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系膜细胞     
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  mesangial cell
     Results 1.Ox-LDL(80μg/ml) stimulated mesangial cell proliferation;
     结果1.Ox-LDL(80μg/ml)刺激系膜细胞增殖;
短句来源
     Results The proliferation of mesangial cells were promoted by LDL of the concentration from 3.125 to 100μg/ml,when the LDL concentration was from 0 to 50μg/ml, the proliferation of mesangial cell was correlated with LDL concentration(r=0.865,P<0.05).
     结果以浓度为3.125~100μg/ml的LDL刺激系膜细胞,可促进系膜细胞的增殖,在LDL3.125~50μg/ml的浓度范围内,系膜细胞的增殖和LDL的浓度呈正相关(r=0.865,P<0.05);
短句来源
     2.Ox-LDL(10μg/ml-80μg/ml)increased the expression of HGMCs TGF-β1 mRNA in a concentration-dependent manner; 3.Atorvastatin (6μg/ml-12μg/ml)inhibited mesangial cell proliferation and attenuated TGF β1 mRNA and p38MAPK expression upregulation induced by Ox-LDL.
     2.Ox-LDL(10μg/ml-80μg/ml)以浓度依赖的方式增加HGMCs TGF-β1 mRNA和p38MAPK蛋白表达,3.Atovastatin(6μg-12μg/ml)抑制系膜细胞增殖,降低ox-LDL引起的TGF-β1 mRNA表达上调,抑制p38MAPK信号途径激活。
短句来源
     The expression of COX-2 mRNA and protein were upregulated by LDL of the concentration from 3.125 to 100.000 μg/mL,when the LDL concentration was from 0.000 to 50.000 μg/mL,the expression of COX-2 mRNA and protein was correlated with LDL concentration and the proliferation of mesangial cell.
     以浓度为3.125~100.000μg/mL的LDL刺激系膜细胞,可上调COX-2mRNA和蛋白的表达,在LDL0.000~50.000μg/mL的范围内,COX-2mRNA和蛋白的表达与LDL浓度、系膜细胞增殖呈正相关。
短句来源
     PGF_2α, U46619 LTC_4,LTD_4 also increased mesangial cell Diacylglycerol (DAG) mass levels.
     PGF2α、U46619、LTC4、LTD4促进系膜细胞合成二脂酰甘油(diacylglycerol,DAG)。
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  mesangial cells
     Results: Stimulated by 0,5,10 ng/ml PDGF-BB for 24 h,the expression of PAI-1 mRNA/GAPDH mRNA of mesangial cells were 0. 296,0. 428,0. 542,respectively.
     结果:0、5、10 ng/ml的PDGF-BB作用于系膜细胞24 h,其PAI-1 mRNA/GAPDH mRNA分别为0.296、0.428、0.542。
短句来源
     The mRNA expression of PDGF-BB, TGF-β1, IL-1P, IL-6, IL-10 and TNF-αin mesangial cells was detected by RT-PCR.
     RT-PCR方法检测系膜细胞血小板源生长因子(PDGF)- BB、IL-1β、IL-6、IL—10、TGF-β1和TNF-αmRNA表达变化。
短句来源
     Methods: IL-13(10 ng/ml and 100 ng/ml), ET-1(10-7 mol/L), methylprednisolone (0.5 μg/ml) and heparin sodium (100 mg/L, 200 mg/L) acted on cultured glomerular mesangial cells and p27 level was assessed by flow cytometry.
     方法不同浓度IL-13(10ng/ml,100ng/ml),ET-1(10-7mol/L),甲基强的松龙0.5μg/ml,肝素钠100mg/L和200mg/L,作用于培养的系膜细胞。 流式细胞仪检测p27表达水平。
短句来源
     Results The proliferation of mesangial cells were promoted by LDL of the concentration from 3.125 to 100μg/ml,when the LDL concentration was from 0 to 50μg/ml, the proliferation of mesangial cell was correlated with LDL concentration(r=0.865,P<0.05).
     结果以浓度为3.125~100μg/ml的LDL刺激系膜细胞,可促进系膜细胞的增殖,在LDL3.125~50μg/ml的浓度范围内,系膜细胞的增殖和LDL的浓度呈正相关(r=0.865,P<0.05);
短句来源
     Stimulated by 10 ng/ml PDGF-BB for 0,12,24,48 h,the expression of PAI-1 mRNA/GAPDH mRNA were 0. 156,0. 345,0. 493,0. 597, respectively. PDGF-BB significantly increased the expression of PAI-1 mRNA of rat mesangial cells in a dose- and time-dependent manner.
     10 ng/ml的PDGF-BB作用系膜细胞0、12、24、48 h,PAI-1 mRNA/GAPDH mRNA分别为0.156、0.345、0.493、0.597,表现为浓度和时间依赖效应。
短句来源
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  glomerular mesangial cells
     Methods: IL-13(10 ng/ml and 100 ng/ml), ET-1(10-7 mol/L), methylprednisolone (0.5 μg/ml) and heparin sodium (100 mg/L, 200 mg/L) acted on cultured glomerular mesangial cells and p27 level was assessed by flow cytometry.
     方法不同浓度IL-13(10ng/ml,100ng/ml),ET-1(10-7mol/L),甲基强的松龙0.5μg/ml,肝素钠100mg/L和200mg/L,作用于培养的系膜细胞。 流式细胞仪检测p27表达水平。
短句来源
     Effects of Niaodujing Ⅱ on Cyclin D_1,CDK_4 in Cultured Glomerular Mesangial Cells in Human
     尿毒净Ⅱ号对人肾系膜细胞Cyclin D_1及CDK_4表达的影响
短句来源
     NF-κB mediated lipoxin A_4 antagonism on TNF-αinduced synthesis of interleukins in glomerular mesangial cells
     NF-κB介导脂氧素A_4拮抗TNF-α所致的系膜细胞白介素的合成
短句来源
     The study on expression of iNOS mRNA in rat glomerular mesangial cells with human complement C5b-9 complexes
     补体C5b-9复合物诱导大鼠肾系膜细胞iNOS mRNA表达的实验研究
短句来源
     Interleukin 1β up-regulated the expression of interleukin 6 in glomerular mesangial cells through the p38MAPK pathway
     白细胞介素1β通过p38信号通路上调系膜细胞表达白细胞介素6
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  rat mesangial cells
     Stimulated by 10 ng/ml PDGF-BB for 0,12,24,48 h,the expression of PAI-1 mRNA/GAPDH mRNA were 0. 156,0. 345,0. 493,0. 597, respectively. PDGF-BB significantly increased the expression of PAI-1 mRNA of rat mesangial cells in a dose- and time-dependent manner.
     10 ng/ml的PDGF-BB作用系膜细胞0、12、24、48 h,PAI-1 mRNA/GAPDH mRNA分别为0.156、0.345、0.493、0.597,表现为浓度和时间依赖效应。
短句来源
     Effect of TGFβ1 on the Expression of Type Ⅰ and Type Ⅳ Collagens in Cultured Rat Mesangial Cells Transfected with Smad4/Smad7 Vector
     TGFβ1对转染Smad4/Smad7基因的大鼠系膜细胞Ⅰ、Ⅳ型胶原表达的影响
短句来源
     Akt1/p27~(kip1) Pathway Mediates Inhibition of LXA_4 on TNF-α-induced Proliferation of Rat Mesangial Cells
     Akt1/p27~(kip1)途径介导脂氧素A_4抑制TNF-α所致的系膜细胞增殖(英文)
短句来源
     Influence of Xiaoke Granules on expression of TGF-β_1 mRNA in rat mesangial cells
     消渴颗粒剂对大鼠系膜细胞TGF-β_1 mRNA表达的影响
短句来源
     PDGF-BB neutralizing antibody suppressed the incorporation of 3H-TdR and the mRNA expression of TGF-β1 in rat mesangial cells transfected with Megsin gene significantly.
     PDGF-BB中和抗体显著抑制系膜细胞转染Megsin基因后细胞内3H-TdR的掺入,并下调稳定表达Megsin基因的大鼠系膜细胞TGF-β1 mRNA表达。
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  mesangial cell
Histological examination showed cell swelling, break-down and massive lipid deposition in renal tubules; perivascular and interstitial cell infiltration and mesangial cell proliferation.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium.
      
Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations.
      
Finally, various antioxidants inhibit mesangial cell activation by HG and ameliorate features of diabetic nephropathy.
      
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  mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
The transcriptional regulation of SCL was studied in vitro in rat mesangial cells (MC).
      
It was reported heparin could inhibit mesangial cells proliferation in vitro.
      
The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
更多          
  glomerular mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
ROS mimic the stimulatory effects of HG and upregulate transforming growth factor-a1, plasminogen activator inhibitor-1, and extracellular matrix (ECM) proteins by glomerular mesangial cells, thus leading to mesangial expansion.
      
Signaling role of PDE isozymes in pathobiology of glomerular mesangial cells
      
Regulatory functions of protein kinase c in glomerular mesangial cells
      
In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade.
      
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  rat mesangial cells
The transcriptional regulation of SCL was studied in vitro in rat mesangial cells (MC).
      
Effects of cyclosporin a on proliferation of cultured rat mesangial cells
      
CGRP stimulates renin secretion in vivo and in vitro and inhibits contraction of isolated rat mesangial cells by angiotensin II.
      
Calcitonin does not affect vascular resistance, renal blood flow and glomerular filtration, and is less potent in stimulating renin secretion, and does not alter contraction of isolated rat mesangial cells by angiotensin II.
      
Our studies have explored the mechanism of IgG uptake by cultured rat mesangial cells.
      
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