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  靶点
    Research on Target and Mechanism of Death of Hepatocellular Carcinoma Cells Induced with Nano-Hydroxyapatite
    纳米羟基磷灰石诱导肝癌细胞死亡的作用靶点及机理研究
短句来源
    The Histological and Pathological Effect and the Study on the Molecular Target of the Inhibition of Celecoxib Combinated with Octreotide on the Growth and Metastasis of Human Gastric Cancer
    塞来昔布联合奥曲肽抑制人体胃癌生长和转移的组织病理反应及分子靶点研究
短句来源
    Experimental Study of New Anti-apoptotic Protein hPEBP4 as a Potential Therapeutic Target for Human Prostate Cancer
    新型抗凋亡分子hPEBP4作为人前列腺癌治疗靶点的实验研究
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    The Precision and Accuracy Analysis of Target Position in X Ray Stereotactic Radiotherapy
    X线立体定向治疗靶点位置精确度分析
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    Survivin may be a new target for breast carcinoma therapy.
    survivin有望成为乳腺癌治疗的一个新靶点
短句来源
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  靶向
    Target Inhibition of eIF4E Expression in Laryngeal Carcinoma by 10-23 Deoxyribozyme
    酶性DNA靶向切割喉癌eIF4E基因促进喉癌细胞凋亡及抑制其增殖的实验研究
短句来源
    Study on Target Therapy of Leukemia by Anti-VEGF
    抗VEGF靶向治疗白血病的研究
短句来源
    The New Candidiate Target Study of Molecular-targeted Therapy for Pancreatic Cancer
    胰腺癌靶向治疗新靶位的研究
短句来源
    ConclusionThe treatment with monoclonal antibody combined with 131-I can target the nuclei of the tumor cells, and then the radioiodine transported into tumor cells destroys them.
    结论单克隆抗体与131I交联后靶向于肿瘤细胞核,与瘤体特异性结合,并将其荷载的放射性核素输送到肿瘤细胞内,由内向外摧毁肿瘤。
短句来源
    Objective: To identify a functional monoclonal antibody 1E2 against lung cancer and its antigen, so as to provide a candidate antibody drug and molecule target for the anti-lung cancer therapy.
    目的:鉴定抑制肺癌细胞生长的功能性单克隆抗体1E2及其抗原,为治疗肺癌提供有潜力的靶向抗体治疗剂和分子靶位。
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  靶标
    Sperm protein 17: a novel target for tumor diagnosis and immunotherapy
    肿瘤诊断与免疫治疗的新靶标精子蛋白17
短句来源
    Experimental Study of Sperm Protein 17 as a Target for diagnosis and treatment of Gynecological Cancers
    精子蛋白17作为妇科肿瘤诊断治疗靶标的基础研究
    To evaluate the relationship between DNMTl overexpression and tumor malignant phenotype and discuss the significance with DNMTl as the target in tumor therapy, RNAi was applied to knockdown DNMT1 expression.
    本研究应用RNAi技术敲降肿瘤细胞中异常高表达的DNA甲基转移酶1(DNMT1),并观察肿瘤细胞恶性表型的变化,以期探讨DNMT1与抑癌基因异常甲基化等肿瘤恶性表型之间的关系,以及DNMT1在肿瘤发生发展中的作用,进而讨论以DNMT1作为RNAi治疗肿瘤靶标的应用前景。
短句来源
    Conclusion quantitation of mRNA of S100A4, S100A6 and S100P is a promising tool for diagnosis of pancreatic cancer, and that they may be a promising therapeutic target for pancreatic cancer.
    结论S100A4、S100A6、S100P可为胰腺癌诊断及基因治疗提供分子靶标,S100A4的检测在评价胰腺癌恶性程度和判断其预后等方面具有一定的临床价值。
短句来源
    Conclusion:Ang2gene palys an important role in the carcinogenesis and progression of gastric cancer,and it can be used as a target for the therapy of anti-angiogenesis in gastric cancer.
    结论:Ang2基因在胃癌的发生、发展中发挥重要作用,可用作胃癌抗血管治疗的靶标
短句来源
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  靶区
    Objective To determine the potential value of ~(18)FDG PET-CT on target volume defini- tion of metastatic lymph nodes in patients with advanced esophageal carcinoma.
    目的分析~(18)FDG PET-CT诊断食管癌淋巴结转移的优势及确定淋巴结放疗靶区的可行性。
短句来源
    In the sub-group of 3 patients with smaller GTVN defined by PET-CT than that by CT(GTVN-PET-CT<GTVN-CT),only one patient was found with a decreased clinical target volume(CTVN-PET-CT<CTVN-CT);
    PET-CT导致GTV缩小(GTVN-PET-CT<GTVN-CT)的3例共涉及3组淋巴结,其中1例临床靶区缩小(CTVN-PET-CT<CTVN-CT);
短句来源
    The acute and chronic toxicities and short-term efficacy of IMRT and conventional radiotherapy were compared. Results:All the 28 patients completed the full course of IMRT. The average dose delivered to the planning target volume(PTV)was 67.5 Gy,and 90% of iso-dose curve(median dose of 63.5 Gy)covered more than 99% gross tumor volume(GTV).
    结果:28例患者均完成全程IMRT,照射靶区内计划靶区体积(planning target volume,PTV)的平均剂量为67.5Gy,90%的等剂量曲线(中位剂量63.5Gy)可以覆盖99%以上的肉眼肿瘤靶区体积(gross tumor volume,GTV)。
短句来源
    The average conformation number was 0.98.The average dose of internal carotid artery spinal cord trachea and mandible in target volume is 3492.5±138.6cGy 344.3±36.2cGy 3487.3±126.3cGy and 2262.4±164.2cGy.
    15例病人组织间近距离治疗靶区内颈内动脉平均剂量3492.5±138.6cGy,脊髓平均剂量344.3±36.2cGy,气管平均剂量3487.3±126.3cCy,颌骨平均剂量2262.4±164.2cGy。
    The Effect of CT Scans Slice Thickness on Gross Target Volume in CT Simulation
    CT模拟定位中扫描层厚对肿瘤靶区体积的影响
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      target
    Its absolute value (|A(u)|) measures the correlation between the signal u emitted by the radar transmitter and its echo after reaching a moving target.
          
