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阿尔茨海默病
相关语句
  alzheimer ' s disease
    The study of the diagnosis of Alzheimer's disease using I8F-FDG PET.
    阿尔茨海默病~(18)F-FDG PET显像诊断的研究
短句来源
    The clinical progress of PET/SPECT receptor imaging of Alzheimer' s disease
    阿尔茨海默病PET/SPECT受体显像的临床研究进展
短句来源
    Study on Alzheimer's disease and vascular dementia using PET
    阿尔茨海默病与血管性痴呆的~(18)F-FDG PET脑显像
短句来源
    Characteristics of ~(18) F-FDG PET and ~(99) Tc~m-ECD SPECT in mild Alzheimer's disease
    轻度阿尔茨海默病的PET与SPECT特征与对比
短句来源
    Objective To study glucose metabolism of the brain in Azheimer's disease by positron emission tomography (PET) , and to investigate the imaging characteristics and diagnosis criteria of 18F-FDG PET in Chinese Alzheimer's disease(AD).
    目的 探讨阿尔茨海默病(AD)脑葡萄糖代谢及其18F-脱氧葡萄糖正电子发射计算机断层扫描(18F-FDG PET)显像的影像学特征和PET诊断标准。
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  相似匹配句对
    Application of PET in Alzheimer disease
    PET在阿尔茨海默中的应用价值
短句来源
    The study of the diagnosis of Alzheimer's disease using I8F-FDG PET.
    阿尔茨海默~(18)F-FDG PET显像诊断的研究
短句来源
    Neurological decompression sickness
    神经减压
短句来源
    CT diagnosis of Fahr 's disease
    Fahr的CT诊断
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  alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
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Objective The purpose of this study was to demonstrate the significance of single photon emission computed tomography (SPECT) in diagnosis of Alzheimer′s disease (AD) and to illustrate its correlation with scores of neuropsychological tests. Methods 22 AD patients and 23 age, gender and education matched normal subjects were studied with SPECT and neuropsychological tests. Results The values in SPECT radioactive count ratio and scores of neuropsychological tests were lower in the AD patients than that in...

Objective The purpose of this study was to demonstrate the significance of single photon emission computed tomography (SPECT) in diagnosis of Alzheimer′s disease (AD) and to illustrate its correlation with scores of neuropsychological tests. Methods 22 AD patients and 23 age, gender and education matched normal subjects were studied with SPECT and neuropsychological tests. Results The values in SPECT radioactive count ratio and scores of neuropsychological tests were lower in the AD patients than that in normal subjects. Difference in SPECT values between AD patients and controls varied with gender. The value of SPECT in right parietal lobe was significantly different between mild, moderate and severe cases within AD group ( P <0.05). Score of MMSE in AD patients was correlated to radioactive count ratio in right parietal lobe ( r =0.51, P < 0.05). Conclusion The results of this study suggest the importance of SPECT in early diagnosis of AD, and the values of SPECT are correlated to their scores of neuropsychological tests.

目的验证单光子发射计算机断层扫描(SPECT)在阿尔茨海默病(AD)诊断中的价值,并了解其与神经心理测定的相关性。方法对22例AD和23名年龄、性别及教育程度均相匹配的正常人进行神经心理学有关量表的评定和SPECT检查。结果AD组各神经心理学测验量表评分及SPECT放射性计数比值均低于正常对照组。两组男性间SPECT放射性计数比值在左右颞上回的差异有非常显著性(P<0.01),左颞下回、左右丘脑和扣带回的差异有显著性(P<0.05)。两组女性间SPECT放射性计数比值在左右颞上、颞下回及左右顶叶的差异有非常显著性(P<0.01)。轻度与中、重度AD之间右顶叶的差异有显著性(P<0.05)。AD患者的简易智能状态检查评分与右顶叶放射性计数比值相关(r=0.51,P<0.05)。结论SPECT对AD早期诊断具有重要意义,并与神经心理测定值有一定相关性。

Objective To study glucose metabolism of the brain in Azheimer's disease by positron emission tomography (PET) , and to investigate the imaging characteristics and diagnosis criteria of 18F-FDG PET in Chinese Alzheimer's disease(AD). Methods Fifty minutes after intravenous administration of F-FDG, brain scan was performed using Siemens ECAT EXACT HR + scanner in 13 patients with AD, 13 patients with non-AD dementia including Pakinson disease with dementia(PDD), vascular dementia (VD) and AD-VD, and 13 age-matched...

