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时间依赖效应
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  time-dependent effect
     (2) RTE showed a dose and time-dependent effect.
     (2)CEM凋亡细胞数随着附子提取物浓度增大和作用时间的延长而增多,呈现出对剂量时间依赖效应
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  time dependent manner
     RESULTS: At the concentrations of 30-120μg/ml, arecoline significantly inhibited EC proliferation in a dose and time dependent manner (P<0.05). Exposure of EC to arecoline (>60μg/ml) led to cell number decreased during a 24 hours of culture and arecoline (120μg/ml) led to the survival rate of EC decreased maximally during a 72 hours of culture(P<0.05).
     结果:30-120μg/ml槟榔碱抑制EC的增殖,并呈浓度和时间依赖效应(P<0.05),601μg/ml槟榔碱干预EC 24h细胞数量减少,120μg/ml槟榔碱干预EC 72h,细胞存活率达到最低(P<0.05)。
     Results: Low concentration of oxLDL(≤200 μg/L) significantly increased the expression of CD40 and CD40L in a dose and time dependent manner.
     结果 :低浓度 ox L DL (≤ 2 0 0μg/ L )可使单核细胞表达 CD40和 CD40 L明显增加 ,具有浓度和时间依赖效应
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     Results Low concentrations of OX_LDL(<200μg/L)can significantly increase the expression of CD40 and CD40L in a dose and time dependent manner.
     结果低浓度OX -LDL(<200μg/L)可使内皮细胞表达CD40 和CD40L含量明显增加 ,具有浓度和时间依赖效应
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     Results Sulfur mustard induced DNA strand breaks in the lymphocytes. Gene and protein expressions of caspase 3 were increased in a time dependent manner.
     结果 硫芥可导致淋巴细胞DNA损伤 ,Caspase 3在基因水平和蛋白水平上表达增加 ,同时发生活化作用 ,具有时间依赖效应
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  time dependent effect
     (2) CVB D also showed time dependent effect, the effect initiated 10 min after 20 μmol/L was perfused in ventricular muscle, the APD 50 , APD 70 and APD 90 were potentiated gradually along with prolongation of action time and reached the peak at 30 40 min, without any potentiation thereafter.
     (2)CVBD还具有时间依赖效应,当20μmol/L灌流心室肌10min后开始出现作用,随着药物作用时间的延长,APD50、APD70和APD90也逐渐增大,但是到30~40min左右时作用达最高峰,此后并不继续延长。
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     After treatment with 400 mg/L AGE-BSA for different duration, MMP-9 activity showed no significant difference at the time point of 12 hour (n=5, P>0.05), but MMP-9 activity was significantly increased in contrast to the control at the time point of 24, 36 and 48 hour, showing the time dependent effect (n=5, P<0.05).
     400mg/L糖基化牛血清白蛋白处理小鼠腹腔巨噬细胞不同时间后,作用12h时基质金属蛋白酶9活性与对照组比差异无显著性(n=5,P>0.05),作用24、36、48h时基质金属蛋白酶9活性均明显高于对照组,呈时间依赖效应(n=5,P<0.05)。
短句来源
     Number of sub G 1 cells significantly increased and bcl 2 protein expression in Raji cells was significantly down regulated assayed by flow cytometry. The relationship between bcl 2 protein and the concentrations of As 2O 3 showed a dose and time dependent effect;
     结果  0 5 μmol/L~ 2 0 μmol/L三氧化二砷抑制B淋巴瘤细胞株Raji细胞生长 ,出现细胞凋亡的形态学改变 ,流式细胞仪检测Raji细胞亚G1期细胞明显增多 ,bcl 2蛋白的表达明显降低 ,呈现剂量时间依赖效应
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  “时间依赖效应”译为未确定词的双语例句
     Stimulated by 10 ng/ml PDGF-BB for 0,12,24,48 h,the expression of PAI-1 mRNA/GAPDH mRNA were 0. 156,0. 345,0. 493,0. 597, respectively. PDGF-BB significantly increased the expression of PAI-1 mRNA of rat mesangial cells in a dose- and time-dependent manner.
     10 ng/ml的PDGF-BB作用系膜细胞0、12、24、48 h,PAI-1 mRNA/GAPDH mRNA分别为0.156、0.345、0.493、0.597,表现为浓度和时间依赖效应
短句来源
     CD44ASODN inhibited the growth of MGC80-3 cells with depression ratios of 31.0%, 46.3% (P<0.01), and 49.6% (P<0.01) at 48 h, 72 h, and 96 h respectively in a time-dependant manner.
     CD44ASODN作用MGC80-3 细胞48 h后,细胞的增生呈现明显的抑制作用,其抑制率为31.0%,72,96 h的抑制率分别为46.3%、49.6% (P<0.01),其增生抑制作用呈时间依赖效应.
短句来源
     [Results] Incubation for 48 hours with 10~50 ng/mL rIL-6 caused concentration and time-dependent stimulation of HK-2 cells proliferation, whereas rIL-6 inhibited HK-2 cells proliferation at 100~200 ng/mL respectively(F=201.582, P< 0.001),(F=43.943,P< 0.001).
     【结果】MTT比色法示,rIL-6在10~50ng/mL作用浓度范围内促进HK-2细胞增殖,呈剂量、时间依赖效应; rIL-6作用浓度为100~200ng/mL时抑制细胞增殖,随作用浓度增加抑制作用加强(F=201.582,P<0.001),(F=43.943,P<0.001)。
短句来源
     Results:In NRK/49F cells, TGF-β_1 enhanced CTGF, FN and Col Ⅲ mRNA expression in a dose- and time-dependent manner.
     结果:TGFβ1能显著增加NRK/49F细胞CTGF、FN和ColⅢmRNA表达,并呈剂量依赖和时间依赖效应
短句来源
     A time dependent marked inhibition in proliferation, DNA synthesis and viability of VSMCs ( P <0 01)could be obtained by 5×10 -4 ~10 -3 kg/L LPS.
     5×10-4~10-3kg/LLPS却抑制VSMC的增殖及DNA的合成,降低其活力(P<001),并呈时间依赖效应
短句来源
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  time-dependent effect
Modeling the time-dependent effect of the Ebbinghaus illusion on grasping
      
