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drug loading
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  载药量
     y=0.277+0.350X1-2.013E-04X3+9.079E-02X4-0.162X5,R=0.953(drug loading).
     y=0.277+0.350X1-2.013E-04X3+9.079E-02X4-0.162X5,r=0.953(载药量)。
短句来源
     Results The diameter of the Gelatin microspheres was in the range of 48~100μm,and the average diameter was 70.70±11.29μm,and the drug loading was 35%.
     结果制备的微球粒径范围为48~100μm,平均粒径为70.70±11.29μm,载药量为35%。
短句来源
     RESULTS: The average diameter of the optimized microcapsules were(14.25±3.52)μm, the drug loading and entrapment efficiency (6.81±0.04)% and (74.13±0.56)%(n=3) respectively.
     结果:优化处方所得载药微囊粒径为(14.25±3.52)μm,载药量为(6.81±0.04)%,包封率为(74.13±0.56)%(n=3)。
短句来源
     The mean diameter of the mitomycin C polybutylcyanoacrylate nanoparticles for injection freshly prepared by emulsion polymerization technique was (106.8±7.2)nm, the average encapsulation efficiency was (92.1 ±2.3)%, drug loading was (7.3±0.2)%.
     采用乳化聚合法新鲜制备的注射用丝裂霉素C聚氰基丙烯酸正丁酯纳米粒平均粒径为(106.8±7.2)nm,平均包封率(92.1±2.3)%,载药量(7.3±0.2)%。
短句来源
     Results The diameter distribution of RES-LIP and RES-GLIP was (100.5±40.2)nm and (80.4±42.3)nm respectively; drug loading was 19.81% and 19.11% respectively,and entrapment efficiency was 96.52% and 95.87% respectively.
     结果RES-LIP和RES-GLIP的粒径分别为(100.5±40.2)nm和(80.4±42.3)nm,载药量分别为19.81%和19.11%,包封率分别为96.52%和95.87%。
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  载药
     RESULTS: The average diameter of the optimized microcapsules were(14.25±3.52)μm, the drug loading and entrapment efficiency (6.81±0.04)% and (74.13±0.56)%(n=3) respectively.
     结果:优化处方所得载药微囊粒径为(14.25±3.52)μm,载药量为(6.81±0.04)%,包封率为(74.13±0.56)%(n=3)。
短句来源
     Thirdly, the drug loading and leasing ratio of P(NIPAm-co-AAm) and PAAc/P(NIPAm-co-AAm) gels was studied.
     研究了组分配比对P(NIPAm-co-AAm)和PAAc/P(NIPAm-co-AAm)凝胶的载药和释药率的影响。
短句来源
     The drug loading was 4.86% w/w.
     平均载药率为4.86% w/w;
短句来源
     The drug loading content was 37.8% and the entrapment efficiency was 77.8%.
     载药粒子粒径为83.3±4.3nm,载药量为37.8%,包封率为77.8%。
短句来源
     The results showed that NPs had smooth external morphology,the average size was approximately 191.0±0.202nm, and the drug loading was 8.2%.
     结果显示载药毫微球表面光滑 ,平均粒径为 191.0± 0 .2 0 2nm ,其载药率为 8.2 % ,药物利用率为2 4 .6 %。
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  “drug loading”译为未确定词的双语例句
     Drug loading of the system is 35mg/L.
     (3)有效药物含量可显著提高至35mg/L ;
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     The mean diameter of the productwith drug loading of 182μg/ml stored at 25℃ protected from light for 120d was (12.8±0.7)nm.
     按优化处方制备的SLN粒径随药物含量增加而略有增大,含量为182μg/ml的SLN25℃避光放置120d,平均粒径为(12.8±0.7)nm。
短句来源
     The drug loading efficiency and encapsulation rate of the substance P nanoparticles was(0.06±0.036)10~(-3)% and(66.28±3.56)% respectively.
     包封率为(66.28±3.56)%。
短句来源
     Results Microspheres obtained from both methods were well spherical. For the microspheres made by the phase separation method,the average size from different PLGA ranged from 22 to 31μm,with drug loading from 42 to 61μg·mg~ -1 and incorporation efficiency 21%~31%.
     结果两种方法所得微球球形较好,相分离法制得的卡铂-PLGA微球,平均粒径为22~31μm,含药量为42~61μg·mg-1、包封率21%~31%;
短句来源
     The size of the two kind of microspheres was about 3.5~6.5 μm and 0 6~2.8 μm respectively. The drug loading was about 10.86% and 8.52% respectively. 5_Fu release from microspheres B was sustained in phosphate buffer solution(pH 7 4) and it was ruled by Higuchi equation.
     研究了微球的一些基本特征 ,包括微球大小、形态与表面状态 ,结果表明微球A及微球B粒径主要分布在 3.5~ 6 .5μm和 0 .6~ 2 8μm范围内 ,药物含量分别为 10 .86 %和 8.52 % ,体外释放实验表明 ,在 pH7.4磷酸盐缓冲溶液中 ,微球B具有显著的缓释作用 ,其释放特征符合Higuchi方程。
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  drug loading
Both entrapment efficiency and release were affected by the technique of preparation, core and coat types, core to coat ratio and drug loading.
      
