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肿瘤坏死因子     
相关语句
  tumor necrosis factor
    Prognostic value of tumor necrosis factor and interleukin-6 in patients with multiple system organ failure and septicemia
    多系统脏器衰竭和败血症患者肿瘤坏死因子和白细胞介素6的水平和意义
短句来源
    THE DETECTION OF SERUM TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH VIRAL HEPATITIS AND ITS CLINICAL SIGNIFICANCE
    病毒性肝炎患者血清肿瘤坏死因子α检测的临床意义
短句来源
    Detection and Significance of Serum Tumor Necrosis Factor Receptors in Patients with Alcoholic Liver Cirrhosis
    酒精性肝硬化患者血清肿瘤坏死因子受体的检测及其临床意义
短句来源
    Dynamic Changes and Clinical Significance of Tumor Necrosis Factor in Patients with Acute Viral Hepatitis
    急性病毒性肝炎血清肿瘤坏死因子动态变化及其临床意义
短句来源
    The role of tumor necrosis factor and phospholipase A 2 in experimental acute hepatic failure in rats
    肿瘤坏死因子及磷脂酶A_2在实验性急性肝衰竭中的作用
短句来源
更多       
  tnf
    Aims: To explore the correlation between expression of β-defensin-2 and pro-inflammatory cytokine, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β in colitis mucosa.
    目的:探讨结肠炎黏膜中β-防御素-2的表达与促炎细胞因子肿瘤坏死因子(TNF)-α和白细胞介素(IL)-1β表达的关系。
短句来源
    Experimental colitis was induced by 8% acetic acid. The expression of tumor necrosis factors (TNF)-α, nuclear factor (NF)-κB, interleukin (IL)-1βand IL-10 in colonic mucosa were determined by immunohistochemistry.
    各实验性结肠炎组大鼠采用8%乙酸灌肠造模,各治疗组给予药物干预,并应用免疫组化技术检测大鼠结肠黏膜肿瘤坏死因子(TNF)-α、核因子(NF)-κB、白细胞介素(IL)-10、IL-1β的表达。
短句来源
    Effects of lactulose on plasm lipoplysaccharide endotoxin(LPS), tumor necrosis factor-α(TNF) and ALT in cirrhotic rats
    乳果糖对肝硬化大鼠血浆内毒素(LPS)肿瘤坏死因子(TNF)及血清ALT的影响研究
短句来源
    A Study of TNF Level in Serum of Patients with Hepatic Cirrhosis and Hepatitis B
    肝硬化及乙型肝炎患者血清肿瘤坏死因子水平的研究
短句来源
    Study of TNFα production and T lymphocyte subsets from PBMC in patients with ulcerative colitis
    溃疡性结肠炎患者肿瘤坏死因子α与T细胞亚群的变化及其相关性研究
短句来源
更多       
  tumour necrosis factor
    Relation of Polymorphisms of Lymphotoxin α and Interleukin 1 Receptor Antagonist Genes to Secretion of Tumour Necrosis Factor α, Soluble Interleukin 2 Receptor and Interleukin 6 in Chinese Patients with Inflammatory Bowel Disease
    炎症性肠病患者淋巴毒素α、白介素1受体拮抗剂基因多态性与肿瘤坏死因子α,可溶性白介素2受体以及白介素6产量的关系
短句来源
    CDP571,a humanised monoclonal antibody to tumour necrosis factor α, fo r moderate to severe Crohn's disease: A randomised, double blind, placebo contr olled trial
    人肿瘤坏死因子α单克隆抗体(CDP571)治疗中重度克罗恩病:一项随机双盲安慰剂对照试验
短句来源
    Results: The genotype 1 and 2 of lymphotoxin α was slightly higher in inflammatory bowel disease than in the healthy control (11/22 vs 1/10, P=0.049) and allele 2 of lymphotoxin α was related to higher tumour necrosis factor α production from peripheral blood mononuclear cells on stimulation.
    结果:炎症性肠病淋巴毒素α基因型1和2杂合子略高于正常对照组(11/12对1/10,P=0049); 而且淋巴毒素α等位基因2与周围血单个核细胞诱生的高水平肿瘤坏死因子α产量有关。
短句来源
    Objective To study the expression and distribution of transforming growth factorβ1(TGFβ1) in liver tissues of mice model of fulmiant hepatic failure induced by tumour necrosis factor α(TNF α).
    目的 探讨肿瘤坏死因子α(TNFα)介导的暴发性肝衰竭动物模型肝组织中转化生长因子 β1(TGFβ1)的表达及分布。
短句来源
    The content of interleukin (IL-1, IL-2) and tumour necrosis factor (TNF)-α in rats colon were detected;
    检测大鼠结肠组织白细胞介素(IL-1、IL-2)、肿瘤坏死因子(TNF-α)、一氧化氮(NO)、髓过氧化物酶(MPO)和丙二醛(MDA)水平;
短句来源
更多       
  tumour necrosis
    Relation of Polymorphisms of Lymphotoxin α and Interleukin 1 Receptor Antagonist Genes to Secretion of Tumour Necrosis Factor α, Soluble Interleukin 2 Receptor and Interleukin 6 in Chinese Patients with Inflammatory Bowel Disease
    炎症性肠病患者淋巴毒素α、白介素1受体拮抗剂基因多态性与肿瘤坏死因子α,可溶性白介素2受体以及白介素6产量的关系
短句来源
    Objective:To study the relationship between the serum hyaluronic acid(HA),activinA(ACTA),tumour necrosis factor-α(TNF-α)and the inflammatory reaction,pathological changes of the liver tissue in patients with chronic hepatitis.
    目的:研究慢性乙肝(CHB)患者血清透明质酸(HA)、激活素A(ACTA)、肿瘤坏死因子-α(TNF-α)含量与肝组织炎症活动及纤维化程度的关系。
短句来源
    CDP571,a humanised monoclonal antibody to tumour necrosis factor α, fo r moderate to severe Crohn's disease: A randomised, double blind, placebo contr olled trial
    人肿瘤坏死因子α单克隆抗体(CDP571)治疗中重度克罗恩病:一项随机双盲安慰剂对照试验
短句来源
    Serum leptin and tumour necrosis factor-α levels in patients with liver cirrhosis
    肝硬化患者血清瘦素、肿瘤坏死因子α水平及其临床意义
短句来源
    Results: The genotype 1 and 2 of lymphotoxin α was slightly higher in inflammatory bowel disease than in the healthy control (11/22 vs 1/10, P=0.049) and allele 2 of lymphotoxin α was related to higher tumour necrosis factor α production from peripheral blood mononuclear cells on stimulation.
    结果:炎症性肠病淋巴毒素α基因型1和2杂合子略高于正常对照组(11/12对1/10,P=0049); 而且淋巴毒素α等位基因2与周围血单个核细胞诱生的高水平肿瘤坏死因子α产量有关。
短句来源
更多       

