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administration
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  给药
    Studies on a New Ophthalmic Route of Administration System with Puerarin
    葛根素眼用新型给药系统的研究
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    After the last administration,blood samples were taken after 30 min,1 h,1.5 h,2 h and 3 h of medication respectively to cultivate T lymphocytes which were taken from M group.
    并分别于第10次给药后30 min、1 h、1.5 h、2 h、3 h取血,分离得试验血清;
短句来源
    ③At 24 hours after the last administration, the external iliac vein blood was sampled to observe the contents of HA, PCⅢ, LN and Hyp in the blood serum.
    ③末次给药后24h,髂外静脉取血,测定血清透明质酸、Ⅲ型前胶原、层粘连蛋白及羟脯氨酸水平。
短句来源
    30min after the administration of medicine to duodenum,the mean heart rate had a significant improvement compared with the control group,and maintained to 120min of the observation period.
    十二指肠给药30min后,平均心率较对照组有明显的提高,并维持至120min观察期。
短句来源
    The duration of administration was 4 weeks, and the weight of mice was measured weekly. After the last administration of the medicines, the serum levels of ALT and AST were measured, the liver index was calculated, and the GSH-PX, GST, and MDA of the liver were measured.
    连续给药4周,每周测1次体重,末次给药后检测血清AST、ALT水平,计算肝脏指数,测定肝脏谷胱甘肽过氧化物酶(GSH-PX)、还原型谷胱甘肽(GST)和丙二醛(MDA)。
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  “administration”译为未确定词的双语例句
    EFFECTIVENESS OF INTRAGASTRIC ADMINISTRATION OF 8102 FOR REMOVAL OF THORIUM-234 IN RATS
    口服络合剂8102对~(234)Th的促排效果
短句来源
    Exhancement of IL--2 Production of Spleen Cells and IL-2 Activity in Aged Mice by Astragalan Administration
    黄芪多糖对老年小鼠脾细胞产生IL-2及IL-2反应性的增强作用
短句来源
    After administration at the doses of 0.25,0.50,1.00 g·kg-1,ip,for 7d in tumor-bearing mice with S180,The extract caused 26.9 %,45.3 %,64.6 % inhibition rates,respectively.
    海蟑螂提取物腹腔注射0.25,0.50,1.00 g. kg-1共7d,对S180的抑瘤率分别为26.9%,45.3%和64.6%。
短句来源
    With the administration of Ganoderma spore,HIF-1α and VEGF were down-regulated at E21 hippocampus and were not detected at P30 hippocampus.
    应用灵芝孢子后,E21海马HIF-1α和VEGF低水平表达,在P30时则未见表达。
短句来源
    Due to study the influence of capsicum fruit and ginseng on the ability of swimming and endurance to hypoxia in mice, the Kunming mice was used as materials. The test was carried out by oral administration of the extract of capsicum (1 g/mL,0.6 g/mL, 0.2 g/mL) and ginseng (1 g/mL) in Kunming mice for 30 days, and the amount of oral administration was 0.2 mL per 10 g bodyweight.
    为探讨辣椒提取液和人参提取液对小白鼠游泳耐力及耐缺氧能力的影响,以小白鼠为试验动物,每d分别采用辣椒提取液(1g/mL,0.6g/mL,0.2g/mL)和人参提取液(1g/mL)进行灌胃30d,灌胃量为0.2mL/10g体重。
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  administration
Overall the pharmacokinetic properties of both isomers were similar in rats, monkeys and humans, with β-isomer exhibiting longer elimination half-life, MRT, volume of distribution and clearance, irrespective of the route of administration.
      
5-FU-PT was given to rats by oral administration at a dosage of 22.5?mg kg-1.
      
In some organs (apart from kidneys, intestinal system, and stomach) the uptake of 99mTc-AA was not significantly affected by the administration of 99mTc with CPR or 99mTc with APAP at 120?min.
      
The administration of 99mTc-AA with PPA in rats caused an increase of the uptake of 99mTc-AA at 120?min in the investigated organs compared to the administration of 99mTc-AA alone.
      
From these data, it may be deduced that the administration of high concentration of 18-methyl norethindrone can displace ketoprofen from its secondary binding site.
      
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1.Twenty-two agents were tested in vitro, and four of them also in vivo for their antituber- culous activity. 2.Ginkgolic.acid,the active principle of ginkgo fruit against tubercle bacilli,was found to exist only in the fleshy part(endocarp)of the fruit.The tuberculostatic action of ginkgolic acid in vitro was not influenced by heating,but the presence of serum raised the minimal effec- tive concentration from 1:400,000 to 1:1000.The results of in vivo tests failed to demonstrate any effect of the different...