The release of drug, however, depends on a balance between the levels of drug, talc, and polymer, whereby desired dissolution and mechanical properties could be controlled by the talc/polymer ratio and the level of drug loading.
      
The prepared beads were evaluated for percent drug loading, drug entrapment efficiency, image, surface topography, buoyancy, and in vitro release.
      
The drug loading value for microparticles was found to be in the range of 37.21% to 87.90%.
      
Drug release rate showed an order of negatively charged >amp;gt; neutral >amp;gt; positively charged liposomes, which is the reverse of the data of drug loading efficiency.
      
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The evaluate of mutagenicity and cytotoxicity on control release drug-load carrier--biodegredable polymer polylactide (PLA) and polylactide-co-glycolide-(PLGA) was determined by micronucleus test, Ames test and cytotoxicity test,

本文以小鼠微核试验,Ames试验及细胞毒性试验对缓释型避孕药载体—生物降解型高分子化合物聚乳酸(PLA)及乳酸-乙醇酸共聚物(RLGA)进行突变性及细胞毒性的评价。PLA和PLGA各处理剂量组及对照组经90天处理后,在不同时间收获细胞,其淋巴细胞微核率均在0-0.3‰范围内,骨髓微核率也在0.8-1.2‰之间,对照组与处理组之间无显著差异。在PLA和PLGA合成中起催化作用的锌酸亚锡经Ames试验测定,不同浓度的锌酸亚锡的回变菌落数均与自发回变无显著差异。细胞毒性试验PLA和PLGA的反应指标为R=%。结果表明,以上各指标均为阴性,表明PLA及PLGA自身在所测试的剂量范围内不具有致突和细胞毒性。

he prepartion technology of mitoxantrone polybutylcyanoacrylate nanospheres(DHAQ-PBCA-NS)was optimized bysingle factor optimization and even design method.The optimum preparation conditions and technology were simple,and might be used in factory. The embedding ratio of DHAQ-PBCA-NS was 84%,and drug loading was 51%. The average diameter ofDHAQ-PBCA-NS 55.11±10.3nm.

采用单因素试验法初选,均匀设计方案精选的方法,优选了制备米托蒽醌聚氰基丙烯酸正丁酯毫微球的优化条件和工艺。使其制备工艺快速、简单,适于工业化生产。制得的米托蒽醌毫微球包封率为84%,载药量为51%,平均球径为55.11±10.13nm。

The advantages of erythrocyte as a new carrier of drug delivery system are reviewed.Technology of encapsulating drugs into erythrocytes,mechanism of drug release,survival characteristics of drug loaded erythrocyte in vivo research done in related fields,as well as some cases in clinical and pharmaceutical application are introduced. Meanwhile,problems met in research of this new carrier are discussed.

对红细胞作为给药系统载体的载药原理,药物包蔽技术,释药机理,体内生存期以及在医药领域中的试验性应用等,作了简要介绍,最后还就该新型载体研究中存在的问题进行了讨论。

 
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