    As the main application it is shown that, in general, a localization operator possesses the Fredholm property, and thus its range is closed in the target space.
          
    Such an estimate is both more representative of the target region and reduces the estimation variance when compared to estimates formed by any single bandlimited window.
          
    These findings provide compelling evidence that DNA is the ultimate target of these drugs that act on the human genome.
          
    CHEMICAL GENOMICS FOR FASTAND INTEGRATED TARGET IDENTIFICATION AND LEAD OPTIMIZATION
          
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    In this article, we investigated the effect of PHA and radiation, seperately or in combination, on the expression of LDH isoenzymes on rat thymus and lympho node cells. We found that the PHA of apropriate dosage was unable to raise the LDHS of lymphocytes nor the proportion of total M-type enzymes -After thfe irradiation with 250 rads from a 60Co source, lymphocytes showed a prominent decrease of LDH1 and an increase of LDH5. The differance waa very significant. The subgroup analysis showed that the; main effect...

    In this article, we investigated the effect of PHA and radiation, seperately or in combination, on the expression of LDH isoenzymes on rat thymus and lympho node cells. We found that the PHA of apropriate dosage was unable to raise the LDHS of lymphocytes nor the proportion of total M-type enzymes -After thfe irradiation with 250 rads from a 60Co source, lymphocytes showed a prominent decrease of LDH1 and an increase of LDH5. The differance waa very significant. The subgroup analysis showed that the; main effect of radiation was to depress the proportion of H type enzyme. The PHA in large dosage could obviously prevent the decrease in lymphocytes irradiated, though not change its LDH isoenzymes composition and spectrum distribution. It is suggested that the biological effect of radiation on lymphocytes might be affected by the functionary state of'target cells. On the other hand, our works may be valuable for further studies on the relation between the extrinsic stimuli and the functionary state of immunopotential cells.

    本文把PHA和电离辐射两种因子,在单独和合并应用的条件下,观察了它们对大鼠胸腺和淋巴结细胞LDH同功酶表达所带来的影响。发现PHA在适宜剂量下,使T细胞LDH_5比例增高。但高剂量PHA对淋巴细胞的LDH_5或总的M型酶的比例均无明显影响。在经250rad~(50)Coγ射线照射后,淋巴细胞表现为LDH_1下降和LDH_5增高,但以LDH_1的下降最为突出,差别非常显著。从亚基分析来看,电离辐射主要使H型酶的比例下降。高剂量PHA虽未见改变正常淋巴细胞的LDH同功酶的组成与谱带分布,但具有明显地防止辐射所引起的LDH_1或H型酶显著下降和LDH_5或M型酶增高的作用。它提示辐射对淋巴细胞的生物效应,受到细胞所处功能状态的影响。这对进一步研究外界刺激的作用与免疫潜能细胞功能状态之间的关系,也有一定参考价值。

    The human macrophage cytotoxicity in vitro was observed by inverted microscope with photographical arrangement and time-lapse cinemicrography.This observation revealed dramatic changes in both effectors and target cells. The macrophage cytotoxicity, tumor cell killing, should go through the tumout cell-macrophage membrane contact. The in vitro cytotoxicity of macrophages from patients with stomach cancer, benign stomach diseases and normal adults were studied and different degrees of cytotxicity effect...

