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retinoic acid     
相关语句
  维甲酸
     Effective of Growth Inhibition and Apoptosis Induction by Retinoic Acid Combined with Adriamycin or Interferon on Transitional Cell Carcinoma of Bladder
     维甲酸联合阿霉素、干扰素对膀胱癌生长抑制和凋亡诱导作用研究
短句来源
     The Embryonic Processes and the Expression of the RAR and Hox Gene in Rat Fetuses with Anorectal Malformations Induced by Retinoic Acid
     维甲酸诱导大鼠肛门直肠畸形模型演变规律、RAR及Hox基因表达的研究
短句来源
     The Experiment Research of the Restrain Effects of Retinoic Acid and Its Alginate Sodium Microspheres on Proliferation
     维甲酸及其海藻酸钠微球抗增殖作用的实验研究
短句来源
     The Experimental Study of after Cataract Inhibition by All=trans Retinoic Acid
     全反式维甲酸抑制后发性白内障的实验研究
短句来源
     The Study of Apoptosis Induced by All-Trans Retinoic Acid in Rat C6 Glioma.
     全反式维甲酸诱导大鼠C6脑胶质瘤凋亡的实验研究
短句来源
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  视黄酸
     Effects of Retinoic Acid on Secretion of Apolipoproteins AⅠ, AⅡ, B100, CⅢ and E by Cultured HepG2 C ells
     视黄酸对培养的HepG2细胞分泌载脂蛋白AⅠ、AⅡ、B100、CⅢ及E的影响
短句来源
     The proliferation of SMMC-7721 human hepatocarcinoma cell line was significantly inhibited by the treatment of 10 μmol/L retinoic acid (RA, all trans) .
     SMMC-7721人肝癌细胞株在10μmol/L的视黄酸(又称维甲酸,Retinoic Acid,RA)处理后,增殖明显受到抑制。
短句来源
     Retinoic Acid Induces Expression of c-fos, c-jun and GM-CSF mRNA in Murine Marrow Stromal Cells
     视黄酸诱导小鼠骨髓基质细胞c-fos,c-jun和GM-CSF mRNA表达
短句来源
     In addition, retinoic acid increased the protein level of p16 (218.75%, P <0.05) and induced p21 protein expression;
     同时,视黄酸增高p16蛋白水平(218.75%, P<0.05),促进p21蛋白表达;
短句来源
     Apoptosis of MCF-7 cells induced by retinoic acid and fusion gene of Fas/RARα
     视黄酸依赖Fas/RARα融合基因诱导MCF-7细胞凋亡的分子机制研究
短句来源
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  维a酸
     Retinoic acid at concentrations of 1,5,10,20μg/mL and elemene at 20,40,60,80μg/mL could induce apoptosis of cultured Colo 16 keratinocytes in vitro.
     浓度为1、5、10、20μg/mL的维A酸和浓度为20、40、60、80μg/mL的榄香烯可促进人角质形成细胞株Colo 16细胞凋亡。
短句来源
     Objective To study the value of fluorescence in situ hybridization (FISH) in detecting retinoic acid receptor alpha (RARα) rearrangement for the diagnosis of acute promyelocytic leukemia (APL).
     目的:研究荧光原位杂交(fluorescence in situhybridization,FISH)检测维A酸受体α(RARα)基因重排对于急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)的诊断价值。
短句来源
     The cumulative irritative index was significantly lower in Group G than that in Group B treated with0.1%retinoic acid(Diweishuang誖)(0.59±0.24),or in0.025%retinoic acid(Diweishuang誖)(0.41±0.22),or in0.05%retinoic acid(VITAMIN誖Cream)(0.25±0.22).
     累积刺激作用最大的0.1%维A酸霜组为0.59±0.24,2组比较差异有显著性(P<0.001)。 0.1%阿达帕林凝胶的累积刺激指数还明显小于0.025%维A酸霜组(0.41±0.22)和0.05%维A酸霜组(0.25±0.22)。
短句来源
     Objective To investigate the effects of all-trans retinoic acid (ATRA), acitretin and tazarotene on apoptosis and Bax/Bcl-2 protein expressions of human melanoma A375 cells.
     目的探讨全反式维A酸(ATRA)、阿维A及他扎罗汀对人黑色素瘤细胞A375凋亡及Bax/Bcl-2蛋白表达的影响及其意义。
短句来源
     Influence of suppressor gene p16 on retinoic acid inducing lung cancer cell A549 differentiation
     抑癌基因p16对维A酸诱导肺癌细胞分化作用的影响
短句来源
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  维生素a酸
     The Differentiation of Human Gastric Adenocarcinoma Cell Line MGc 80-3 Induced by Retinoic Acid (RA) in Vitro
     维生素A酸(RA)诱导人胃腺癌细胞系MGc 80-3分化
     THE DIFFERENTIATION OF HUMAN GASTRIC ADENOCARCINOMA CELL LINE MGc 80-3 INDUCED BY RETINOIC ACID
     维生素A酸对人胃腺癌MGc 80-3细胞的诱导分化
     EXPRESSION OF RETINOIC ACID RECEPTOR γ GENE IN ES CELLS AND ITS EFFECT ON THEIR DIFFERENTIATION AND APOPTOSIS
     维生素A酸受体γ基因表达及其对ES细胞分化和凋亡的影响
短句来源
     OBSERVATION ON ULTRASTRUCTURAL CHANGES IN F9 MOUSE EMBRYONAL CARCINOMA CELLS DURING RETINOIC ACID INDUCED DIFFERENTIATION
     维生素A酸诱导小鼠F9胚胎性癌细胞分化的超微结构观察
短句来源
     Respiratory burst function of the differentiating HL-60 cells induced by retinoic acid
     维生素A酸诱导分化的人早幼粒白血病细胞系HL-60的呼吸爆发功能
短句来源
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  retinoic acid
Retinoic acid, the most commonly used inducer of differentiation of the embryonic stem cells, induces different types of differentiation when applied at different concentrations.
      
