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系膜细胞
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  mesangial cell
    INHIBITION OF HUMAN MESANGIAL CELL PROLIFERATION BY CALCIUM ANTAGONISTS
    钙拮抗剂对系膜细胞增殖的抑制作用
短句来源
    Effects of CsA combined with T4 on cultured human mesangial cell proliferationand its expression and synthesis ofinterleukin6
    环孢素A联合雷公藤单体T_4对人系膜细胞增殖及其表达、合成白细胞介素-6的影响
短句来源
    Establishment of mesangial cell gene transfer vector expressing interleukin10
    表达白细胞介素10的系膜细胞基因转移载体的建立
短句来源
    Rat Mesangial Cell Transfected by Human Transforming Growth Factor β1 Gene Upregulates the Expression of Matrix Metalloproteinase 2
    大鼠肾脏系膜细胞转染人TGF-β1基因可增强MMP-2表达
短句来源
    The role of AT_1 receptor and cyclin kinase inhibitor p27 protein in angiotensin Ⅱ-induced hypertrophy of mesangial cell
    血管紧张素Ⅱ受体1及周期素激酶抑制剂p27在血管紧张素Ⅱ诱导系膜细胞肥大中的作用
短句来源
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  mesangial cells
    Effect of rIL - 1 on bioactivity and gene expression of IL - 6 in mesangial cells
    重组白细胞介素1对系膜细胞产生与表达白细胞介素6的影响
短句来源
    EFFECT OF INTERLEUKIN1 ON SUBFAMILY OF MITOGENACTIVATED PROTEIN KINASES IN RENAL MESANGIAL CELLS
    白细胞介素1对肾系膜细胞分裂原活化蛋白激酶不同亚类的作用
短句来源
    Inhibitory effect of phorbol 12-myristate 13-acetate and angiotensin-(1-7) on angiotensin Ⅱmediated proliferation and secretion of cultured rat glomerular mesangial cells
    血管紧张素-(1-7)和佛波醇酯拮抗血管紧张素Ⅱ诱导的大鼠系膜细胞增殖及分泌
短句来源
    Construction of Eukaryotic Expression Vector Containing Lipoxin A_4 Receptor Homologue Gene and Its Transfection into Mesangial Cells
    含脂氧素A_4受体同源基因真核表达载体的构建与转染系膜细胞
短句来源
    Methods: Ang-(1-7) and PMA was used in cultured rat glomerular mesangial cells induced by AngⅡ, synthesis of DNA and protein, change of cell number were observed for rat GMC proliferation. Secretion of PcⅢ and HA was measured by radioimmunoassay in culture medium of rat GMC.
    方法:在AngⅡ诱导培养的大鼠系膜细胞中,应用Ang-(1-7)及PMA,通过测定大鼠GMCDNA、蛋白质合成、细胞数目及Ⅲ型前胶原(PcⅢ)和透明质酸(HA)等指标,观察大鼠GMC增殖和分泌情况。
短句来源
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  intercapillary cells
    Measurement of telomere length of intercapillary cells by real-time quantitative PCR
    定量聚合酶链反应对系膜细胞端粒长度的测定研究
短句来源
    After isolation of the DNA, the telomere lengths of intercapillary cells from ten-week-old rats and twenty-eight-month-old rats were detected with real-time quatitative PCR.
    方法:分别取年轻(10周龄)和老年(28月龄)SD大鼠的肾脏,分离、培养出肾小球系膜细胞,提取DNA后,采用实时荧光定量PCR对两组大鼠系膜细胞端粒DNA长度进行检测。
短句来源
  “系膜细胞”译为未确定词的双语例句
    These changes were pronounced with prolongation of experimental time. PAI 1 mRNA expression increased significantly at 24hr (0.45%±0.06% vs 0.65%±0.08%, P <0.05), however more marked increase of PAI 1 mRNA expression at 48hr (0.51± 0.08% vs 0.92±0.10%, P <0.01).
    AGE-BSA作用系膜细胞24小时后,PAI-1基因表达显著增加(0.65%±0.08%,对照0.45%±0.06%,P<0.05); 48小时后PAI-1基因表达增加更趋显著(0.92%±0.10%,对照0.51±0.08,P<0.01)。
短句来源
    Methods MsC proliferation was determined by 3 HTdR incorporation. IL6mRNA expression and protein synthesis were measured by RTPCR and ELISA respectively.
    方法用3H-TdR掺入率法测定人系膜细胞(MsC)增殖,用逆转录-聚合酶链反应(RT-PCR)和ELISA法测定细胞IL-6mRNA表达及培养上清IL-6含量。
短句来源
    Methods Northern blot hybrid technique and computer graph analysis were used to detect the expression of TGF-β mRNA in MC.
    方法 运用Northernblot杂交技术并结合计算机图像分析 ,观察LDL刺激培养的鼠肾小球系膜细胞 (MC)增殖过程中 ,系膜细胞TGF - βmRNA表达的动态变化。
短句来源
    The results indicates that the real-time quantitative PCR is a successful method for telomere measurement.
    结论:随增龄大鼠肾脏系膜细胞端粒长度缩短,实时荧光定量PCR测定端粒DNA长度的方法可行。
短句来源
    EFFECTS OF COLLAGEN I AND ENDOTHELIN ON PRO- LIFERATION AND PRODUCTION OF EXTRACE- LLULAR MATRIXES IN VITRO OF GLOME- RULAR ENDOTHELIAL AND MESAN- GIAL CELLS
    Ⅰ型胶原、内皮素对肾小球内皮细胞及系膜细胞产生细胞外基质的影响
短句来源
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  mesangial cell
Histological examination showed cell swelling, break-down and massive lipid deposition in renal tubules; perivascular and interstitial cell infiltration and mesangial cell proliferation.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium.
      
Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations.
      
Finally, various antioxidants inhibit mesangial cell activation by HG and ameliorate features of diabetic nephropathy.
      
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  mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
The transcriptional regulation of SCL was studied in vitro in rat mesangial cells (MC).
      
It was reported heparin could inhibit mesangial cells proliferation in vitro.
      
The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
更多          
  intercapillary cells
No differences were noted between benign haemagioendotheliomas from children or adults: neither tumour showed the presence of antigens in intercapillary cells.
      


We observed 12 kidneys, 10 ureteres and 7 bladders of newborn, measured maximal diameters of all the segments in the nephron, and worked out the mean and standard error of every group. The principal findings are tke following. (1) The renal development of the newborn

本文观察了新生儿肾脏12例、输尿管10例和膀胱7例,测量了肾单位各段的最大直径,计算出均数与标准差。结果表明:1.新生儿肾的发育程度与体重有关,新生儿的体重从1400~3200g,肾皮质浅层的生肾区逐渐变薄、消失,生肾区内的肾小体呈S形,肾小管为实心细胞团;肾皮质的肾小体从5~6代逐渐增加到10多代,每个肾小体的体积逐渐增大,肾小管管径逐渐增粗,致密斑的细胞由矮变高;球外系膜细胞逐渐增多;集合管上皮细胞由深染的立方细胞变成淡染的柱状细胞。2.皮质深层的肾小体已分化成熟,而浅层的较幼稚。3.出生后存活时间越长,肾单位各段的直径越大,表明出生后肾继续发育。4.细段上皮细胞为立方形。

Huma glomerular mesangial cell (MC) and endothelial cell (EC) -were cultured, and stimulated by collagen I (col I ) or endothelin (ET) respectively, It was found that the number of EC counted and the level of laminin and FN in the supernatant of EC were increased in the group of adding Col I than that of control, The number of MC counted in the group of ET were slightly increased. It was also found that the level of collagen Ⅳ and FN in the supernatant of MC were increased in the group of adding Col I than that...

Huma glomerular mesangial cell (MC) and endothelial cell (EC) -were cultured, and stimulated by collagen I (col I ) or endothelin (ET) respectively, It was found that the number of EC counted and the level of laminin and FN in the supernatant of EC were increased in the group of adding Col I than that of control, The number of MC counted in the group of ET were slightly increased. It was also found that the level of collagen Ⅳ and FN in the supernatant of MC were increased in the group of adding Col I than that of control. The FN released by MC could be induced by ET.

本文观察了Ⅰ型胶原、内皮素对肾小球内皮细胞、系膜细胞增殖的影响,同时探讨了Ⅰ型胶原和内皮素对培养的内皮细胞及系膜细胞产生层粘连蛋白、纤连蛋白和Ⅳ型胶原的影响。结果提示:Ⅰ型胶原可以明显促进内皮细胞的增殖(P<0.01),内皮素对系膜细胞的增殖有一定作用:Ⅰ型胶原可以促进内皮细胞产生层粘连蛋白和纤连蛋白,并可以促进系膜细胞产生Ⅳ型胶原;内皮素可以促进系膜细胞产生FN增多(P<0.05)。

Objective:Quantitative analysis of expression of endothelin B receptor(ETB-R)gene in rat heart,liver,lung,kidney and cuItured glomerular mesangial cells(MC)were observed. Methods:Se-mi-quantitative reverse transcription and polymerase chain reaction(SqRT-pCR)was used and com-pared with Northern blot hybridization. Results:EIB-R gene was expressed in all the above organs and MC,and highest expression level in the lung,moderate in the heart and kidney, but lowest in the liver. Conclusion:Different expression level...

Objective:Quantitative analysis of expression of endothelin B receptor(ETB-R)gene in rat heart,liver,lung,kidney and cuItured glomerular mesangial cells(MC)were observed. Methods:Se-mi-quantitative reverse transcription and polymerase chain reaction(SqRT-pCR)was used and com-pared with Northern blot hybridization. Results:EIB-R gene was expressed in all the above organs and MC,and highest expression level in the lung,moderate in the heart and kidney, but lowest in the liver. Conclusion:Different expression level of ETB-R gene in various organs imply that the effects of en-dothelin on different organs were not similar.The MC were target cells of endothelin in kidney.

目的:定量检测B型内皮素受体(ETB-R)基因在大鼠心、肝、肺、肾等器官及培养的肾小球系膜细胞(MC)的表达。方法:半定量逆转录。多聚酶链反应技术(SqRT-PCR),并以NorthernEP印迹法作对照。结果:ETB-R基因在上述器官及MC均有表达,而表达水平依次为肺、心、肾和肝。结论:ETB-R在不同器官有不同水平的基因表达,说明内皮素对不同器官的效应不同;MC是内皮素在肾内发挥作用的靶细胞。

 
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