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combined effect
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  联合作用
    Experimental Study of Combined Effect with Fluoride and Aluminum
    氟铝联合作用实验研究
短句来源
    COMBINED EFFECT OF NOISE AND CISPLATIN ON HEARING
    顺铂和噪声联合作用对听觉器官的影响
短句来源
    Combined effect of lead and cadmium on lipid peroxidation in renal tubular epithelial cells of rats
    铅镉联合作用对大鼠肾小管上皮细胞脂质过氧化的影响
短句来源
    In order to investigate the combined effect of chrysotile and cigarette smoking on the production of reactivated oxygen species in human embryo lung(HEL) cells,the production of H 2O 2, O ·- 2 and OH were determined in HEL cells which were incubated with chrysotile(CH) and cigarette smoking solution(CSS) separately or simultaneously.
    为探讨温石棉(CH)与吸烟联合作用于人胚肺(HEL)细胞时对反应体系中活性氧产生的影响,本研究采用不同剂量的CH和香烟烟溶液(CSS)单独及联合作用于HEL细胞,观察了H2O2、O—·2和·OH的产生情况。
短句来源
    What was more surprising was that inhibition of RM and Cht by the combined effect of SM, CM and PC could be completely or to a considerable extent counteracted by the concomitant action of A6. However, another traditional Chinese medicine Astragalus membranaceus Bge has no significant influence on RM or Cht either.
    中药抗炎6号(浓度1:30)能促进RM和Cht,且可完全解除或在很大程度上抵消SM、CM,PC联合作用对RM和Cht的抑制作用; 黄芪对RM和Cht均无明显影响。
短句来源
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  复合作用
    There was significant combined effect between the sustained hyperthermia in longer time and cigarette smoking , and there was a significant difference compared with the neurobehavioral of those only in single hyperthermia(p<0.01).
    同时还表明持续长时间 (>1.5min)的高温与香烟联合对仔鼠上述神经行为具有复合作用 ,与单独高温组比较有明显差异 (p<0 .0 1)。
短句来源
    There was significant combined effect between the sustained hyperthermia of longer time and cigarette smoking,and there was a significant difference compared with the neurobehavioral of those only in single hyperthermia( P <0 01).
    同时还表明持续较长时间的高温 (>1 5分钟 )与香烟联合对仔鼠上述神经行为具有复合作用 ,与单独高温组比较有显著性差异 (P <0 0 1)。
短句来源
  “combined effect”译为未确定词的双语例句
    A New Method Evaluating the Combined Effect of Drugs by “Q Value”——“Double 30 Method”
    用Q值估计合并用药效果的新方法——“双30法”
短句来源
    The combined effect of vitamins E, C and B_2 on blood sugar in mice
    维生素E、C和B_2联用对小鼠血糠的影响
短句来源
    Combined effect of selenium and fluoride on the thickness of PSD and the activity of SOD in mice′s brain
    硒氟联用对小鼠脑内PSD厚度及SOD活性的影响
短句来源
    The combined effect of isoniazid and rifampicin on the activities of CYP4501A2 and CYP4503A4 in primary hepatocytes from healthy human adults
    异烟肼和利福平联合用药对健康成人原代肝细胞CYP450同工酶1A2和3A4活性的影响
短句来源
    Combined Effect of Clarithromycin and Gatifloxacin on Pseudomonas Aeruginosa Biofilms in Vitro
    克拉霉素和加替沙星联合应用对铜绿假单胞菌生物被膜的体外作用
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  combined effect
A combined effect of iron deficiency and root anoxia on the biochemical composition, function, and structure of pea leaf chloroplasts was studied.
      
Strains considered for introduction into the environment for bioremediation should be assessed with regard to their susceptibility to the combined effect of anthropogenic and natural stress factors.
      
The coefficients of combined effect of these compounds or their dithioanalogs with permethrin were determined.
      
Combined Effect of Diazepam and GABAA-ergic Ligands on the Activity of Cl--ATPase in Plasma Membrane of Bream Brain (Abramis bra
      
We studied the combined effect of diazepam and GABAA-ergic ligands on the activity of Cl--ATPase in plasma membrane of bream brain.
      
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As has been generally accepted, the ventricular fibrillation (VF) occasionally occuring during antimonial therapy may arise from the combined effects of antimonials on the heart muscle itself and on the vegetative nerves. Basing upon the experimental data accumulated in years, two hypotheses have been proposed to explain the nervous mechanism of the pathogenesis of this toxic arrhythmia, one emphasizing the vagal role therein and the other the sympathetic. It was reported in our previous paper that after...

