分类中 的翻译结果: 查询用时:0.578秒
图标索引 在分类学科中查询
所有学科
神经病学
精神病学
中药学
临床医学
基础医学
药学
中医学
生物学
特种医学
更多类别查询

图标索引 历史查询
 

阿尔茨海默病     
相关语句
  alzheimer disease
    Forty patients with senile dementia were studied by the method of computer EEG topography (CET). The patients with cerebral infarction with normal intellect and the healthy elderly persons served as control. 16 cases of Alzheimer disease (AD) was group A, 24 cases of multiple infarction dementia (MID) was group B, 25 cases of cerebral infarction with normal intellect was group C, 21 cases of healthy elderly person was group D.
    本文报告应用脑电地形图(CET)研究老年期痴呆患者40例的变化,其中阿尔茨海默病(A组)16例,多发梗塞性痴呆(B组)24例,并与脑梗塞25例(C组)、健康老年人21例(D组)进行对照研究。
短句来源
    Objective To investigate the neuropsychological pattern of different dementia severity in Alzheimer Disease(AD).
    目的 研究阿尔茨海默病(AD) 不同痴呆严重程度时的神经心理模式特点。
短句来源
    Objectives To investigate the neurotoxicity of beta amyloid (Aβ) consisting of senile plaques in Alzheimer disease (AD) in the animal model.
    目的 探讨β淀粉样蛋白 (Aβ)海马内注射的神经毒性 ,并对应用此方法建立阿尔茨海默病 (AD)的动物模型进行初步评价。
短句来源
  alzheimer ' s disease
    Objective To investigate the levels and clinical significance of β-amyloid peptide1-42(Aβ1-42) in cerebrospinal fluid(CSF) of patients with Alzheimer's disease(AD) and Parkinson's dementia(PDD).
    目的探讨在阿尔茨海默病(AD)和帕金森痴呆(PDD)患者脑脊液(CSF)中tau蛋白和β淀粉样蛋白(Aβ1-42)的水平及临床意义。
短句来源
    A study of changes of fas antigen in cerebrospinal fluid of patients with Alzheimer's disease
    阿尔茨海默病患者脑脊液中Fas抗原含量的变化
短句来源
    Parkinson's disease and Alzheimer's disease
    帕金森病与阿尔茨海默病
短句来源
    Relationship of apolipoprotein E gene polymorphism to Parkinson's disease and Alzheimer's disease
    载脂蛋白E基因多态与帕金森病和阿尔茨海默病的关联
短句来源
    Alpha-2 macroglobulin gene polymorphism in patients with Parkinson's disease and Alzheimer's disease
    α_2-巨球蛋白基因多态在帕金森病及阿尔茨海默病中的分布
短句来源
更多       
  alzheimer ′ s disease
    To detect the levels of β amyloid protein(Aβ)in cerebrospinal fluid(CSF)of patients with Alzheimer′s disease(AD)and vascular dementia(VD).
    研究了阿尔茨海默病 (Alzheimer′sdisease ,AD)和血管性痴呆 (vasculardementia ,VD)患者脑脊液中淀粉样蛋白(Aβ1-4 2 )的含量并探讨其意义。
短句来源
  alzheimer ’ s disease
    2. The BDV p24 fragments in peripheral blood mononuclear cells(PBMCs) were detected by FQ-nRT-PCR from 158 patients withneuropsychiatric disorders [including 60 cases with unknown causes ofviral encephalitis diagnosed clinically, 20 cases of multiple sclerosis, 15 ofGuillain-Barre syndrome (acute 12 and chronic 3, respectively), 12Parkinson’s disease, 2 Alzheimer’s disease, 31 schizophrenia, and 16 mood(or affective) disorder, respectively], and 112 healthy blood donors.
    2、用已建立的 FQ-nRT-PCR 检测 158 份神经精神疾病患者[其中原因未明的病毒性脑炎 62 例、多发性硬化 20 例、吉兰-巴雷综合征 15例(急性 12 例、慢性 3 例)、帕金森病 12 例、阿尔茨海默病 2 例、精神分裂症 31 例和情感障碍 16 例]和 112 例健康对照外周血单个核细胞(PBMCs)中 BDV p24 基因片段。
短句来源
    In the brains of Alzheimer’s disease patients amyloid beta-peptide(Aβ) is the major component of senile plaque.
    β淀粉样蛋白(β-amyloid Peptide,Aβ)是阿尔茨海默病的主要致病因子。
短句来源

