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系膜细胞
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  mesangial cell
    The possible role of IL—1 autocrine and paracrine in mesangial cell(MSc)
    白细胞介素1刺激系膜细胞IL—1转化生长因子β基因表达
短句来源
    INHIBITION OF HUMAN MESANGIAL CELL PROLIFERATION BY CALCIUM ANTAGONISTS
    钙拮抗剂对系膜细胞增殖的抑制作用
短句来源
    Effects of CsA combined with T4 on cultured human mesangial cell proliferationand its expression and synthesis ofinterleukin6
    环孢素A联合雷公藤单体T_4对人系膜细胞增殖及其表达、合成白细胞介素-6的影响
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    The role of AT_1 receptor and cyclin kinase inhibitor p27 protein in angiotensin Ⅱ-induced hypertrophy of mesangial cell
    血管紧张素Ⅱ受体1及周期素激酶抑制剂p27在血管紧张素Ⅱ诱导系膜细胞肥大中的作用
短句来源
    Expression of Acidic Ribosomal Protein P0 by Transfecting Human TGF-β1 Gene into Rat Mesangial Cell
    转染人TGF-β1基因对大鼠系膜细胞酸性核糖体蛋白P0表达的影响
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  mesangial cells
    The Inhibitive Effects and Mechanisms of PPARγ1 on the Extracellular Matrix of Mesangial Cells
    PPARγ1对系膜细胞外基质生成的抑制作用及其机制
短句来源
    Effect of Emodin on c- myc proto- oncogene expression in mesangial cells
    大黄素对系膜细胞c-myc原癌基因表达的影响
短句来源
    Role of transforming growth factor-βin the growth inhibition by cultured rat mesangial cells in
    转化生长因子β在高糖培养条件下系膜细胞生长抑制中的作用
短句来源
    DUAL MODULATORY EFFECTS OF U 46619 ON DNA SYNTHESIS OF MESANGIAL CELLS
    U46619双向调节系膜细胞DNA合成的研究
短句来源
    Effect of rIL - 1 on bioactivity and gene expression of IL - 6 in mesangial cells
    重组白细胞介素1对系膜细胞产生与表达白细胞介素6的影响
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  “系膜细胞”译为未确定词的双语例句
    Emodin inhibited SV-40 transgenic inesan-gial cell proliferation and C-myc mRNA ex-pression
    大黄素对SV-40转基因小鼠系膜细胞生长和c-mycmRNA表达的影响
短句来源
    3. I-IMC which were incubated inmedium alone did not express JL-1ca and MCP-1 mRNA, and constitutivemRNA expression in unstimulated cells was found for TNF-a, IL-113, IL-8,and TGF-f31. LPS significantly upregulated TNF-c, JL-1c, IL-13, MCP-1, IL-8, and TGF-j31 mRNA expression.
    3.正常培养状态下,系膜细胞组成型表达TNF-α、IL-1β、IL-8和TGF-β1 mRNA,而不表达IL-南京医科大学硕士学位论文la和 MCPI mRNA。 LPS刺激后上述细胞因子表达显著上调。
短句来源
    5. p65AS-ODN inhibited the expression of p65 mRNA and protein in dose-dependent fasion, where sense and mismatch ODN did not show any effect onall of these.
    5.p65反义ODN呈剂量依赖性阻断体外培养的系膜细胞 p65 mRNA及蛋白表达,正义及错配ODN对p65的表达没有阻断作用。
短句来源
    It was found that recombinant IL-1β,IL-6 and TNFα stimulated GMC to synthesize and release PAF in a dose-dependent manner.
    结果发现,它们均能诱导系膜细胞合成和分泌PAF,IL-1β、IL-6和TNFα的诱生作用并呈一定的剂量依赖关系。
短句来源
    These changes were pronounced with prolongation of experimental time. PAI 1 mRNA expression increased significantly at 24hr (0.45%±0.06% vs 0.65%±0.08%, P <0.05), however more marked increase of PAI 1 mRNA expression at 48hr (0.51± 0.08% vs 0.92±0.10%, P <0.01).
    AGE-BSA作用系膜细胞24小时后,PAI-1基因表达显著增加(0.65%±0.08%,对照0.45%±0.06%,P<0.05); 48小时后PAI-1基因表达增加更趋显著(0.92%±0.10%,对照0.51±0.08,P<0.01)。
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  mesangial cell
Histological examination showed cell swelling, break-down and massive lipid deposition in renal tubules; perivascular and interstitial cell infiltration and mesangial cell proliferation.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium.
      
Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations.
      