The second set of experiments evaluated the time-dependent effect of G-CSF when singly injected or given after carboplatin injections for 5 days only at 3:00 p.m.
      
We examined the time-dependent effect of testicular ischemia on germ cell apoptosis in the contralateral testis in a rat.
      
The results of electrophoretic mobility measurements demonstrated the huge time-dependent effect of polymeric layers adsorbed on oxides and modified clays.
      
Time-dependent effect of sectioning carotid sinus nerves on the vagally mediated baroreflex
      
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  time dependent manner
Caco-2 cells were found to transport 14C-butyrate in a concentration and time dependent manner.
      
Results showed during liver I/R injury, NF-kappaB activation was induced in a time dependent manner.
      
Curcumin could selectively inhibit the proliferation of Raji cells in a dose and time dependent manner, with the inhibition rate being 52.47%-82.18% (P>amp;lt;0.01).
      
Ox-LDL, but not native low-density lipoprotein (LDL), was found to be cytotoxic to both cell types in a dose and time dependent manner.
      
Co(II) was taken up in a dose and time dependent manner.
      
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  time dependent effect
Time dependent effect of indomethacin on the stimulation of protein synthesis in isolated rabbit muscle by insulin
      
Raclopride, on the other hand, produced only a weak time dependent effect in the VTA.
      
Some smaller trials have found no effect of aspirin on blood pressure control and others have shown a time dependent effect.
      
Therefore, a time dependent effect could not be demonstrated in this study.
      
The addition of NaCl created a charge shielding effect that reduced the time dependent effect.
      
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Viscous debris flow slurry is a solid-liquid mixture with high concentration. It is of high concentration and unit weight,wide range of grain-size,as well as complex rheologic behaviour.The shear test for viscous debris flow slurry at the northern section of Chengdu-Kunming Railway by the rotating cylinder vicometer RV 12 shows: the rheologic parameters ( apparent viscosity η. and yield stress τ(?) ) pressnt time-dependent effect, i. e. viscosity-time relations.η, decreases with increase of shear rate,but it...

Viscous debris flow slurry is a solid-liquid mixture with high concentration. It is of high concentration and unit weight,wide range of grain-size,as well as complex rheologic behaviour.The shear test for viscous debris flow slurry at the northern section of Chengdu-Kunming Railway by the rotating cylinder vicometer RV 12 shows: the rheologic parameters ( apparent viscosity η. and yield stress τ(?) ) pressnt time-dependent effect, i. e. viscosity-time relations.η, decreases with increase of shear rate,but it would increase with increase of shear time. As Fig. 2,while rotor speed n=512r/min,shear stress τincreases 12. 60pa and η. 27mpa·s in shear time of 18 minutes.τy, is the structure strength of slurry, τy, increases with increase of sheaf time. As Fig. 3,in the processes of shear rate variation,τy, rises from 8. 40pa to 79. 60pa. Therefore,the variation shows the time-dependent effect of slurry structure to time.Viscous debris flow slurry is of the rheologic behavious for negative-thixotropy. It thickens with increase of time. The rheologic parameter increases with increase of time,but time-dependent effect of slurry may weaken with increase of time.

