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  sildenafil
Intracerebral haemorrhage associated with sildenafil citrate
      
The drug Viagra (sildenafil) has drawn public attention to aphrodisiacs.
      
Non Erectile Dysfunction Application of Sildenafil
      
Der selektive Phosphodiesterase-5-(PDE5-)Inhibitor Sildenafil ist im Vergleich zu den vorgenannten Substanzen bereits am n?chsten zur klinischen Zulassung.
      
Sildenafil erwies sich bei verschiedenen Formen der pulmonalen Hypertonie als starker pulmonal selektiver Vasodilatator.
      
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s: Objectives: To evaluate the efficacy and safety of Viagra on men with ED of various etiologies. Methods: This study was a double blind, randomized (placebo:Viagra,1:3), placebo controlled, flexible dose study of Viagra oral tablets(25, 50 and 100mg) taken over 8 weeks. A total of 84 subjects were screened and randomized. Results: The primary efficacy variables (Questions 3 and 4 from IIEF) revealed a statistically significant( P <0.0001) improvement over placebo with an effective rate of 86% on...

s: Objectives: To evaluate the efficacy and safety of Viagra on men with ED of various etiologies. Methods: This study was a double blind, randomized (placebo:Viagra,1:3), placebo controlled, flexible dose study of Viagra oral tablets(25, 50 and 100mg) taken over 8 weeks. A total of 84 subjects were screened and randomized. Results: The primary efficacy variables (Questions 3 and 4 from IIEF) revealed a statistically significant( P <0.0001) improvement over placebo with an effective rate of 86% on Viagra vs 37% on placebo. The secondary efficacy variables supported the conclusion of the primary efficacy variables and included the remaining 13 IIEF questions,event log data(assessing the proportion of successful attempts at sexual intercourse, 71.8% on Viagra vs 17.0% on placebo), and the global assessment question(treatment had improved their erections,87.3% on Viagra vs 36.8% on placebo) .Viagra was well tolerated.The incidence of adverse events was higher for Viagra(33.3%) than for placebo(19.0%). Conclusions: Oral Viagra is an effective, well tolerated treatment for various erectile dysfunction.

目的 :评估万艾可 (Viagra○R)治疗男性勃起功能障碍 (ED)的有效性和安全性。 方法 :本试验为双盲、随机(安慰剂 :西地那非 ,1:3)、安慰剂对照、剂量可调整 (2 5、5 0和 10 0mg)、持续 12周的临床研究。共有 84名受试者参与本研究。 结果 :对主要疗效指标 (IIEF问题 3、4)的分析结果显示 ,万艾可对ED病人达到和维持勃起能力的改善作用显著优于安慰剂 (P <0 .0 0 0 1) ,万艾可的临床总有效率为 86 % ,显著高于安慰剂 (37% ) ;对心理性、器质性和混合性ED的有效率分别为 83%、79%和 81% (安慰剂组分别为 5 0 %、33%和 30 % )。同时 ,对次要疗效指标评估 (IIEF其余 13个问题、记事表和总评题 )亦显示 ,万艾可改善性生活的作用明显优于安慰剂 ;万艾可组性交成功率平均为71.8% ,显著高于安慰剂组 (17.0 % ) ;有 87.3%的万艾可组受试者认为研究药物改善了其勃起功能 ,显著高于安慰剂组 (36 .8% )。无 1名受试者因不良事件而中断研究 ,万艾可组的不良事件发生率 (33.3% )较安慰剂组高...

目的 :评估万艾可 (Viagra○R)治疗男性勃起功能障碍 (ED)的有效性和安全性。 方法 :本试验为双盲、随机(安慰剂 :西地那非 ,1:3)、安慰剂对照、剂量可调整 (2 5、5 0和 10 0mg)、持续 12周的临床研究。共有 84名受试者参与本研究。 结果 :对主要疗效指标 (IIEF问题 3、4)的分析结果显示 ,万艾可对ED病人达到和维持勃起能力的改善作用显著优于安慰剂 (P <0 .0 0 0 1) ,万艾可的临床总有效率为 86 % ,显著高于安慰剂 (37% ) ;对心理性、器质性和混合性ED的有效率分别为 83%、79%和 81% (安慰剂组分别为 5 0 %、33%和 30 % )。同时 ,对次要疗效指标评估 (IIEF其余 13个问题、记事表和总评题 )亦显示 ,万艾可改善性生活的作用明显优于安慰剂 ;万艾可组性交成功率平均为71.8% ,显著高于安慰剂组 (17.0 % ) ;有 87.3%的万艾可组受试者认为研究药物改善了其勃起功能 ,显著高于安慰剂组 (36 .8% )。无 1名受试者因不良事件而中断研究 ,万艾可组的不良事件发生率 (33.3% )较安慰剂组高(19.0 % ) ,但绝大多数为轻度、一过性的。 结论 :口服万艾可是一种可治疗各种病因导致的勃起功能障碍安全有效的药物 ,按需服用时能很好耐受。