 

查询“阿尔茨海默病”译词为其他词的双语例句

 

查询“阿尔茨海默病”译词为用户自定义的双语例句

    我想查看译文中含有:的双语例句
例句
为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。
  alzheimer disease
Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
      
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
      
It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
      
Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
      
Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
      
更多          
  alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          
  alzheimer ′ s disease
The apoE gene has been identified as a major susceptibility locus for late-onset Alzheimer′s disease (LOAD).
      
  其他


Forty patients with senile dementia were studied by the method of computer EEG topography (CET). The patients with cerebral infarction with normal intellect and the healthy elderly persons served as control. 16 cases of Alzheimer disease (AD) was group A, 24 cases of multiple infarction dementia (MID) was group B, 25 cases of cerebral infarction with normal intellect was group C, 21 cases of healthy elderly person was group D. The spectrum power of σ band and θ band in group A, B, C was higher than that in group...

Forty patients with senile dementia were studied by the method of computer EEG topography (CET). The patients with cerebral infarction with normal intellect and the healthy elderly persons served as control. 16 cases of Alzheimer disease (AD) was group A, 24 cases of multiple infarction dementia (MID) was group B, 25 cases of cerebral infarction with normal intellect was group C, 21 cases of healthy elderly person was group D. The spectrum power of σ band and θ band in group A, B, C was higher than that in group D(P<0.05). In comparison with group D, the spectrum power of a band reduced significantly in 8 cases(50%) of group A, in nearly 10% of cases of group B and group C. The spectrum power of α_1 band was more increased in group A,B than that in group C.

本文报告应用脑电地形图(CET)研究老年期痴呆患者40例的变化,其中阿尔茨海默病(A组)16例,多发梗塞性痴呆(B组)24例,并与脑梗塞25例(C组)、健康老年人21例(D组)进行对照研究。A、B、C三组的δ和θ频带功率高于D组(P<0.05。)A组的α频带功率低于其他组,以α_2、α_3频带降低显著。而A、B两组的α_1频带功率较D、C组增高。讨论了老年期痴呆脑电地形图的变化。

Objective:To investigate the amyloid deposition components of extracellular matrix (ECM) in leptomenigeal and cortical arterial vessels for analysing the relationship between the pathological changes and cerebral haemorrhage.Methods:Immunohistochemistry was performed on samples obtained from 10 autopsy cases with marked amyloid angiopath (9 Alzheimers disease and one Downs syndrome) and control group of 8 postmortem cases without encephalopathy. We used a number of primary monoclonal and polyclonal antisera...

Objective:To investigate the amyloid deposition components of extracellular matrix (ECM) in leptomenigeal and cortical arterial vessels for analysing the relationship between the pathological changes and cerebral haemorrhage.Methods:Immunohistochemistry was performed on samples obtained from 10 autopsy cases with marked amyloid angiopath (9 Alzheimers disease and one Downs syndrome) and control group of 8 postmortem cases without encephalopathy. We used a number of primary monoclonal and polyclonal antisera to visulise different components of extracellular matrix, smooth muscle cells and endothelial cells under the microscope. Results:Pronounced reduction of glucose transporter presented in the endothelial cells of the blood vessel of amyloid angiopathies. The deposition of ECM material indicating luminin and collagen IV occured particularly in the media, but the actin was absent. The immunostaining markers of advantitia did not reveal much changes compared with the controls.Conclusion:(1)The prominent pathological changes of cerebral amyloid angiopathes were the degeneration of smooth muscle in the media of arteries and arterioles.(2)Severe amyloid angiopathy with deposition of collagen type IV and luminin and loss of the actin protein in the parts of the media may make the arteries and arterioles more susceptible to ruptures and haemorrhages than vessels in other microangiopathies..

