Compared with the control, time dependent changes of NOS and nNOS positive neurons in the hippocampal CA 1 and CA 3 areas on lead exposed rats were as follow: CA 1 and CA 3 areas nNOS positive neurons were increased(P<0.05) after lead-exposed for 6h;
The number of SS and SSmRNA positive neurons in CA 1 area of lead exposed rats were significantly smaller than those of the control rats (23 27±4 58 and 37 60±9 69 respectively v.s 40 38±7 61 and 53 48±10 22 respectively, P <0 01).
The numbers of SS and SSmRNA positive neurons in CA 3 area of lead exposed rats were smaller than that of the controls rats (12 16±3 40 and 16 18±6 19 respectively v.s 17 68±5 86 and 25 93±7 47 respectively, P <0 05).
Methods: Chronic lead treated animal models were acquired by feeding the male postwean Wistar rats with 0.015%,0.10%,0.15% acetate lead in drinking water for 3 months,[Ca 2+ ] i was determined after LTP of hippocampus was induced by high frequency stimulation (HFS).
Non-occupational lead exposure and hypertension in Pakistani adults
Based on the long historical association and the provocative findings of blood pressure effects at low level of lead exposure a study was carried out to determine if an association existed between low blood lead concentration and hypertension.
Evaluation of the effect of lead exposure on the liver in Egyptian lead tank welders
Chronic, low-level lead exposure causes hypertension in both animals and humans.
In lead workers, the mobilization of bone lead causes an "internal" lead exposure and affects the blood lead level considerably.
The method has been applied to the determination of trace lead in blood samples of 41 healthy persons, 44 occupationally lead-exposed workers and 33 policemen on duty controlling the traffic for a period of more than 8 years.
Lead-exposed neonatal rats are frequently used as a model for plumbism in children.
Urinary aminolevulinic acid (U-ALA) was also determined in both control (3.37±0.89 mg ALA/g creatinine) and exposed groups (12.39±6.18 mg ALA/g creatinine) and U-ALA excretion was statistically higher (p>amp;lt;0.05) in lead-exposed workers.
Additionally, the statistically significant correlation (r2=0.880, p>amp;lt;0.01) between U-ALA excretion and HFC percentage in lead-exposed workers supported the probability of ALA mediated indirect mechanism for lead genotoxicity.
On the other hand, the amounts of hemoglobin (Hb) and urinary delta-aminolevulinic acid (ALA) in the group of lead-exposed workers kept the normal levels.
Both stimulation and suppression of immune response have been demonstrated in lead exposed animals and humans depending on the T helper (Th)1 vs Th2 response.
In the present study control rats and lead exposed rats which did not have any retardation of growth were examined by radioimmunological assay of myelin basic protein (MBP) of homogenates of cerebrum and cerebellum at 30, 60 and 120 days of age.
Evaluation of the use of salivary lead levels as a surrogate of blood lead or plasma lead levels in lead exposed subjects
The relationship between these biomarkers was assessed in a lead exposed population.
Taken together, these results suggest that salivary lead may not be used as a biomarker to diagnose lead exposure nor as a surrogate of plasma lead levels at least for low to moderately lead exposed population.
The levels of lead in the kidneys were higher in the group given lead acetate in their drinking water and fed the semipurified diet than in the lead treated group fed the pelleted diet.
The influence of testosterone propionate on the concentration of Zincprotoporphyrin in blood (ZPP) of castrated lead treated rabbits was investigated.
However, the 24-h uptake after 3 months and 4 months of treatment did not differ significantly from the lead treated reference groups.
Screening the library by reverse Northern analysis revealed that between 20 and 25% of clones selected from the library were differentially regulated in lead treated plants.
After differential screening, we isolated several differentially expressed cDNA clones, including a type 2 metallothionein (MT) gene which is involved in detoxification and homeostasis and shown to be differentially regulated in lead treated plants.