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cyclic gmp
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  环鸟苷酸
     AIM:To determine the levels of angiotensinⅡ(AngⅡ),endothelin 1(ET 1),nitri c oxide(NO) and cyclic GMP(cGMP) in the varicose great saphenous vein in order t o probe into the possible function of vasodilating and vasoconstricting factors in the pathogenesis of varicose vein.
     目的:测定曲张大隐静脉内血浆血管紧张素Ⅱ(angiotensinⅡ,AngⅡ)、内皮素-1、一氧化氮和环鸟苷酸水平的变化,以期探讨血管舒张因子和收缩因子在大隐静脉曲张形成过程中可能发挥的作用。
短句来源
     Cyclic AMP(cAMP) and cyclic GMP(cGMP) are of pivotal importance in determining many aspects of cellular function.
     环腺苷酸(cAMP)和环鸟苷酸(cGMP)对于细胞的许多功能有重要作用。
短句来源
  “cyclic gmp”译为未确定词的双语例句
     The self-association constant, K_α=3.12±0.7M~(-1) at 30℃ can be estimated from the concentration-dependent chemical shifts of H'_1 and H_8. The self-association affinity of cyclic GMP is larger than that of cyclic AMP.
     通过对cGMP分子的H_8和H_1质子化学位移与浓度的依赖关系求出缔合常数,K_α=3.12±0.7M~(-1),(温度30℃)。
短句来源
     The self-association constant,K_α=3.12±0.7 M~(-1) at30℃ can be estimated from the concentration-dependent chemical shifts of H′_1 andH_8.The self-association affinity of cyclic GMP is larger than that of cyclic AMP.
     通过对cGMP 分子的H_8和H_1质子化学位移与浓度的依赖关系求出缔合常数,K_α=3.12±0.7M~(-1),(温度30℃)。
短句来源
     Cerebral I/R model was reproduced in SD rats of I group and T group. HO-1 activity, cyclic GMP (cGMP) in the brain and COHb in blood were evaluated respectively at 1, 3, 12, 24, and 48 hours after global cerebral I/R and compared to those of the S group.
     I组和T组建立大鼠全脑缺血/再灌注模型,分别于脑缺血/再灌注1、3、12、24和48h各时间点检测脑组织匀浆HO1活性、环磷酸鸟苷(cGMP)及血中COHb含量,并与S组比较。
短句来源
     Cyclic nucleotide-gated ion channels (CNGs) are nonselective cation channels and opened by the direct binding of cyclic nucleotides, cyclic GMP and cyclic AMP.
     环核苷酸门控离子通道(cyclic nucleotide-gated ion channels,CNG)是非选择性的阳离子通道,直接被环核苷酸活化.
短句来源
     Before operation,the plasma cyclic GMP concentrations in patient group were sig- nificantly higher than those in the control group(22.00±1.66vs 6.25±0.23 pmol/ ml,P<0.001),and were significantly correlated to the cardiac function,mean pul- monary artery pressure and mean left atrial pressure.
     术前血浆 cGMP 浓度为22.00±1.66pmol/ml,较正常对照组的6.25±0.23pmol/ml 明显升高,与心功能、平均肺动脉压和平均左房压有一定的相关性,术后3~4周降至13.07±0.76pmol/ml。
短句来源
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  相似匹配句对
     Regulation of Cell Function by Cyclic GMP.
     cGMP对细胞功能的调控
短句来源
     Studies on the Dimer Stacking Conformation of Cyclic GMP
     环化鸟苷酸双聚体堆积构象的研究
短句来源
     Profile on GMP
     浅谈对GMP的认识
短句来源
     D—CYCLIC CRAPHS
     D—Cyclic图
短句来源
     Cyclic Esotropia
     周期性内斜视(附23例报告)
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  cyclic gmp
Cyclic GMP-Binding Activity in Avena sativa Seedlings
      
Binding of 3H-labeled cyclic GMP (3H-cGMP) to the structural components of subcellular fractions was studied in oat seedlings.
      
Oxygen-mediated pulmonary vasodilation and plasma levels of endothelin-1, atrial natriuretic peptide and cyclic GMP in patients
      
This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP) while cycle AMP (cAMP) levels were not different from values, measured during normoxia.
      
Experimental data are presented, which suggest that EDRF may act by direct stimulation of guanylate cyclase, resulting in smooth muscle relaxation due to increased smooth muscle cyclic GMP levels.
      
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Experiments were designed to observe the effect of four kinds of cyclic nucleo-tides on DNA synthesis in ovariectomized rat uterus and to compare with the effectof estradiol,by using the incorporation of ~3H-thymidine into DNA in uterine tis-sue as criterion.When 1 μg of estradiol was injected subcutaneously,a significant increasein the incorporation of ~3H-thymidine into DNA in uterine tissue was observed.A similar effect was observed after intrauterine injection of 16 mM cyclic AMPor cyclic...

Experiments were designed to observe the effect of four kinds of cyclic nucleo-tides on DNA synthesis in ovariectomized rat uterus and to compare with the effectof estradiol,by using the incorporation of ~3H-thymidine into DNA in uterine tis-sue as criterion.When 1 μg of estradiol was injected subcutaneously,a significant increasein the incorporation of ~3H-thymidine into DNA in uterine tissue was observed.A similar effect was observed after intrauterine injection of 16 mM cyclic AMPor cyclic UMP,but there was no effect with the same concentration of cyclic CMPand cyclic GMP.It was proposed that the stimulating effect of cyclic AMP and cyclic UMPon DNA synthesis is probably one of the mechanisms inducing the implantationof blastocysts in rats.