Finally, various antioxidants inhibit mesangial cell activation by HG and ameliorate features of diabetic nephropathy.
      
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  mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
The transcriptional regulation of SCL was studied in vitro in rat mesangial cells (MC).
      
It was reported heparin could inhibit mesangial cells proliferation in vitro.
      
The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
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The accumulation of extracellular matrix is a prominent feature of progressive glomerulonephritisand glomerulosclerosis. The autocrine and paracrine of cytokines play a central role in the pathogenesisof glomerulonephritis and glomerulosclerosis.To evaluate the role of IL-1 on glomerulosclerosis, 1. we observed IL-1 and TGFβ mRNA ge-ne expression and cellular matrix accumulation during the development of glomerulosclerosis, 2. alsoeffect of rIL-1β on stimulating cultured MSc expressing IL-1 and TGFβ mRNA gene...

The accumulation of extracellular matrix is a prominent feature of progressive glomerulonephritisand glomerulosclerosis. The autocrine and paracrine of cytokines play a central role in the pathogenesisof glomerulonephritis and glomerulosclerosis.To evaluate the role of IL-1 on glomerulosclerosis, 1. we observed IL-1 and TGFβ mRNA ge-ne expression and cellular matrix accumulation during the development of glomerulosclerosis, 2. alsoeffect of rIL-1β on stimulating cultured MSc expressing IL-1 and TGFβ mRNA gene and producingcellular matrix were studied, 3. The influence of Dexamethasone (Dex.), Calcitonin generelated peptide(CGRP). Tamm-Horsfall glycoprotein (THP) on the suppression of IL-1 production and its increasingeffects on MSc proliferation was investigated.The exploration of both experimental and cellular studies indicates the IL-1 plays an impor-tant role in the development of glomerulosclerosis. These drugs antagonized IL-1 in MSc level whichmay stop the pathogenesis circle of MSc and IL-1.

本文利用分子杂交技术研究了在系膜增殖性肾小球炎症硬化过程中白细胞介素1(IL-1)及转化生长因子β(TGFβ)基因表达及系膜细胞IL-1的自分泌和旁分泌作用与细胞外基质合成的关系;研究了3种药物对于系膜细胞产生IL-1的影响。结果证实IL-1和TGFβ在肾小球炎症硬化过程中起着重要作用。

It was reported that autocrine and paracrine of cytokines play a central role in the pathogenesis of glomeru-

本文应用分子生物学技术证明培养的肾小球系膜细胞有 TGFβmRNA 基因表达。并且 IL—1可促进系膜细胞 IL—1、TGFβ基因表达,提示细胞因子的自分泌和旁分泌在肾小球炎症硬化过程中起着重要作用.

Our previous investigation proved that Emodin can inhibit the proliferation of mesangial cells. To explore its possible molecular mechanism, the effect of Emodin on the expression of c-myc mRNA in cultured rat mesangial cells were observed by dot hybridization. Mesangial cells (2×10~6) made quiescent by exposure to a defined serum-free medium were used in the experiment. Addition of LPS(10μg/ml) resulted in a high level expression of the proto-oncogene c-myc mRNA within 30 min which persisted for 6h. Interestingly,...

Our previous investigation proved that Emodin can inhibit the proliferation of mesangial cells. To explore its possible molecular mechanism, the effect of Emodin on the expression of c-myc mRNA in cultured rat mesangial cells were observed by dot hybridization. Mesangial cells (2×10~6) made quiescent by exposure to a defined serum-free medium were used in the experiment. Addition of LPS(10μg/ml) resulted in a high level expression of the proto-oncogene c-myc mRNA within 30 min which persisted for 6h. Interestingly, this effect can ben inhibited promptly by Emodin (25μg/ml) in 30 min and peaked in 2.5h. It was suggested that Emodin may participate in the regulation of cell-cycle, and the down-regulation effect of Emodin on c-mye mRNA over-expression might contribute to the inhibitory action of Emodin on mesangial cell proliferation.

为了进一步阐明大黄抑制系膜细胞增殖作用的分子机理。本研究应用斑点杂交技术观察了大黄素对大鼠系膜细胞c-myc原癌基因mRNA表达的影响,发现大黄素能有效地抑制由LPS诱导的系膜细胞c-myc癌基因的过度表达,加大黄素0.5h后c-myc mRNA的表达比原有水平降低50%,2.5h后降低75%,一直持续到6h后。该结果表明,大黄素可能通过影响c-myc癌基因表达而参与细胞周期的调控,其对LPS诱导c-myc癌基因mRNA过度表达的负性调节体用,可能是它抑制系膜细胞增殖的机理之一。

 
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