1.Twenty-two agents were tested in vitro, and four of them also in vivo for their antituber- culous activity. 2.Ginkgolic.acid,the active principle of ginkgo fruit against tubercle bacilli,was found to exist only in the fleshy part(endocarp)of the fruit.The tuberculostatic action of ginkgolic acid in vitro was not influenced by heating,but the presence of serum raised the minimal effec- tive concentration from 1:400,000 to 1:1000.The results of in vivo tests failed to demonstrate any effect of the different parts of ginkgo fruit in- cluding ginkgolic acid on the experimental tuber- culosis of mice.No apparent difference was found between the activity of ginkgo fruit with or without previous preparation with vegetable oil. 3.(?)In vitro,garlic exhibited rather weak tuberculostatic action,which decreased slightly in thè presence of serum.The in vitro effect of the winter garlic was better than that of the spring one.No curative effect was exerted by garlic on the experimental tuberculosis of mice. 4.The minimal tuberculostatic concentra- tion of berberine in vitro was found to be around 1:4000,and the èffect slightly decreased in the presence of serum.The development of experi- mental tuberculosis of mice was delayed by the administration of berberine sulfate in daily oral doses of 1.5—2.5 gm./kg. 5.There was definite curative effect of stepharanthine on the experimental tuberculosis of mice in daily doses of 200 mg./kg.;significant toxicity appeared,however,at that dosage level. 6.No significant tuberculostatic effect in vitro was found among other crude drugs. 7.“Hei pao”was ineffective in vitro,while citrinin was definitely effective and its minimal tuberculostatic concentration determined as 1:20.000. 8.Amon synthetic compounds tested,the in vitro tuberculostatic potency of an isomer of PAS was only one-hundredth of that of sodium para- amino-salicylate.The tuberculostatic effects of four sulfones were not satisfactory.The minimal tuberculostatic concentration in vitro of syn- thotic compound Ⅵ was 1:200,000. 9.It was found that the effectlve ranges of the concentration and dosage of thiosemicarba- sone in viro and in vivo were very broad,and the lower margins were comparable with those of isonicotinyl hydrazine.These facts may explain the elinieal effectiveness of thiosemicarbazone used in small doses.

1.在玻器内试验了22种药物,在动物体内试验了四种药物的抗结核杆菌作用。2.白果的抗结核杆菌有效成分(白果酸)仅存在于白果果浆中。白果酸在玻器内的抗菌作用不受加热的影响;但血清能使其最低有效浓度从1:400,000跃至1:1000。白果各部分及白果酸对小鼠的实验结核症并无肯定的疗效。油浸过的白果与未浸过的作用并无显著不同。3.大蒜在玻器内具有较弱的抗结核杆菌作用,遇血清则效力略减;冬季大蒜比春季大蒜的效力高。对小鼠的实验结核症并无疗效。4.黄连硷在玻器内的最低抑制结核杆菌浓度是1:4000左右,遇血清则效力略减。每日食入硫酸黄连硷约1.5—2.5克/公斤时,可以延缓小鼠实验结核症的发展。5.使他肺安定每日200毫克/公斤时,对小鼠实验结核症有肯定的疗效,但已表现相当大的毒性。香豆素在玻器内当浓度为1:2000时有部分抗结核杆菌作用。6.其他生药中,仅韭菜及青蒜在修改的都氏培养基中具有微弱的抗结核杆菌能力,但在尤氏培养基中无效。7.海宝在玻器内无效,橘霉素的最低制菌浓度是1:20,000。8.所试的化学合成品中,对氨水杨酸的同质异构物的抗结核杆菌作用仅为对氨水杨酸钠的1/100。砜类化合物的抗结核杆菌作用很微弱...

