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系膜细胞     
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  mesangial cell
    Lovastatin in regulation of mesangial cell proliferation and activity of TGF-β1 promoter in rats
    洛伐他汀对大鼠系膜细胞增殖及TGF-β1基因启动子活性的调控
短句来源
    Results: The volume densities of vascular endothelium, mesangial cell and mesangial area in SHR group were significantly increased compared to those in WKY group ( P < 0. 01).
    结果:与正常血压对照鼠比较,高血压鼠血管内皮细胞、系膜细胞体密度明显增大(P<0.01),显示增生较前者活跃,可见较多的电子致密物聚积并使整个系膜区体密度扩大(P<0.01)。
短句来源
    RESULTS: L-Arg induced inhibition of human mesangial cell lines (HMCL) in a concentration-and time-dependent manner.
    结果:L-arg呈剂量和时间依赖性抑制人系膜细胞增殖;
短句来源
    Objective:To study the effect of lovastatin on the proliferation of rat mesangial cell(RMC) and the activity of TGF-β1 gene promoter.
    目的:观察洛伐他汀对大鼠系膜细胞增殖及对人TGF-β1基因启动子活性的作用。
短句来源
    Objective To investigate the effect of curcumin and rapamycin used alone, combined use of curcumin and rapamycin, and PI3K/Akt specific inhibitor LY294002 on serum-induced rat glomerular mesangial cell proliferation.
    目的观察比较姜黄素、雷帕霉素单用和联用以及磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)特异抑制剂LY294002对体外培养的大鼠肾系膜细胞增殖的影响。
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  mesangial cells
    α-Tocopherol Inhibits Activator Protein 1 Binding and TGF-β_1 Expression Induced by High Glucose in Rat Mesangial Cells
    α-生育酚抑制高糖诱导大鼠系膜细胞AP-1活性及TGFβ_1表达
短句来源
    Effect of L-?Arginine on the Proliferation of Human Mesangial Cells
    L-精氨酸对人肾系膜细胞增殖的影响
短句来源
    EFFECT OF ANGIOTENSIN Ⅱ AND ITS RECEPTOR ANTAGONIST ON EXPRESS ION OF CONNECTIVE TISSUE GROWTH FACTOR I N MESANGIAL CELLS
    血管紧张素Ⅱ及其受体拮抗剂在系膜细胞培养中对结缔组织生长因子表达的影响
短句来源
    Effects of L-arginine on the proliferation of human renal mesangial cells
    L-精氨酸对人肾系膜细胞增殖的影响
短句来源
    Effects of breviscapine on protein expression of c-fos,c-jun in glomerular mesangial cells cultured under high glucose conditions
    灯盏花素对高糖环境肾系膜细胞c-fos、c-jun蛋白表达的影响
短句来源
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  glomerular mesangial cells
    Effects of breviscapine on protein expression of c-fos,c-jun in glomerular mesangial cells cultured under high glucose conditions
    灯盏花素对高糖环境肾系膜细胞c-fos、c-jun蛋白表达的影响
短句来源
    Effect of valsartan on scavenger receptor mRNA expression in human glomerular mesangial cells
    缬沙坦对人肾系膜细胞清道夫受体表达的影响
短句来源
    Effects of valsartan on the expression of STAT1 and STAT3 in glomerular mesangial cells under high concentration of glucose
    缬沙坦对高糖培养系膜细胞信号转导和转录活化因子1、3表达的影响
短句来源
    Effect of valsartan on up-regulating expression of ERK induced by high glucose in glomerular mesangial cells
    缬沙坦对高糖上调系膜细胞细胞外调节蛋白激酶表达的影响
短句来源
    Effect of combination of curcumin and rapamycin on proliferation of rat glomerular mesangial cells
    姜黄素和雷帕霉素联用抑制大鼠肾系膜细胞增殖的效果观察
短句来源
更多       
  glomerular mesangial cell
    Objective To investigate the effect of curcumin and rapamycin used alone, combined use of curcumin and rapamycin, and PI3K/Akt specific inhibitor LY294002 on serum-induced rat glomerular mesangial cell proliferation.
    目的观察比较姜黄素、雷帕霉素单用和联用以及磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)特异抑制剂LY294002对体外培养的大鼠肾系膜细胞增殖的影响。
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  mesangial cell
Histological examination showed cell swelling, break-down and massive lipid deposition in renal tubules; perivascular and interstitial cell infiltration and mesangial cell proliferation.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
Results Normal human mesangial cell (NHMC) proliferation was higher in high glucose (HG) medium than in low glucose (LG) medium.
      
