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   细胞信号通路 的翻译结果: 查询用时:1.246秒
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细胞信号通路     
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  cell signaling pathway
     Like other kinds of carcinoma, the genesis and development of esophageal cancer relat to cell signaling pathway.
     与其它肿瘤一样,食管癌的发生发展与细胞信号通路密切相关。
短句来源
     RNAi has made a wide application in disease gene therapy, functional genomics and cell signaling pathway analysis,to name just a few.
     RNAi技术在疾病的基因治疗、功能基因组学及细胞信号通路分析等力面具有广阔的应用前景。
短句来源
  signal transduction pathway
     Meanwhile, pAKT (the key protein kinase in PI3K/AKT signal transduction pathway), P53 and PTEN were measured by Western blot in order to illuminate the possible mechanism LTA regulating Survivin.
     用Western blot方法检测PI3K/AKT细胞信号通路中关键蛋白激酶AKT的磷酸化型pAKT(Thr308)以及P53、PTEN表达改变,探讨LTA下调Survivin表达的可能机制。
短句来源
     Biotherapy drugs alone or combination with chemotherapy include: cytokines, hematopoietic growth factors, dentritic cell, epidermal growth factor receptor-tyrosine ki-nase inhibitors (EGFR-TKIs), angiostatin and endostatin, matrix metalloproteinases (MMPs), modulatin of signal transduction pathway, antisense therapeutic agents, monoclonal antibody target agents and genetherapy.
     单用或与化疗相结合的生物治疗药物有:细胞因子、造血生长因子、树突状细胞、表皮生长因子受体-酪氨酸激酶抑制剂、血管抑素和内皮抑素、基质金属蛋白酶抑制剂、细胞信号通路调节剂、反义治疗药物、单克隆抗体靶向药物和基因治疗等。
短句来源
  cellular signal pathway
     Application of Fluorescence Resonance Energy Transfer (FRET) Technique in the Study of Cellular Signal Pathway
     荧光共振能量转移(FRET)技术在细胞信号通路研究中的应用
短句来源
     The biological processes are mainly involved in the acute phase response,the activation of immune response,cellular signal pathway,and the suppression of lipid metabolism in liver after oral administration of plasmid DNA.
     灌胃外源质粒DNA后,肝脏组织主要表现为急性时相反应的加强、免疫反应的活化、细胞信号通路的活化以及脂质代谢途径的抑制。
短句来源
  “细胞信号通路”译为未确定词的双语例句
     Casein kinase 1 (CK1) was one of the pioneer protein kinase activities that have been isolated, and was named for its character that strongly phosporylating casein.
     CK1α是casein kinase 1(酪蛋白激酶1)家族的一个成员,对Wnt、Hedgehog、TGFβ、NF-AT等细胞信号通路有重要的调节作用。
短句来源
     Research progress of anti-tumor mechanisms of ginsenoside Rh2(G-Rh2) extracted from ginseng was expounded, and the anti-tumor activity and mechanisms of G-Rh2 were discussed on regulating signal access system of tumor cells, reversing abnormal differentiation and tolerance of tumor cells, reducing telomerase activity of tumor cells, strengthening immunological ability, improving anti-tumor (ability), and interdicting synthesis and metabolism of tumor cellular important components etc.
     论述了从人参中提取的有效成分人参皂苷-Rh2(G-Rh2)的抗肿瘤机理的研究进展,并探讨了G-Rh2在调节肿瘤细胞信号通路系统、逆转肿瘤细胞的异常分化与耐药性、降低肿瘤细胞端粒酶活性、增强机体免疫力、提高抗肿瘤能力以及阻断肿瘤细胞某些重要成分的合成与代谢等方面的抗肿瘤活性及其作用机理。
短句来源
     Objective To investigate the activation state of mitogen activating protein kinase-extracellular signal-regulated kinase1/2(MAPK~(ERK1/2)) pathway in periphery blood mononuclear cells(PBMC) of patients with lupus nephritis(LN).
     目的目的观察有丝分裂原激活的蛋白激酶-细胞外调节激酶(MAPKERK1/2)细胞信号通路在系统性红斑狼疮(SLE)并肾炎(LN)患者外周血单个核细胞(PBMC)活化状态,探讨MAPKERK1/2通路在LN患者免疫异常中的作用及临床意义。
短句来源
     CONCLUSIONS: TSA exhibits significant antitumor effect against LNCaP cells through depletion of AR.
     结论:TSA能够清除对细胞生长具有重要作用的AR细胞信号通路,从而对前列腺癌LNCaP细胞发挥抑制作用。
短句来源
     3) After treatment by uPA-ATF, the phosphorylation level of P44 in GCT cultured cells is much higher than the control.
     将uPA-ATF加入培养的骨巨细胞瘤细胞后,细胞信号通路上的p44蛋白磷酸化水平明显增高。
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  cell signaling pathway
The actions appeared to be at the level of the gonadotroph membrane and the cell signaling pathway involving Ca2+ and protein kinase C (PKC).
      
