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administration
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  给药
    TERATOGENIC EFFECTS OF ROUTES OFDIFFERENT ADMINISTRATION OF 2-N, N-BIS (HYDROXYMETHYL)AMINO-1, 3, 4-THIADIAZOLE (BIS-HM-A-TDA)ON PREGNANT RATS AND DETOXICATION OF NICOTINAMIDE (NA) AND NICOTINIC ACID (NIA)
    2-N.N-双(羟甲基氨基)-1.3.4-噻二唑不同给药途径处理对妊娠大白鼠的致畸效应及菸酰胺和菸酸的解毒作用
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    PHARMACOKINETICS OF AMIKACIN AFTER INTRATRACHEAL ADMINISTRATION IN TRACHEOTOMY PATIENTS
    气管切开病人丁胺卡那霉素气管内给药的药物动力学
短句来源
    Effects of Trichosanthin(TCS)on Serum Specific IgE and IgG Antibodies by Different Routes of Administration
    天花粉不同给药途径及加用地塞米松对血清特异性IgE和IgG抗体的影响
短句来源
    Studies on pharmacokinetics of pefloxacin by oral administration
    培氟沙星口服给药的药物动力学研究
短句来源
    Pharmacokinetics investigation of 5-fluorouracil after three routes of administration
    5-氟尿嘧啶三种给药途径和药代动力学
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  投药
    We have synthesized Hydroxypiperaquine Phosphate (HPQP) as a new antimalarial drug in 1971. Studies have shown that the drug has markedly therapeutic effects on experimental silicosis after administration to rats 100mg/kg by oral twice per week and the treatment was performed either in the earlier or later course of silicosis.
    磷酸羟基哌喹是我校研制的一种抗疟新药。 经对大鼠实验性矽肺治疗表明,按100mg/kg体重每周两次的剂量,于病程早期或晚期投药,均有显著的疗效。
短句来源
    Accord-ing to Eagl's theory and the serum cefatzidimeconcentration 7 hours after adminstration in 6 healthy volunteers most bacteria, evenstaphylococcus aureus, can be inhibited; so, the administration of 2g q 12 h. iv ofceftazidime is reasonable.
    根据投药后7h的血药浓度尚能抑制绝大多数的细菌(甚至金黄色葡萄球菌亦能被抑制)及Eagl氏的理论,作者认为每12h静脉投药2g是合理的.
短句来源
    Urine samples of 6 hours before and 6 hours after DMPS administration were collected and the urinary mercury levels were determined by cold vapor atomic absorption spectrophotometry,The results indicated that the mean urinary mercury levels in the five groups exposed to mercury were significantly higher than those of corresponding referent groups both before and after DMPS administration.
    分别收集投药前6小时和投药后6小时的全部尿样,用冷原子发生器原子吸收分光光度法测定尿汞含量。 结果显示5组接汞人群无论投药前或投药后,尿汞均值均明显地高于相应的对照组;
短句来源
    The administration of the DMPS provocation in five groups exposed to mercury resulted in 24,87,48,44 and 86-fold increase,respectively,of 6 hour urinary mercury compared with those during the 6 hour period before the administration of this chelating agent.
    5组接汞人群用药后尿汞排泄比投药前分别增加了24、87、48、44和86倍;
短句来源
    and proximal half of the results were exceed 8 μg/ml, when cephazoline administered 1.5gm iv. Q12hrs. Therefore, the principle of administration of such antibiotics must know well about the dose, times and limit properly.
    应用头孢唑啉钠1.5g静脉滴注,8h间隔血液谷浓度始终可维持在8μg/ml以上,12h间隔有近于半数超过8μg/ml,因此,两种用药间隔时间均可选用,但须考虑临床具体患者情况,老年人宜用等间隔投药,药量以每次1.5g为适宜。
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  “administration”译为未确定词的双语例句
    Study on Absorption of Hyaluronic Acid after Oral Administration and Its Mechanism
    透明质酸口服吸收及其机制的研究
短句来源
    STUDIES ON ANTIBILHARZIAL DRUGS ⅩⅪ.TOXICITY AND THERAPEUTIC ACTIVITY OF Sb-58,Sb-126 AND TWSb AND THE DISTRIBUTION AND EXCRETION OF ANTIMONY AFTER ADMINISTRATION OF THESE COMPOUNDS
    防治血吸虫病药物的研究 ⅩⅪ.Sb-58,Sb-126与 TWSb 的毒性、疗效及锑的分布和排泄
短句来源
    PREMATURITY OF HUMAN ENDOMETRIUM AFTER ORAL ADMINISTRATION OF PROGESTIN No.1 COMPOUND TABLET
    口服复方孕素1号片后人体子宫内膜的提早转化
短句来源
    THE EXPERIMENTAL TREATMENT FOR SODIUM CYANIDE INTOXICATION BY COMBINED ADMINISTRATION OF CHLORPROMAZINE, Co_2EDTA AND SODIUM THIOSUIFATE
    氯丙嗪、Co_2EDTA和硫代硫酸钠对氰化钠中毒的实验治疗
短句来源
    THE TREATMENT OF 292 CASES ACUTE PYOGENIC INFECTIONS BY INTRAVENOUS ADMINISTRATION OF MEDEMYCIN
    注射用麦迪霉素治疗急性感染性疾病292例的临床总结
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  administration
Overall the pharmacokinetic properties of both isomers were similar in rats, monkeys and humans, with β-isomer exhibiting longer elimination half-life, MRT, volume of distribution and clearance, irrespective of the route of administration.
      
