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gene
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  基因
    Construction and Immunological Study of a DNA Vaccine from a Hybrid Gene of Protective Antigens of Plasmodium falciparum
    恶性疟原虫保护性抗原复合基因DNA疫苗的构建及免疫学特征研究
短句来源
    Study of human FEN-1 gene function and its role in the development of genetic instability
    FEN-1基因功能及其在遗传不稳定形成中的作用研究
短句来源
    Application of ribosomal RNA gene ITS and IGS regions in the molecular identification and classification fungi
    核糖体RNA基因间隔区ITS及IGS在真菌分子生物学鉴定和分型中的应用
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    Cloing,expression and activity study of vacuolating cytotoxin A gene of Helicobacter pylori
    幽门螺杆菌空泡毒素基因分段克隆、表达和活性研究
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    Study on the role of ybtE gene in enteroaggregative Escherichia coli
    肠聚集性大肠杆菌中ybtE基因作用的研究
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  “gene”译为未确定词的双语例句
    Preparation and Characterization study of Gene Engineering Antibody against Platelets GP
    抗血小板膜糖蛋白基因工程抗体的制备和性质研究
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    Gene Transfer of huCTLA4-Ig to Induce Immune Tolerance of Rat Liver Graft
    基因转移huCTLA4-Ig诱导大鼠移植肝免疫耐受的实验研究
短句来源
    Preparation of Recombinant Human Glucagon-like Peptide-1 by Gene Engineering and Studies on Its Biological Activities
    基因工程制备重组人胰高血糖素样肽-1及其生物学活性研究
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    Study on the Impact of Hot-spot Mutations in HBV/C Gene on the Immune Response of Mice by Gene Transfer Mediated by Recombinant Adenovirus
    用腺病毒载体介导的基因转移研究HBV/C区热点变异对小鼠免疫应答的影响
短句来源
    Pathological Detection of Fhit and p53 Gene in Bronchial Hyperplastic Epithelial Lesions
    支气管上皮增生性病变FHIT及p53的病理学检测分析
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  gene
NEW TECHNOLOGY FOR DRUG DISCOVERY BASED UPON INSERTION OF LIGANDS INTO GENE SEQUENCES BY NUCLEAR RECEPTOR PROTEINS
      
A gene regulatory mechanism has been proposed in which steroid hormones and certain other drugs bind to nuclear receptor proteins followed by transfer to DNA where they are inserted between base pairs.
      
Polymerase chain reaction was used to amplify a 439-bp fragment of a 65,000-kDa (Mr) heat shock protein gene (hsp65) of Mycobacterium.
      
Cloning of an APETALA3 homologous gene (PtAP3) from Populus tomentosa and genetic transformation of its sense and anti-sense con
      
A pair of primers were designed according to published literature on Populus trichocarpa gene (PTD), and PtAP3, an AP3 homologous gene from Populus tomentosa was isolated by PCR using genomic DNA of the male clone of P.
      
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A new type of haemoglobinopathy is reported. The patient, a 23-year old female born in Yemen (PDRY), was hospitalized due to severe abdominal pain. She was found to show sickle-cell trait. Her red cells contained approximately 15% HbA, 18% HbP, 1.8% HbA. and 65% slow mobility haemoglobin. The slow mobility haemoglobin was analyzed and shown to be haemoglobin. S (α2β2 6Glu→Val). The patient was considered as a double heterozygote for both haemoglobin S and δβ+ thalassemia genes. This type of haemoglobinopathy...

A new type of haemoglobinopathy is reported. The patient, a 23-year old female born in Yemen (PDRY), was hospitalized due to severe abdominal pain. She was found to show sickle-cell trait. Her red cells contained approximately 15% HbA, 18% HbP, 1.8% HbA. and 65% slow mobility haemoglobin. The slow mobility haemoglobin was analyzed and shown to be haemoglobin. S (α2β2 6Glu→Val). The patient was considered as a double heterozygote for both haemoglobin S and δβ+ thalassemia genes. This type of haemoglobinopathy has never been reported before so far as we know. The diagnosis, molecular genetics and molecular pathology about this disease are discussed.

