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target
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    Experimental Research on a Recombinant Mycobacterium Smegmatis Therapeutic Vaccine Delivering GLS/IL-12 to Specific Target
    向递送GLS/IL-12真核共表达质粒的重组耻垢分枝杆菌治疗性活疫苗的实验研究
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    Keratinocytes as a Target for Gene Transfection and Gene Expression
    以角朊细胞作细胞进行基因转染、基因表达的实验研究
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    Experimental Study on Target Cells of Pseudomonas aeroginosa Exotoxin A
    绿脓杆菌外毒素A细胞的实验研究
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    Identification of Monoclonal Antibody against Trichinella spiralis and Analysis Its Target Antigen
    一株抗旋毛虫单抗的鉴定及其抗原的分析
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    Determination of Molecular Weight of Cellular Target Antigensof Monoclonal Antibodies Using Non-Radioactive Labelling Method
    用非同位素法测定抗细胞性单抗抗原分子量
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  靶点
    Results:DRz-X29 could cleave the target that was predicted by sketch of secondary structure in given conditions.
    结果:特定反应条件下,DRz-X29成功对二级结构模拟预测的底物靶点进行了特异切割。
短句来源
    Since dual signal transduction system possesses important role in the pathogenicity aspect of the pathogenic bacterium,therefore,take it as a target in anti-infection therapy will have good application prospects.
    由于二元信号转导系统在病原菌的致病性方面具有重要作用,将其作为抗感染治疗中的靶点具有良好的应用前景。
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    A new target for cellular protection Na~+-Ca~(2+) exchanger
    细胞保护新靶点——Na~+-Ca~(2+)交换体
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    Lectin-like Oxidized Low-Density Lipoprotein Receptor-1-A New Target of Drug Action
    血凝素样氧化低密度脂蛋白受体1——新的药物作用靶点
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    B7-H4:a new target for immunoregulation and oncotherapy
    B7-H4——免疫调控以及肿瘤治疗的新靶点
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  靶向
    Experimental Research on a Recombinant Mycobacterium Smegmatis Therapeutic Vaccine Delivering GLS/IL-12 to Specific Target
    靶向递送GLS/IL-12真核共表达质粒的重组耻垢分枝杆菌治疗性活疫苗的实验研究
短句来源
    Objective To construct the target siRNA vector to peroxisome proliferator-activated receptor-γ( PPAR-γ).
    目的构建靶向过氧化物酶体增殖活化受体-γ(PPAR-γ)基因的siRNA载体。
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    The construction of KDR promoter drive TNFR retrovirus vector and its target expression
    KDR启动子驱动的TNFR逆转录病毒载体构建及其靶向表达
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    Suicide Genes or p53 Gene and p53 Target Genes as Targets for Cancer Gene Therapy by Ionizing Radiation
    辐射介导自杀基因和p53及其靶基因靶向治疗
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    Construction of target siRNA vector to PPAR-γ gene
    靶向过氧化物酶体增殖活化受体-γ基因siRNA载体的构建
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  “target”译为未确定词的双语例句
    Construction and Application of the Cell Strains with Down-regulated Expressed hOGG1 Genes Which Target to Oxidative DNA Damage and Repair
    DNA氧化损伤修复基因HOGG1低表达细胞株的建立及其应用研究
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    The Microinjection of Target Genes into Cultured Cells in Vitro
    外源基因对体外培养单个细胞的显微注射
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    A COMPLEX OF INTERMEDIATE FILAMENT PROTEIN-DNA:A TARGET FOR AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS?
    A COMPLEX OF INTERMEDIATE FILAMENT PROTEIN-DNA:A TARGET FOR AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS?
短句来源
    Human cytomegalovirus matrix protein PP150 is one of target antigens for CTL recognition
    人巨细胞病毒基质蛋白PP150是CTL识别的提呈抗原之一
短句来源
    CONCLUSION:In the construction of capillary DNA biosensors,EB can be taken as the fluorescent marker to detect the target oligonucleotide.
    结论:在毛细管DNA传感器构建中,溴化乙锭可作为荧光标记物对模式寡核苷酸进行检测。
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  target
Its absolute value (|A(u)|) measures the correlation between the signal u emitted by the radar transmitter and its echo after reaching a moving target.
      
As the main application it is shown that, in general, a localization operator possesses the Fredholm property, and thus its range is closed in the target space.
      
