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   gene 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:0.173秒
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gene
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  基因
    Investigation of Melatonin Receptor subtype Protein and Gene Expression in Human Embryos
    人胚胎组织褪黑素受体亚型蛋白和基因表达的研究
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    An experimental study on the gene therapy of rheumatoid arthritis by antisense vasculuar endothelial growth factor(VEGF)transfection
    类风湿性关节炎的反义VEGF基因治疗实验研究
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    Sp3 Gene's Organization and the Genetic Relativity with Multiple Sclerosis
    Sp3基因结构及其与多发性硬化遗传相关性研究
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    Mapping the Disease Gene in a Disseminated Superficial Actinic Porokeratosis Family and Study Susceptibility Genes of Late-onset Type 2 Diabetes Mellitus
    对一个弥漫性浅表性光敏性汗孔角化症家系致病基因的定位和对迟发型2型糖尿病易感基因的研究
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    Study on the Polymorphisms and Function of the Insulin Receptor Substrate-1 (IRS-1) Gene 5'-flanking Region in Chinese Patients with Type 2 Diabetes Mellitus
    2型糖尿病患者胰岛素受体底物-1(IRS-1)基因5'-侧翼调控序列多态性与功能的研究
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  “gene”译为未确定词的双语例句
    Gene Mapping and Mutation Detection in Families with Hereditary Spastic Paraplegia
    遗传性痉挛性截瘫家系的基因定位与突变检测
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    The Gene Therapy and Mechanism Study of Wound Healing Impairment in STZ-Diabetic Mice
    STZ糖尿病小鼠创伤难愈的转基因治疗及机制研究
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    Prevention and Treatment of Experimental Autoimmune Thyroiditis by Adenovirus-mediated Gene Transfer of CIITA Mutant
    腺病毒介导CIITA突变体基因转移防治实验性自身免疫性甲状腺炎的研究
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    Inhibition of mRNA Expression of Silicotic Collagen Gene by Tetrandrine
    汉防己甲素抑制矽肺胶原mRNA表达的研究
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    A Clinical Primary Study of Obese Gene Product in Obese Patients
    肥胖患者肥胖蛋白的临床初步研究
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  gene
NEW TECHNOLOGY FOR DRUG DISCOVERY BASED UPON INSERTION OF LIGANDS INTO GENE SEQUENCES BY NUCLEAR RECEPTOR PROTEINS
      
A gene regulatory mechanism has been proposed in which steroid hormones and certain other drugs bind to nuclear receptor proteins followed by transfer to DNA where they are inserted between base pairs.
      
Polymerase chain reaction was used to amplify a 439-bp fragment of a 65,000-kDa (Mr) heat shock protein gene (hsp65) of Mycobacterium.
      
Cloning of an APETALA3 homologous gene (PtAP3) from Populus tomentosa and genetic transformation of its sense and anti-sense con
      
A pair of primers were designed according to published literature on Populus trichocarpa gene (PTD), and PtAP3, an AP3 homologous gene from Populus tomentosa was isolated by PCR using genomic DNA of the male clone of P.
      
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In this paper 27 cases of oculopha-ryngeal muscular dystrophy are repor-ted. The 27 patients are some of the49 descendants from one family for aperiod of 5 generations. The patientⅢ 5, 43 years old, came to our out-patient department for consultation in1981, complaining of bilateral ptosisfor 8 years, of external ophthalmo-plegia for 3 years and of difficulty inswallowing for 2 years. In his familyhistory, it was found that there were26 patients having clinical symptomssimilar to those of this patients. 23patients...

