Results: The positive expression rates of p53 protein were 42.1%(16/38),10%(2/20),and 0%(0/10) in oral tongue squamous cell carcinoma,precancerous lesion,and normal oral mucosal tissues,respectively(P < 0.05).
Methods The tongue carcinoma lymphatic metastasis model of the nude mouse was established by injecting Tca 8113 cells into the nail pad. We collected the regurgitant lymph nodes after 4 weeks and detected RECK,MMP-9 and MMP-2 levels by immunohistochemistry and Western blot assay.
[Objective] To investigate the therapeutic efficacy of combination therapy with 8-Br-cAMP(8-Bromo3': 5'-cyclic adenosine monophosphate) and herpes simplex virus thymidine kinase (HSV-TK)/ganciclovir (GCV) system in the treatment of tongue squamous carcinoma xenografts.
Results The incidence of occult metastases with oral squamous cell carcinomawas 16.67%(15/90),however,the highest ocult metastase rate in patients with squamous cell carcinoma of tongue was 18.18%(10/55).
To investigate the effects of ATRA, acitretin and tazarotene on the growth and apoptosis of human tongue squamous cell carcinoma cell line Tca8113.
Acitretin may be an alternative medicine for the prevention and treatment of tongue squamous cell carcinoma.
Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using wh
By utilizing the Affymetrix GeneChip Chromosome Copy Number Tool, the allelic imbalance profiles for the advanced stage oral tongue squamous cell carcinoma (OTSCC) were generated based on 10?K and 100?K SNP mapping array results.
An orthotopic nude mouse model of oral tongue squamous cell carcinoma.