对成昆铁路北段一些粘性泥石流浆体所作的剪切试验结果表明,流变参数[含:表观粘度η和屈服应力(极限静切力)τ]随时间推移而变化。粘性泥石流浆体的流变参数具有时间依赖效应,随剪切时间推移而递增。粘性泥石流浆体呈现出反触变性的流变行为,随时间推移而变稠,就此越发变得不易流动。

Oxidized low density lipoprotein may induce damages to endothelial cells. There is a close relationship between the endothelial cell injury and the development and progressing of atherosclerosis. Here we compared the effects of oxidatively modified low density lipoprotein ( O-LDL ) and tert-butyl hydroperoxide ( tbooH ) on the production of prostacyclin ( PG I2 ) , activity of selenium-glutathione per-oxidase ( SeGSH-Px ) , content of lipoperoxide ( Lpo ) and ratio of SeGSH-Px/Lpo in cultured human umbilical...

Oxidized low density lipoprotein may induce damages to endothelial cells. There is a close relationship between the endothelial cell injury and the development and progressing of atherosclerosis. Here we compared the effects of oxidatively modified low density lipoprotein ( O-LDL ) and tert-butyl hydroperoxide ( tbooH ) on the production of prostacyclin ( PG I2 ) , activity of selenium-glutathione per-oxidase ( SeGSH-Px ) , content of lipoperoxide ( Lpo ) and ratio of SeGSH-Px/Lpo in cultured human umbilical cord vein endothelial cells ( EC ) at various intervals of incubation time (Oh, 24h, 48h, 72h ) .Results of the present study showed thatO-LDL and tbooH both induced time-dependent alterations in the PGl2 prodution, SeGSH-Px activity、 Lpo content and SeGSH-Px/Lpo ratio in EC. The effects of tbooH on EC were consistent with those of O-LDL. The results obtained indicate that the effects of O-LDL on EC are similar to those of tbooH, which suggests that the injury of EC by O-LDL is in fact the result of effects of Lpo.

以培养的人脐静脉内皮细胞(EC)为损伤模型,观察到氧化修饰的低密度脂蛋白(O—LDL,100μg/ml和叔丁基脂氢过氧化物(tbooH,10~(-2)mM)对内皮细胞的硒—谷胱甘肽过氧化物酶(SeGSH—Px)的活性,前列腺环素(PGI_2)的生成,脂质过氧化物(Lpo)含量及SeGSH—Px/Lpo比值有明显的时间依赖效应,即随作用时间的延长,O—LDL和tbooH使EC的SeGSH—Px活性下降,PGI_2生成减少,SeGSH—Px/Lpo比值降低;而Lpo含量则增加。提示O—LDL对EC的损伤实质是脂质过氧化物的作用。

The effect of HPD plus light on cell-free DNA synthesis catalyzed bypartially purified DNA-dependent DNA polymeras ea from hepatoma ceIls was studied by us-ing calf thymus DNA of thermal denaturation as template。 The results showed that the DNAsynthesis system w as markedly inhibited by toth HPD and light treatment, and the degree ofinhibition was dependent on the HPD concentration and exposure time。 No changes could beobserved when either HPD or light irradiation was used alone .This inhibition could not...

The effect of HPD plus light on cell-free DNA synthesis catalyzed bypartially purified DNA-dependent DNA polymeras ea from hepatoma ceIls was studied by us-ing calf thymus DNA of thermal denaturation as template。 The results showed that the DNAsynthesis system w as markedly inhibited by toth HPD and light treatment, and the degree ofinhibition was dependent on the HPD concentration and exposure time。 No changes could beobserved when either HPD or light irradiation was used alone .This inhibition could not bereversed by in creasing DNA concentration but could be abolished by increasing enzyme con-centmtion.Preincube tion of HPD with the enzyme preduced stronger inhibition than that withdNTPs when exposed to lighl However, the strongest inhibition would be caused after prei-ncubetion of HPD with the enzyme and DNA treether under light activation。 These resultssuggest that the enzyme may be the major target for photosensitizing effect and HPD phot-osensitization not only suppre ased the enzyme activity but also destroved the structure andfunction of DNA template, which led to the strongest inhibition of DNA synthesis

本文从腹水型肝癌细胞部分纯化了依赖于DNA的DNA聚合酶。,以热变性的小牛胸腺DNA为模板,观察了HPD的光敏效应对这-DNA合成体系的影响。结果表明,单独的HPD或光照对无细胞体系DNA合成无影响;而既用HPD处理,又经光照后的DNA合成系统表现出明显的抑制作用。此抑制作用呈显著的剂量和时间的依赖效应关系.HPD的光敏反应与DNA模板非竞争性地作用于酶。增加模板量不能使抑制作用逆转:而增加酶量可使抑制作用部分逆转。四种脱氧核苷三磷酸与HPD预保温未见抑制作用;酶与HPD预保温后抑制率比对照组增加两倍;而酶和DNA一起与之预保温后抑制率则增加近4倍。捉示HPA的光敏效应是既抑制了酶活性又破坏了DNA模板的结构和功能,从而发挥最大的抑制作用。

 
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