As has been generally accepted, the ventricular fibrillation (VF) occasionally occuring during antimonial therapy may arise from the combined effects of antimonials on the heart muscle itself and on the vegetative nerves. Basing upon the experimental data accumulated in years, two hypotheses have been proposed to explain the nervous mechanism of the pathogenesis of this toxic arrhythmia, one emphasizing the vagal role therein and the other the sympathetic. It was reported in our previous paper that after repeated challenges with ascending doses of potassium antimony tartrate (PAT) combined with fibrillating electric shocks, a large dose of PAT per se could usually induce VF, and this PAT-induced VF could be prevented by prior sympathectomy or reserpinization. In the present investigation the catecholamine (CA) content of rabbit ventricles was determined biologically under the same experimental conditions as previously described. The mean CA content of the ventricles of the saline control group was found to be 1.13±0.06μg/g wet tissue, and that of the electric shock control group 1.72±0.45μg/g, which was characterized by very wide fluctuations among different members in the group, the difference between these two control groups being, however, statistically insignificant. In the group of PAT combined with electric shocks, we noticed the same effects of PAT as previously described, namely, the lowering of VF electric threshold, acceleration of heart rate and the occurrence of PAT-induced VF, and in addition, we found that the CA content of this group significantly dropped to 0.65±0.05μg/g. The CA content of another group, in which ascending doses of PAT were similarly administered without accompaniment of electric shocks averaged 0.47±0.08μg/g, a value also significantly lower than that of the saline control. Reserpinization totally abolished the PAT-induced VF and almost completely depleted the heart's CA store. These data give direct support to our previous postulate that cardiac catechol amines play an important role in the development of the PAT-induced VF. Besides CA content, the acetylcholine (ACh) content of the ventricles of groups of rabbits were also assayed biologically. The saline control group gave a mean value of 0.323±0.013 μg/g, which could neither be changed by PAT in a single large dose or in a course of "3 days treatment", nor by prior vagotomy or atropinization in addition to a large dose of PAT. Moreover, reserpine, in doses effectively protecting rabbits against the PAT-induced VF, did not materially change the ACh content of rabbit ventricles, while larger doses of it markedly elevated that of guinea pig ventricles. From these results, another postulate of ours that the vagus does not take an essential part in this experimental arrhythmia seems to be further substantiated.

前文报导,在麻醉兎观察酒石酸銻鉀(簡称銻鉀)对电致心室顫动的影响实驗中,发現在实驗后期,大剂量銻鉀本身也能产生心室顫动,而这种銻致性心室顫动能被預先切断交感神經或利血平化所防止。本文采用与前文相同的实驗模型和条件,对家兎心室內儿茶酚胺含量进行了生物测定。发現盐水对照组心室儿茶酚胺含量平均为1.13±0.06微克/克。电刺激对照組为1.72±0.45,虽与盐水对照组相比在統計学上差別不显著,但波动較大。在电刺激加銻鉀组中,銻鉀能显著降低全部动物的电致顫阈,稍加速心率,并使6/11兎出現銻致性心室顫动,心室儿茶酚胺含显著减少至0.65±0.05。单注射銻钾組心肌儿茶酚胺含量平均为0.47±0.08,較盐水对照組显著减少,但与电刺激加銻鉀组差別不显著。利血平化(0.1毫克/公斤/天,共2次)后,兎心儿茶酚胺充份地被耗竭,含量降至0.032±0.003,耗竭程度达97%。利血平化后电刺激加銻鉀组的心室儿茶酚胺含量为0.041±0.010,銻致性心室顫动并不出現。上述資料对前文的推論提出直接証明,卽儿茶酚胺在該种心律紊乱发病机制中具有重要意义。除儿茶酚胺含量外,我們又进行了心室乙酰胆碱含量的测定,发現正常盐水对照家兎心...

