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系膜细胞
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  mesangial cell
    Results: Curcumin at the concentration equal or over 6. 25 μmol/L was able to inhibit the proliferation of mesangial cell in a dose-dependent manner.
    结果:当姜黄素浓度≥6.25μmol/L时,系膜细胞增殖明显受到抑制,且表现为浓度依赖性;
短句来源
    Experiment of SHENLUONING Which Effect on IgA Nephropathy Model Mouse Mesangial Cell, Extracellular Matrix and Cytokines
    肾络宁对IgA肾病模型大鼠系膜细胞、细胞外基质和相关细胞因子影响的实验研究
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    The proliferation, apoptosis, and cell cycle of mesangial cell and fibroblast were deteeted by MTT assay and flow cytometny respectively.
    应用MTT法和流式细胞仪检测系膜细胞和成纤维细胞增殖、凋亡和细胞周期。
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    BST could induce fibroblast and mesangial cell apoptosis, and could reduce the cell aggregation due to enhanced mitogen, reduce the number of fibroblasts and mesangial cells by cell apoptosis.
    保肾片能诱导成纤维细胞和系膜细胞发生凋亡,通过细胞凋亡对抗因有丝分裂增强所致的细胞聚集,减少成纤维细胞和系膜细胞数量。
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    The results observed by transmission electric microscope showed that GBM had been thick, some of which were obscure, and epithelium hernia mixed in full or a part, besides, the hiatus of filtering membrane broadened, so did mesargial area, and the number of mesangial cell increased.
    DM对照组光镜下可见肾小球系膜区弥漫性增宽,PAS阳性的均质蛋白性物质明显增多,肾小球ECM增多,系膜细胞轻度增生,肾小球基底膜(GBM)增厚等表现,透射电镜观察结果为肾小球基底膜呈阶段性增厚,有的模糊不清,上皮足突广泛融合或部分融合,滤过膜间隙增大,系膜区扩大,系膜细胞增多。
短句来源
  mesangial cells
    Methods: Got SD rats kidney for culture of fibroblasts, added the rats serum with different concentration of BST to fibroblasts, added the human serum from healthy volunteers with diHerents concentration of BST to mesangial cells.
    方法:取SD大鼠肾脏作成纤维细胞体外培养,以保肾片喂服SD大鼠,取不同浓度含药大鼠血清加入体外培养的成纤维细胞中。 以健康志愿者服用保肾片,取不同浓度含药人血清加入系膜细胞培养体系中。
短句来源
    Results ~ BST inhibited the proliferation of mesangial cells and fibroblasts significantly not by cytotoxxn.
    结果:保肾片具有显著抑制成纤维细胞和系膜细胞增殖的作用,而且保肾片抑制成纤维细胞和系膜细胞增殖的作用不是以细胞毒方式进行的。
短句来源
    The mechanism of Chinese patent medicine Baoshen Tablet may be associated with lowering endothelial oxidation LDL receptors, cellular proliferative factor TGF-β, the mRNA expression of the main ingredient of extra-cellular matrix Ⅰ,Ⅳ collagen in kidney and inhibition of proliferation and apoptosis of mesangial cells.
    最后以摘要形式报告了3类中药保肾片治疗CRF的作用机制可能与降低肾脏中的内皮氧化LDL受体、细胞增殖因子TGF - β、细胞外基质主要成分Ⅰ、Ⅳ型胶原的mRNA表达 ,抑制系膜细胞增殖及促进其凋亡有关
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    Results: The mesangial areas and number of mesangial cells were significantly greater in the nephropathy group than those in the treated group and the control group (P<0.01), and there were some differences between the treated and the control group(P<0.05).
    结果:系膜区面积和系膜细胞数在肾病组中最大,与治疗组和正常对照组比差异有显著性意义(P<0. 01),治疗组与正常对照组之间也存在显著性差异(P<0. 05)。
短句来源
    In Pearson’scorrelation analysis, the mesangial areas and the number of mesangial cells had positive correlation with the amount of proteinuria, the serum level of cholesterol and triglyceride in the fourth week (P<0.01), and had negative correlation with the serum albumin (P<0.01).
    相关分析提示,注射多柔比星 4周时系膜区面积和系膜细胞数与尿蛋白、血清胆固醇及三酰甘油呈正相关(P<0. 01),与血清清蛋白呈负相关(P<0. 01)。
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  “系膜细胞”译为未确定词的双语例句
    In Shenluoning group and Shenyan Kangfu tablet group,expression of Mesangial Cell-α,α-SMA,FN,ICAM-1 significantly decreased(P<0.01),deposit of IgA and proliferation of matrix slightly increased,RBC,BUN,content of Cr in blood obviously decreased.
    肾络宁及肾炎康复片组α-SMA、FN、ICAM-1表达明显减低(P<0.01),IgA轻度沉积,系膜细胞及基质轻度增多,血尿、蛋白尿及血肌酐明显减低。
短句来源
    The levels of β 2 MG,RBP and NAG in the urine and the levels of BUN and SCr in the blood were all much lower in group one than in group two.
    肾间质损害细胞浸润、系膜细胞及基质增生均明显比对照组轻 ,尿 β2 - MG、RBP、NAG及血 BUN、SCr均明显低于对照组 ( P<0 .0 1~ 0 .0 5)。
短句来源
    These inhibitory ability of curcumin at the concentration equal or over 50μmol/L was superior to that of dexamethasone.
    当姜黄素浓度≥50 μmol/L时,姜黄素抑制系膜细胞增殖的作用明显强于地塞米松(P<0.05)。
短句来源
    Conclusion:Shenbining may affect the expression of bax and bcl-2 and induce to apoptosis in Mesangial proliferative glomerulonephritis.
    结论 :肾必宁可能通过影响凋亡调控基因bax、bcl- 2的表达 ,诱导肾小球细胞凋亡 ,进而抑制系膜增生性肾小球肾炎系膜细胞增殖
短句来源
    Experimental research:1 The experiment about protective effect on Tongshenluo capsule acting on kidney of DN rat : Removal of half kidney
    3通肾络含药血清对体外培养大鼠肾系膜细胞增生抑制实验:SD大鼠给予通肾络灌胃7d(1.57g/kg,相当于治疗剂量16倍),末次灌药2h后采血,制取含药血清,作用于以MEM为培养基的系膜细胞株(下同),实验分
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  mesangial cell
Histological examination showed cell swelling, break-down and massive lipid deposition in renal tubules; perivascular and interstitial cell infiltration and mesangial cell proliferation.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium.
      
Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations.
      
Finally, various antioxidants inhibit mesangial cell activation by HG and ameliorate features of diabetic nephropathy.
      
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  mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
The transcriptional regulation of SCL was studied in vitro in rat mesangial cells (MC).
      
It was reported heparin could inhibit mesangial cells proliferation in vitro.
      
The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
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By injection of C-BSA,immune-Complex in situ type glomerulonephritis was reproduced in rabbits and treated with Mai-Luo-Tong(group M)and Natural Indigo(group Q).The results showed that proteinuria in the treated groups M and Q was decreased.The difference between group M and control group was statistcally significant(P<0.05).IgG and C3 deposited on renal capillary wall as revealed by fluorescence microscopy.Deposition of IgG in group M and C3 in group Q were milder than in C group,Under light and electron microscope,although...

By injection of C-BSA,immune-Complex in situ type glomerulonephritis was reproduced in rabbits and treated with Mai-Luo-Tong(group M)and Natural Indigo(group Q).The results showed that proteinuria in the treated groups M and Q was decreased.The difference between group M and control group was statistcally significant(P<0.05).IgG and C3 deposited on renal capillary wall as revealed by fluorescence microscopy.Deposition of IgG in group M and C3 in group Q were milder than in C group,Under light and electron microscope,although in all groups glomerular basement membrane was irregularly thickened and dense eletron deposited under epithelium in the treated group,microthrombus,erythrocytes and platelets aggregation and leukocytes impactionn were not seen within glomerular capillaries.Also in groups M,Q,C mesangium cell count was 66.55±7.75,92.87±17.89 and 99.40±18.53 respectively, and significant differences were found between groups M and Q and groups C(P<0.01).No apparrent glomerular fibrosis was found in the treated groups.