 

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      tumor necrosis factor
    Tumor necrosis factor (TNF)-α-converting enzyme (TACE) is the major protease responsible for processing pro-TNF-α from membrane-anchored precursors to secreted TNF-α.
          
    The LPSs studied stimulated the production of tumor necrosis factor (TNF) and nitric oxide (NO) by mouse peritoneal macrophages.
          
    The concentration of tumor necrosis factor decreased threefold in the peripheral blood of bulbectomized mice 1.5 months after surgery.
          
    Changes in Sphingomyelinase Activity, Tumor Necrosis Factor α Level, and Lipid Peroxidation Intensity in the Course of Developme
          
    Changes in sphingomyelinase activity, tumor necrosis factor α expression, and level of lipid peroxidation products in the course of development of cholestatic liver injury have been studied.
          
    更多          
      tnf
    Tumor necrosis factor (TNF)-α-converting enzyme (TACE) is the major protease responsible for processing pro-TNF-α from membrane-anchored precursors to secreted TNF-α.
          
    A synthetic peptide was shown to bind to TACE and to inhibit TNF-α release from lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMC) by up to 60.3%.
          
    Fluorescence-activated cell sorter (FACS) analysis revealed that the peptide mediated the accumulation of TNF-α on an LPS-stimulated PBMC surface.
          
    Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice treated by percutan
          
    The LPSs studied stimulated the production of tumor necrosis factor (TNF) and nitric oxide (NO) by mouse peritoneal macrophages.
          
    更多          
      tumour necrosis factor
    Cytokines, especially tumour necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1), promote the inflammatory reactions in the subarachnoid space.
          
    A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neu
          
    No clear-cut relationships emerged between IL10 levels and those of tumour necrosis factor alpha and transforming growth factor beta, or between IL10 and lymphocyte subsets in peripheral blood.
          
    Tumour necrosis factor alpha is elevated in serum and cerebrospinal fluid in multiple sclerosis and inflammatory neuropathies
          
    Tumour necrosis factor alpha (TNFα) is a peptide that is derived from T lymphocytes and macrophages and is used as a marker of activated cellular immune responses.
          
    更多          
      tumour necrosis
    Cytokines, especially tumour necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1), promote the inflammatory reactions in the subarachnoid space.
          
    A soluble form of tumour necrosis factor receptor in cerebrospinal fluid and serum of HTLV-I-associated myelopathy and other neu
          
    No clear-cut relationships emerged between IL10 levels and those of tumour necrosis factor alpha and transforming growth factor beta, or between IL10 and lymphocyte subsets in peripheral blood.
          
    Tumour necrosis factor alpha is elevated in serum and cerebrospinal fluid in multiple sclerosis and inflammatory neuropathies
          
    Tumour necrosis factor alpha (TNFα) is a peptide that is derived from T lymphocytes and macrophages and is used as a marker of activated cellular immune responses.
          