5-FU-PT was given to rats by oral administration at a dosage of 22.5?mg kg-1.
      
In some organs (apart from kidneys, intestinal system, and stomach) the uptake of 99mTc-AA was not significantly affected by the administration of 99mTc with CPR or 99mTc with APAP at 120?min.
      
The administration of 99mTc-AA with PPA in rats caused an increase of the uptake of 99mTc-AA at 120?min in the investigated organs compared to the administration of 99mTc-AA alone.
      
From these data, it may be deduced that the administration of high concentration of 18-methyl norethindrone can displace ketoprofen from its secondary binding site.
      
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This work was done on six esophageal fistula dogs to observe the effect of sham feeding upon sugar tolerance. Sugar tolerance test was done by the intravenous administration of 40% glucose solution in dosage of 0.5 g/kg body weight.Approximately one minute was required for this injection.Venous blood for sugar determina- tion was taken from the fore legs just before the injection and also 15,30, 45,60,90 and 120 minutes after it.Sham feeding commenced immediately after the injection of glucose and lasted...

This work was done on six esophageal fistula dogs to observe the effect of sham feeding upon sugar tolerance. Sugar tolerance test was done by the intravenous administration of 40% glucose solution in dosage of 0.5 g/kg body weight.Approximately one minute was required for this injection.Venous blood for sugar determina- tion was taken from the fore legs just before the injection and also 15,30, 45,60,90 and 120 minutes after it.Sham feeding commenced immediately after the injection of glucose and lasted usually 14 minutes.The results were as follows: (1)It was observed on 6 dogs and in 15 experiments that the normal sugar tolerance curves (without sham feeding) were fairly uniform.The average peak value of blood sugar concentration in samples taken 15 minutes after glucose administration was 165 mg% and blood sugar concentration returned to the original level within 60—90 minutes. (2)A marked change of the sugar tolerance curves was observed after sham feeding.The average peak value of blood sugar concentration in samples taken 15 minutes after glucose administration was 138 mg % and blood sugar concentration returned to the original level 15—30 minutes sooner than that seen in the experiments without sham feeding. (3)The above experiments were repeated on two of the dogs after bilateral supradiaphragmatic vagotomy and on one dog after denervation of the pancreas.No effect upon sugar tolerance was observed after sham feeding. These results further verify our previous work that the excitation of the vago-insulin system can be brought about by sham feeding.

本工作用具有食道瘘的狗,观察假饲对糖耐量的影响并分析其机制。糖耐量测验的方法系由静脉注入40%葡萄糖溶液0.5克/千克体重。在注射前以及从注射葡萄糖时开始,每隔15、30、45、60、90及120分钟,分别由静脉取血,分析血糖浓度。假饲是在注射葡萄糖后立即开始的,假饲时间一般为14分钟。实验结果如下:(一)正常糖耐量曲线(不进行假饲)一般是相当恒定的。由静脉注射葡萄糖后15分钟,血糖浓度平均为165毫克%,并且一般在注射后60—90分钟内血糖浓度即恢复至注射前的水平。(二)当由静脉注射葡萄糖后立即进行假饲,结果使正常糖耐量显著增加,也就是使正常糖耐量曲线呈显著的减退性变化:血糖浓度在注射后的15分钟时,平均最高仅达138毫克%,并且在注射后45—60分钟内血糖浓度即恢复至原有水平。(三)当切断膈上的两侧迷走神经或切除胰腺的一切外来神经后,重复以上实验,结果假饲对糖耐量并无影响。因此,本工作更较明确地证明:假饲的进食动作确能唤起中枢神经系统的兴奋,通过迷走神经反射地引起胰岛素的分泌。