Such an estimate is both more representative of the target region and reduces the estimation variance when compared to estimates formed by any single bandlimited window.
      
These findings provide compelling evidence that DNA is the ultimate target of these drugs that act on the human genome.
      
CHEMICAL GENOMICS FOR FASTAND INTEGRATED TARGET IDENTIFICATION AND LEAD OPTIMIZATION
      
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In this paper, we report for thefirst time the mediation of cytotoxicimmune reactions against human livercancer cells in vitro by xenogeneic "im-mune" RNA. The human liver cancercell strain (BEL-7402) employed wasestablished in tissue culture in ourlaboratory by explant from a surgicalspecimen. The cell-mediated assayusing ~(125)I-iododeoxyuridine (~(125)IUdR)-labeled target cells was used for thestudies. Normal, nonimmune humanperipheral blood lymphocytes were con-verted into "killer cells", which effectedimmune...

In this paper, we report for thefirst time the mediation of cytotoxicimmune reactions against human livercancer cells in vitro by xenogeneic "im-mune" RNA. The human liver cancercell strain (BEL-7402) employed wasestablished in tissue culture in ourlaboratory by explant from a surgicalspecimen. The cell-mediated assayusing ~(125)I-iododeoxyuridine (~(125)IUdR)-labeled target cells was used for thestudies. Normal, nonimmune humanperipheral blood lymphocytes were con-verted into "killer cells", which effectedimmune cytolysis of human liver cancercells, by incubation with "immune"RNA extracted from the lymph nodesand spleens of sheep which had pre-viously been immunized with the hu-man liver cancer cells being studied.It was observed that the cytotoxicityindex of lymphocytes increased signi-ficantly after incubation with "immune"RNA in ten experiments. The controlRNA from sheep non-specifically im-munized with complete Freund's adju-vent did not enhance cytotoxicity indexof lymphocytes except in one experi-ment. The immune response mediatedby the "immune" RNA was abrogatedwhen the "immune" RNA was treatedwith RNase prior to incubation withlymphocytes. Treatment with DNaseor pronase did not effect the activityof the "immune" RNA. From thesestudies, it was demonstrated that thexenogeneic "immune" RNA couldtransfer the cell-mediated immunitydirected against the surface antigenson the human liver cancer cells tonormal human lymphocytes. Thus, itwould be suggested that xenogeneic"immune" RNA might be consideredas an approach to immunotherapy forhuman hepatocarcinoma.

从人肝癌细胞(BEL-7402)高度免疫过的绵羊的淋巴器官中抽提的肝癌“免疫”RNA,和正常人外周血淋巴细胞温育后,在体外能介导肝癌细胞的免疫细胞溶解。用5-~(125)碘-2′-脱氧尿嘧啶核苷标记人肝癌靶细胞的微量细胞毒性试验进行测定时观察到,正常人淋巴细胞经肝癌“免疫”RNA处理后,其细胞毒性指数在16次实验中有10次有显著增高,但是,在与对照RNA温育后其细胞毒性指数(除一次实验外)均未出现有显著意义的变化。肝癌“免疫”RNA在用RNA酶降解后,传递细胞毒性免疫反应的活性即消失,而用DNA酶或灰链霉菌蛋白酶处理,却仍保持这种传递能力。由此证明,异种“免疫”RNA能够把针对人肝癌细胞表面抗原的细胞免疫性传递给正常人淋巴细胞。

HRP was injected into: (1) areas 4,6 of unilateral cortex of 2 rats, and (2) unilateral ventral nuclei of 12 rats in order to study the connections of the thalamic VL and the distribution of the cells of origin. The main results are as follows:1. Following injection of the solution of HRP into areas 4,6 of unilateral cortex, labeled neurons appeared in the ipsilateral VL. This result indicates that the thalamic VL sends fibers to areas 4,6 of the cortex.Following injection of HRP into the thalamic VL, a number...