前文报导,在麻醉兎观察酒石酸銻鉀(簡称銻鉀)对电致心室顫动的影响实驗中,发現在实驗后期,大剂量銻鉀本身也能产生心室顫动,而这种銻致性心室顫动能被預先切断交感神經或利血平化所防止。本文采用与前文相同的实驗模型和条件,对家兎心室內儿茶酚胺含量进行了生物测定。发現盐水对照组心室儿茶酚胺含量平均为1.13±0.06微克/克。电刺激对照組为1.72±0.45,虽与盐水对照组相比在統計学上差別不显著,但波动較大。在电刺激加銻鉀组中,銻鉀能显著降低全部动物的电致顫阈,稍加速心率,并使6/11兎出現銻致性心室顫动,心室儿茶酚胺含显著减少至0.65±0.05。单注射銻钾組心肌儿茶酚胺含量平均为0.47±0.08,較盐水对照組显著减少,但与电刺激加銻鉀组差別不显著。利血平化(0.1毫克/公斤/天,共2次)后,兎心儿茶酚胺充份地被耗竭,含量降至0.032±0.003,耗竭程度达97%。利血平化后电刺激加銻鉀组的心室儿茶酚胺含量为0.041±0.010,銻致性心室顫动并不出現。上述資料对前文的推論提出直接証明,卽儿茶酚胺在該种心律紊乱发病机制中具有重要意义。除儿茶酚胺含量外,我們又进行了心室乙酰胆碱含量的测定,发現正常盐水对照家兎心室乙酰胆碱含量平均为0.323±0.013微克/克。銻鉀一次大剂量注射或銻鉀三日給药法均不明显改变其含量。預先切断迷走神經或注射大剂量阿托品后再給大剂量銻鉀,也对心室乙酰胆碱含量无明显影响。因此完全不能証实黄铭新等关于这方面的报导。利血平在对家兎銻致性顫动具有防止作用的剂量下并不影响心室乙酰胆碱含量,較大剂量却能显著提高豚鼠心室乙酰胆碱的含量(P<0.01)。这些資料也完全支持前文所作出的推論,卽迷走神經在这种实驗性心律紊乱发病机制中的意义不大。

The effects of scopolamine,desoxyephedrine,amphetamine,caffeine, morphine,reserpine,chlorpromazine,pontobarbital and meprobamate,and their combined effects on the spontaneous activity of albino mice were determined by the photocell activity cage method. Scopolamine at 0.1 and 0.2 mg/kg intraperitoneally caused a decrease in activi- ty,while 2—4 mg/kg elicited an increase.Desoxyephedrine,amphetamine and morphine alone increased the activity;chlorpromazine and reserpine caused a decrease. In all cases...

The effects of scopolamine,desoxyephedrine,amphetamine,caffeine, morphine,reserpine,chlorpromazine,pontobarbital and meprobamate,and their combined effects on the spontaneous activity of albino mice were determined by the photocell activity cage method. Scopolamine at 0.1 and 0.2 mg/kg intraperitoneally caused a decrease in activi- ty,while 2—4 mg/kg elicited an increase.Desoxyephedrine,amphetamine and morphine alone increased the activity;chlorpromazine and reserpine caused a decrease. In all cases changes in the activity ratio appeared to be in proportion with the dose level.The mice exhibited increased activity under small doses of pentobarbital or meprobamate,but the activity was decreased by larger doses. The increase of activity elicited by scopolamine was exhibited only during the first 20 minutes following the entrance of mice into the cage,after which such an effect was not detectable.The increase of activity following desoxyephedrine,amphe- tamine or morphine was however enhanced progressively throughout a period of 10— 50 minutes,although to various extents.The mice receiving pentobarbital or mepro- bamate exhibited increased activity in the first 10 or 20 minutes,but showed signifi- cantly less activity than the control mice when the observation was prolonged. The combined effects of scopolamine with other central stimulants and depres- sants revealed its dualistic action.The fact that scopolamine in a dose of 4 mg/kg synergized with the stimulating effects of amphetamine,desoxyephedrine,caffeine and morphine,and antagonized the depressive effect of chiorpromazine and reserpine showed that it acted as a stimulant.In combination with either pentobarbital or mep- robamate,scopolamine at the same dose level,synergized with the depressive effects of these agents,the activity of mice being markedly decreased as if they had received large doses of the latter agents.These results showed that scopolamine acted also as a depressant.The results of combinations of other drugs showed that amphetamine synergized with caffeine and morphine and antagonized the effect of chlorpromazine and reserpine,exhibitied only central stimulating action.Chlorpromazine antagonized the stimulating effect of amphetamine and morphine and synergized with the depres- sive effect of pontobarbital,meprobamate,and reserpine,showing solely a central de- pression.Morphine however exhibited synergism with amphetamine on one hand and with chlorpromazine and reserpine on the other,showing also a dualistic action.