本文报道一种新型的血红蛋白病。患者出生于也门民主人民共和国,女性,23岁。有腹痛和镰状细胞特征,其红细胞内含有大约15%HbA、18%HbF、1.8%HbA_2和15%慢速血红蛋白。结构分析证明,慢速泳动的血红蛋白是血红蛋白S,β_(6Glu-Val)。因此认为病人是血红蛋白S和δβ~+地中海贫血基因的双重杂合子。本病在世界上首例发现。我们对本病进行了诊断,并从分子遗传学和分子病理学方面进行了讨论。

Three virus-resistant L cell mutants were selected with mutagen-selec-tion method. These mutant cell lines were found to show marked changes in interferon induction and action systems. An accelerated interferon induction response was observed in mutant cell cultures when they were exposed to NDV. Induced mutant cells synthesized interferon mRNA more quickly, and the interferon titers after induction with poly 1 : C were higher in mutant cell lines than in the parent cell line. One virus-resistant L cell mutant...

Three virus-resistant L cell mutants were selected with mutagen-selec-tion method. These mutant cell lines were found to show marked changes in interferon induction and action systems. An accelerated interferon induction response was observed in mutant cell cultures when they were exposed to NDV. Induced mutant cells synthesized interferon mRNA more quickly, and the interferon titers after induction with poly 1 : C were higher in mutant cell lines than in the parent cell line. One virus-resistant L cell mutant was found to be more sensitive to the anti-cell-division activity caused by intracellular pppA2'P5'A2'P5'A.Results suggested that changes in interferon gene expression might account for the antiviral activity of these cell mutants.

用亚硝基胍诱变、VSV攻击选育的方法获得 3株抗病毒 L细胞系,后者对VSV、Sindbis病毒、痘菌病毒有明显的抗病毒性质。抗病毒细胞系的干扰素诱生系统和活性发挥系统都发生了明显的改变,表现在对病毒攻击发生干扰素加速反应以及提高对“细胞内”2-5P3A3的抑制细胞分裂活性的敏感性。对抗病毒细胞系干扰素基因表达的变异机理进行了讨论。

Observations on the morphology of BJAB cells were made before and after infection with Epstein-Barr Virus (EB virus) under scanning electron microscope. The surface of uninfected BJAB cells was covered with filopodia instead of microvilli which are the major surface feature of cultivated Burkitt lymphoma cells. One day after infection, the filopodia became somewhat thick and short in a portion of cells, while in the others the filopodia even virtually disappeared and the surfaces seemed to be undulated with...

Observations on the morphology of BJAB cells were made before and after infection with Epstein-Barr Virus (EB virus) under scanning electron microscope. The surface of uninfected BJAB cells was covered with filopodia instead of microvilli which are the major surface feature of cultivated Burkitt lymphoma cells. One day after infection, the filopodia became somewhat thick and short in a portion of cells, while in the others the filopodia even virtually disappeared and the surfaces seemed to be undulated with varying number of scattered "fingerlike" projections. This type of surface morphology was more predominant in the third day's infected preparations, and furthermore, clusters of blebs began to be observed. The number of bleb cells increased afterwards, at the seventh day a majority of cells had a "bleb-like excresence" appearance, very similar to the characteristic surface morphology of human myeloma cells. This typical surface architecture maintained without observable change during cell passages in vitro at least for five months. Since infection with inactivated EB virus could not induce such effects on BJAB cells as that mentioned above, it is considered the presence of EB virus genome and the expression of viral gene(s) might be involved in the changes of BJAB cell surface morphology.

在扫描电镜下观察BjAB细胞在感染EB病毒以后表面形态的变化。未受感染的BjAB细胞以表面布满丝状伪足者最多见。感染1天后,部分细胞丝状伪足缩短变粗,另部分则丝状伪足几乎全部消失,细胞表面略现皱褶和分布着疏散的“手指样”结构。感染后3天时细胞突出的变化是表面皱褶更明显,更多见;而且开始看到表面泡状结构。这种泡状结构的细胞在感染5天时数量增多,而7天后大部分细胞已呈“泡样瘤”状。观察感染后5个月的细胞,这种表面结构仍保持不变。由于用灭活的EB病毒在相同条件下感染这种细胞,表面形态未见改变,所以这种表面形态的变化应与EB病毒感染,并设想同EB病毒基因组的存在和表达有关。

 
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