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免疫耐受诱导     
相关语句
  tolerance induction
     Immunologic tolerance induction for pancreatic islet xenotransplantation
     异种胰岛移植的免疫耐受诱导
短句来源
  induce immune tolerance
     Objective To investigate whether TGF-β_1 gene modified dendritic cells could induce immune tolerance in islet xenotransplantation.
     目的探讨转化生长因子(TGF)-β1基因修饰的树突状细胞(dendriticcell,DC)对异种胰岛移植的免疫耐受诱导作用。
短句来源
  immunologic tolerance induction
     Immunologic tolerance induction for pancreatic islet xenotransplantation
     异种胰岛移植的免疫耐受诱导
短句来源
  induction of immunologic tolerance
     BACKGROUND & OBJECTIVE: As a non-vital organ, transplantation of larynx lags behind that of the other organs, but it is supposed that if induction of immunologic tolerance of the host to the allograft comes true, larynx transplantation would be an optimal approach for management of advanced laryngeal cancer as well as functional reconstruction of the larynx.
     背景与目的:喉为非生命必需器官,喉移植研究一直滞后于其它生命必需器官的移植,然而,一旦宿主对移植喉的免疫耐受诱导成功,那么,喉移植将是晚期喉癌治疗和喉功能重建的重要手段。
短句来源
     This study was designed to establish a modified rat model of larynx transplantation to improve survival rate of the recipients and vitality of the allografts, and provide an optimal rat model for further research on immunology and induction of immunologic tolerance in larynx transplantation.
     本研究的目的在于建立改良鼠喉移植模型,提高受体鼠和移植喉的存活率,为喉移植抗免疫排斥和免疫耐受诱导研究提供动物模型。
短句来源

 

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      tolerance induction
    Additionally, we highlight the potential importance of different routes of allergic sensitization and the role of oral tolerance induction in the pathogenesis and prevention of food allergy.
          
    This review focuses on recent advances in tolerance induction in experimental animal models and discusses their relevance to the development of protocols for the induction and maintenance of clinical transplant tolerance.
          
    Here, we explore the prospect of using hESCs and their derivatives for immunomodulation and tolerance induction.
          
    Self-tolerance induction is largely a reflection of negative selection (deletion) of autoreactive T cells in the thymus.
          
    Tolerance induction for solid organ grafts with donor-derived hematopoietic reconstitution
          
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      induce immune tolerance
    The human gut offers more than 200 m2 of mucosal surface, where direct interactions between the immune system and foreign antigens take place to eliminate pathogens or induce immune tolerance toward food antigens or normal gut flora.
          
    It has been shown that immature DC can induce immune tolerance and prolong allograft survival.
          
    These results suggest that portal venous infusion may be an effective approach for immature DC to induce immune tolerance or hyporesponsiveness against donor antigens, and prolong allograft survival.
          
    In the present study we investigated whether prior gene transfer to the retina, which is suspected to induce immune tolerance, could alleviate the immune response occurring after retrovirus mediated gene transfer to the liver.
          
    We conclude that although the retina behaves as an immunoprivileged site, gene expression in the subretinal space is not sufficient to induce immune tolerance to a transgene product expressed in the liver.
          
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      induction of immunologic tolerance
    Induction of immunologic tolerance is highly desirable in the treatment and prevention of allergy and other immune disease states in which the immune response to foreign or self antigens has become overactive.
          
    The development of recombinant allergens and varieties of allergens will improve diagnostic possibilities and bring new therapeutic options, such as hyposensitization and induction of immunologic tolerance.
          
    The development of recombinant allergens and varieties of allergens will improve diagnostic possibilities and bring new therapeutic options, such as hyposensitization and induction of immunologic tolerance.
          
    The induction of immunologic tolerance to solid organ allografts is a subject of intense investigation because of the morbidity and mortality associated with standard immunosuppressive therapy.
          
    The induction of immunologic tolerance to allow islet grafts to endure and prevail, without the hardship of chronic immunosuppressive therapy, is a major goal in this field.
          
    更多          


    Immunotolerance in mice was induced by intraperitoneal injection of synthetic proteolipid (PLP) peptide.It completely prevented the development of PLP-induced active experimental allergic encephalomyelitis (EAE) and passive EAE and suggested that PLP may play a dominant role in EAE pathogenesis.The mechanism of tolerance may be independent of the thymus and involved the non-specific immune system..

    腹腔注射脂蛋白(PLP)进行免疫耐受诱导,可保护小鼠既不发生PLP引起的主动性实验变态反应性脑脊髓炎(EAE)又不发生PLP特异性淋巴细胞引起的被动性EAE。提示在EAE发病过程中,PLP较髓鞘硷性蛋白(MBP)更具作用。免疫耐受的机理可能为非胸腺依赖性且与非特异性免疫有一定关系。

    The mouse heart was transplanted into the neck of rat using the cuff technique described by Heron with a little modification. The graft accending aorta to the host common carotiel artery and the graft pulmonary artery to the host exteral jugular vein were performed. 22 times of formal transplantation were done with the successful rate being 86%. The mean survival time was 2 .10±0. 80 days. The method is easy, quick and reliable- The superficial cervical localigation of the transplant is easily observed. This...

    The mouse heart was transplanted into the neck of rat using the cuff technique described by Heron with a little modification. The graft accending aorta to the host common carotiel artery and the graft pulmonary artery to the host exteral jugular vein were performed. 22 times of formal transplantation were done with the successful rate being 86%. The mean survival time was 2 .10±0. 80 days. The method is easy, quick and reliable- The superficial cervical localigation of the transplant is easily observed. This is a good model to observe the hyperacute rejection(HAR),to induce the translantation tolerance, and to screen the new immunosuppressive agents.

    采用Heron袖套法进行异种(小鼠→大鼠)心脏移植,异位移植于颈部皮下,供体主动脉接受体颈内动脉,供体肺动脉接受体项外静脉,并对手术方法进行了部分改进。进行正式手术22次,成功率86%,移植后平均存活时间2.10±0.80天;该方法简单、迅速、可靠,移植于颈部易于观察,对于超急性排斥反应的观察以及免疫耐受的诱导,抗免疫排斥药物筛选是一位得推广的动物模型。

    This paper reported rat parathyroid implantation intrathymically. The median survival times(MST) of allografts were 36.8 d, significantly longer than those of parathyroid implanted under kidney capsule. The MST of allografts implanted intrathymically were 65 5 d, when ATS administered at the time of implantation, and some (3/8) of allografts survived indefinitely. The results suggested that the thymus may be an immunoprivileged site for parathyroid transplantation and may play an important role during the induction...

    This paper reported rat parathyroid implantation intrathymically. The median survival times(MST) of allografts were 36.8 d, significantly longer than those of parathyroid implanted under kidney capsule. The MST of allografts implanted intrathymically were 65 5 d, when ATS administered at the time of implantation, and some (3/8) of allografts survived indefinitely. The results suggested that the thymus may be an immunoprivileged site for parathyroid transplantation and may play an important role during the induction of immunologic tolerance.

    将同种甲状旁腺移植于大鼠胸腺内,并与移植于肾包膜下甲状旁腺的效果进行了比较。移植于胸腺内者其平均存活期(35.8d)明显长于肾包膜下移植(15.2d)。如果在移植的同时应用抗胸腺淋巴细胞血清,则胸腺内移植者平均存活期为65.5d,部分(3/8)胸腺内移植者可达到长期存活。结果认为胸腺可能为甲状旁腺移植的最理想免疫特许区,而且在免疫耐受的诱导中具有重要作用。

     
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