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sodium dichloroacetate
相关语句
  二氯乙酸钠
     Determination of Sodium Dichloroacetate in Serum of Rabbit by Ion-Pair RP-HPLC
     反相离子对色谱法测定兔血清中二氯乙酸钠的浓度
短句来源
     Determination of concentration of sodium dichloroacetate in serum of rabbits
     家兔血清中二氯乙酸钠浓度的测定
短句来源
     Determination of Sodium Dichloroacetate in Serum of Rabbits
     高效液相色谱法测定血清中二氯乙酸钠的浓度
短句来源
     Objective:To establish the method of determination of concentration of sodium dichloroacetate in serum of rabbits.
     目的:建立用反相离子对色谱法测定家兔血清中游离二氯乙酸钠( D C A Na)浓度的方法。
短句来源
  “sodium dichloroacetate”译为未确定词的双语例句
     Determination of serum sodium dichloroacetate content in rabbits us-ing ultraviolet spectrophotometry
     紫外分光光度法测定兔血清中二氯乙酸钠浓度
短句来源
     Experimental Studies on the Effects of Sodium Dichloroacetate on Brain Lactic Acid Levels in Lobal Ischmic Rats
     二氯醋酸钠对大鼠缺血性脑乳酸含量影响的实验研究
短句来源
     ULTRASTRUCTURAL OBSERVATIONS OF THE PROTECTIVE EFFECT OF SODIUM DICHLOROACETATE ON CEREBRAL CORTICAL NEURONS IN ISCHEMIC RATS
     二氯醋酸钠在保护急性缺血性大鼠脑的超微结构观察
短句来源
     This experimental study showed the great increase of concentration of brain lactic acid after global ischemia for 30 minute followed by lh or 2h reperfusion(P<0.00l),and the apparent lowering effect of sodium dichloroacetate(DCA) on brain lactate concentration when treatment either before or after ischemia with 25 mg(P<0. 00l) in the blobal ischemic model induced by 4一vesseloc clusion。
     本研究结果发现大鼠前脑完全性缺血30分钟,分别再灌注1小时和2小时后,脑乳酸均明显高于对照组(P<0.001)。 而无论缺血前或后应用二氯醋酸钠25mg/kg后,均可显著降低不同灌流期的脑乳酸含量(P<0.001)。
短句来源
     The objective of this experiment was to observe the influence of sodium dichloroacetate on cerebral cor-tical neurons ultrastructural changes in different periods of reperfusion.
     本实验旨在研究二氯醋酸钠对大鼠前脑完全性缺血不同灌流期脑皮层神经无超微结构的影响。
短句来源
  相似匹配句对
     Determination of Sodium Dichloroacetate in Serum of Rabbits
     高效液相色谱法测定血清中二氯乙酸钠的浓度
短句来源
     Determination of concentration of sodium dichloroacetate in serum of rabbits
     家兔血清中二氯乙酸钠浓度的测定
短句来源
     Sulbenicillin Sodium
     磺苄青霉素钠
短句来源
     sodium citrate;
     柠檬酸钠;
短句来源
     Dichloroacetate has the effect of antiapoptosis.
     DCA对缺氧复氧损伤引起的肥大心肌细胞凋亡有抑制作用。
短句来源
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  sodium dichloroacetate
The activity of PDHC to sodium dichloroacetate (DCA), known as the activator of PDHC, was also examined.
      
Beneficial effect of sodium dichloroacetate in muscle cytochrome C oxidase deficiency
      
The metabolic effects of sodium dichloroacetate in the suckling newborn rat
      
His symptoms resolved after treatment with oral sodium dichloroacetate, which lowered his lactate levels.
      


The authors determined serum sodium dichloroacetate(DCA-Na)content in rabbits using ultravio-let,spectrophotometry with a wavelength of 265 nm.The mean recovery rate was 101.4%,the intra-day and inter-day cv was 3.3% and 3.8%,respectively,and minimal detectable level was 1 mg/L.Pharmacokinetic study on DCA-Na was carried out in rabbits receiving a single intravenous injection of DCA-Na (180 mg/kg).The changes in serum DCA-Na concentration were best described by a 1-compartment open model using PKBP-N1...

The authors determined serum sodium dichloroacetate(DCA-Na)content in rabbits using ultravio-let,spectrophotometry with a wavelength of 265 nm.The mean recovery rate was 101.4%,the intra-day and inter-day cv was 3.3% and 3.8%,respectively,and minimal detectable level was 1 mg/L.Pharmacokinetic study on DCA-Na was carried out in rabbits receiving a single intravenous injection of DCA-Na (180 mg/kg).The changes in serum DCA-Na concentration were best described by a 1-compartment open model using PKBP-N1 program.The main parameters obtained were as follows:T1/2 0.67 h,Vd0.28 L/kg,Cl0.31 L/ kg/h and AUC 605.1mg·h/L.