Solutions of potassium antimony tartrate and sodium antimony gluconate were given per os to infected rabbits.Although their oral dosages were,respectively,9 and 4 times as much as their intravenous ones,the therapeutic results of the oral groups were far inferior to those of intrave- nous groups,while the animal mortalities of the former decidely higher than those of the later. In similar doses,one preparation (kindly supplied to us by Hsing Hwa)of the enteric tablets of potas- sium antimony tartrate was tried...

Solutions of potassium antimony tartrate and sodium antimony gluconate were given per os to infected rabbits.Although their oral dosages were,respectively,9 and 4 times as much as their intravenous ones,the therapeutic results of the oral groups were far inferior to those of intrave- nous groups,while the animal mortalities of the former decidely higher than those of the later. In similar doses,one preparation (kindly supplied to us by Hsing Hwa)of the enteric tablets of potas- sium antimony tartrate was tried and found to be useless,in view of its great potentialities the oral route of administration for antimony com- pounds is worth further and more intensive inves- tigation.

应用酒石酸锑钾与葡萄精酸锑~(Ⅲ)钠溶液的经口给药法,试治家兎血吸虫病,确有相当疗效。口服剂量虽较注射剂量分别加至九倍与四倍,但其疗效仍远不如注射法给药各组,而动物死亡率反较高。延长治程而酌减每次口服剂量,经口给药与静脉给药适当结合,仍不能提高其安全性。所试的酒石酸锑钾肠溶片在相同剂量时完全无效。口服锑剂的进一步研究应在吸收控制与剂型改进两方面努力。

The LD_(50) of ammonium antimony gluconate (AAG) after intraperitoneal injection was 16.8mg/kg for mice fed on a diet containing 0.01% thyroxine, 166mg/kg for mice on a diet containing 0.1% propylthiouracil and 90mg/kg for control mice It is concluded that feeding mice with thyroxine for two weeks significantly increases the susceptibility of the mice to the acute toxicity of AAG, whereas propylthiouracil feeding increases the resistance of the mice. After intraperitoneal injection of Sb~(124)-labelled AAG to...

The LD_(50) of ammonium antimony gluconate (AAG) after intraperitoneal injection was 16.8mg/kg for mice fed on a diet containing 0.01% thyroxine, 166mg/kg for mice on a diet containing 0.1% propylthiouracil and 90mg/kg for control mice It is concluded that feeding mice with thyroxine for two weeks significantly increases the susceptibility of the mice to the acute toxicity of AAG, whereas propylthiouracil feeding increases the resistance of the mice. After intraperitoneal injection of Sb~(124)-labelled AAG to normal rats or rats fed thyroxine or propylthiouracil, high radioactivity levels were found in the liver and the gastrointestinal tract (including its contents), while the Sb~(124) levels in the kidney, thyroid, blood, spleen, lung and other tissues were very low. There seems to be no significant difference between the distribution patterns of radioactivity in tissues for the three groups of rats. The excretions of Sb~(124) for the three groups were also similar. It appears that the difference in toxicity of AAG between control rats and rats with altered thyroid function is not explicable by differences in the distribution and excretion of antimony after administration of AAG.

小鼠連續服用甲狀腺素兩週後,對銻銨急性毒性的敏感性顯著增加,而連續服用丙基硫氧嘧啶,則可增加對銻銨急性毒性的耐受性。腹腔注射銻銨於甲狀腺機能亢進狀態,甲狀腺機能不足及正常大鼠後,銻~(124)在组織中分佈的濃度均以肝及胃腸道为最高,腎臟次之,在甲狀腺中的濃度均很低。腹腔注射銻”銨後,銻~(124)的排泄總量三组動物無明顯區别。因此,銻銨對甲狀腺機能亢進狀態,甲狀腺機能不足及正常小鼠毒性的不同,似並非由於注射銻銨後,銻的分佈和排泄不同所致。

 
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