Conclusions This study suggests that glucose can accelerate mesangial cell proliferation while heparin can reduce proliferation, being more obvious at high glucose concentrations.
      
Finally, various antioxidants inhibit mesangial cell activation by HG and ameliorate features of diabetic nephropathy.
      
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  mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
The transcriptional regulation of SCL was studied in vitro in rat mesangial cells (MC).
      
It was reported heparin could inhibit mesangial cells proliferation in vitro.
      
The main aim of this study is to explore whether heparin inhibits proliferation of mesangial cells grown in high glucose concentration and to measure the effect of heparin on matrix metalloproteinases (MMPs) expression in mesangial cells.
      
A metabolic (WST-1) assay was used to measure mesangial cell proliferation and Western blot analysis was used to measure MMPs expression of mesangial cells.
      
更多          
  glomerular mesangial cells
Cloning and high-level expression of plasminogen activator inhibitor-1 cDNA derived from human glomerular mesangial cells
      
ROS mimic the stimulatory effects of HG and upregulate transforming growth factor-a1, plasminogen activator inhibitor-1, and extracellular matrix (ECM) proteins by glomerular mesangial cells, thus leading to mesangial expansion.
      
Signaling role of PDE isozymes in pathobiology of glomerular mesangial cells
      
Regulatory functions of protein kinase c in glomerular mesangial cells
      
In glomerular mesangial cells protein kinase C fulfills two major functions: it contributes to hormone-induced prostaglandin formation, and it acts as a negative feedback regulator of the inositol lipid signalling cascade.
      
更多          
  glomerular mesangial cell
Increasing evidence supports a role for glomerular mesangial cell proliferation and overproduction of extracellular matrix by mesangial cells in the development of focal or diffuse glomerulosclerosis.
      
Protective effects of polyphenols against cadmium-induced glomerular mesangial cell myocontracture
      
Administration of anti-Thy 1 antibody in rats is a model of acute glomerular mesangial cell death due to their expression of the Thy 1.1 epitope.
      
Although previous studies have demonstrated that glomerular mesangial cell (GMCs) injury might be a feature of Thy-1?N, the mechanism of the disease (i.e., GMC apoptosis) remains unclear.
      
coli VT to the glomerular mesangial cell, with consequent effects on renal function.
      
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  其他


The cultured mesangial cell(MSc)went through three serial passages before being us ing.Quantitation of MSc growth rate was obtained by measuring the ratio of 3H+TdR uptake in a medium containg various concertrations of T4.IL-1 activity was tested by 3 H-TdR in corporation in C578L/c mice thymocytes.The results show that T4 inhibited MSc prolifera tion and IL-1 production.

无菌条件下分离提取人胚胎肾小球体外培养,以传代3~5次的系膜细胞,采用3H-胸腺嘧啶核苷( ̄3H-TdR)掺入法和胸腺细胞增殖法观察在不同浓度和不同作用时间雷公藤单体T_4对系膜细胞增殖及其白介素-1(IL-1)产生的影响。结果显示,雷公藤单体T_4明显抑制系膜细胞增殖及IL-1产生,其抑制作用的强弱呈剂量和时间依赖关系。本实验为进一步探讨雷公藤的免疫抑制作用和治疗肾小球疾病的机理提供了新的、有意义的实验依据。

The nephrotoxicity of FK506 and CsA was studied in experimental animals with homologous skin graft.The histopathological changes were similar in both groups,These were glomerular mensangium hyper plasia and cloudy swelling of the renal tubule cells.Furthermore,there was a rise of serum BUN and SC,a rise of P450 in the renal tissue,an elevation of ET,TXB_2,AⅠand AⅡ and a decrease of PGI_2 in the renal tissue.All the above findings correlated with nephrotoxicity.Verapamil in a dose of 10mg·kg ̄(-1)·d ̄(-1) could...