本工作以~3H-胸腺嘧啶核苷掺入子宫 DNA 为指标,观察了四种环核苷酸对大鼠子宫 DNA 合成的影响,并与雌二醇的作用进行了比较。结果表明,皮下注射1微克17β-雌二醇确能明显地促进子宫组织的 DNA 合成。同时,我们还证明,宫内注射16mM cAMP 或 cUMP 也明显地促进子宫组织的 DNA 合成。但是,同样浓度的 cCmP 和 cGMP 对子宫组织的 DNA 合成则并无明显影响。根据以上结果,我们推测,cMP 和 cUMP 对子宫组织 DNA 合成的促进作用很可能是它们引起胚泡着床的机理之一。

Protein binding assay and radio-immunoassay were applied respectively to the measurement of cyclic AMP and cyclic GMP in left ventricular muscle of rat. All animals in this experiment were anesthetized with urethane. The cAMP content measured in control rats is 81.7±16,5 (mean±S. D.) pico mole per 100 mg wet tissue weight, and the cGMP content is 3.2±0.4, therefore the cAMP/cGMP ratio is 26.1±6.4.When points “Nei Guan” and “Shen Men” were stimulated by electric acupuncture of certain strength and...

Protein binding assay and radio-immunoassay were applied respectively to the measurement of cyclic AMP and cyclic GMP in left ventricular muscle of rat. All animals in this experiment were anesthetized with urethane. The cAMP content measured in control rats is 81.7±16,5 (mean±S. D.) pico mole per 100 mg wet tissue weight, and the cGMP content is 3.2±0.4, therefore the cAMP/cGMP ratio is 26.1±6.4.When points “Nei Guan” and “Shen Men” were stimulated by electric acupuncture of certain strength and frequency, both cAMP and cGMP in cardiac muscle decreased slightly, while the cAMP/cGMP ratio remained unchanged.In cardie muscles, taken from rats with fast-type arrhythmia induced by aconitine, there was a significant decrease in cAMP content (44.9±6.8) and a slight decrease in cGMP content, and consequently a much lowered cAMP/cGMP ratio (17.2±3,6). When treated with electric acupuncture at points “Nei Guan” and “Shen Men”, the cAMP level in arrhythmic cardiac muscles increased, and the cAMP/cGMP ratio rose toward the control level (22.4±4.8).Besides, in cardiac muscles taken from rats with slow-type arrhythmia induced by verapamil, there was an obvious rise in cAMP content (203.6±35.4) and no significant change in cGMP content, and therefore a much higher cAMP/cGMP ratio (72.5±26.5) than that of control. In this case, acupuncture treatment caused a decrease in cAMP level (99.6±28.6) and an increase in cGMP level, consequently a lowering of cAMP/cGMP ratio toward control level (23.3±6.0).It is likely that the abnormal levels of cAMP, cGMP aa well as cAMP/cGMP ratio can be regulated to control levels by acupuncture treatment. This mode of regulation is a biphasic action, i. e., those levels higher than control may be decre-ased, and those lower than control may be increased, for this reason we call it the “push and pull” regulatory action of acupuncture. In animals with jugular vagotomy of both sides, this kind of regulation is entirely absent. The cAMP/cGMP ratio never returns to control value. Therefore the curative effect of acupuncture requires an intact nervous conduction pathway.The above experimental results provide a molecular basis for the curative effect of acupuncture in arrhythmic models.

采用蛋白结合法与放射免疫法测定了大鼠左心室肌cAMP与cGMP含量。麻醉大鼠仅给电针刺激,心室肌cAMP和cGMP水平都有所下降,但cAMP/cGMP比值保持正常。乌头碱诱发快速型心律失常后,心室肌cAMP明显下降,cGMP略有下降,而cAMP/cGMP比值也明显下降。电针刺激“内关”、“神门”能使cAMP值回升,并使cAMP/cGMP比值趋向对照值。异搏定诱发缓慢型心律失常后,心室肌cAMP水平显著升高,cGMP无明显变化,而cAMP/cGMP比值明显高于对照值。电针治疗能使cAMP下降,cGMP升高,从而使cAMP/cGMP比值趋向对照值。针刺对异常cAMP、cGMP水平以及异常cAMP/cGMP比值有调节趋向对照值的作用。这种调节作用是双重的,高于正常生理水平则降低之,低于正常生理水平则升高之,可称为“推挽”调节作用。切断两侧颈部迷走神经后,针刺不再显示这种调节作用。在整体实验中,针刺“内关”、“神门”既可缩短快速型心律失常持续时间,又可缩短缓慢型心律失常持续时间。本实验为针刺在整体和器官水平的疗效提供了分子生物学基础。

The proton magnetic resonance chemical shifts of cyclic AMP and cyclic GMP are analysed and compared. The self-association constant, K_α=3.12±0.7M~(-1) at 30℃ can be estimated from the concentration-dependent chemical shifts of H'_1 and H_8. The self-association affinity of cyclic GMP is larger than that of cyclic AMP. Finally, a mode for the association of cyclic GMP in a neutral aqueous~2(H_2O) solution was assumed.

本文分析和比较了环状腺嘌呤核苷一磷酸(cAMP)和环状鸟嘌呤核苷一磷酸(cGMP)~1HNMR谱的化学位移。通过对cGMP分子的H_8和H_1质子化学位移与浓度的依赖关系求出缔合常数,K_α=3.12±0.7M~(-1),(温度30℃)。cGMP自缔合的亲合力大于cAMP。假设了环状鸟嘌呤核苷一磷酸在中性重水溶液中的缔合模型。

 
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