1.在玻器内试验了22种药物,在动物体内试验了四种药物的抗结核杆菌作用。2.白果的抗结核杆菌有效成分(白果酸)仅存在于白果果浆中。白果酸在玻器内的抗菌作用不受加热的影响;但血清能使其最低有效浓度从1:400,000跃至1:1000。白果各部分及白果酸对小鼠的实验结核症并无肯定的疗效。油浸过的白果与未浸过的作用并无显著不同。3.大蒜在玻器内具有较弱的抗结核杆菌作用,遇血清则效力略减;冬季大蒜比春季大蒜的效力高。对小鼠的实验结核症并无疗效。4.黄连硷在玻器内的最低抑制结核杆菌浓度是1:4000左右,遇血清则效力略减。每日食入硫酸黄连硷约1.5—2.5克/公斤时,可以延缓小鼠实验结核症的发展。5.使他肺安定每日200毫克/公斤时,对小鼠实验结核症有肯定的疗效,但已表现相当大的毒性。香豆素在玻器内当浓度为1:2000时有部分抗结核杆菌作用。6.其他生药中,仅韭菜及青蒜在修改的都氏培养基中具有微弱的抗结核杆菌能力,但在尤氏培养基中无效。7.海宝在玻器内无效,橘霉素的最低制菌浓度是1:20,000。8.所试的化学合成品中,对氨水杨酸的同质异构物的抗结核杆菌作用仅为对氨水杨酸钠的1/100。砜类化合物的抗结核杆菌作用很微弱。合成品〔Ⅵ〕的最低制菌浓度是1:200,000。9.硫脲胺的部分制菌浓度范围和其对小鼠实验结核症有效剂量的范围都很广,可以追及异烟肼的水平,这可解释临床上其剂量很小,但仍能生效的原因。

Intravenous injection of the aqueous extract of Salsola collina produced marked and prolonged hypotensive effect in anaesthetized dogs. Repeated administrations showed no marked tachyphylaxis. The drug had no influence on the hypotensive action of acetylcholine and the depressor response induced by electric stimulation of the peripheral end of vagus nerve. Its hypotensive effect was not blocked by previous administration of atropine, but reduced to some extent in vagotomized animals. Hence it had no effect...

Intravenous injection of the aqueous extract of Salsola collina produced marked and prolonged hypotensive effect in anaesthetized dogs. Repeated administrations showed no marked tachyphylaxis. The drug had no influence on the hypotensive action of acetylcholine and the depressor response induced by electric stimulation of the peripheral end of vagus nerve. Its hypotensive effect was not blocked by previous administration of atropine, but reduced to some extent in vagotomized animals. Hence it had no effect on the M-cholinergic system. It did not reveal any adrenolytic and ganglion-blocking action. During the period of hypotension, the pressor responses induced by serial occlusions of common carotid arteries and electric stimulation of the central end of sciatic nerve were inhibited or eliminated. The hypotensive effect was not influenced by bilateral section of the sinus nerves. Besides, the drug gave a reflex vasodilating effect in perfused isolated rabbit's ear with the innervation intact. Therefore it is suggested that the hypotensive mechanism was mainly due to an inhibition of the vasomotor centre or the central sympathetic structure. The aquaeous extract of Salsola collina exhibited a pronounced sedative action. It reduced the spontaneous activity, prolonged the pentobarbital induced sleeping time and potentiated the effect of nonsleeping doses of chloral hydrate to induce sleeping, but had no effect on the convulsion and death caused by strychnine and metrazol. In mice, by the method of motor defense conditioned reflex, subcutaneous injection of Salsola collina 3g/kg had no marked influence on the conditioned reflexes. When the doses were raised to 5, 10g/kg, it prolonged the latency of conditioned reflexes, partly abolished the conditioned reflexes, but did not alter the differentiation. At the dosage of 20g/kg, this effect was more pronounced. In subcutaneous doses of 5, 10g/kg, it accelerated the disappearance of positive conditioned reactions. In mice the acute LD_(50) by the subcutaneous route was found to be 56g/kg.

猪毛菜浸膏对麻醉动物有明显持久降压作用,无明显快速耐受現象。猪毛菜对乙酰胆碱及刺激迷走神經离中端所致降压作用无影响,阿託品不阻断猪毛菜的降压作用。双側迷走神經切断后,猪毛菜降压作用略減弱。猪毛菜不阻断頸上交感神經传导,亦无明显抗腎上腺素作用。猪毛菜抑制因压迫頸总动脉及刺激坐骨神經向中端所致的升压反射,二側竇神經切除亦不影响其降压作用。在猪毛菜引起降压作用时,带神經离体兔耳血管反射性扩张,因此推测猪毛菜对血管运动中枢或交感中枢有抑制作用。猪毛菜5,10克/公斤皮下注射能显著减少小白鼠自由活动。20克/公斤延长戊巴比妥鈉(35毫克/公斤)催眠作用的时間,并使非催眠剂量的水合氯醛(200毫克/公斤)产生催眠作用。但不能对抗中枢惊厥药(戊四氮及士的宁)的惊厥及致死作用。在小白鼠防御运动条件反射实驗中,皮下注射猪毛菜3克/公斤,对条件反射活动无明显影响。5克/公斤,10克/公斤时能使条件反射时延长,強化次数增加,分化相无变化。20克/公斤时条件反射显著抑制。5,10克/公斤皮下注射均能加速阳性条件反射消褪过程。小白鼠皮下注射猪毛菜LD_(50)为56克/公斤,大白鼠腹腔注射8克/公斤卽死亡。家兔口服(灌胃)40克/公斤...

