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阿尔茨海默病     
相关语句
  alzheimer ' s disease
    So, modulating the metabolism and effects of PAF (e.g., blocking the PAF receptor) may become important strategies of intervention of Alzheimer's disease, HIV-associated dementia or post-ischemic neuronal death.
    调控PAF的代谢及其效应(如阻断PAF受体)将成为干预阿尔茨海默病、HIV相关性痴呆以及脑缺血的重要策略。
短句来源
    Protective Effects of Dipfluzine on the Brain in Alzheimer's Disease Rats and Naturally Aged Rats
    双苯氟嗪对阿尔茨海默病大鼠及自然衰老大鼠的脑保护作用
短句来源
    Experimental Study on Prevention and Treatment of Chemical Drugs Induced Alzheimer's Disease with Vitamin E and Tetramethylpyrazine
    维生素E和川芎嗪防治化学药物诱导的阿尔茨海默病的实验研究
短句来源
    Alzheimer's disease (AD) is a disorder associated with progressive degeneration in memory and in the recognition functions of old people.
    早老性痴呆即阿尔茨海默病(Alzheimer's Disease,AD)是一种以进行性高级认知功能障碍和记忆功能丧失为特征的老年性疾病。
短句来源
    Alzheimer's disease(AD) is a kind of degenerative neurodisease.
    阿尔茨海默病(AD)是一种脑神经退变性疾病。
短句来源
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  alzheimer ′ s disease
    Objective The purpose of this study was to explore the relation between Ca 2+ in brain cells and Alzheimer′s disease(AD).
    目的探讨脑内细胞钙离子与发生阿尔茨海默病(AD)之间的关系。
短句来源
    I 2 receptor is related to some diseases, such as depression, Parkinson′s disease, Huntington′s disease, opioid addiction and Alzheimer′s disease.
    咪唑啉I2 受体与抑郁症、帕金森病、亨廷顿病、阿片成瘾及阿尔茨海默病等疾病的发生有关。
短句来源
  alzheimer ’ s disease
    Effects of naoyikang on capability of learning and memory in Alzheimer’s disease model mice
    脑益康对阿尔茨海默病模型小鼠学习记忆的影响
短句来源
    With the coming era of aging, the incidence of Alzheimer’s Disease(AD) develops increasingly which has been the focus of the whole society.
    随着人口老龄化时代的到来,老年性痴呆,即阿尔茨海默病(Alzhei- mer’s disease, AD)的发病率日益增高,已经成为了社会日益关注的问题。
短句来源
    Antagonistic Effect of Melatonin on Alzheimer’s disease-like cell and Phosphorylated Tau ProteinObjective:To establish an Alzheimer’s disease cell model induced by okadaic acid(OA) ,explore the antagonistic effective of melatonin in relation to phosphorylated tau protein .
    目的:建立冈田酸诱导的阿尔茨海默病细胞模型,研究褪黑素抗AD样细胞效应及其与磷酸化tau蛋白的关系。
短句来源
  “阿尔茨海默病”译为未确定词的双语例句
    Antagonistic Effect of Melatonin on Alzheimer's Disease-like Cell and Phosphorylated Tau Protein
    褪黑素抗阿尔茨海默病样细胞效应和磷酸化tau蛋白
短句来源
    Objective To observe the expression of nicotinic acetylcholine receptor(nAchR) in the brain's fimbria/fornix transected rats,the effect of ectogenic estrogen on it,and its relation with Alzhelmer's disease(AD).
    目的以双侧穹隆-海马伞切断制作阿尔茨海默病(AD)大鼠模型,观察脑内海马CA1区和皮层区烟碱型乙酰胆碱受体(nAchR)表达的变化,探讨与AD相关的发病机制,并观察雌激素的干预作用。
短句来源
    The current hypothesis for the cause of this disease is that it is the result of aberrant production of β-amyloid (Aβ) and plaque deposition in the brain. Aβ_ 42 , less soluble and forming the major component of the amyloid plaques, is generated via the cleavage of β-amyloid protein precursor (β-APP) by γ-secretase, a key enzyme in the production of Aβ.
    近来研究认为阿尔茨海默病的产生主要起因于β淀粉样蛋白(β-amyloid,Aβ)在大脑内的沉积,而由γ-分泌酶切割β淀粉样前体蛋白产生的疏水性Aβ42是形成Aβ的主要原因,γ-分泌酶是防治阿尔茨海默病很有潜力的靶点。
短句来源
    Development of new agents for treatment of Alzehemer' s disease
    阿尔茨海默病新药开发现状
短句来源
    Synergistic Effects between Galanthamine and Meclofenoxate
    复方加兰他敏改善阿尔茨海默病的药效学及机制研究
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  alzheimer disease
Effect of homocysteine and nitric oxide levels on specific Computed Axial Tomography measurements in Alzheimer disease
      
