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cyclic gmp
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  “cyclic gmp”译为未确定词的双语例句
    Objective To investigate the effects of melatonin on contents of hippocampal cyclic GMP in L-glutamate(Glu)-induced seizures in rats.
    目的探讨褪黑素(melatonin,MT)对谷氨酸(glutamate,Glu)致痫大鼠海马cGMP水平的影响。
短句来源
    Cerebral I/R model was reproduced in SD rats of I group and T group. HO-1 activity, cyclic GMP (cGMP) in the brain and COHb in blood were evaluated respectively at 1, 3, 12, 24, and 48 hours after global cerebral I/R and compared to those of the S group.
    I组和T组建立大鼠全脑缺血/再灌注模型,分别于脑缺血/再灌注1、3、12、24和48h各时间点检测脑组织匀浆HO1活性、环磷酸鸟苷(cGMP)及血中COHb含量,并与S组比较。
短句来源
    Effects of Melatonin on Contents of Hippocampal Cyclic GMP in L-Glutamate-induced Seizures in Rats
    褪黑素对谷氨酸致痫大鼠脑内cGMP水平的影响
短句来源
    Plasma cyclic nucleotides were measured for 55 outpatients with migraine. Plasma cyclic AMP and cyclic GMP were simultaneously observed in 44 outpatients with migraine.
    本文研究了55例偏头痛血浆环核苷酸含量变化,并对44例同步测了血浆CAMP、CGMP。
短句来源
    The changes in behaviors and EEG were observed and recorded,and cyclic GMP in brain was determined by using radioimmunoassay.
    观察并记录动物行为学及脑电图(EEG)改变,应用放射免疫方法检测各组动物脑内cGMP水平。
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  cyclic gmp
Cyclic GMP-Binding Activity in Avena sativa Seedlings
      
Binding of 3H-labeled cyclic GMP (3H-cGMP) to the structural components of subcellular fractions was studied in oat seedlings.
      
Oxygen-mediated pulmonary vasodilation and plasma levels of endothelin-1, atrial natriuretic peptide and cyclic GMP in patients
      
This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP) while cycle AMP (cAMP) levels were not different from values, measured during normoxia.
      
Experimental data are presented, which suggest that EDRF may act by direct stimulation of guanylate cyclase, resulting in smooth muscle relaxation due to increased smooth muscle cyclic GMP levels.
      
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Plasma cyclic nucleotides were measured for 55 outpatients with migraine. Plasma cyclic AMP and cyclic GMP were simultaneously observed in 44 outpatients with migraine. A significant increase of plasma cyclic AMP was found during earlier attack periods. The measurements of plasma cyclic GMP daryng attackfree periods demonstrated significantly lower levels. An increased ratio of cyclic AMP to cyclic AMP was feundto cyclic GMP was also observed during attack—free...

Plasma cyclic nucleotides were measured for 55 outpatients with migraine. Plasma cyclic AMP and cyclic GMP were simultaneously observed in 44 outpatients with migraine. A significant increase of plasma cyclic AMP was found during earlier attack periods. The measurements of plasma cyclic GMP daryng attackfree periods demonstrated significantly lower levels. An increased ratio of cyclic AMP to cyclic AMP was feundto cyclic GMP was also observed during attack—free periods. these results indicate that abnormal metabolism of cyclic nucleotides is associated with pahogenesis of migraine.

本文研究了55例偏头痛血浆环核苷酸含量变化,并对44例同步测了血浆CAMP、CGMP。结果表明偏头痛发作早期血浆CAMP较对照组明显升高,P<0.01;间歇期血浆CGMP较对照组明显降低,P<0.01;CAMP/CGMP比值在间歇期较对照组明显升高,P<0.01。提示偏头痛的发病机理与环核苷酸代谢异常有关。

Objective: To observe the changes of hemeoxygenase-1 (HO-1) activity in cerebral tissue, carboxyhemoglobin (COHb) level in blood of rats during global cerebral ischemia/reperfusion (I/R) and the influence of L-tetrahydropalmatine (L-THP) on them. Methods: Seventy-seven Sprague-Dawley (SD) rats were randomly divided into sham-operated group (S group, n=7), I/R group (I group, n=35) and L-2THP treatment group (T group, n=35). Cerebral I/R model was reproduced in SD rats of I group and T group. HO-1 activity, cyclic...

Objective: To observe the changes of hemeoxygenase-1 (HO-1) activity in cerebral tissue, carboxyhemoglobin (COHb) level in blood of rats during global cerebral ischemia/reperfusion (I/R) and the influence of L-tetrahydropalmatine (L-THP) on them. Methods: Seventy-seven Sprague-Dawley (SD) rats were randomly divided into sham-operated group (S group, n=7), I/R group (I group, n=35) and L-2THP treatment group (T group, n=35). Cerebral I/R model was reproduced in SD rats of I group and T group. HO-1 activity, cyclic GMP (cGMP) in the brain and COHb in blood were evaluated respectively at 1, 3, 12, 24, and 48 hours after global cerebral I/R and compared to those of the S group. Results: ① HOCD*21 activity, COHb content and cGMP level in I group increased as compared with those in S group after global cerebral I/R (all P<0.01). ② HO-21 activity and COHb content of T group were significantly lower than those of I group at 1, 12, 24, and 48 hours after cerebral I/R (all P<0.01), at 3 hours they were slightly lower than those of I group, the difference being not significant; HOCD*21 activities at all time points were higher than those of S group(all P<0.01); COHb contents at 24, 48 hours were slightly lower than those of S group, the difference being not significant, and at all the other time points the COHb contents were higher than those of S group (all P<0.01). cGMP level of T group was significantly lower than that of I group at all time points (all P<0.01 ), but higher than those of S group (all P<0.01 ). ③Hematoxylin and eosin (HE) stain showed that the number of surviving neurons in hippocampus CA1 region of I group was decreased at 3, 12, 24, and 48 hours after cerebral I/R (all P<0.01), but there was no significant change at 1 hour. The number of surviving neurons in T group was much higher than that in I group (P<0.01). Conclusion: L-THP could decrease carbon monoxide content and cGMP level by inhibiting HO-1 activity. The mechanism of neuro protective effect of L-THP is via increasing the number of survival neurons and ameliorating the I/R injury.