    更多          


    The relationship between hepatic fibrosis degree and levels of hyaluronic acid (HA), tumour necrosis factor (TNF) was reported in New Zealand rabbits and advanced cases of schis-tosomiasis japonica hepatic fibrosis. The rabbits infected with Schistosoma japonicum were equally divided into 2 groups, a group was treated with praziquantel. Twenty-eight weeks after challenge, all animals were sacrificed. The degree of hepatic fibrosis showed significant difference (P<0. 001) in both groups. The level of serum TNF...

    The relationship between hepatic fibrosis degree and levels of hyaluronic acid (HA), tumour necrosis factor (TNF) was reported in New Zealand rabbits and advanced cases of schis-tosomiasis japonica hepatic fibrosis. The rabbits infected with Schistosoma japonicum were equally divided into 2 groups, a group was treated with praziquantel. Twenty-eight weeks after challenge, all animals were sacrificed. The degree of hepatic fibrosis showed significant difference (P<0. 001) in both groups. The level of serum TNF was correlated with hepatic fibrosis degree by pathological examination hepatic collagen content and HA etc. parameters of hepatic fibrosis. The results of advanced cases were similar to that of rabbits. It suggests that the level of serum TNF is a better parameter of hepatic fibrosis.

    本文报道血吸虫病肝纤维化兔与病人(晚期)的血清透明质酸(HA)和肿瘤坏死因子—α(TNF)与肝纤维化程度的关系。感染日本血吸虫新西兰兔随机分为两组,其中一组经杀虫治疗,均在感染后28周解剖,两组间肝纤维化程度有明显差异(P<0.001)。血清TNF水平与肝组织学检查肝纤维化程度、肝胶原含量及血清肝纤维化指标HA等相关。晚期病人亦获类似的结果。提示血清TNF水平可作为肝纤维化一个较好的指标。

    Tumor necrosis factor(TNF)and inter-leukin-6(IL-6)are the main mediators involved inthe pathophysiology of multiple system organ fail-ure(MSOF)and septicermia.Using a senstiveenzyme-linked immunosorbent assay(ELISA),wemeasured serun TNF levels in 12 MSOF patientsand 14 patients with septicemia.At the same time,sreum IL-6 levels were measured in the same pa-tients using MTT chromatometry.The resultsshowed:(1)TNF and IL-6 levels in patients withMSOF and septicemia significantly nigher thannormal individuals(P<0.001...

    Tumor necrosis factor(TNF)and inter-leukin-6(IL-6)are the main mediators involved inthe pathophysiology of multiple system organ fail-ure(MSOF)and septicermia.Using a senstiveenzyme-linked immunosorbent assay(ELISA),wemeasured serun TNF levels in 12 MSOF patientsand 14 patients with septicemia.At the same time,sreum IL-6 levels were measured in the same pa-tients using MTT chromatometry.The resultsshowed:(1)TNF and IL-6 levels in patients withMSOF and septicemia significantly nigher thannormal individuals(P<0.001 respectively).TNFlevel was positively correlated with IL-6 level(r=0.68,P<0.05).Basides.hyper lactlcemia wasfound to be concomitant with the elevation of TNFand IL-6.(2)In MSOF patients,TNF and IL-6levels were significantly higher in those who died(n=5)than those who survived(n=7)(P<0.01respectively).There were inverse ratio betweenTNF,IL-6 levels and the survival rate in MSOFpatients.(3)TNF level was inversely proportionalto the survival rate in septicemic patients,in whomaccompanied hyper lacticemia was found propor-tional to the survival rate.This study demonstratedthat circulating TNF and IL-6 were closely relatedto the pathophysiology of MSOF and septicemia,also,TNF and IL-6 are important tests in pre-dicting the prognosis of the patients with MSOFand septicemia.

    应用单克隆抗体的ELISA法检测12例多系统脏器衰竭(MSOF)患者、14例败血症患者血清肿瘤坏死因子(TNF)水平,同时应用MTT比色法测定患者血清白细胞介素6(IL-6)活性。结果:MSOF和败血症患者的TNF和IL-6水平明显高于正常(P均<0.01),两者的升高呈显著相关(r=0.68),并且伴有高乳酸血症。MSOF患者TNF和IL-6水平与生存率成反比,死亡组(n=5)均高于生存组(n=7),P均<0.01。败血症患者的生存率与TNF水平成反比且伴高乳酸血症。上述研究表明:TNF与IL-6在MSOF的发病过程中起着重要作用,同时也是判定MSOF和败血症患者预后方面的重要指标。

    Pathological changes of the mucous membrane or

    本文用胃镜观察了99例重型病毒性肝炎患者的上消化道粘膜变化。急重型、亚重型肝炎患者83.3%有急性胃粘膜病变,表现为胃壁粘膜抓痕样条状充血、水肿、散在新鲜出血点等。慢性重型肝炎患者以肝硬化伴门脉高压者胃粘膜病变较多,发生率也高。急重型肝炎和亚急重型肝炎的机理可能与肿瘤坏死因子的作用、凝血因子合成障碍、患者的低氧血症及酸碱失衡有关。慢性重型肝炎患者除上述因素外,可能还存在内毒素的作用,门脉的高压作用和高胃泌素血症等。

     
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