Objective To study glucose metabolism of the brain in Azheimer's disease by positron emission tomography (PET) , and to investigate the imaging characteristics and diagnosis criteria of 18F-FDG PET in Chinese Alzheimer's disease(AD). Methods Fifty minutes after intravenous administration of F-FDG, brain scan was performed using Siemens ECAT EXACT HR + scanner in 13 patients with AD, 13 patients with non-AD dementia including Pakinson disease with dementia(PDD), vascular dementia (VD) and AD-VD, and 13 age-matched healthy subjects. The transaxial, coronal and sagittal images were reconstructed by computer. Semiquantitative analysis was applied to assess the metabolic function of the brain by the ratio of mean radioactivity of cerebral lode to cerebellum (Rcl/cb). PET scan was compared with magnetic resonance imaging (MRI). Results 100% of AD patients showed abnormal PET imagines, whereas 76.92% of AD patients' showed abnormal MRI. The characteristics of PET imagines of AD patients had three patterns: (1) bilateral parietal, temporal, hippocampus and forntal or occipital lobe symmetrical hypometabolism in 69.23% AD cases; (2)bilateral temporal and hippocampus or frontal lobe symmetrical hypometabolism in 23.08% AD cases; (3)bilateral parietal symmetrical hypometabolism in 7.69% AD cases. The PET imagines of non-AD dementia showed that asymmetrical and multiple foci with decreased radioactivity and hypometabolism in 92.31% cases. The areas of hypometabolism were in nigro-striatum system, thalamus and cerebral. Conclusions Excluding cerebral structural lesions in brain with MRI, bilateral or symmetrical cerebral hypometabolism found in FDG PET can be considered as the special characteristics and diagnosis criteria of Alzheimer's disease. It is very important for the early diagnosis of AD and be differentiated from non-AD dementia .

目的 探讨阿尔茨海默病(AD)脑葡萄糖代谢及其18F-脱氧葡萄糖正电子发射计算机断层扫描(18F-FDG PET)显像的影像学特征和PET诊断标准。方法 静脉注射18F-FDG后行脑断层显像,检查13例 AD、13例非AD痴呆及13例正常人。获得纹状体、丘脑、黑质、顶叶、颞叶、额叶、枕叶、海马单位面积放射性计数与小脑计数的比值(Rcl/cb),进行半定量分析,并与MR进行对照。结果AD患者PET异常率为100%,MR异常者占10/13。PET显像特征:①对称性双侧颞顶叶及海马伴额叶或枕叶代谢减低占9例(9/13);②双侧颞叶对称性代谢减低伴海马或额叶代谢下降占3例(3/13);③双顶叶对称性代谢降低1例(1/13)。12例(12/13)非AD痴呆表现为不对称、多发性代谢降低,降低区位于黑质、纹状体、丘脑及脑皮质区,MR异常率为11/13。结论 在除外脑内结构特异性损害基础上,PET发现对称性双颞顶叶、海马或颞叶、顶叶,伴或不伴枕叶、额叶代谢下降,可诊断AD。PET对AD早期诊断及鉴别诊断具有临床意义。

Objective To understand the features of brain blood flow perfusion in elderly depressive patients, in an effort to supplj experimental evidence for the related neuroscientific assumptions. Methods 26 normai aged, 22 elderly depressive patients ( KD) and 26 patients with Alzheimer's disease (AD) were recruited and conducted with SPECT for brain blood flow perfusion. Re-sults ED showed significantly lower perfusion in right parietai lobe, bilateral frontal lobes and bilateral occipital lobes compared with normai...

Objective To understand the features of brain blood flow perfusion in elderly depressive patients, in an effort to supplj experimental evidence for the related neuroscientific assumptions. Methods 26 normai aged, 22 elderly depressive patients ( KD) and 26 patients with Alzheimer's disease (AD) were recruited and conducted with SPECT for brain blood flow perfusion. Re-sults ED showed significantly lower perfusion in right parietai lobe, bilateral frontal lobes and bilateral occipital lobes compared with normai aged, but obviously higher perfusion in cingulate, bilateral temporal lobes, bilateral basai ganglia and also bilateral ihalamus eompared vvith AD. Bilateral perfusion asymmetry was found in ED at following areas, including bilateral temporal lobes, bilateral (rontal lobes and bilateral occipital lobes with their left-side perfusion lower than right-side, and bilateral thalarnus as well vvith its higher left-side perfusion compared to the right. Discriminant analysis found 5 perfusion indes of corresponding areas were rhosen to enter into discriminant function, they vvere right parietai lobe, left temporal lobe, left prontal lobe, left occipital lobe and cingulate. The sensitivity and specificity of the discriminant function in diagnosing ED were 100% and 94.2%, respectively. Conclusions ED appears to have certain perfusion characleristics either of general depression or of its own. Those areas which perfusion indiees entering into discriminant function are thought to be supportive to the assumption for mood regulatory circus to cer-lain exlent, in which frontal lobe, limbic system and other related cortex are supposed to be involved.

目的 了解老年期抑郁症(ED)的脑血流灌注特点,为相关神经科学理论提供实验室数据。方法 对26名健康老人、22例ED及26例阿尔茨海默病(Alzheimer’s disease,AD)患者作脑血流灌注检查。结果 与健康老人相比,ED存在右顶叶、双侧额叶和双侧枕叶低灌注(P<0.05),与AD相比,ED的扣带回、双侧颞叶、双侧基底节和双侧丘脑灌注明显较高(P<0.05)。ED在颞叶、额叶、枕叶和丘脑处的双侧灌注不对称(P<0.05),除丘脑灌注为左侧高于右侧外,其余均为左侧低于右侧。判别分析结果为右顶叶、左颞叶、左额叶、左枕叶和扣带回进入判别方程,ED的判别方程对ED诊断的敏感性和特异性分别为100%和94.2%。结论 ED脑血流灌注兼具一般抑郁症和本身的特点,右顶叶、左颞叶、左额叶、左枕叶和扣带回灌注对ED的诊断有重要意义,支持额叶、边缘系统及其它相关区域共同构成情绪调节回路的假设。

 
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