In the early 1990's, a new cell signaling pathway was described.
      
Akt pathway is an important cell signaling pathway involved in drug resistance.
      
In the left panel, a T cell signaling pathway is shown.
      
One interesting merlin interactor that operates within a critical Schwann cell signaling pathway is HRS.
      
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  cell signal transduction
This review summarizes recent data on various groups of lysophospholipid receptors and their cell signal transduction pathways.
      
In this article, we review how pluripotent stem cell signal transduction mechanisms and transcription factor circuitries integrate information provided by the microenvironment.
      
CD19/Lyn complex formation also regulates phosphorylation of CD22 and FcγRIIB, which inhibit B cell signal transduction through the recruitment of the SHP1 and SHIP phosphatases.
      
Biological functions of these proteins are related to cell signal transduction, cell proliferation, cell motility, glycolysis, regulation of transcription, oxidative stress processes, and protein folding.
      
However, not all patients with severe defects in B-cell development have mutations in BTK or the components of the B-cell signal transduction complex.
      
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  signal transduction pathway
Nucleoside Diphosphate Kinase Is a Possible Component of the Ethylene Signal Transduction Pathway
      
Data obtained in three different systems indicated that SF HB-EGF possesses a mitogenic activity but utilizes a signal transduction pathway other than that of HB-EGF.
      
The inconsistencies between phenotypes detected in this study may be prerequisites for the identification of new genes responsible for this signal transduction pathway or new mutations in the known genes that determine other phenotypic combinations.
      
Previous phenotypic analysis assigned six of these strains to a physiological group of strains with changed activity of the Ras/cAMP signal transduction pathway.
      
The results are collated with the data on yeast phenotypes associated with a lower activity of the Ras/cAMP signal transduction pathway.
      
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  其他


To explore the effects of lipopolysaccharide binding protein (LBP) on toll like receptor 4 (TLR4) pathway in alveolar macrophages of acute lung injury induced by lipopolysaccharide (LPS) in rats. The TNF αconcentration, IL 1β and IL 18 mRNA expression in alveolar macrophages (AMφ) from rats challenged with LPS or LPS + LBP or LPS+LBP+multi LBP antibody (mLBPab) were measured with ELISA and semi quantative reverse transcription polymerase chain reaction (RT PCR) respectively. The expression of TLR4 was...

To explore the effects of lipopolysaccharide binding protein (LBP) on toll like receptor 4 (TLR4) pathway in alveolar macrophages of acute lung injury induced by lipopolysaccharide (LPS) in rats. The TNF αconcentration, IL 1β and IL 18 mRNA expression in alveolar macrophages (AMφ) from rats challenged with LPS or LPS + LBP or LPS+LBP+multi LBP antibody (mLBPab) were measured with ELISA and semi quantative reverse transcription polymerase chain reaction (RT PCR) respectively. The expression of TLR4 was determined with RT PCR and Western blot. The results showed that: the TNF α concentration ,IL 1β, IL 18 mRNA expressions and TLR4 expression were increased significantly in the AMφ stimulated with LPS +LBP compared with single LPS stimulation group. However, mLBPab blocked these effects. It is suggested that LBP could enhance the trans membrane transduction function of LPS via TLR4 in rat AMφ and these might be the main reason that LBP could enhance the inflammatory activity of LPS, and LBP antibody could be used to alleviate such morbid conditions such as SIRS, acute lung injury, ARDS, and septic syndrome.

