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慢性重型乙肝
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  chronic severe hepatitis b
     Methods CP and precore gene was sequenced directly from sera of 75 patients with chronic hepatitis B(CHB)and 14 patients with chronic severe hepatitis B(CSH),after amplification by the polymerase chain reaction.
     方法 通过DNA扩增、基因序列分析检测 75例慢性乙型肝炎 (CHB)和 14例慢性重型乙肝 (CSH)患者血清的HBVCP和前C基因序列 ,通过微粒子发光法定量检测血清中HBeAg的含量及通过荧光定量PCR技术定量检测血清中的HBVDNA。
短句来源
     Objective To study the effects of mutations in the core promoter (CP) and the precore/core gene of hepatitis B virus (HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers (ASC) and the severity of patients with chronic hepatitis B.Methods CP and precore/core gene were sequenced directly from sera of four ASCs,twenty-seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B after amplication by the polymerase chain reaction.
     目的 研究乙型肝炎病毒 (HBV)C基因启动子 (CP)和前C/C基因变异与无症状慢性HBV携带者 (ASC)的肝炎发作及慢性乙肝病情严重性的关系。 方法 通过PCR及其产物直接测序 ,检测 4例ASC、2 7例慢性乙肝和 3例慢性重型乙肝病人血清的HBVCP和前C/C基因序列 ,并定量检测HBVDNA。
短句来源
     Objective To study the effects of mutations in the core promoter (CP) and the precore/core gene of hepatitis B virus ( HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers(AsC) and the severity of chronic hepatitis B.Methods CP and precore/core gene were sequenced directly from sera of four AsCs,twenty seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B,after amplification by the polymerase chain reaction.
     目的 :研究乙型肝炎病毒 (HBV)C基因启动子 (CP)变异与无症状慢性HBV携带者 (AsC)肝炎发作及慢性乙肝病情严重性的关系。 方法 :通过PCR及其产物直接测序 ,检测 4例AsC、2 7例慢性乙肝和 3例慢性重型乙肝病人血清的HBVCP和前C/C基因序列 ,并定量检测病人血清的HBVDNA。
短句来源
     To study the effects of mutations in the core promoter(CP)and the precore/core gene of hepatitis B virus (HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers (AsC) and the severity of patients with chronic hepatitis B. CP and precore/core gene were sequenced directly from sera of four AsCs, twenty-seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B, after amplication by the polymerase chain reaction.
     研究乙型肝炎病毒 (HBV)C基因启动子 (CP)变异与无症状慢性HBV携带者 (AsC)肝炎发作及与慢性乙肝病情的关系。 通过PCR及其产物直接测序 ,检测 4例AsC、2 7例慢性乙肝和 3例慢性重型乙肝患者血清的HBVCP序列 ,并定量测定血清的HBVDNA。
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     Effects of lipo-PGE_1 injection on serum TNF-αin patients with chronic severe hepatitis B
     前列地尔对慢性重型乙肝患者血清肿瘤坏死因子-α的影响
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  chronic serious hepatitis
     Establish and Application of the ELISA Method in Detection of sFas - sFasL Complements in Patients with Chronic Serious Hepatitis
     慢性重型乙肝病人血清sFas-sFasL复合体ELISA检测方法的建立及应用
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  severer hepatitis
     There was remarkably different at serum IAP level in patients between chronic hepatitis and severer hepatitis(t=3.99,P<0.05).
     慢性乙肝和慢性重型乙肝组两组之间IAP比较亦有显著性差异(t=3.99,P<0.05)。
短句来源
     The level of serum IgG、IgA and IgM in patients between chronic hepatitis and severer hepatitis groups were signifiacntly different(P<0.05).