给兔注射阳离子化牛血清白蛋白复制免疫复合物肾炎后,分别给中药脉络通和青黛治疗。结果表明:治疗后,蛋白尿在脉络通治疗组(M)、青黛治疗组(Q)明显减少,尽管Q组与实验对照组(C)相比无统计学差异(P>0.05),但M组与C组相比P<0.05。在荧光显微镜下,见IgG和C3呈颗粒状和线样沉积在肾脏毛细血管壁,M组IgG、Q组C3沉积的强度均较C组弱(P均<0.05)。光镜和电镜下3组均显示肾小球基底膜不规则增厚,上皮下电子致密物沉积,但在肾小球毛细血管内未见微血栓、红细胞及血小板积聚和白细胞嵌顿。其系膜细胞数,在M、Q、C组中分别为66.55±7.75、92.87±17.89、99.40±18.53个,M、Q组与C组相比有统计学差异(P<0.01)。治疗兔肾小球亦无纤维化。

Methods of complex formula serum pharmacology and immunology were taken, to observe the effect of modified Zhuling Tang (MZLT) on IL-6 in. The results showed: the secretion of IL-6 was only a few in normal mesangium cell, while it was increased in the cell induced by endotox- in ,MZLT had significantly inhibited effect with dosage dependent on the IL-6, thus MZLT could inhibit the proliferation of mesangium cell.

采用复方血清给药和免疫学方法检测指标,观察加味猪苓汤对内毒素诱导的肾小球系膜细胞中白细胞介素-6(IL-6)产生的影响。结果表明:IL-6在正常系膜细胞中分泌量极微,而内毒素诱导的系膜细胞中IL-6产生增加,加味猪苓汤对IL-6产生有明显的抑制作用,并呈剂量依赖关系。结论:该方能抑制系膜细胞中IL-6的产生,从而抑制肾小球系膜的增生。

For exploring the relationship between the expression of mesenteric cell cycle modulator and TCM syndromes in chronic glomerulonephritis(CGN),the TCM syndromes in 32 cases of CGN were differentiated and the specimen of renal biopsy had been examined with the methods of pathological routing and immunohistochemistry such as P\-\{27\} and PCNA The results showed that P\-\{27\} was the highest in class I of pathological damage and PCNA in class Ⅲ...

For exploring the relationship between the expression of mesenteric cell cycle modulator and TCM syndromes in chronic glomerulonephritis(CGN),the TCM syndromes in 32 cases of CGN were differentiated and the specimen of renal biopsy had been examined with the methods of pathological routing and immunohistochemistry such as P\-\{27\} and PCNA The results showed that P\-\{27\} was the highest in class I of pathological damage and PCNA in class Ⅲ The ranked correlation analysis between P\-\{27\}/PCNA and pathological classifications was negative(r= 0 6984) while that between pathological classifications and TCM syndromes and between PCNA and TCM syndromes were positive(r=0 6174,0 6914 respectively) Conclusions:in CGN,the test of P\-\{27\} and PCNA is practical for the judgment of proliferation or inhibition of mesangical cell in CGN;TCM syndromes are closely related to degree of pathological damage;It can be further inferred that the pathological foundations of TCM syndromes translation are related to the expression of P\-\{27\} and PCNA \;

为探讨中医证型与慢性肾炎周期调控蛋白表达的关系 ,对 32例慢性肾炎患者进行中医辨证分型 ,并将肾活检标本分别行常规病理检查及 P2 7、PCNA的免疫组化检查。结果 : 级病理损害以P2 7表达最高 , 级病理损害以 PCNA表达最高 ,P2 7/PCNA比值与病理分级的等级相关分析 r=-0 .6984 ,呈负相关 ;中医证型与病理分级、P2 7/PCNA比值的等级相关分析 ,其 r分别为 0 .6914、0 .6174 ,呈正相关。结论 :P2 7、PCNA作为判断慢性肾炎的系膜细胞增殖或抑制 ,有其实用性 ;中医证型与病理分级程度密切相关 ;进一步推测中医证型的转化 ,其病理基础与 P2 7、PCNA表达相关。

 
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