HRP was injected into: (1) areas 4,6 of unilateral cortex of 2 rats, and (2) unilateral ventral nuclei of 12 rats in order to study the connections of the thalamic VL and the distribution of the cells of origin. The main results are as follows:1. Following injection of the solution of HRP into areas 4,6 of unilateral cortex, labeled neurons appeared in the ipsilateral VL. This result indicates that the thalamic VL sends fibers to areas 4,6 of the cortex.Following injection of HRP into the thalamic VL, a number of labeled neurons were present in areas 4,6 and 3, 1, 2 of ipsilateral cortex. They were situated in the deep lamina of the cortex. The reciprocal connections between the thalamic VL and the cortex may imply the existence of a feedback system.2. In the medial part of the ipsilateral pallidus, labeled neurons could be found after the injection of HRP into VL. This is the indication of the presence of a globus-thalamic VL pathway in the rat. There were a set of labeled neurons in the ipsilateral reticular zone of the substantia nigra. So experimental results show the possibility of the existence of a nigrothalamic tract. It arises from the reticukr zone of the substantia nigra. Many labeled neurons were found in the dentate nucleus of the contralateral hemisphere of cerebellum. This demonstrates that projections of the dentate nucleus into the VL are strong. Labeled neurons were identified in the contralateral fastigial nucleus and nucleus interpositus of cerebellum. It is suggested that a pathway may be present between the fastigial nucleus and thalamic VL in the rat.From the above it becomes apparent that the thalamic VL is a common target of the projections of the cerebellum, substantia nigra and globus pallidus. Here occurs a convergence with a functional relationship among their fibers.

将HRP注入:(1)2只大白鼠一侧皮质的4、6区和(2)12只大白鼠一侧丘脑VL核,利用神经纤维轴浆运输的原理,研究丘脑腹外侧核的纤维连系和标记神经元的分布。研究的主要结果; 1.对一侧大脑皮质的4、6区注射HRP后,同侧丘脑VL核出现了标记神经元,这结果说明VL核传出纤维主要投射至4、6区。在VL核注射HRP后,标记神经元出现于同侧皮质的4、6区和3、1、2区,位于皮质的深层。丘脑VL核与皮质之间的这种往返纤维联系提示,在它们之间可能存在着一反馈系统。 2.给丘脑VL核注射HRP后,同侧的苍白球内侧部,可发现标记神经元,证明苍白球——丘脑通路存在。同侧的黑质网状带出现一组标记神经元,说明黑质丘脑通路存在,该通路起于黑质的网状带。许多标记神经元存在于对侧小脑齿状核,此可证明,大白鼠的小脑齿状核投射至丘脑VL核的纤维是强大的。在对侧的小脑顶核和间位核可找见标记神经元,提示顶核有纤维投射至丘脑VL核。由此可见,丘脑VL是小脑、黑质、 苍白球和皮质投射纤维的公共靶,在此,它们的纤维之间必然构成具有功能关系的会聚。

Observations on the distribution of 14C-gossypol and double labelled 14C-gossypol and 3H-ouabain in subcellular fractions of rat testes and site of gossypol action were reported.The radioactivity of 14C in rat testicular mitochondria was the highest among 5 subcellular fraction and 2-3 times higher than that in the other four subcellular fractions, being highly significant. Double labelling experiments also demonstrated that distribution of radioactive 14C and 3H in mitochondria being the highest.These findings...

Observations on the distribution of 14C-gossypol and double labelled 14C-gossypol and 3H-ouabain in subcellular fractions of rat testes and site of gossypol action were reported.The radioactivity of 14C in rat testicular mitochondria was the highest among 5 subcellular fraction and 2-3 times higher than that in the other four subcellular fractions, being highly significant. Double labelling experiments also demonstrated that distribution of radioactive 14C and 3H in mitochondria being the highest.These findings presented further evidences in supporting the postulate that the mitochondrial protein being readily bound to uncoupling substances in intact mitochondria and suggested that mitochondria might be the target cellular organelle served as an acting site of gossypol in interrupting sper-matogenesis.The relationship between the binding of mitochondrial protein with gossypol and the critical site of gossypol action was discussed.

~(14)C-棉酚在大鼠睾丸五种亚细胞组分中,以线粒体中含量最高,放射活性较其他组分高2~3倍,差别显著。~(14)C-棉酚和~3H-哇巴因双标记实验也表明,双标记的放射活性高峰均集中于线粒体,其次为细胞膜。这二种细胞组分的~(14)C和~3H放射活性均分别较其他组分高,差异显著。这有力地支持线粒体蛋白质容易与解偶联物质结合的论点,并为线粒体是棉酚的敏感靶子细胞器以及棉酚通过干扰线粒体功能而中断精子发生过程的假说提供了直接证据。

 
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