     慢性乙肝和慢性重型乙肝组之间IgGI、gAI、gM水平比较差异亦有显著性(P<0.05)。
短句来源
     The levels of serum PTA among chronic hepatitis,acute hepatitis and severer hepatitis were remarkably different(P<0.01).
     慢性重型乙肝组PAB降低最为明显,与急性乙肝、慢性乙肝组比较差异亦有显著性(P<0.01)。
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  “慢性重型乙肝”译为未确定词的双语例句
     Methods The expression of membrane CD14、CD14 mRNA and TLR4 mRNA in the peripheral blood monocytes (PBMs) from 30 cases of chronic severe hepatitis patients、20 cases of chronic hepatitis B patients and 10 cases of healthy controls were detected by flow cytometry and reverse transcription-polymerase reaction (RT-PCR) methods. Moreover, the level of plasma endotoxin and serum sCD14 were assayed by limulus amebocyte lysate test and ELISA respectively.
     方法 采用流式细胞术和逆转录-聚合酶链反应(RT-PCR)方法检测30例慢性重型乙肝患者、20例慢性乙肝患者和10例正常人外周血单核细胞上膜型CD14(mCD14)、CD14 mRNA以及TLR4 mRNA的水平,应用动态浊度法和ELISA双抗体夹心法检测血浆内毒素及血清可溶性CD14(sCD14)的水平。
短句来源
     Serum IAP level in chronic hepatitis and severe hepatitis was much lower than that of in the normal group(t=3.38,P<0.01;t=6.55,P<0.01).
     同时检测血清总胆红素(TB il)和凝血酶原活动度(PTA)。 慢性乙肝患者和慢性重型乙肝组IAP明显降低,与正常对照组比较差异有显著性(t=3.38,P<0.01;t=6.55,P<0.01);
短句来源
     [Objective] To study the relationship between the expression of NKG2D gene in immunocytes and the severity of patients with chronic hepatitis B.[Methods] Blood samples were obtained from 20 patients with chronic fulminant hepatitis B,10 with asymtomatic surface antigen carriers and 10 healthy people(control group). NK cells were sorted and expression of NKG2D gene were quantitatively determined by Flow cytometry and immunofluorescent techniques.
     目的分析乙型肝炎免疫细胞NKG2D表达与肝病重型化的关系。 方法应用免疫荧光技术和流式细胞术(FCM)分选20例慢性重型乙肝(FHB)、10例无症状表面抗原携带者(ASC)、10例健康对照的外周血NK细胞,并定量分析NKG2D表达。
短句来源
     Results The expression of CD14 mRNA and TLR4 mRNA in peripheral blood mononuclear cells (PBMCs) were significantly higher in chronic severe hepatitis patients(2.65±0.47 and 1.36±0.25, respectively)than those in healthy controls (0.96±0.35 and 0.64±0.12, respectively p<0.01) and in chronic hepatitis patients (1.24±0.31 and 0.81±0.16 , respectively p<0.01 ).
     结果 慢性重型乙肝组患者外周血单个核细胞CD14 mRNA和TLR4 mRNA表达水平分别为2.65±0.47 、1.36±0.25,明显高于慢性乙肝患者(1.24±0.31 、0.81±0.16, p<0.01)和对照组(0.96±0.35 、0.64±0.12, p<0.01)。
短句来源
     The level of plasma endotoxin and serum sCD14 was also remarkably higher in chronic severe hepatitis patients (0.651±0.548 and 6.736±3.018, respectively ) than those in healthy controls (0.0246 ±0.0279 and 2.447±1.281, respectively P<0.01) and in chronic hepatitis patients (0.0531±0.0483 and 3.215±1.654, respectively P<0.01). But there was no significantly difference on the level of mCD14 among three groups.
     同时慢性重型乙肝组患者血浆内毒素、血清sCD14水平(分别为0.651±0.548 、6.736±3.018)均高于慢性乙肝组(0.0531±0.0483、3.215±1.654, P<0.01)和健康对照组(0.0246 ±0.0279 、2.447±1.281, P<0.01),但慢性重型乙肝组患者外周血单核细胞mCD14表达水平与慢性乙肝组、对照组相比较,差异无非常显著意义。
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  chronic severe hepatitis b
Discriminant function for prognostic indexes and probability of death in chronic severe hepatitis B
      