In this paper 27 cases of oculopha-ryngeal muscular dystrophy are repor-ted. The 27 patients are some of the49 descendants from one family for aperiod of 5 generations. The patientⅢ 5, 43 years old, came to our out-patient department for consultation in1981, complaining of bilateral ptosisfor 8 years, of external ophthalmo-plegia for 3 years and of difficulty inswallowing for 2 years. In his familyhistory, it was found that there were26 patients having clinical symptomssimilar to those of this patients. 23patients survived and 4 patients died.The age range of onset was 3~20years. The course of illness was 1~42years. The initial symptom was pto-sis, which usually occurred in all pa-tients. 15 patients had hoarsness andswallowing difficulty. 16 patients hadthe sign of external ophthalmoplegia.2 patients felt weakness of orbicularmuscles of eye and mouth. One patientexperienced weakness of neck muscles.Both the abnormal electromyographicchanges and muscular biopsy findingswere compatible with those of primarymuscular dystrophy. There was aslight increase of the levels of serumCPK and serum LDH in 8 patients. From pedigree analysis, this dis-ease is a genetic disease with autosomaldominance. Several members in everygeneration, both females and males,were affected and the number of pa-tients was over 50%. On examinationthe chromosomal patterns in 3 patientswere normal. It is suggested that thepathogenic gene might be transmitted tothe descendants. This resulted in theoccurrence of the disease. However, in our patients, the aver-age age of onset was rather young andabout half of the patients had externalophthalmoplegia. It is evident thatthese manifestations differ from thegenetically determined, typical oculo-pharyngeal muscular dystroohy. Sotheir disease should be considered as avariant of oculopharyngeal musculardystrophy. We consider that the patho-genic gene probably produces muta-tion or the phenotype may not be thesame as that of the typical oculo-pharyngeal muscular dystrophy.

本文报告一家系五代49个成员中27人罹患眼咽型肌营养不良症的临床和遗传分析。患者均有眼睑下垂,16例伴眼外肌麻痹,15例有咽喉肌麻痹,仅2例轻度面肌及双上肢近端肌无力,8例患者血清CPK及LDH_1的均值增高。根据家系分析属常染色体显性遗传,3例染色体核型分析正常。其临床表现与典型的家族性哏咽型肌营养不良症不完全相同,故本组病例的疾病基因可能发生了变异。

35 insulin-dependent diabetes mellitus (IDDM) patients and 53 normal healthy individuals in Shanghai were HLA typed. Second AOHWC workshop sera including HLA-A, -B, -C and -DE reagents were used. Moreover, phenotype frequencies of the variants of the HLA-linked genetic markers including GLO, Bf and C2 were determined. The results showed that phenotype frequencies of two antigens, i. e., All and Cw4, were decreased in patient group. After applying a correction factor for the number of comparisons made at each...

35 insulin-dependent diabetes mellitus (IDDM) patients and 53 normal healthy individuals in Shanghai were HLA typed. Second AOHWC workshop sera including HLA-A, -B, -C and -DE reagents were used. Moreover, phenotype frequencies of the variants of the HLA-linked genetic markers including GLO, Bf and C2 were determined. The results showed that phenotype frequencies of two antigens, i. e., All and Cw4, were decreased in patient group. After applying a correction factor for the number of comparisons made at each locus, there were still significant differences. Phenotype frequencies of two HLA-DR antigens, i. e., DR3 and DRw9, were increased in IDDM group. The deviation of DR3 was not significant in two groups when corrected for the number of comparisons made for HLA-DR locus. DRW9 was very significantly increased in IDDM patient group (Pcorr. = 0.00062).Our results suggested that there appeared to be two HLA-DR antigens which were associated with IDDM in Chinese population. It is very likely that there do exist two susceptibility genes of IDDM, one linked with DR3 and the other with DRW9.

本文对35名胰岛素依赖型糖尿病病人(IDDM)及53名正常人进行了HLA分型。分型试剂由第二届亚洲大洋洲组织相容性专题讨论会提供包括HLA-A、B、C和DR。同时测定了第六条染色体的遗传标志包括GLO、Bf和C2的变异体。 结果发现病人组A11和CW4的表现型频率减低,校正后仍有显著意义。病人组DR3和DRW9表现型频率与对照组比较有增高,特别是DRW9校正后仍然有非常显著的意义(校正p值为0.00062)。 我们的结果提示中国人IDDM病人可能存在二个HLA-DR抗原与IDDM相关联。

The pheny thiocaramid (PTC) gustatory ability of 101 hyperthyroidism patients and 146 edmic goiter patients have been tested by thresholds method. It is discovered that the PTC taste-blindness percentage, peak value of gustatory ability and recessive gene frequency of hyperthyroidism patients are effectively higher than the normal people. Hyperthyroidism inheritance type may be as multiple gene inherited disease and relatively to the character and manner of single non-dominant inheritance.

本文对101例甲亢病人及146例地甲病人用阈值法作PTC尝味能力测定,发现甲亢病人PTC味盲百分率、尝味能力峰值及隐性基因频率均明显高于正常人,考虑甲亢遗传方式为多基因遗传病,但与单基因不显性遗传的性状,有相关性。

 
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