Results: The level of SOD in the retina tissue in the exiperimental group was significantly lower than that in the self-controlling group in 1,3 and 7 day respectively after acute ocular hypertension (P<0.01),which was near to the self-controlling group in 15 day (P>0.05).
The level of MDA in the retina tissue in the exiperimental group was significantly higher than that in the self-controlling group in 1,3,7 and 15 day respectively after acute ocular hypertension (P<0.01).
Result:1. Change of the intraocular pressure: Model contrast group and ginkgo leaf group experiment rabbit eyes in high intraocular pressure state all the time(P>0.05), feel at ease group, use medicine group compares jointly with thiophene(P<0. 01).
The common complications after the operation were corneal endothelial edema in 89 eyes (4 0%), corneal decompensation in 2 eyes (0 1%), temporary intraocular hypertension in 28 eyes (1 2%), pupillary dilatation in 7 eyes (0 3%), retinal detachment in 8 eyes (0 4%), cystoid macular edema in 24 eyes (1 1%) and displacement of intraocular lens in 8 eyes (0 4%).
Conclusion: The contents of TXA_2 and PGI_2 are obviously increased after intraocular hypertension injury and the balance between TXA_2 and PGI_2 is damaged in rabbit optic nerves, which might be one of the important reasons for damage to optic nerves.
The average level of ANF in plasma was 130. 32±47. 54pg/ml at normal IOP, 278. 68±54. 44pg/ml at high IOP after 2h, 284. 68± 63. 78pg/ml after 4h, compared with levels at normal IOP ,P< 0. 01 (t= 5. 41, 5. 48 ,respectively).
After undergoing scleral buckling and simple pars plana vitrectomy,the highest mean postoperative IOP was 21.04±7.49mmHg and 20.43±7.79mmHg on day 1,respectively. The incidence of high IOP was 5/23(21.7%)and 6/35(17.1%)respectively.
Ocular hypertension group was prone to have thicker cornea than average.
Effect of scleral expansion band on ocular hypertension: Canadian phase 1 study
A prospective, nonrandomized, controlled, phase 1 clinical trial was conducted to evaluate use of the scleral expansion band for lowering elevated intraocular pressure (IOP) in patients with ocular hypertension or primary open-angle glaucoma.
Scleral expansion band procedure: Therapy for ocular hypertension and primary open-angle glaucoma
By increasing the pore size, SRP is a new therapeutic and preventive modality for ocular hypertension and primary open-angle glaucoma.
The proposed method was successfully applied to the determination of Asp and Glu levels in rabbit retina samples with different stages of intraocular hypertension.
Emergency endovascular therapy using the transvenous approach to treat severe intracranial or intraocular hypertension and multifocal haemorrhagic venous infarction due to cerebral sinus thrombosis or dural fistulas is also described.
Histopathological evaluation of retinal damage during intraocular hypertension in rabbit: Involvement of ganglion cells and nerv
We used an experimental model of intraocular hypertension to compare early changes in retinal ganglion cell (RGC) density with the thickness of the nerve fiber layer (NFL).
We found a significant correlation between RGC loss and cell area at 4 days (P>amp;lt;0.01; Cc=0.86) and at 10 days (P>amp;lt;0.002; Cc=0.91) of intraocular hypertension.
The diurnal variations in IOP cannot be a major contributing factor to the log-normal pattern of distribution of IOP in the albino rabbit, since a log-normal pattern of distribution was observed after the exclusion of the evening (high IOP) data.
This experiment suggests that seriously injured eyes must be protected from high IOP; if IOP elevation is required during vitrectomy, it is essential to reduce the duration of interruption of blood flow to a minimum.
The reason for this is, that it would appear that those persons most at risk of developing higher degrees of myopia have a high IOP.
The considerable deviation from the Goldmann readings in the high IOP range requires further modifications of The Tono-Pen.
The indications for operation were: visual field progression in 15 eyes, too high IOP in 13 eyes and severe visual field defects (central island and/or centro coecal visual field defects) in 9 eyes.