Injection of RXR, PPAR-α, or PPAR-γ agonists-9-cis-retinoic acid (5 mg/kg), bezafibrate (10 mg/kg), or rosiglitazone (10 mg/kg), respectively-30 min before zymosan or LPS injection led to significant decrease of lipid synthesis.
      
Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line.
      
Effects of Juvenoids and Retinoic Acid on Development of Larvae and Nymphs in the Tick Ixodes ricinus L.
      
Similar effects were also described for retinoic acid.
      
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Effects of nine retinoids on carinogenesis of the forestomach in mice were studied. RⅠ, RⅡ, RⅢ, RⅥ, and RⅧ showed significaut inhibitory effect. RⅠ[N-(4-ethoxycarbophenyl) Retinanide] appeared to be the most effective, reproducible and has not been reported in the literature. No toxic effect was observed with therapeutic dose of RⅠ, and no sign of hypervitaminosis A was noticed with dosage as high as 6 times the therapeutic dose. However hypervitamnosis A was induced with retinoic acid at the some dose....

Effects of nine retinoids on carinogenesis of the forestomach in mice were studied. RⅠ, RⅡ, RⅢ, RⅥ, and RⅧ showed significaut inhibitory effect. RⅠ[N-(4-ethoxycarbophenyl) Retinanide] appeared to be the most effective, reproducible and has not been reported in the literature. No toxic effect was observed with therapeutic dose of RⅠ, and no sign of hypervitaminosis A was noticed with dosage as high as 6 times the therapeutic dose. However hypervitamnosis A was induced with retinoic acid at the some dose. The toxiciity of RⅡ appeared to the much less than that of retinoic acid.Autoradiography using H~3-thymidine showed marked inhibitory effect of RⅡ on DNA synthesis in the forestomach epithelium of mice.