    The human macrophage cytotoxicity in vitro was observed by inverted microscope with photographical arrangement and time-lapse cinemicrography.This observation revealed dramatic changes in both effectors and target cells. The macrophage cytotoxicity, tumor cell killing, should go through the tumout cell-macrophage membrane contact. The in vitro cytotoxicity of macrophages from patients with stomach cancer, benign stomach diseases and normal adults were studied and different degrees of cytotxicity effect observed. It was found that pre-cultivation of macrophages from stomach cancer patients still had cytotoxicic effects on gastric carcinoma cell line. In cultivation of macrophages from stomach cancer patients, the cell-free exudate had no influence on the target cells.The experimental results are discussed.

    本文应用了附有摄影装置的倒置显微镜与缩时定格显微电影摄影观察了人巨噬细胞体外细胞毒作用。这观察发现了效应细胞与靶细胞之间戏剧性的变化:巨噬细胞细胞毒对肿瘤细胞的杀伤必须通过这两种细胞的膜接触这一步骤。本实验分别观察了胃癌患者、良性胃疾患患者以及正常人的巨噬细胞体外细胞毒作用,发现这些细胞毒作用有强弱程度的不同。实验还发现胃癌患者的巨噬细胞经预培养后对胃癌细胞株仍有细胞毒作用。还看到胃癌患者巨噬细胞培养上清液不影响靶细胞的生长。本文最后对实验观察的结果进行了讨论。

    The role of inbred LACA mouseperitoneal macrophages against tumorand effect of thymic peptide (TP)on the macrophage tumoricidal acti-vity in vitro and in vivo were studied. Macrophage cytolytic and cytos-tatic activities were measured by an18-hr ~(51)Cr-release assay and a 24-hrtritiated-thymidine incorporation in-hibition assay respectively.Sarcoma180 (S180) was used as target cell.Macrophages were also tested for anti-tumor activity in vivo by injecting amixture of peritoneal macrophages andS180 cells...

    The role of inbred LACA mouseperitoneal macrophages against tumorand effect of thymic peptide (TP)on the macrophage tumoricidal acti-vity in vitro and in vivo were studied. Macrophage cytolytic and cytos-tatic activities were measured by an18-hr ~(51)Cr-release assay and a 24-hrtritiated-thymidine incorporation in-hibition assay respectively.Sarcoma180 (S180) was used as target cell.Macrophages were also tested for anti-tumor activity in vivo by injecting amixture of peritoneal macrophages andS180 cells into normal LACA micesubcutaneously.It was found that re-sident macrophages of normal and tu-mor-bearing mice possessed both cyto-lytic and cytostatic activities whichwere nonspecific in nature.Targetcell killing by macrophages wasstrongly influenced by effector to targetcell ratio (E:T);a low concentrationof macrophages (E:T<5:1) augment-ed S180 cell proliferation.Adminis-tration of TP together with cyclopho-sphamide (CY) to tumor-bearing micewas able to overcome the suppressioninduced by CT on macrophage.Invivo experiments showed that macrophages from tumor-bearing mice,rather than those from normal mice,were capable of prolonging mean sur-vival time (MST) and increasingsurvival rate of tumor-bearing miceat E:T of 5:1.At E:T of 2.5:1,macrophages from TP-treated tumor-bearing mice prolonged MST significantly,but those from untreated tumor-bearing mice failed to do so.TPcould not enhance cytotoxic activityof resident macrophages after in vitroincubation for 24hrs while ConAconditioned medium could.It ap-pears that TP,a immunomodulatingagent,affects to some extent the anti-tumor activity of macrophage indirect-ly.

    用~(51)Gr释放、~3H-TdR掺入抑制及混合接种等方法观察了LACA纯系小鼠腹腔巨噬细胞体内体外对于S180肿瘤细胞的细胞毒效应以及胸腺肽对此作用的影响。结果表明,正常鼠和带瘤鼠的巨噬细胞在体外均可抑制或杀伤肿瘤细胞,E/T比例影响这一效应,E/T比例<5:1时巨噬细胞促进S180细胞的体外增殖。与单独应用环磷酰胺相比较,胸腺肽与环磷酰胺合用可增强巨噬细胞的细胞毒功能。正常鼠的巨噬细胞在体内混合接种实验中无作用,带瘤鼠的巨噬细胞在E/T比例为5:1时可延长生存期,提高存活率;而经胸腺肽处理的带瘤鼠的巨噬细胞在E/T比例为2.5:1时即可延长生存期。胸腺肽体外不能直接激活巨噬细胞,而Con A条件培液则具有这一功能。提示胸腺肽可通过一间接途径对带瘤鼠的巨噬细胞的抗瘤功能表现某种程度的调节作用。

     
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