作者建立检测二氯乙酸钠血清浓度的紫外分光光度法,平均回收率为101.4%,日内变异为3.3%,日间变异为3.8%,最低检测浓度为1mg/L.应用本法研究二氯乙酸钠(iv,180mg/kg)在兔体内的药代动力学,主要药代动力学参数为:T1/2=0.67h,Vd=0.28L/kg,K=1.1h-1,Cl=0.31L/kg/h,AUC=605.1mg·h/L.

Pharmacokinetic study on intravenously administered sodium dichloroacetate(DCA-Na)was car-ried out in rabbits using reversed-phase ion-pair high performance liquid chromatography.The changes inDCA-Na serum concentration of each group were best described as one-compartment open model.In the iv180 mg/kg group,T1/2 was 0.67 h,Cl 0.31 L/(kg·h)and Vd 0.28 L/kg.The main parameters of infusion(inf)50,100 and 200 mg/kg groups showed no significant difference,the mean values being T1/2 0.71 h,Vd0.44 L/kg and Cl...

Pharmacokinetic study on intravenously administered sodium dichloroacetate(DCA-Na)was car-ried out in rabbits using reversed-phase ion-pair high performance liquid chromatography.The changes inDCA-Na serum concentration of each group were best described as one-compartment open model.In the iv180 mg/kg group,T1/2 was 0.67 h,Cl 0.31 L/(kg·h)and Vd 0.28 L/kg.The main parameters of infusion(inf)50,100 and 200 mg/kg groups showed no significant difference,the mean values being T1/2 0.71 h,Vd0.44 L/kg and Cl 0.42 L/(kg·h).However,in the inf 300 mg/kg group,parameters such as T1/2 1.01 hand Cl 0.30 L/(kg·h) were significantly different from those of other inf groups,suggesting that DCA-Namight have a nonlinear pharmacokinetic process.Serum protein binding rate of DCA-Na measured by ultrafil-tration was lower than 38%.

作者用反相离子对高效液相色谱法研究二氯乙酸钠(DCA-Na)在兔体内的药物动力学.静脉给药各组的血清中DCA-Na浓度的变化均符合一室开放模型.ivDCA-Na180mg/kg组:T1/20.67h,Cl0.31L/(kg·h),Vd0.28L/kg.静脉输注(inf)50,100和200mg/kg组间的主要药动学参数无显著差异,均值为T1/20.71,Vd0.44L/kg,Cl0.42L/(kg·h).inf300mg/kg组的T1/21.01h,Cl0.30L/(kg·h),明显不同于其它inf组,提示DCA-Na可能存在非线性药物动力学.超滤法研究其血清蛋白结合率低于38%.

An ion-pair RP-HPLC method was established for the determination of sodium dichloroacetate (DCA- Na) in rabbit serum. The derivative of DCA-Na was produced through reacting DCA-Na with hydrazine hydrate in basic solution (100℃) . The PH was adjusted to 2~3. The mobile phase consisted of a mixture of H_2O-CH_3OH-IPR-B_8 (64 :34 :2 PH=3. 0) . The analytical column was Zorbax ODS (4. 6mm×250mm 5μm) . The derivative of DCA-Na was detected at 265nm and sensitivity of 0. 04 AUFS, recovery was 98. 0± 3.6%.The...

An ion-pair RP-HPLC method was established for the determination of sodium dichloroacetate (DCA- Na) in rabbit serum. The derivative of DCA-Na was produced through reacting DCA-Na with hydrazine hydrate in basic solution (100℃) . The PH was adjusted to 2~3. The mobile phase consisted of a mixture of H_2O-CH_3OH-IPR-B_8 (64 :34 :2 PH=3. 0) . The analytical column was Zorbax ODS (4. 6mm×250mm 5μm) . The derivative of DCA-Na was detected at 265nm and sensitivity of 0. 04 AUFS, recovery was 98. 0± 3.6%.The RSD's of within-day and day-to-day were less than 5.0%. The method has been applied to pharmacokinetics study.

建立了反相离子对色谱法测定兔血清中二氯乙酸钠含量的方法。DCA-Na在碱性条件下加热与水合肼定量生成稳定且有较强吸收系数的腙,以离子对色谱试剂IPR-B_8为对离子,在ZorbaxODS(4.6mm×250mm)柱上,以水-甲醇-IPR-B_8(64:34:2,V/V)为流动相得到较好的分离,灵敏度0.04AUFS,在265nm处测定,衍生物线性范围在0.6~50.0μg/ml,r=0.9994,平均回收率为98.0±3.6%,日内及日间精密度RSD分别为2.6%和3.3%。以本法测定了DCA-Na在兔体内的血药浓度及药代动力学参数。

 
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