We aimed to determine a discriminant function for prognosis in chronic severe hepatitis B (CSHB), by discriminant analysis of prognostic indexes and probability of death.
      
The discriminant function is an objective, convenient, and practical method to assess the prognosis of chronic severe hepatitis B.
      


The assay of sIL-2R and T lymphocyte subgroup in 21 cases of serious HB patients revealed that serum sIL-2R in patients of acute and subacute or chronic serious HB was significantly higher than those in normal controls, P<0.001, but the CD + 4 lymphocytes in all these patients obviously decreased and CD + 8 lymphocytes notably increased when comppared with that in normal group, P<0.01. The results showed that increasing of sIL-2R is associated with the activation of CD + 8 cells which is mainly of cytotoxicity...

The assay of sIL-2R and T lymphocyte subgroup in 21 cases of serious HB patients revealed that serum sIL-2R in patients of acute and subacute or chronic serious HB was significantly higher than those in normal controls, P<0.001, but the CD + 4 lymphocytes in all these patients obviously decreased and CD + 8 lymphocytes notably increased when comppared with that in normal group, P<0.01. The results showed that increasing of sIL-2R is associated with the activation of CD + 8 cells which is mainly of cytotoxicity T lymphoeytes that play an important role in the pathogenesis of acute and subacute serious HB. The different expression of CD + 4 and CD + 8 in acute and chronic serious HB suggests a different pathogenetic mechanism between them.

对21例重型乙型肝炎患者白细胞介素2受体(sIL-2R)及T淋巴细胞亚群检测发现,急性及亚急性重型、慢性重型肝炎患者的sIL-2R均显著增高,与正常对照比较,P<0001。急性、亚急性重型及慢性重型乙型肝炎患者的CD+4明显降低,CD+8则显著升高,与对照组比较,P均<001。检测证实sIL-2R增高与活化的CD+8具有相关性,表明活化的CD+8细胞主要是细胞毒性T细胞(CTL),其在急性和亚急性重型肝炎发病中可能起重要作用。CD+4、CD+8细胞在急性和慢性重型乙肝中表达的不同,提示二者发病机制不同。

Objective To study the effects of mutations in the core promoter (CP) and the precore/core gene of hepatitis B virus (HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers (ASC) and the severity of patients with chronic hepatitis B.Methods CP and precore/core gene were sequenced directly from sera of four ASCs,twenty-seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B after amplication...

Objective To study the effects of mutations in the core promoter (CP) and the precore/core gene of hepatitis B virus (HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers (ASC) and the severity of patients with chronic hepatitis B.Methods CP and precore/core gene were sequenced directly from sera of four ASCs,twenty-seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B after amplication by the polymerase chain reaction.Results Clusters of mutations in CP region,an A-to-C mutation at nucleotide (nt) 1726,an A-to-T mutation at nt 1727 and a C-to-G mutation at nt 1730 were observed in eight of eleven ASCs developing acute exacerbation,none of five ASCs with no or obscure signs and gentle rise in ALT,or none of four ASCs without abnormal ALT.Moreover,the clustering mutations were found negative in the state of ASC and positive after acute exacerbation in a subject.Five patients with both the clustering mutations and the double mutations (an A-to-T mutation at nt 1762 and a G-to-A mutation at nt 1764)manifested severe hepatitis or active cirrhosis with high level of serum HBV DNA,HBV DNA positive by dot blot,HBeAg negative and Anti-HBe positive in serum.Conclusion The clustering mutations are associated with acute exacerbation in HBV ASCs,and co-existence in the clustering mutations and the double mutations is related to the severity of chronic hepatitis B.

目的 研究乙型肝炎病毒 (HBV)C基因启动子 (CP)和前C/C基因变异与无症状慢性HBV携带者 (ASC)的肝炎发作及慢性乙肝病情严重性的关系。方法 通过PCR及其产物直接测序 ,检测 4例ASC、2 7例慢性乙肝和 3例慢性重型乙肝病人血清的HBVCP和前C/C基因序列 ,并定量检测HBVDNA。结果  (1)CP主要变异为nt172 6 1730聚集变异 (172 6A→C、172 7A→T、1730C→G)和nt176 2 176 4双变异 (176 2A→T和 176 4G→A)。前C区主要变异为 1896G→A。C基因变异常使C蛋白aa5、13、2 7、6 0、87、97及 130发生置换。 (2 )CP聚集变异与ASC首次肝炎急性发作有关 ,11例中 ,8例出现CP聚集变异。 (3)CP聚集变异合并CP双变异的乙肝病人 ,临床上或表现为重型肝炎或迅速进展为活动性肝硬化、HBVDNA高水平、HBeAg/抗HBe转换。 结论 同前C/C基因比较 ,CP变异与慢性乙肝病人的临床表现可能更为密切

Objective To study the effects of mutations in the core promoter (CP) and the precore/core gene of hepatitis B virus ( HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers(AsC) and the severity of chronic hepatitis B.Methods CP and precore/core gene were sequenced directly from sera of four AsCs,twenty seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B,after amplification by the polymerase chain reaction.Results (1)The mutations in CP region consisted...