We describe a patient who was clinically diagnosed with familial early-onset Alzheimer disease (AD) carrying both the E318G substitution in presenilin 1 (PSEN1) and an insertion of 7 octapeptide coding repeats in the prion protein gene (PRNP).
      
It is far from clear that DLBD represents a specific disease entity rather an intermediate variant between Alzheimer disease and idiopathic parkinsonian syndromes.
      
Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis
      
Working memory and FDG-PET dissociate early and late onset Alzheimer disease patients
      
更多          
  alzheimer ' s disease
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
Mutations in presenilin 1 (PS1) gene are closely associated with the early onset of familial Alzheimer's disease (EOFAD).
      
Prospects of Non-drug Approaches to Alzheimer's Disease
      
According to the immune status indices and our previous data on behavioral, biochemical, and morphological changes induced in bulbectomized mice, they have common symptoms with the Alzheimer's disease.
      
更多          
  alzheimer ′ s disease
The apoE gene has been identified as a major susceptibility locus for late-onset Alzheimer′s disease (LOAD).
      
  其他


Objective The purpose of this study was to explore the relation between Ca 2+ in brain cells and Alzheimer′s disease(AD). Methods The experimental rats were injected an excitotoxin, kanic acid (KA) to destroy the nucleus basal of Meynert (NBM) to made a brain pathological model of Alzheimer ,s disease. The effect of KA on brain cells Ca 2+ in sucking rats were tested with Fura 2/AM. Nikadipine, KCl, as the voltage dependent calcium channel ,s activator and blockade were used to determine that...

Objective The purpose of this study was to explore the relation between Ca 2+ in brain cells and Alzheimer′s disease(AD). Methods The experimental rats were injected an excitotoxin, kanic acid (KA) to destroy the nucleus basal of Meynert (NBM) to made a brain pathological model of Alzheimer ,s disease. The effect of KA on brain cells Ca 2+ in sucking rats were tested with Fura 2/AM. Nikadipine, KCl, as the voltage dependent calcium channel ,s activator and blockade were used to determine that KA through what channel made Ca 2+ to flow into brain cells. Results KA with different concentration could increase the [Ca 2+ ]i in brain cells of sucking rats ( P <0.05). KA caused Ca 2+ to flow into brain cells through the voltage dependent calcium channel. In addition, glutamate, as an excitotoxin, though receptor dependent calcium channel increased [Ca 2+ ]i in brain cells ( P <0.05). Conclusion It is suggested that KA could cause the overload of Ca 2+ in brain cells, which may be linked to the development of AD.

目的探讨脑内细胞钙离子与发生阿尔茨海默病(AD)之间的关系。方法用兴奋性神经毒海人藻酸(KA)破坏Meynert基底核(NBM),复制出与人类AD相似的大鼠脑神经病理改变模型。采用Fura-2/AM测定乳鼠脑细胞游离钙的方法观察KA的影响。同时应用尼卡地平、氯化钾作为电压依赖性钙通道阻滞剂与激动剂,确定KA是通过何种钙通道促使钙内流的。结果用不同浓度KA均可以使乳鼠脑细胞胞浆游离钙浓度明显升高(P<0.05),并证实KA是通过电压依赖性钙通道使钙离子流入脑细胞的。用同属兴奋性神经毒的谷氨酸可通过受体依赖性钙通道使脑细胞胞浆游离钙增多(P<0.05)。结论KA可使鼠脑细胞内钙超载,后者与AD的发生有关。

These notes introduce the definition, criteria of diagnosis and selection for Alzheimer's Disease. The main goals of AD treatment are established : symptomatic improvement; slowing or arrest; primary prevention. This guideline concentrates on assessment of symptomatic improvement in so far as, for the time being, experience is lacking in either slowing or arresting of symptom progression or in the primary prevention of disease. Improvement of symptoms should be assessed in three areas : 1. cognition; 2. activities...