本文报道9种维生素甲酸衍生物对小鼠前胃上皮癌变的影响,其中有抑制作用的有:RⅠ、RⅡ、RⅢ、RⅥ及RⅧ,尤以RⅠ[N-(4-乙氧羰基苯基)维甲酰胺][N-(4-Ethoxycarbophenyl)Retinamide]抑制上皮癌变作用明显,并可重复,文献上未见报道。RⅠ在治疗剂量下(1.1×10~(-4)M/kg)未出现毒性,六倍于治疗剂量,亦未见高维生素甲症,而相应剂量的维甲酸,引起明显的高维生素甲症,RⅠ毒性远较维甲酸小。用氚—胸腺嘧啶核苷放射自显影方法,观察到RⅡ对小鼠前胃上皮细胞DNA合成有明显的抑制作用。

In search of agents for tumor prevention, attempt to improve the biological activity of the parent compound, retinoic acid, was carried out by preparing its esters and amides through which the physical and chemical properties and pharmacodynamics might be changed. Twenty-seven retinoic acid esters and retinamides were prepared by treating the corresponding amine and alcohol with retinyl chloride which was obtained from retinoic acid and phosphorous trichloride. Animal tests of part of the compounds...

In search of agents for tumor prevention, attempt to improve the biological activity of the parent compound, retinoic acid, was carried out by preparing its esters and amides through which the physical and chemical properties and pharmacodynamics might be changed. Twenty-seven retinoic acid esters and retinamides were prepared by treating the corresponding amine and alcohol with retinyl chloride which was obtained from retinoic acid and phosphorous trichloride. Animal tests of part of the compounds reported in this paper showed that some of them exhibited preventive activity against carcinogenic action of nitrososarcosine among which compound (1), N-(4-ethoxycarbophenyl) retinamide showed higher activity and lower toxicity.

为寻找防癌药物,从改变维甲酸的结构、物化性质,以改变在体内的运转、分布和生物活性,达到提高疗效,降低毒性的目的,而合成了27个维甲酸酯和酰胺衍生物。部分化合物已进行预防致癌实验。结果证明,有些化合物有效,其中维甲酰(4-乙氧羰基苯胺)(1)的效果较好,毒性低,可能是一个有希望的防癌化合物。

Using chick embryo metatarsal skin organ culture, the biological activities of 8 kinds of new retinoids were tested. The results of investigation of 684 samples were reported. RI ( N-4-ethoxycarbophenyl-retinamide ) was a retinoid derivative, which showed a higher inhibitory rate on carcino-genesis in vivo and a marked inhibition on keratosis in vitro. It showed that this method was highly sensitive, with high reproducibility and easy to perform. Comparative studies on inhibitory effects of RI, retinoic acid,...

Using chick embryo metatarsal skin organ culture, the biological activities of 8 kinds of new retinoids were tested. The results of investigation of 684 samples were reported. RI ( N-4-ethoxycarbophenyl-retinamide ) was a retinoid derivative, which showed a higher inhibitory rate on carcino-genesis in vivo and a marked inhibition on keratosis in vitro. It showed that this method was highly sensitive, with high reproducibility and easy to perform. Comparative studies on inhibitory effects of RI, retinoic acid, and natural retinol showed that the effect of RI was higher than retinol and lower than retinoic acid. Photo-degradation of retinoids was different. After exposing to light for 1 hour the biological activity of RI decreased, but not that of RII and RVIII.

用13天龄鸡胚脚掌皮肤体外培养,测定8种新维甲酸衍生物的活性发现。RⅠ(N-(4-乙氧羰基苯基)维甲酰胺)在体内对上皮癌变的抑制率最高,在体外抑制角化率亦最强。本方法简便、灵敏、重复性强,是一种较好的初筛方法。RⅠ抑制角化率的作用较天然维甲醇高,而低于维甲酸。RⅠ光解后活性降低。RⅡ和RⅧ光照1小时不受影响。

 
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