目的:研究脑淀粉样血管病的脑膜及皮层动脉细胞外间质淀粉样沉淀物成份,探讨该病理改变与脑出血的关系。方法:研究标本取自于10例生前患有脑淀粉样性血管病死亡者(9例阿尔茨海默病,1例先天性愚型)。另设对照组8例,均为非脑病病故者。利用免疫组化ABC法,将针对细胞外间质各种胶元成份以及平滑肌和内皮细胞的单克隆、多克隆抗体与组织切片进行免疫组化染色,显微镜下观察。结果:血管内皮细胞层葡萄糖转运酶减少,中层ECM主要沉淀物是淀粉样物质、层蛋白和Ⅳ型胶元,纤维型胶元缺如;外层改变轻微。结论:(1)脑淀粉样血管病的病理改变主要发生在血管中层,以平滑肌变性为显著;(2)脑淀粉样变性血管ECM主要沉淀物是淀粉样物质、层蛋白和Ⅳ型胶元,并伴有纤维型胶元缺如,造成血管壁的脆性增加,易引起脑出血

Abnormal phosphorylation of microtubule associated protein τ is one of the major mechanism in Alzheimer neurofibrillary degeneration. It was found that casein kinase 1 (CK 1), cyclic AMP dependent protein kinase (PKA) and glycogen synthase kinase 3 (GSK 3) differentially phosphorylate humanτ(τ3L) and thus inhibit its biological activity. Morever, the phosphorylation and inhibition of this activity of τ by GSK 3 is significantly increased if τ is prephosphorylated by PKA. Under this condition, only neglectable...

Abnormal phosphorylation of microtubule associated protein τ is one of the major mechanism in Alzheimer neurofibrillary degeneration. It was found that casein kinase 1 (CK 1), cyclic AMP dependent protein kinase (PKA) and glycogen synthase kinase 3 (GSK 3) differentially phosphorylate humanτ(τ3L) and thus inhibit its biological activity. Morever, the phosphorylation and inhibition of this activity of τ by GSK 3 is significantly increased if τ is prephosphorylated by PKA. Under this condition, only neglectable microtubles could be seen by electron microscopy . The data suggest that a synergistic role of PKA and GSK 3 might be involved in abnormal phosphorlation and functional inhibition of τ in Alzheimer disease.

微管相关蛋白τ的异常磷酸化是阿尔茨海默病( A D) 神经原纤维退变的重要机制之一. 研究发现: 酪蛋白激酶1 ( C K1) ,c A M P 依赖性蛋白激酶( P K A) 和糖原合成酶激酶3 ( G S K3) 均可不同程度催化重组τ蛋白发生磷酸化, 从而不同程度抑制τ蛋白促微管组装的生物学功能. 如果先将τ蛋白与 P K A 预温2 h 后再和 G S K3温育, 则发现τ蛋白磷酸化程度比单纯用 G S K3 处理显著增高, 生物学活性则显著降低, 电镜检测几乎看不见微管形成. 结果提示: P K A 和 G S K3 在τ蛋白的 A D 样磷酸化及其功能抑制中具有正性协同作用

 
<< 更多相关文摘    
图标索引 相关查询

 


 
CNKI小工具
在英文学术搜索中查有关阿尔茨海默病的内容
在知识搜索中查有关阿尔茨海默病的内容
在数字搜索中查有关阿尔茨海默病的内容
在概念知识元中查有关阿尔茨海默病的内容
在学术趋势中查有关阿尔茨海默病的内容
 
 

CNKI主页设CNKI翻译助手为主页 | 收藏CNKI翻译助手 | 广告服务 | 英文学术搜索
版权图标  2008 CNKI-中国知网
京ICP证040431号 互联网出版许可证 新出网证(京)字008号
北京市公安局海淀分局 备案号:110 1081725
版权图标 2008中国知网(cnki) 中国学术期刊(光盘版)电子杂志社