In order to investigate the efficacy of sildenafil (Viagra TM ) and Yohimbine for male erectile dysfunction (ED). This meta analysis of 234 cases with ED (organic 41%, Psychogenic 46%,mixed 13%) were randomly assigned into two groups by double blind method. Patients in sildenafil group were treated with sildenafil 50mg to 100mg once daily approximately 1 hour before sexual activity over 4 to 12 weeks. Patients in control group were given 5.4 mg to 10.8mg of yohimbine thrice daily for 4 to 12 weeks. After...

In order to investigate the efficacy of sildenafil (Viagra TM ) and Yohimbine for male erectile dysfunction (ED). This meta analysis of 234 cases with ED (organic 41%, Psychogenic 46%,mixed 13%) were randomly assigned into two groups by double blind method. Patients in sildenafil group were treated with sildenafil 50mg to 100mg once daily approximately 1 hour before sexual activity over 4 to 12 weeks. Patients in control group were given 5.4 mg to 10.8mg of yohimbine thrice daily for 4 to 12 weeks. After 4 to 12 weeks, the effective rates of 50mg and 100mg sildenafil group were 61.19% and 79.10% respectively. While the reponse rates of the control group were 26.66% and 40%. ( P <0.01). The results indiacte that silenafil, at doses of 50mg and 100mg is effective in men with ED.

为了对照性研究应用西地那非 (Sildenafil,ViagraTM)和育亨宾治疗男子阴茎勃起功能障碍 (ED)的效果。把 2 34例ED(器质性 41 % ,心理性 46 % ,混合性 1 3% )随机双盲分为两组 ,西地那非组 1 34例 ,用西地那非 5 0~ 1 0 0mg ,性交前 6 0分钟口服 ,每天一次 ,连服 2天后 ,改为 2~ 3天服一次 ,连用 4~ 1 2周。育亨宾组 1 0 0例 ,用育亨宾 (Yohimbine) 5 .4~ 1 0 .8mg ,每天服 3次 ,连用 4~ 1 2周。结果表明西地那非组口服西地那非 5 0~ 1 0 0mg后 ,有效率为 6 1 .1 9~ 79.1 0 % ,育亨宾组的有效率为 40 % ,两组疗效经统计学处理有显著性差别 (P <0 .0 1 )。本资料显示西地那非治疗各种原因的ED是安全有效的 ,副作用少而轻 ,可以长期治疗 ,相比之下育亨宾的效果较差

Erectile dysfunction has become the disease as concerned so much, with complex causes. Therapeutic drugs for erectile dysfunction, which are administried both parenterally and orally, were introduced, such as alprostadil, dinoprostone, phentolamine, papaverine, moxisylyte, testosterone, calcitonin gene related peptide, phentolamine meylate, bromocriptine, apomorphine, trazodone, arginine, sildenafil, et al. Their characteristics of action, clinical use and development update were also described.

男性性机能障碍成为社会广泛关注的疾病 ,且其形成原因复杂。目前 ,治疗该疾病的给药方法主要有注射和口服两种 ,经注射途径给药的药物有 :前列地尔、前列腺素E1和E2 、罂粟碱、莫西赛利、睾酮及拟降钙素肽 ;经口服途径给药的药物有 :甲磺酸酚妥拉明、溴隐亭、阿朴吗啡、曲唑酮、精氨酸和西地那非等。本文介绍了上述两种给药途径的治疗男性性机能障碍药物的作用特点、临床应用及开发状况。

 
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