为研究脂多糖结合蛋白 (LBP)对内毒素 (LPS)急性肺损伤大鼠TLR4肺巨噬细胞信号通路的影响 ,探讨LBP对LPS炎症反应增敏作用的部分机制 ,运用RT PCR和ELISA方法分别检测LBP对LPS刺激后大鼠肺巨噬细胞IL 1β、IL 18mRNA表达与TNF α分泌量的作用 ,同时用RT PCR与Westernblot检测其TLR4mRNA与蛋白的表达水平。结果显示 ,LBP显著增加LPS刺激后大鼠肺巨噬细胞TNF α的分泌和IL 1β、IL 18mRNA的表达 ,同时也增加TLR4的mRNA与蛋白表达水平 ,而LBP多抗能阻断上述作用。说明LBP可增强由TLR4介导的LPS信号跨膜转导功能 ,这可能是LBP对LPS起增敏作用的重要分子机制之一。

Objective: To study the effect of MNNG on inducement of non-targeted mutation and activation of several cellular signal transduction pathways, and to determine whether the activation of these signaling pathways was dependent on the DNA-damage. Methods: Vero cells were enucleated by discontinuous density centrifugation. The PKA activities were measured by enzyme-linked immunosorbent assay. The status of cell membrane receptors was studied with immunofluorescent staining and confocal microscopy. Results: In enucleated...

Objective: To study the effect of MNNG on inducement of non-targeted mutation and activation of several cellular signal transduction pathways, and to determine whether the activation of these signaling pathways was dependent on the DNA-damage. Methods: Vero cells were enucleated by discontinuous density centrifugation. The PKA activities were measured by enzyme-linked immunosorbent assay. The status of cell membrane receptors was studied with immunofluorescent staining and confocal microscopy. Results: In enucleated cytoplasts, MNNG-treatment increased PKA activity for about 2.3-fold in accordance with the 2.7-fold up-regulation of PKA activity in whole vero cells exposed to MNNG. The clustering of cell surface receptors of epidermal growth factor and tumor necrosis factor α was also observed in cells exposed to MNNG; this phenomenon was also found in enucleated cells. Conclusion: The results indicate that the initiation of signal cascades induced by low concentration of MNNG might be associated with its interaction with cell surface receptors and/or direct activation of related signal proteins but not its DNA damage.

目的 :研究基因组 DNA损伤与细胞信号通路激活的关系以及低浓度 N-甲基 - N’-硝基 - N-亚硝基胍(MNNG)对细胞膜表面受体的影响。方法 :采用 ELISA法来检测蛋白激酶 A(PKA)的活性 ,不连续梯度密度离心法完成细胞脱核 ,以及免疫荧光法和激光共聚焦显微镜观察细胞表面受体聚集情况。结果 :0 .2 μmol/ L MNNG能在脱核细胞中引起 PKA活性升高 2 .3倍 ,并可在 5 min内引起 vero细胞表面生长因子受体和肿瘤坏死因子 α受体的聚集 ;在脱核细胞中 ,表面受体聚集现象与在完整细胞中一样。结论 :低浓度 MNNG对 PKA的激活和诱导细胞表面受体聚集均不依赖于基因组 DNA的损伤 ,表明细胞信号转导通路的起源可能位于细胞膜或者细胞质中。

The biotherapy combination with chemotherapy for malignancy should be recently considered, along with research progress in chemotherapy and biotherapy. Biotherapy drugs alone or combination with chemotherapy include: cytokines, hematopoietic growth factors, dentritic cell, epidermal growth factor receptor-tyrosine ki-nase inhibitors (EGFR-TKIs), angiostatin and endostatin, matrix metalloproteinases (MMPs), modulatin of signal transduction pathway, antisense therapeutic agents, monoclonal antibody target agents...

The biotherapy combination with chemotherapy for malignancy should be recently considered, along with research progress in chemotherapy and biotherapy. Biotherapy drugs alone or combination with chemotherapy include: cytokines, hematopoietic growth factors, dentritic cell, epidermal growth factor receptor-tyrosine ki-nase inhibitors (EGFR-TKIs), angiostatin and endostatin, matrix metalloproteinases (MMPs), modulatin of signal transduction pathway, antisense therapeutic agents, monoclonal antibody target agents and genetherapy. The clinical application categories include: concurrent bio-chemotherapy, sequential bio-chemotherapy and salvage biotherapy after chemotherapy failure.

随着化疗和生物治疗研究的进展,人们在思考如何把生物治疗与化学治疗相结合治疗恶性肿瘤。单用或与化疗相结合的生物治疗药物有:细胞因子、造血生长因子、树突状细胞、表皮生长因子受体-酪氨酸激酶抑制剂、血管抑素和内皮抑素、基质金属蛋白酶抑制剂、细胞信号通路调节剂、反义治疗药物、单克隆抗体靶向药物和基因治疗等。恶性肿瘤生物化疗的临床应用类别包括:同步性生物化学疗法,序贯性生物化学疗法和化疗失败后的补救性生物治疗。

 
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