Objective To study the effects of mutations in the core promoter (CP) and the precore/core gene of hepatitis B virus ( HBV) on acute clinical exacerbation in chronic asymptomatic HBV carriers(AsC) and the severity of chronic hepatitis B.Methods CP and precore/core gene were sequenced directly from sera of four AsCs,twenty seven patients with chronic hepatitis B and three patients with chronic severe hepatitis B,after amplification by the polymerase chain reaction.Results (1)The mutations in CP region consisted of the double mutations(1726 A→T and 1764 G→A) and the clustering mutations(1726 A→C,1727 A→T,1730 C→G).(2)Clustering mutations in CP associated with AsC developing acute exacerbation.They were observed in eight of eleven AsC developing acute exacerbation,while five patients with chronic hepatitis B with obscure signs and four AsC had no clustering mutations in CP.Moreover,the clustering mutations were found negative in the state of AsC and positive after acute exacerbation in a subject.(3)The patients with both the clustering mutations and the double mutations manifested severe hepatitis or active cirrhosis with high level of serum HBV DNA, HBV DNA positive by dot blot,HBeAg negative and Anti HBe positive in serum.Conclusion The clustering mutations in CP region are associated with acute exacerbation in AsC,and co existence of the clustering mutations and the double mutations is related to the severity of chronic hepatitis B.

目的 :研究乙型肝炎病毒 (HBV)C基因启动子 (CP)变异与无症状慢性HBV携带者 (AsC)肝炎发作及慢性乙肝病情严重性的关系。方法 :通过PCR及其产物直接测序 ,检测 4例AsC、2 7例慢性乙肝和 3例慢性重型乙肝病人血清的HBVCP和前C/C基因序列 ,并定量检测病人血清的HBVDNA。结果 :( 1)CP主要变异除核苷酸 (nt) 176 2 176 4双变异( 176 2A→T和 176 4G→A)外 ,还存在nt172 6 1730聚集变异 ( 172 6A→C、172 7A→T、1730C→G)。 ( 2 ) 11例首次急性发作的慢性乙肝病人中 (既往均有AsC史 ) ,8例出现CP聚集变异。而 5例隐匿起病的慢性乙肝病人和 4例AsC无一例出现该变异 ,且 1例在AsC状态时无CP变异 ,肝炎发作时出现CP聚集变异。 ( 3)CP聚集变异合并CP双变异的乙肝病人 ,临床上或表现为重型肝炎或迅速进展为活动性肝硬变 ,HBVDNA水平高滴度 ,HBVDNA(斑点法 )阳性 ,HBeAg/抗HBe转换。结论 :CP聚集变异与AsC肝炎急性发作有关 ;CP聚集变异与CP双变异同时...

目的 :研究乙型肝炎病毒 (HBV)C基因启动子 (CP)变异与无症状慢性HBV携带者 (AsC)肝炎发作及慢性乙肝病情严重性的关系。方法 :通过PCR及其产物直接测序 ,检测 4例AsC、2 7例慢性乙肝和 3例慢性重型乙肝病人血清的HBVCP和前C/C基因序列 ,并定量检测病人血清的HBVDNA。结果 :( 1)CP主要变异除核苷酸 (nt) 176 2 176 4双变异( 176 2A→T和 176 4G→A)外 ,还存在nt172 6 1730聚集变异 ( 172 6A→C、172 7A→T、1730C→G)。 ( 2 ) 11例首次急性发作的慢性乙肝病人中 (既往均有AsC史 ) ,8例出现CP聚集变异。而 5例隐匿起病的慢性乙肝病人和 4例AsC无一例出现该变异 ,且 1例在AsC状态时无CP变异 ,肝炎发作时出现CP聚集变异。 ( 3)CP聚集变异合并CP双变异的乙肝病人 ,临床上或表现为重型肝炎或迅速进展为活动性肝硬变 ,HBVDNA水平高滴度 ,HBVDNA(斑点法 )阳性 ,HBeAg/抗HBe转换。结论 :CP聚集变异与AsC肝炎急性发作有关 ;CP聚集变异与CP双变异同时存在 ,使慢性乙肝病人病情加重

 
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