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氯氮平     
相关语句
  clozapine
    Variation of leucocytic counts in relation to the oral administration of clozapine in 1434 pateints
    1434例口服氯氮平患者的白细胞计数改变
短句来源
    A study on damage effects of chlorpromazine and clozapine upon chromosomes of human lymphocytes in vivo.
    氯丙嗪及氯氮平对人体内淋巴细胞染色体损伤效应的探讨
短句来源
    A comparative study of the clinical effect of clozapine and chlorpromazine on schizophrenia type Ⅰ
    氯氮平、氯丙嗪治疗Ⅰ型精神分裂症疗效及副反应观察
短句来源
    Clinical Efficacy in Treatment of 210 Cases Ⅰ,Ⅱ Type Schizophrenia with Clozapine and Chlorpromazine
    氯氮平和氯丙嗪对210例Ⅰ、Ⅱ型精神分裂症的疗效观察
短句来源
    A study of clinical effect of clozapine in the treatment of negative symptoms of schizophrenia with chlorpromazine as controlled trial
    氯氮平和氯丙嗪治疗精神分裂症阴性症状临床疗效的对照研究
短句来源
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  taking clozapine
    Results After taking clozapine, 82% cases showed EEG changes and 92% cases with BEAM changes.
    结果 服用氯氮平6周后,82%患者有EEG改变,92%患者有BEAM改变。
短句来源
    Method: PANSS, TESS and serum clozapine level were evaluated in 66 schizophrenics taking clozapine alone.
    方法 给66例精神分裂症患者单服氯氮平,并且评价了0和4周的PANSS,4周的TESS和氯氮平血清浓度。
短句来源
    Method: Memory, attention, executive function were assessed with WMS, Cancellation test and WCST before and aftter 8 weeks of treatment in 57 patients taking clozapine or risperidone.
    方法 对57例接受氯氮平或维思通治疗的精神分裂症病人,采用韦氏记忆量表、数字划销测验、威斯康星卡片分类测验评估其治疗前和治疗8周后记忆、注意及执行功能。
短句来源
    In order to inquire into the curative effect of promethazine in the treatment of salivation produced by clozapine, 98 male patients who had salivation after singly taking clozapine were selected and treated with promethazine (25-50mg/day).
    为探讨异丙嗪治疗氯氮平所致流涎的疗效,选取98例男性病人,单服氯氮平后出现流涎副反应,用异丙嗪(25~50mg/日)治疗。
短句来源
    Methods It was fixed for dose in 39 inpatients with schizophrenia taking clozapine from 2nd weekend to 4th weekend.
    方法 给 39例精神分裂症病人服氯氮平治疗 ,在第 2~ 4周末剂量固定不变。
短句来源
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  clozapine treatment
    The effect of risperidone and clozapine treatment on serum interleukin 8,interleukin 15 in Schizophrenis.
    利培酮、氯氮平对精神分裂症血清IL-8、IL-15浓度的影响
短句来源
    Immune indices changes in schizophrenic patients before and after clozapine treatment
    精神分裂症患者氯氮平治疗前后免疫指标的变化
短句来源
    The changes of plasma IL-6, sIL-6R and IL-13 in patients with first-episode schizophrenia before and after clozapine treatment.
    首发精神分裂症患者氯氮平治疗前后血浆白细胞介素6,13及可溶性白细胞介素6受体水平的变化
短句来源
    Investigation on Life Quality of 52 Psychotic Patients Undergoing Clozapine Treatment for 10 Years
    52例精神病患者应用氯氮平10年后的生活质量现状调查
短句来源
    As for 123 schizophrenics,a logistic regression analysis revealed that ECT (electric convulsive therapy) or clozapine treatment was correlated with the abnormal BEAM (P<0.01),and bad treatment efficiency was correlated with the abnormal BEP (P<0.05).
    2.精神分裂症患者的脑电异常率又受治疗手段的影响,ECT治疗和氯氮平治疗均使患者BEAM异常率增高(P<0.01); 接受氯氮平治疗者,BEP异常率见低(P<0.01),另外,BEP异常与疗效也存在一定的相关性(P<0.05),疗效好者,BEP异常率低。
短句来源
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  “氯氮平”译为未确定词的双语例句
    Methods 30 in-patients who met the criteria for paranoid schizophrenia in the CCMD-3 were randomly selected as research group and 20 healthy volunteers as control group.
    方法随机选取30例住院患者为实验组,均符合《中国精神障碍分类与诊断标准》第3版精神分裂症偏执型诊断标准,入组后单用氯氮平治疗; 选取20例健康志愿者作为对照组。
    Serum nitric oxide level in positive and negative schizophrenia and its clinical significance
    氯氮平治疗对以阳性或阴性症状为主的精神分裂症患者血清一氧化氮含量的影响
短句来源
    Relationship Between Clozapine-induced Abnormal Lipid Metabolism and Interleukin-6
    氯氮平所致脂质代谢异常与白介素6及其受体的关系
短句来源
    Clinical Analysis of Consciousness Disorder Caused by Clozepine during Heroin Detoxification
    海洛因依赖者氯氮平引起意识障碍的临床分析
短句来源
    Changes of IL-6 in plasma and cerebrospinal fluid of schizophrenics with clozap-ine.
    氯氮平治疗前后精神分裂症患者血浆及脑脊液中IL-6的变化
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  clozapine
In the group with abnormal HbA1c and clozapine therapy, 2HPG was higher after the study [(9.5 ± 1.8) mmol/L] than that before the study [(7.2 ± 1.4) mmol/L] and the difference was statistically significant (P >amp;lt; 0.01).
      