猪毛菜浸膏对麻醉动物有明显持久降压作用,无明显快速耐受現象。猪毛菜对乙酰胆碱及刺激迷走神經离中端所致降压作用无影响,阿託品不阻断猪毛菜的降压作用。双側迷走神經切断后,猪毛菜降压作用略減弱。猪毛菜不阻断頸上交感神經传导,亦无明显抗腎上腺素作用。猪毛菜抑制因压迫頸总动脉及刺激坐骨神經向中端所致的升压反射,二側竇神經切除亦不影响其降压作用。在猪毛菜引起降压作用时,带神經离体兔耳血管反射性扩张,因此推测猪毛菜对血管运动中枢或交感中枢有抑制作用。猪毛菜5,10克/公斤皮下注射能显著减少小白鼠自由活动。20克/公斤延长戊巴比妥鈉(35毫克/公斤)催眠作用的时間,并使非催眠剂量的水合氯醛(200毫克/公斤)产生催眠作用。但不能对抗中枢惊厥药(戊四氮及士的宁)的惊厥及致死作用。在小白鼠防御运动条件反射实驗中,皮下注射猪毛菜3克/公斤,对条件反射活动无明显影响。5克/公斤,10克/公斤时能使条件反射时延长,強化次数增加,分化相无变化。20克/公斤时条件反射显著抑制。5,10克/公斤皮下注射均能加速阳性条件反射消褪过程。小白鼠皮下注射猪毛菜LD_(50)为56克/公斤,大白鼠腹腔注射8克/公斤卽死亡。家兔口服(灌胃)40克/公斤未見毒性反应,80克/公斤时可見死亡。

The LD_(50) in mice was found to be 19.4 g/kg and 0.98±0.075 g/kg respectively for the infusion and crude extract of Chou-wu-tung, given by intravenous injections. The subacute toxicity is negligible when the infusion was crally administered to rats (0.25—2.5 g/kg/day) for 60 days, except that some animals showed quietness, slight fall of systolic pressure and soft stool. No apparent toxic effects were observed. A crude extract and infusion of Chou-wu-tung, when injected intravenously at respective dosages...

The LD_(50) in mice was found to be 19.4 g/kg and 0.98±0.075 g/kg respectively for the infusion and crude extract of Chou-wu-tung, given by intravenous injections. The subacute toxicity is negligible when the infusion was crally administered to rats (0.25—2.5 g/kg/day) for 60 days, except that some animals showed quietness, slight fall of systolic pressure and soft stool. No apparent toxic effects were observed. A crude extract and infusion of Chou-wu-tung, when injected intravenously at respective dosages of 50—100 mg/kg and 150 mg/kg, produced primary and secondary falls of blood pressure on anaesthetized rats and dogs, but with intramuscular injection or oral administration, only the secondary fall of blood pressure was apparent. This hypotensive effect might last for 2—3 hours. Intravenous injection of the decoction to anaesthetized animals produced only primary fall of blood pressure, the infusions of alcohol, ether and ,chloroform, given by the same route, did not lower the blood pressure. Twenty-eight renal hypertensive rats were divided into three groups, the first (11 rats) and the second (7 rats) groups were treated with the infusion at respective dosages of 0.5 g/kg/day and 5 g/kg/day, and the third (10 rats) with the crude extract at 50 mg/kg/day. The drug was given to all the rats for 2 weeks by oral administration. Hypotensive effect was observed in 3—10 days after medication, and became more remarkable in the second week of the therapeutic period or the first week after cessation of medication; the blood pressure dropped 57.4%. The blood pressure in most rats returned in 2 weeks, and in some rats in 2—4 days or 4 weeks after the stopping of medication.

1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给肾型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压作用可达原值...

1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给肾型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压作用可达原值的57.4%。多数高血压大鼠的血压在停药后的第二周恢复,少数在停药的2—4天或4周后恢复。

 
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