The nephrotoxicity of FK506 and CsA was studied in experimental animals with homologous skin graft.The histopathological changes were similar in both groups,These were glomerular mensangium hyper plasia and cloudy swelling of the renal tubule cells.Furthermore,there was a rise of serum BUN and SC,a rise of P450 in the renal tissue,an elevation of ET,TXB_2,AⅠand AⅡ and a decrease of PGI_2 in the renal tissue.All the above findings correlated with nephrotoxicity.Verapamil in a dose of 10mg·kg ̄(-1)·d ̄(-1) could decrease the serum level of BUN and SCr and abolish the cloudy swelling of renal tubules and therfore would able to prevent and treat the nephrotoxicity.

为研究FK506的肾毒性机理及防治,大鼠皮肤移植模型分组口服FK506、CsA及钙离子拮抗剂异搏定。结果:组织形态学提示FK506与CsA一样可引起肾小球系膜细胞增生,肾小管上皮细胞浊肿样变,同时使BUN和SCr增高,肾组织匀浆P450含量增加,表明其与CsA一样损害肾功能。另外FK506使肾组织匀浆中内皮素(ET)、血栓素B_2(TXB_2)和AⅠ、AⅡ增高,而PGI_2下降,提示上述血管活性物质与肾毒性有关。应用异搏定(10mg·kg_(-1)·d_(-1))后,血BUN、SCr,及肾匀浆P450含量下降,同时肾小球系膜增生减轻,肾小管上皮细胞浊肿消失,提示异搏定对FK506的肾毒性有防治作用。

PURPOSE To study the effect of conditioned media from CyA treated endothelial cell and endothelin(ET)on Ca2+ mobilization and contraction in cultured mesangial cell(MsC) and smooth muscel cell(SMC).METHODS Intracellular free Ca2+ ([Ca2+ ]i ) concentration were measured using Fura-2AM. Cell contraction was evaluated by a digital imaging analysis system.RESULTS Basal concentration of [Ca2+ ]i were not affected by media from endothelial cell; but the conditioned media from CyA 0. 1mg/L for 24 hours treated endothelial...

PURPOSE To study the effect of conditioned media from CyA treated endothelial cell and endothelin(ET)on Ca2+ mobilization and contraction in cultured mesangial cell(MsC) and smooth muscel cell(SMC).METHODS Intracellular free Ca2+ ([Ca2+ ]i ) concentration were measured using Fura-2AM. Cell contraction was evaluated by a digital imaging analysis system.RESULTS Basal concentration of [Ca2+ ]i were not affected by media from endothelial cell; but the conditioned media from CyA 0. 1mg/L for 24 hours treated endothelial cell and ET 0. 1 × 10-6 mol/L significantlyaugmented concentration of [Ca2+ ]i(P<0. 01 ), and induced concomitant contraction of MsC and SMC.CONCLUSIONS These results suggest that cellular mechanisms of CyA- induced nephrotoxicity and hypertension appears at least in part to be an alteration in the pattern of ET release and to act through endothelialreceptor on MsC and SMC, which may contribute to the increase of mean arterial blood pressure and reducingultrafiltration coefficient in CyA nephrotoxicity and hypertension.

研究环孢素A(CyA)引起肾毒性和高血压毒性的可能机制。在培养的大鼠肾小球系膜细胞(MsC),血管平滑肌细胞(SMC)中,加入CyA作用的内皮细胞上清液及内皮素(ET),在光镜下动态观察上述两种细胞的收缩反应,以微尺测量细胞表面面积,并以Fura-2AM荧光负载法测细胞内游离钙([Ca2+」i)。结果:GyA作用的内皮细胞上清液与ET一样,可使MsC、SMC的细胞内[Ca2+]i明显增加并产生持续的收缩反应。结论:CyA引起肾毒性和高血压毒性的主要机制可能与CyA对内皮细胞的细胞毒作用,导致的以ET为主的诸多血管活性肽的合成和分泌增加,它们作用在MsC、SMC的相应受体,导致肾血流及血压的改变有关。

 
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