In the abnormal HbA1c group, 2HPG after the study was higher in the clozapine treatment group [(9.5 ± 1.8) mmol/L] than in the risperidone treatment group [(7.4 ± 1.7) mmol/L] and the chlorpromazine treatment group [(7.3 ± 1.6) mmol/L].
      
A pilot trial of clozapine in the treatment of cervical dystonia
      
Clozapine may also improve dyskinesia without worsening akinesia, but it requires strict haematological monitoring.
      
Atypical antipsychotics such as clozapine and olanzapine are recommended, though the former is not available in Japan.
      
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  taking clozapine
All patients had normal EEGs before taking clozapine.
      
Taking clozapine and olanzapine together, 6/27 (22.2%) females and 3/47 (6.4%) males fulfilled criteria for binge eating disorder, 3/27 (11.1%) females and 2/47 (4.3%) males for bulimia nervosa.
      
About one-third of people taking clozapine will see some benefit within six weeks.
      
Age, sex, and race did not contribute to the risk of readmission for patients taking clozapine.
      
Agranulocytosis developed in three patients while they were taking clozapine, all of whom recovered fully after they stopped taking the drug.
      
更多          
  clozapine treatment
In the abnormal HbA1c group, 2HPG after the study was higher in the clozapine treatment group [(9.5 ± 1.8) mmol/L] than in the risperidone treatment group [(7.4 ± 1.7) mmol/L] and the chlorpromazine treatment group [(7.3 ± 1.6) mmol/L].
      
Limited evidence suggests that clozapine treatment may be associated with reduced substance abuse, with weaker evidence suggesting that other novel antipsychotics may have similar, but potentially less potent, effects.
      
Neither acute nor chronic clozapine treatment significantly affected the expression of these mRNAs in any brain area investigated, except for a decrease in trkB expression in the granule cells of the olfactory bulb.
      
Apparently, their physicians are not aware that these patients can be salvaged for ongoing clozapine treatment.
      
This case dramatizes the importance of lithium (or G-CSF) augmentation in those patients to maintain clozapine treatment so that their neutropenia can be reversed, and they can continue to benefit from the unique antipsychotic qualities of clozapine.
      
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From July 1986 to July 1988, 1434 hospitalized patients were treated with clozapine according to their psychiatric disturbances.Among them 239 patients (16.7%)had abnormal leucocytic counts, 188 patients given definite leucocytosis within 29 ± 6 d while 51 patients, leukopenia 33±4 d.The causes of these variations were studied.Suggestions of management and prevention were preliminary outlined.

1986年7月—1988年7月服用氯氮平治疗的住院患者共1434例,有白细胞计数改变的239例(16.7%),其中包括白细胞升高188例(78.7%),白细胞减少51例(21.3%),平均各在29d和33d发生改变。本文分析白细胞改变原因,并提出初步处理意见。

The micronuclear rates and rates of fragility expression of lymphocytes in 20 schizophrenic patients treated with chlor-promazine(CPZ) and 19, patients treated with clozapine (CZP) were measured before and after treatment. It was found that the micronuclear rates in both CPZ and CZP groups after the treatment were significantly higher than those before the treatment (p<0.01),wnile the rates of fragility expression in both groups showed no significant difference(p>0.2) before and after the trentment. It suggested...

The micronuclear rates and rates of fragility expression of lymphocytes in 20 schizophrenic patients treated with chlor-promazine(CPZ) and 19, patients treated with clozapine (CZP) were measured before and after treatment. It was found that the micronuclear rates in both CPZ and CZP groups after the treatment were significantly higher than those before the treatment (p<0.01),wnile the rates of fragility expression in both groups showed no significant difference(p>0.2) before and after the trentment. It suggested that both CPZ and CZP had certain mutagenic risk. The results may be a reference for rationally selecting antipsychotics for the schizophrenic patients during child-bearing period. Key Words Chlorpromazine Clozapine Micronuclear Fragility of chromosomes

本文对20例服用氯丙嗪及19例服用氟氮平治疗的精神分裂症病人,在服药前后分别进行了外周血淋巴细胞微核率和染色体脆性表达率的检测,结果发现:(1)氯丙嗪及氯氮平两组治疗后的淋巴细胞微核率均显著高于治疗前(P<0.01);(2)两组的染色体脆性表达率在治疗前后均无显著性差异(P>0.2)。提示氯丙嗪及氯氮平具有一定的诱变危害性。本研究结果可作为临床上育龄期病人合理选择抗精神病药物之参考。

ECG changes in 346 in-patients treated with psychotropics were transversely studied. The rate of ECG abnormalities was 65.0%. The ECG changes under the age 20 and over the age 60 were frequently encountered than those of other ages. Clozapine and tricyclic antidepressants affected ECG significantly. The rate of ECG abnormalities caused by a single drug was significantly lower than that caused by a combination of two or more drugs. The changes of ST-T waves were predominant. There were no significant relations...

ECG changes in 346 in-patients treated with psychotropics were transversely studied. The rate of ECG abnormalities was 65.0%. The ECG changes under the age 20 and over the age 60 were frequently encountered than those of other ages. Clozapine and tricyclic antidepressants affected ECG significantly. The rate of ECG abnormalities caused by a single drug was significantly lower than that caused by a combination of two or more drugs. The changes of ST-T waves were predominant. There were no significant relations between the dosages or durations of psychotropics treatment and the ECG abnormalities. The rational use of psychotropics and the detection of ECG periodically are very important.

对346例住院患者在用精神药物治疗中ECG变化作动态观察。发现ECG异常率65.0%,20a以下及60a以上年龄组ECG异常率高于其他年龄组,氯氮平及三环类药物对ECG影响明显,单用药ECG异常率显著低于合并用药。药物所致ECG改变以ST-T变化居首位。指出合理用药及定期随访的重要性。

 
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