用光电管装置观察了东莨菪硷、去氧麻黄硷、苯丙胺、咖啡因、吗啡、利血平、氯丙嗪、戊巴比妥及密尔通对小鼠自主活动的影响,以及东莨菪硷与这些中枢兴奋药和抑制药的合并效应。腹腔注射0.1、0.2毫克/公斤东莨菪硷使小鼠自主活动减少,2—40毫克/公斤使活动增加。去氧麻黄硷、苯丙胺及吗啡使活动明显增加,活动指数随剂量加大而增高。氯丙嗪及利血平使活动减少,活动指数随剂量之增加而递减,戊巴比妥及密尔通小剂量使活动增多,大剂量使活动减少。东莨菪硷使活动增加表现在动物进入活动箱的开始20分钟内,20分钟后活动增加不明显;而去氧麻黄硷、苯丙胺及吗啡使活动增加,表现为20分钟后活动指数仍相继增大。给戊巴比妥及密尔通的动物,在放入活动箱后,开始活动增加,随后却表现为活动减少。东莨菪硷与其他中枢兴奋药及抑制药合并应用时,表现出中枢兴奋及抑制的两面作用。腹腔注射4毫克/公斤东莨菪硷使苯丙胺、去氧麻黄硷、咖啡因、吗啡所引起的活动增加更为加强,并对抗利血平及氯丙嗪所引起的活动减少,表现了中枢兴奋作用。同剂量的东莨菪硷与戊巴比妥及密尔通合用使活动明显减少,结果与后面二药在大剂量时的效应相同,表现了东莨菪硷与二药之间中枢抑制作用的协同。其他中枢...

用光电管装置观察了东莨菪硷、去氧麻黄硷、苯丙胺、咖啡因、吗啡、利血平、氯丙嗪、戊巴比妥及密尔通对小鼠自主活动的影响,以及东莨菪硷与这些中枢兴奋药和抑制药的合并效应。腹腔注射0.1、0.2毫克/公斤东莨菪硷使小鼠自主活动减少,2—40毫克/公斤使活动增加。去氧麻黄硷、苯丙胺及吗啡使活动明显增加,活动指数随剂量加大而增高。氯丙嗪及利血平使活动减少,活动指数随剂量之增加而递减,戊巴比妥及密尔通小剂量使活动增多,大剂量使活动减少。东莨菪硷使活动增加表现在动物进入活动箱的开始20分钟内,20分钟后活动增加不明显;而去氧麻黄硷、苯丙胺及吗啡使活动增加,表现为20分钟后活动指数仍相继增大。给戊巴比妥及密尔通的动物,在放入活动箱后,开始活动增加,随后却表现为活动减少。东莨菪硷与其他中枢兴奋药及抑制药合并应用时,表现出中枢兴奋及抑制的两面作用。腹腔注射4毫克/公斤东莨菪硷使苯丙胺、去氧麻黄硷、咖啡因、吗啡所引起的活动增加更为加强,并对抗利血平及氯丙嗪所引起的活动减少,表现了中枢兴奋作用。同剂量的东莨菪硷与戊巴比妥及密尔通合用使活动明显减少,结果与后面二药在大剂量时的效应相同,表现了东莨菪硷与二药之间中枢抑制作用的协同。其他中枢兴奋药及抑制药的合并效应如苯丙胺与咖啡因及吗啡协同,并对抗氯丙嗪及利血平的作用,表现了中枢兴奋作用。氯丙嗪对抗苯丙胺及吗啡,并与戊巴比妥、密尔通及利血平协同,表现为中枢抑制作用。吗啡在合并应用中表现出既和苯丙胺的兴奋作用协同,又和氯丙嗪的抑制作用协同,也表现出两面作用。

By analyzing the effect of the methaqualone with promethazine hydrochloride, according to T. R. derived from Loewe's method and Q_(50) of probalility sum method developed in our laboratory, the result indicated that the combined effect of the two drugs was synergistic. In addition, as viewed from the values of Q, the pharmaoological property of methaqualong and promethazine hydrochloride in combination was changeable with the dose levels of methaqualone: antagonistic with small dose, synergistic with large...

By analyzing the effect of the methaqualone with promethazine hydrochloride, according to T. R. derived from Loewe's method and Q_(50) of probalility sum method developed in our laboratory, the result indicated that the combined effect of the two drugs was synergistic. In addition, as viewed from the values of Q, the pharmaoological property of methaqualong and promethazine hydrochloride in combination was changeable with the dose levels of methaqualone: antagonistic with small dose, synergistic with large dose.

以小白鼠翻正反射消失3分钟以上为指标,研究盐酸异丙嗪20mg/kg与安眠酮合并应用的效果,并以概率和法及Loewe的等效线法进行分析,结果表明概率和法比较灵敏。从Q值及剂量效应线可以看出,盐酸异丙嗪与安眠酮二者之间的关系是随安眠酮的剂量而定,大剂量时协同,而小剂量时拮抗。

 
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