These notes introduce the definition, criteria of diagnosis and selection for Alzheimer's Disease. The main goals of AD treatment are established : symptomatic improvement; slowing or arrest; primary prevention. This guideline concentrates on assessment of symptomatic improvement in so far as, for the time being, experience is lacking in either slowing or arresting of symptom progression or in the primary prevention of disease. Improvement of symptoms should be assessed in three areas : 1. cognition; 2. activities of daily living; 3. overall clinical response. It suggests making assessment in various areas by many kinds of instrument. Phase III controlled clinical trials aimed at demonstrating short term improvement should last 6 months. After the end of the treatment administration, the state of the patient should be observed for at least 2 months.

本文介绍了阿尔茨海默病痴呆的定义及诊断标准。确定了AD疗效评价的主要目标是:症状改善;减慢或阻止症状的发展;初级预防。目前在后两个方面还缺乏经验,所以对症状改善的评价应为重点,包括认知功能测试、日常生活能力量表及临床总体评价。建议用多种适当的测试工具对不同方面进行评价。为确定短期疗效,设有对照的Ⅲ期临床试验应持续6个月,停药后应随访2个月。

Alzheimer′s disease (AD) animal models were made by damaging bilateral nucleus basalis of Meynert (NBM) of elderly rats (20-22 month) with quinolinic acid(150 nmol in 2 μL for each NBM, given d 3 after administration of test drugs). Activity of choline acetyltransferase(ChAT) was measured by radiochemistry assay. One time training passive avoidance step down and water maze spatial localization task were used to observe effects of ginsenoside of stem and leaf(GSL) in combination with choline...

Alzheimer′s disease (AD) animal models were made by damaging bilateral nucleus basalis of Meynert (NBM) of elderly rats (20-22 month) with quinolinic acid(150 nmol in 2 μL for each NBM, given d 3 after administration of test drugs). Activity of choline acetyltransferase(ChAT) was measured by radiochemistry assay. One time training passive avoidance step down and water maze spatial localization task were used to observe effects of ginsenoside of stem and leaf(GSL) in combination with choline on learning and memory of AD model rats. The result showed that by oral administration of GSL(400 mg·kg -1 ·d -1 ) in combination with choline(200 mg·kg -1 ·d -1 ), the number of error in step down test after 13 d administration and the training times to reach the criterion on water maze task after 16 d administration were decreased significantly. Whereas activity of ChAT was increased obviously after 19 d administration. The effect of GSL in combination with choline was more remarkable than that of GSL or choline alone which suggests synergic effect. So GSL in combination with choline can synergically reduce the impairment of learning and memory of AD model rats and the mechanism may be involved in enhancing the function of central cholinergic system.

应用喹啉酸 (每侧 1 50 nmol,2 μL,给受试药后 d3注射 )损毁老年大鼠双侧 Meynert基底核制备阿尔茨海默病 (AD)动物模型 ,放射化学法测定胆碱乙酰基转移酶 (Ch AT)活性 ,一次性训练被动回避跳台实验和水迷宫空间分辨能力测试 ,观察人参茎叶皂甙 (GSL )和胆碱合用对 AD模型大鼠学习记忆的影响 .结果显示 :GSL(40 0 mg·kg-1·d-1)和胆碱 (2 0 0 mg·kg-1· d-1)合用 ig给药 ,大鼠在跳台中出现的错误反应次数 (给药 1 3d)和学会迷宫训练次数 (给药 1 6d)显著减少 ,大脑皮层 Ch AT活性明显升高 (给药 1 9d) ,且均比两药单用效应明显 ,呈协同作用 .表明 GSL和胆碱合用有协同改善 AD模型大鼠学习记忆障碍的作用 ,其机理与协同提高Ch AT活性 ,增强中枢胆碱能神经功能有关

 
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