目的:观察全脑缺血/再灌注大鼠全血碳氧血红蛋白(COHb)含量、脑组织血红素氧化酶1(HO1)活性的变化及左旋四氢巴马汀(L THP)对其的影响。方法:77只SD大鼠随机分为假手术组(S组,n=7)、脑缺血/再灌注组(I组,n=35)及L THP治疗组(T组,n=35)。I组和T组建立大鼠全脑缺血/再灌注模型,分别于脑缺血/再灌注1、3、12、24和48h各时间点检测脑组织匀浆HO1活性、环磷酸鸟苷(cGMP)及血中COHb含量,并与S组比较。结果:1I组在脑缺血/再灌注后HO1活性、COHb含量及cGMP水平均明显高于S组(P均<0.01)。2T组的HO1活性及COHb在脑缺血/再灌注1、12、24和48h时均显著低于I组(P均<0.01),3h时略低于I组,差异无显著性;HO1活性在各时间点均高于S组(P均<0.01);COHb含量在24h和48h时略低于S组,但差异无显著性,其余各时间点均高于S组(P均<0.01);cGMP水平均显著低于I组(P均<0.01),但高于S组(P<0.01)。3苏木素伊红(HE)染色I组海马CA1区存活神经元数目在脑缺血/再灌注3h后显著减少(P<0.01),应用L THP...

目的:观察全脑缺血/再灌注大鼠全血碳氧血红蛋白(COHb)含量、脑组织血红素氧化酶1(HO1)活性的变化及左旋四氢巴马汀(L THP)对其的影响。方法:77只SD大鼠随机分为假手术组(S组,n=7)、脑缺血/再灌注组(I组,n=35)及L THP治疗组(T组,n=35)。I组和T组建立大鼠全脑缺血/再灌注模型,分别于脑缺血/再灌注1、3、12、24和48h各时间点检测脑组织匀浆HO1活性、环磷酸鸟苷(cGMP)及血中COHb含量,并与S组比较。结果:1I组在脑缺血/再灌注后HO1活性、COHb含量及cGMP水平均明显高于S组(P均<0.01)。2T组的HO1活性及COHb在脑缺血/再灌注1、12、24和48h时均显著低于I组(P均<0.01),3h时略低于I组,差异无显著性;HO1活性在各时间点均高于S组(P均<0.01);COHb含量在24h和48h时略低于S组,但差异无显著性,其余各时间点均高于S组(P均<0.01);cGMP水平均显著低于I组(P均<0.01),但高于S组(P<0.01)。3苏木素伊红(HE)染色I组海马CA1区存活神经元数目在脑缺血/再灌注3h后显著减少(P<0.01),应用L THP后存活神经元数目明显高于I组(P<0.01)。结论:L THP可通过抑制HO1活性使一氧化碳(CO)和cGMP水平下降,减少神经元丢失,提高存活神经元数目,减轻脑缺血/再灌注损伤。

Objective To investigate the effects of melatonin on contents of hippocampal cyclic GMP in L-glutamate(Glu)-induced seizures in rats.Methods Forty healthy male SD rats were randomly divided into 4 groups (n=10 in each group):control group(group A),Glu group(group B),MT+Glu group(group C) and Luzidole+MT+Glu group(group D).The changes in behaviors and EEG were observed and recorded,and cyclic GMP in brain was determined by using radioimmunoassay.Results Observation on behaviors and EEG revealed that...

Objective To investigate the effects of melatonin on contents of hippocampal cyclic GMP in L-glutamate(Glu)-induced seizures in rats.Methods Forty healthy male SD rats were randomly divided into 4 groups (n=10 in each group):control group(group A),Glu group(group B),MT+Glu group(group C) and Luzidole+MT+Glu group(group D).The changes in behaviors and EEG were observed and recorded,and cyclic GMP in brain was determined by using radioimmunoassay.Results Observation on behaviors and EEG revealed that the rats in groups B and D had seizure onsets and frequent seizure discharge.But in group C,the seizure onset was not obvious and no frequent seizure discharge occurred.Radioimmunoassay showed that the cGMP levels in hippocampus of groups B,C and D were significantly higher than in group A(P<0.05),while the cGMP levels were significantly decreased in group C as compared with groups B and D(P<0.05).Conclusion Melatonin may prevent Glu-induced seizures in rats,and cGMP may play a role in this procedure.

目的探讨褪黑素(melatonin,MT)对谷氨酸(glutamate,Glu)致痫大鼠海马cGMP水平的影响。方法将健康SD雄性大鼠随机分为A、B、C、D 4组,每组10只,分别为对照组、Glu组、MT+Glu组和Luzidole+MT+Glu组。观察并记录动物行为学及脑电图(EEG)改变,应用放射免疫方法检测各组动物脑内cGMP水平。结果行为学观察和EEG显示,B组和D组大鼠均出现痫性发作,并出现频发性痫性放电,C组大鼠痫性发作不明显,无频发性痫性放电出现;放射免疫分析结果显示,与A组比较,B、C、D组海马cGMP含量显著升高(均P<0.05);C组较B组和D组cGMP水平明显降低(P<0.05)。结论MT对Glu致痫有抑制作用,此作用可能是通过MT受体作用于cGMP实现的。

 
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